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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret jlhuret@AtlasGeneticsOncology.org
Donations are also welcome
If each casual visitor gives 3 Euros or Dollars, the Atlas is saved in a week !
If each professional gives 100 Euros or Dollars once a year (now), the Atlas is saved in 2 weeks !
Don't let the Atlas imminent demise
Note: we send fiscal receipts for donations equal or above 50 Euros or Dollars

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CASP4 (caspase 4, apoptosis-related cysteine peptidase)

Identity

Other namesICE(rel)II
ICEREL-II
ICH-2
Mih1/TX
TX
HGNC (Hugo) CASP4
LocusID (NCBI) 837
Location 11q22.3
Location_base_pair Starts at 104813594 and ends at 104839325 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CASP4   1505
Cards
Entrez_Gene (NCBI)CASP4  837  caspase 4, apoptosis-related cysteine peptidase
GeneCards (Weizmann)CASP4
Ensembl hg19 (Hinxton)ENSG00000196954 [Gene_View]  chr11:104813594-104839325 [Contig_View]  CASP4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000196954 [Gene_View]  chr11:104813594-104839325 [Contig_View]  CASP4 [Vega]
ICGC DataPortalENSG00000196954
cBioPortalCASP4
AceView (NCBI)CASP4
Genatlas (Paris)CASP4
WikiGenes837
SOURCE (Princeton)CASP4
Genomic and cartography
GoldenPath hg19 (UCSC)CASP4  -     chr11:104813594-104839325 -  11q22.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CASP4  -     11q22.3   [Description]    (hg38-Dec_2013)
EnsemblCASP4 - 11q22.3 [CytoView hg19]  CASP4 - 11q22.3 [CytoView hg38]
Mapping of homologs : NCBICASP4 [Mapview hg19]  CASP4 [Mapview hg38]
OMIM602664   
Gene and transcription
Genbank (Entrez)AI128358 AK057094 AK225751 AK296081 AK304222
RefSeq transcript (Entrez)NM_001225 NM_033306 NM_033307
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_033899 NW_004929381
Consensus coding sequences : CCDS (NCBI)CASP4
Cluster EST : UnigeneHs.138378 [ NCBI ]
CGAP (NCI)Hs.138378
Alternative Splicing : Fast-db (Paris)GSHG0006139
Alternative Splicing GalleryENSG00000196954
Gene ExpressionCASP4 [ NCBI-GEO ]     CASP4 [ SEEK ]   CASP4 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49662 (Uniprot)
NextProtP49662  [Medical]
With graphics : InterProP49662
Splice isoforms : SwissVarP49662 (Swissvar)
Catalytic activity : Enzyme3.4.22.57 [ Enzyme-Expasy ]   3.4.22.573.4.22.57 [ IntEnz-EBI ]   3.4.22.57 [ BRENDA ]   3.4.22.57 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)CARD (PS50209)    CASPASE_CYS (PS01122)    CASPASE_HIS (PS01121)    CASPASE_P10 (PS50207)    CASPASE_P20 (PS50208)   
Domains : Interpro (EBI)CARD    Caspase-like_dom    Caspase_ICE-type    DEATH-like_dom    Pept_C14_caspase    Pept_C14_ICE_p20    Pept_C14_ICE_p20_AS    Pept_C14_p10    Pept_C14A_p45_core   
Related proteins : CluSTrP49662
Domain families : Pfam (Sanger)CARD (PF00619)    Peptidase_C14 (PF00656)   
Domain families : Pfam (NCBI)pfam00619    pfam00656   
Domain families : Smart (EMBL)CARD (SM00114)  CASc (SM00115)  
DMDM Disease mutations837
Blocks (Seattle)P49662
Human Protein AtlasENSG00000196954
Peptide AtlasP49662
HPRD04047
IPIIPI00027725   IPI00941180   IPI00910956   IPI00383774   IPI00376080   IPI00974338   IPI00983433   
Protein Interaction databases
DIP (DOE-UCLA)P49662
IntAct (EBI)P49662
FunCoupENSG00000196954
BioGRIDCASP4
IntegromeDBCASP4
STRING (EMBL)CASP4
Ontologies - Pathways
QuickGOP49662
Ontology : AmiGOcytoplasm  mitochondrion  endoplasmic reticulum  endoplasmic reticulum membrane  proteolysis  apoptotic process  regulation of apoptotic process  regulation of inflammatory response  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  IPAF inflammasome complex  NLRP3 inflammasome complex  AIM2 inflammasome complex  intrinsic apoptotic signaling pathway  execution phase of apoptosis  cysteine-type endopeptidase activity involved in execution phase of apoptosis  
Ontology : EGO-EBIcytoplasm  mitochondrion  endoplasmic reticulum  endoplasmic reticulum membrane  proteolysis  apoptotic process  regulation of apoptotic process  regulation of inflammatory response  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  IPAF inflammasome complex  NLRP3 inflammasome complex  AIM2 inflammasome complex  intrinsic apoptotic signaling pathway  execution phase of apoptosis  cysteine-type endopeptidase activity involved in execution phase of apoptosis  
Pathways : BIOCARTACaspase Cascade in Apoptosis [Genes]   
Protein Interaction DatabaseCASP4
DoCM (Curated mutations)CASP4
Wikipedia pathwaysCASP4
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerCASP4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CASP4
dbVarCASP4
ClinVarCASP4
1000_GenomesCASP4 
Exome Variant ServerCASP4
SNP (GeneSNP Utah)CASP4
SNP : HGBaseCASP4
Genetic variants : HAPMAPCASP4
Genomic Variants (DGV)CASP4 [DGVbeta]
Mutations
ICGC Data PortalENSG00000196954 
Somatic Mutations in Cancer : COSMICCASP4 
CONAN: Copy Number AnalysisCASP4 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)11:104813594-104839325
Mutations and Diseases : HGMDCASP4
OMIM602664   
MedgenCASP4
NextProtP49662 [Medical]
GENETestsCASP4
Disease Genetic AssociationCASP4
Huge Navigator CASP4 [HugePedia]  CASP4 [HugeCancerGEM]
snp3D : Map Gene to Disease837
DGIdb (Drug Gene Interaction db)CASP4
General knowledge
Homologs : HomoloGeneCASP4
Homology/Alignments : Family Browser (UCSC)CASP4
Phylogenetic Trees/Animal Genes : TreeFamCASP4
Chemical/Protein Interactions : CTD837
Chemical/Pharm GKB GenePA26088
Clinical trialCASP4
Cancer Resource (Charite)ENSG00000196954
Other databases
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
CoreMineCASP4
GoPubMedCASP4
iHOPCASP4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Mar 28 14:56:51 CET 2015

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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.