CASP3 (caspase 3)

2003-08-01  

Identity

HGNC
LOCATION
4q35.1
LOCUSID
ALIAS
CPP32,CPP32B,SCA-1

Other Information

Locus ID:

NCBI: 836
MIM: 600636
HGNC: 1504
Ensembl: ENSG00000164305

Variants:

dbSNP: 836
ClinVar: 836
TCGA: ENSG00000164305
COSMIC: CASP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164305ENST00000308394P42574
ENSG00000164305ENST00000393585A8MVM1
ENSG00000164305ENST00000393588A8MVM1
ENSG00000164305ENST00000447121C9JXR7
ENSG00000164305ENST00000517513A8MVM1
ENSG00000164305ENST00000523916P42574

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
p53 signaling pathwayKEGGko04115
ApoptosisKEGGko04210
Natural killer cell mediated cytotoxicityKEGGko04650
Alzheimer's diseaseKEGGko05010
Amyotrophic lateral sclerosis (ALS)KEGGko05014
Huntington's diseaseKEGGko05016
Epithelial cell signaling in Helicobacter pylori infectionKEGGko05120
Colorectal cancerKEGGko05210
MAPK signaling pathwayKEGGhsa04010
p53 signaling pathwayKEGGhsa04115
ApoptosisKEGGhsa04210
Natural killer cell mediated cytotoxicityKEGGhsa04650
Alzheimer's diseaseKEGGhsa05010
Parkinson's diseaseKEGGhsa05012
Amyotrophic lateral sclerosis (ALS)KEGGhsa05014
Huntington's diseaseKEGGhsa05016
Epithelial cell signaling in Helicobacter pylori infectionKEGGhsa05120
Pathways in cancerKEGGhsa05200
Colorectal cancerKEGGhsa05210
Viral myocarditisKEGGhsa05416
AmoebiasisKEGGko05146
AmoebiasisKEGGhsa05146
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
PertussisKEGGko05133
PertussisKEGGhsa05133
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
LegionellosisKEGGko05134
LegionellosisKEGGhsa05134
Serotonergic synapseKEGGhsa04726
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Hepatitis BKEGGhsa05161
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
Apoptotic machineryKEGGhsa_M00685
Apoptotic machineryKEGGM00685
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
Cell death signalling via NRAGE, NRIF and NADEREACTOMER-HSA-204998
NADE modulates death signallingREACTOMER-HSA-205025
Signaling by HippoREACTOMER-HSA-2028269
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Caspase activation via extrinsic apoptotic signalling pathwayREACTOMER-HSA-5357769
Ligand-independent caspase activation via DCCREACTOMER-HSA-418889
Intrinsic Pathway for ApoptosisREACTOMER-HSA-109606
Apoptotic factor-mediated responseREACTOMER-HSA-111471
Cytochrome c-mediated apoptotic responseREACTOMER-HSA-111461
Activation of caspases through apoptosome-mediated cleavageREACTOMER-HSA-111459
SMAC-mediated apoptotic responseREACTOMER-HSA-111469
SMAC binds to IAPsREACTOMER-HSA-111463
SMAC-mediated dissociation of IAP:caspase complexesREACTOMER-HSA-111464
Apoptotic execution phaseREACTOMER-HSA-75153
Apoptotic cleavage of cellular proteinsREACTOMER-HSA-111465
Caspase-mediated cleavage of cytoskeletal proteinsREACTOMER-HSA-264870
Apoptotic cleavage of cell adhesion proteinsREACTOMER-HSA-351906
Apoptosis induced DNA fragmentationREACTOMER-HSA-140342
Activation of DNA fragmentation factorREACTOMER-HSA-211227
Stimulation of the cell death response by PAK-2p34REACTOMER-HSA-211736
AGE-RAGE signaling pathway in diabetic complicationsKEGGko04933
AGE-RAGE signaling pathway in diabetic complicationsKEGGhsa04933
Apoptosis - multiple speciesKEGGko04215
Apoptosis - multiple speciesKEGGhsa04215
Platinum drug resistanceKEGGko01524
Platinum drug resistanceKEGGhsa01524
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA26094CASP9GenePathwayassociated
PA448871celecoxibChemicalPathwayassociated22336956
PA95CCNB1GenePathwayassociated

References

Pubmed IDYearTitleCitations
128096032003Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal.226
284594302017Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin.156
187236802008Executioner caspase-3 and caspase-7 are functionally distinct proteases.155
245531402014A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3.132
124835362002Down-regulation of caspase 3 in breast cancer: a possible mechanism for chemoresistance.98
125158252003Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis.96
195496852009Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis.94
217245512011In vitro and in vivo selective antitumor activity of a novel orally bioavailable proteasome inhibitor MLN9708 against multiple myeloma cells.94
155645122004Overexpression of 7a, a protein specifically encoded by the severe acute respiratory syndrome coronavirus, induces apoptosis via a caspase-dependent pathway.92
169830892006Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis.91

Citation

Dessen P

CASP3 (caspase 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/920/casp3