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CASP3 (caspase 3)

Identity

Alias_namescaspase 3, apoptosis-related cysteine protease
caspase 3, apoptosis-related cysteine peptidase
Alias_symbol (synonym)CPP32
CPP32B
Yama
apopain
Other aliasSCA-1
HGNC (Hugo) CASP3
LocusID (NCBI) 836
Atlas_Id 920
Location 4q35.1  [Link to chromosome band 4q35]
Location_base_pair Starts at 185548850 and ends at 185570629 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CASP3   1504
Cards
Entrez_Gene (NCBI)CASP3  836  caspase 3
AliasesCPP32; CPP32B; SCA-1
GeneCards (Weizmann)CASP3
Ensembl hg19 (Hinxton)ENSG00000164305 [Gene_View]  chr4:185548850-185570629 [Contig_View]  CASP3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000164305 [Gene_View]  chr4:185548850-185570629 [Contig_View]  CASP3 [Vega]
ICGC DataPortalENSG00000164305
TCGA cBioPortalCASP3
AceView (NCBI)CASP3
Genatlas (Paris)CASP3
WikiGenes836
SOURCE (Princeton)CASP3
Genetics Home Reference (NIH)CASP3
Genomic and cartography
GoldenPath hg19 (UCSC)CASP3  -     chr4:185548850-185570629 -  4q35.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CASP3  -     4q35.1   [Description]    (hg38-Dec_2013)
EnsemblCASP3 - 4q35.1 [CytoView hg19]  CASP3 - 4q35.1 [CytoView hg38]
Mapping of homologs : NCBICASP3 [Mapview hg19]  CASP3 [Mapview hg38]
OMIM600636   
Gene and transcription
Genbank (Entrez)AJ413269 AK291337 AU127028 AU133051 BC016926
RefSeq transcript (Entrez)NM_004346 NM_032991
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)CASP3
Cluster EST : UnigeneHs.141125 [ NCBI ]
CGAP (NCI)Hs.141125
Alternative Splicing GalleryENSG00000164305
Gene ExpressionCASP3 [ NCBI-GEO ]   CASP3 [ EBI - ARRAY_EXPRESS ]   CASP3 [ SEEK ]   CASP3 [ MEM ]
Gene Expression Viewer (FireBrowse)CASP3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)836
GTEX Portal (Tissue expression)CASP3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP42574   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP42574  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP42574
Splice isoforms : SwissVarP42574
Catalytic activity : Enzyme3.4.22.56 [ Enzyme-Expasy ]   3.4.22.563.4.22.56 [ IntEnz-EBI ]   3.4.22.56 [ BRENDA ]   3.4.22.56 [ KEGG ]   
PhosPhoSitePlusP42574
Domaine pattern : Prosite (Expaxy)CASPASE_CYS (PS01122)    CASPASE_HIS (PS01121)    CASPASE_P10 (PS50207)    CASPASE_P20 (PS50208)   
Domains : Interpro (EBI)Caspase-like_dom    Caspase_3    Caspase_cys_AS    Caspase_his_AS    Pept_C14_p10    Pept_C14_p20    Pept_C14A_HD   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)CASc (SM00115)  
Conserved Domain (NCBI)CASP3
DMDM Disease mutations836
Blocks (Seattle)CASP3
PDB (SRS)1CP3    1GFW    1I3O    1NME    1NMQ    1NMS    1PAU    1QX3    1RE1    1RHJ    1RHK    1RHM    1RHQ    1RHR    1RHU    2C1E    2C2K    2C2M    2C2O    2CDR    2CJX    2CJY    2CNK    2CNL    2CNN    2CNO    2DKO    2H5I    2H5J    2H65    2J30    2J31    2J32    2J33    2XYG    2XYH    2XYP    2XZD    2XZT    2Y0B    3DEH    3DEI    3DEJ    3DEK    3EDQ    3GJQ    3GJR    3GJS    3GJT    3H0E    3ITN    3KJF    3PCX    3PD0    3PD1    4DCJ    4DCO    4DCP    4EHA    4EHD    4EHF    4EHH    4EHK    4EHL    4EHN    4JJE    4JQY    4JQZ    4JR0    4PRY    4PS0    4QTX    4QTY    4QU0    4QU5    4QU8    4QU9    4QUA    4QUB    4QUD    4QUE    4QUG    4QUH    4QUI    4QUJ    4QUL   
PDB (PDBSum)1CP3    1GFW    1I3O    1NME    1NMQ    1NMS    1PAU    1QX3    1RE1    1RHJ    1RHK    1RHM    1RHQ    1RHR    1RHU    2C1E    2C2K    2C2M    2C2O    2CDR    2CJX    2CJY    2CNK    2CNL    2CNN    2CNO    2DKO    2H5I    2H5J    2H65    2J30    2J31    2J32    2J33    2XYG    2XYH    2XYP    2XZD    2XZT    2Y0B    3DEH    3DEI    3DEJ    3DEK    3EDQ    3GJQ    3GJR    3GJS    3GJT    3H0E    3ITN    3KJF    3PCX    3PD0    3PD1    4DCJ    4DCO    4DCP    4EHA    4EHD    4EHF    4EHH    4EHK    4EHL    4EHN    4JJE    4JQY    4JQZ    4JR0    4PRY    4PS0    4QTX    4QTY    4QU0    4QU5    4QU8    4QU9    4QUA    4QUB    4QUD    4QUE    4QUG    4QUH    4QUI    4QUJ    4QUL   
PDB (IMB)1CP3    1GFW    1I3O    1NME    1NMQ    1NMS    1PAU    1QX3    1RE1    1RHJ    1RHK    1RHM    1RHQ    1RHR    1RHU    2C1E    2C2K    2C2M    2C2O    2CDR    2CJX    2CJY    2CNK    2CNL    2CNN    2CNO    2DKO    2H5I    2H5J    2H65    2J30    2J31    2J32    2J33    2XYG    2XYH    2XYP    2XZD    2XZT    2Y0B    3DEH    3DEI    3DEJ    3DEK    3EDQ    3GJQ    3GJR    3GJS    3GJT    3H0E    3ITN    3KJF    3PCX    3PD0    3PD1    4DCJ    4DCO    4DCP    4EHA    4EHD    4EHF    4EHH    4EHK    4EHL    4EHN    4JJE    4JQY    4JQZ    4JR0    4PRY    4PS0    4QTX    4QTY    4QU0    4QU5    4QU8    4QU9    4QUA    4QUB    4QUD    4QUE    4QUG    4QUH    4QUI    4QUJ    4QUL   
PDB (RSDB)1CP3    1GFW    1I3O    1NME    1NMQ    1NMS    1PAU    1QX3    1RE1    1RHJ    1RHK    1RHM    1RHQ    1RHR    1RHU    2C1E    2C2K    2C2M    2C2O    2CDR    2CJX    2CJY    2CNK    2CNL    2CNN    2CNO    2DKO    2H5I    2H5J    2H65    2J30    2J31    2J32    2J33    2XYG    2XYH    2XYP    2XZD    2XZT    2Y0B    3DEH    3DEI    3DEJ    3DEK    3EDQ    3GJQ    3GJR    3GJS    3GJT    3H0E    3ITN    3KJF    3PCX    3PD0    3PD1    4DCJ    4DCO    4DCP    4EHA    4EHD    4EHF    4EHH    4EHK    4EHL    4EHN    4JJE    4JQY    4JQZ    4JR0    4PRY    4PS0    4QTX    4QTY    4QU0    4QU5    4QU8    4QU9    4QUA    4QUB    4QUD    4QUE    4QUG    4QUH    4QUI    4QUJ    4QUL   
Structural Biology KnowledgeBase1CP3    1GFW    1I3O    1NME    1NMQ    1NMS    1PAU    1QX3    1RE1    1RHJ    1RHK    1RHM    1RHQ    1RHR    1RHU    2C1E    2C2K    2C2M    2C2O    2CDR    2CJX    2CJY    2CNK    2CNL    2CNN    2CNO    2DKO    2H5I    2H5J    2H65    2J30    2J31    2J32    2J33    2XYG    2XYH    2XYP    2XZD    2XZT    2Y0B    3DEH    3DEI    3DEJ    3DEK    3EDQ    3GJQ    3GJR    3GJS    3GJT    3H0E    3ITN    3KJF    3PCX    3PD0    3PD1    4DCJ    4DCO    4DCP    4EHA    4EHD    4EHF    4EHH    4EHK    4EHL    4EHN    4JJE    4JQY    4JQZ    4JR0    4PRY    4PS0    4QTX    4QTY    4QU0    4QU5    4QU8    4QU9    4QUA    4QUB    4QUD    4QUE    4QUG    4QUH    4QUI    4QUJ    4QUL   
SCOP (Structural Classification of Proteins)1CP3    1GFW    1I3O    1NME    1NMQ    1NMS    1PAU    1QX3    1RE1    1RHJ    1RHK    1RHM    1RHQ    1RHR    1RHU    2C1E    2C2K    2C2M    2C2O    2CDR    2CJX    2CJY    2CNK    2CNL    2CNN    2CNO    2DKO    2H5I    2H5J    2H65    2J30    2J31    2J32    2J33    2XYG    2XYH    2XYP    2XZD    2XZT    2Y0B    3DEH    3DEI    3DEJ    3DEK    3EDQ    3GJQ    3GJR    3GJS    3GJT    3H0E    3ITN    3KJF    3PCX    3PD0    3PD1    4DCJ    4DCO    4DCP    4EHA    4EHD    4EHF    4EHH    4EHK    4EHL    4EHN    4JJE    4JQY    4JQZ    4JR0    4PRY    4PS0    4QTX    4QTY    4QU0    4QU5    4QU8    4QU9    4QUA    4QUB    4QUD    4QUE    4QUG    4QUH    4QUI    4QUJ    4QUL   
CATH (Classification of proteins structures)1CP3    1GFW    1I3O    1NME    1NMQ    1NMS    1PAU    1QX3    1RE1    1RHJ    1RHK    1RHM    1RHQ    1RHR    1RHU    2C1E    2C2K    2C2M    2C2O    2CDR    2CJX    2CJY    2CNK    2CNL    2CNN    2CNO    2DKO    2H5I    2H5J    2H65    2J30    2J31    2J32    2J33    2XYG    2XYH    2XYP    2XZD    2XZT    2Y0B    3DEH    3DEI    3DEJ    3DEK    3EDQ    3GJQ    3GJR    3GJS    3GJT    3H0E    3ITN    3KJF    3PCX    3PD0    3PD1    4DCJ    4DCO    4DCP    4EHA    4EHD    4EHF    4EHH    4EHK    4EHL    4EHN    4JJE    4JQY    4JQZ    4JR0    4PRY    4PS0    4QTX    4QTY    4QU0    4QU5    4QU8    4QU9    4QUA    4QUB    4QUD    4QUE    4QUG    4QUH    4QUI    4QUJ    4QUL   
SuperfamilyP42574
Human Protein AtlasENSG00000164305
Peptide AtlasP42574
HPRD02799
IPIIPI00292140   IPI00553172   IPI00798166   
Protein Interaction databases
DIP (DOE-UCLA)P42574
IntAct (EBI)P42574
FunCoupENSG00000164305
BioGRIDCASP3
STRING (EMBL)CASP3
ZODIACCASP3
Ontologies - Pathways
QuickGOP42574
Ontology : AmiGOresponse to hypoxia  B cell homeostasis  protease binding  aspartic-type endopeptidase activity  cysteine-type endopeptidase activity  cysteine-type endopeptidase activity  cyclin-dependent protein serine/threonine kinase inhibitor activity  death receptor binding  protein binding  nucleus  nucleoplasm  cytosol  cytosol  plasma membrane  apoptotic DNA fragmentation  proteolysis  apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  cellular component disassembly involved in execution phase of apoptosis  cellular response to DNA damage stimulus  heart development  sensory perception of sound  learning or memory  peptidase activity  activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c  cysteine-type endopeptidase activator activity involved in apoptotic process  response to UV  response to glucose  response to X-ray  phospholipase A2 activator activity  regulation of macroautophagy  hippocampus development  neuron differentiation  keratinocyte differentiation  erythrocyte differentiation  erythrocyte differentiation  platelet formation  negative regulation of B cell proliferation  death-inducing signaling complex  response to cobalt ion  response to estradiol  protein complex binding  response to lipopolysaccharide  glial cell apoptotic process  response to tumor necrosis factor  response to nicotine  hippo signaling  wound healing  response to drug  response to hydrogen peroxide  T cell homeostasis  negative regulation of apoptotic process  response to amino acid  positive regulation of neuron apoptotic process  membrane raft  cell fate commitment  negative regulation of cyclin-dependent protein serine/threonine kinase activity  negative regulation of activated T cell proliferation  response to antibiotic  neurotrophin TRK receptor signaling pathway  response to glucocorticoid  neuron apoptotic process  cellular response to organic cyclic compound  cysteine-type endopeptidase activity involved in apoptotic process  cysteine-type endopeptidase activity involved in apoptotic process  apoptotic signaling pathway  extrinsic apoptotic signaling pathway in absence of ligand  execution phase of apoptosis  execution phase of apoptosis  cysteine-type endopeptidase activity involved in execution phase of apoptosis  
Ontology : EGO-EBIresponse to hypoxia  B cell homeostasis  protease binding  aspartic-type endopeptidase activity  cysteine-type endopeptidase activity  cysteine-type endopeptidase activity  cyclin-dependent protein serine/threonine kinase inhibitor activity  death receptor binding  protein binding  nucleus  nucleoplasm  cytosol  cytosol  plasma membrane  apoptotic DNA fragmentation  proteolysis  apoptotic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  cellular component disassembly involved in execution phase of apoptosis  cellular response to DNA damage stimulus  heart development  sensory perception of sound  learning or memory  peptidase activity  activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c  cysteine-type endopeptidase activator activity involved in apoptotic process  response to UV  response to glucose  response to X-ray  phospholipase A2 activator activity  regulation of macroautophagy  hippocampus development  neuron differentiation  keratinocyte differentiation  erythrocyte differentiation  erythrocyte differentiation  platelet formation  negative regulation of B cell proliferation  death-inducing signaling complex  response to cobalt ion  response to estradiol  protein complex binding  response to lipopolysaccharide  glial cell apoptotic process  response to tumor necrosis factor  response to nicotine  hippo signaling  wound healing  response to drug  response to hydrogen peroxide  T cell homeostasis  negative regulation of apoptotic process  response to amino acid  positive regulation of neuron apoptotic process  membrane raft  cell fate commitment  negative regulation of cyclin-dependent protein serine/threonine kinase activity  negative regulation of activated T cell proliferation  response to antibiotic  neurotrophin TRK receptor signaling pathway  response to glucocorticoid  neuron apoptotic process  cellular response to organic cyclic compound  cysteine-type endopeptidase activity involved in apoptotic process  cysteine-type endopeptidase activity involved in apoptotic process  apoptotic signaling pathway  extrinsic apoptotic signaling pathway in absence of ligand  execution phase of apoptosis  execution phase of apoptosis  cysteine-type endopeptidase activity involved in execution phase of apoptosis  
Pathways : BIOCARTAApoptotic DNA fragmentation and tissue homeostasis [Genes]    FAS signaling pathway ( CD95 ) [Genes]    TNFR1 Signaling Pathway [Genes]    HIV-I Nef: negative effector of Fas and TNF [Genes]    D4-GDI Signaling Pathway [Genes]    TSP-1 Induced Apoptosis in Microvascular Endothelial Cell [Genes]    B Cell Survival Pathway [Genes]    Apoptotic Signaling in Response to DNA Damage [Genes]    Stress Induction of HSP Regulation [Genes]    Caspase Cascade in Apoptosis [Genes]    Induction of apoptosis through DR3 and DR4/5 Death Receptors [Genes]    Role of Mitochondria in Apoptotic Signaling [Genes]   
Pathways : KEGGMAPK signaling pathway    p53 signaling pathway    Apoptosis    Natural killer cell mediated cytotoxicity    TNF signaling pathway    Serotonergic synapse    Non-alcoholic fatty liver disease (NAFLD)    Alzheimer's disease    Parkinson's disease    Amyotrophic lateral sclerosis (ALS)    Huntington's disease    Epithelial cell signaling in Helicobacter pylori infection    Pertussis    Legionellosis    Toxoplasmosis    Amoebiasis    Tuberculosis    Hepatitis B    Herpes simplex infection    Pathways in cancer    Viral carcinogenesis    Proteoglycans in cancer    MicroRNAs in cancer    Colorectal cancer    Viral myocarditis   
NDEx NetworkCASP3
Atlas of Cancer Signalling NetworkCASP3
Wikipedia pathwaysCASP3
Orthology - Evolution
OrthoDB836
GeneTree (enSembl)ENSG00000164305
Phylogenetic Trees/Animal Genes : TreeFamCASP3
HOVERGENP42574
HOGENOMP42574
Homologs : HomoloGeneCASP3
Homology/Alignments : Family Browser (UCSC)CASP3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCASP3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CASP3
dbVarCASP3
ClinVarCASP3
1000_GenomesCASP3 
Exome Variant ServerCASP3
ExAC (Exome Aggregation Consortium)CASP3 (select the gene name)
Genetic variants : HAPMAP836
Genomic Variants (DGV)CASP3 [DGVbeta]
DECIPHER (Syndromes)4:185548850-185570629  ENSG00000164305
CONAN: Copy Number AnalysisCASP3 
Mutations
ICGC Data PortalCASP3 
TCGA Data PortalCASP3 
Broad Tumor PortalCASP3
OASIS PortalCASP3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCASP3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCASP3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CASP3
DgiDB (Drug Gene Interaction Database)CASP3
DoCM (Curated mutations)CASP3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CASP3 (select a term)
intoGenCASP3
Cancer3DCASP3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600636   
Orphanet
MedgenCASP3
Genetic Testing Registry CASP3
NextProtP42574 [Medical]
TSGene836
GENETestsCASP3
Huge Navigator CASP3 [HugePedia]
snp3D : Map Gene to Disease836
BioCentury BCIQCASP3
ClinGenCASP3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD836
Chemical/Pharm GKB GenePA26087
Clinical trialCASP3
Miscellaneous
canSAR (ICR)CASP3 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCASP3
EVEXCASP3
GoPubMedCASP3
iHOPCASP3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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