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CASP4 (caspase 4, apoptosis-related cysteine peptidase)

Identity

Other namesICE(rel)II
ICEREL-II
ICH-2
Mih1/TX
TX
HGNC (Hugo) CASP4
LocusID (NCBI) 837
Location 11q22.3
Location_base_pair Starts at 104813594 and ends at 104839325 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CASP4   1505
Cards
Entrez_Gene (NCBI)CASP4  837  caspase 4, apoptosis-related cysteine peptidase
GeneCards (Weizmann)CASP4
Ensembl (Hinxton)ENSG00000196954 [Gene_View]  chr11:104813594-104839325 [Contig_View]  CASP4 [Vega]
ICGC DataPortalENSG00000196954
cBioPortalCASP4
AceView (NCBI)CASP4
Genatlas (Paris)CASP4
WikiGenes837
SOURCE (Princeton)NM_001225 NM_033306 NM_033307
Genomic and cartography
GoldenPath (UCSC)CASP4  -  11q22.3   chr11:104813594-104839325 -  11q22.3   [Description]    (hg19-Feb_2009)
EnsemblCASP4 - 11q22.3 [CytoView]
Mapping of homologs : NCBICASP4 [Mapview]
OMIM602664   
Gene and transcription
Genbank (Entrez)AI128358 AK057094 AK225751 AK296081 AK304222
RefSeq transcript (Entrez)NM_001225 NM_033306 NM_033307
RefSeq genomic (Entrez)AC_000143 NC_000011 NC_018922 NT_033899 NW_001838042 NW_004929381
Consensus coding sequences : CCDS (NCBI)CASP4
Cluster EST : UnigeneHs.138378 [ NCBI ]
CGAP (NCI)Hs.138378
Alternative Splicing : Fast-db (Paris)GSHG0006139
Alternative Splicing GalleryENSG00000196954
Gene ExpressionCASP4 [ NCBI-GEO ]     CASP4 [ SEEK ]   CASP4 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49662 (Uniprot)
NextProtP49662  [Medical]
With graphics : InterProP49662
Splice isoforms : SwissVarP49662 (Swissvar)
Catalytic activity : Enzyme3.4.22.57 [ Enzyme-Expasy ]   3.4.22.573.4.22.57 [ IntEnz-EBI ]   3.4.22.57 [ BRENDA ]   3.4.22.57 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)CARD (PS50209)    CASPASE_CYS (PS01122)    CASPASE_HIS (PS01121)    CASPASE_P10 (PS50207)    CASPASE_P20 (PS50208)   
Domains : Interpro (EBI)CARD [organisation]   Caspase-like_dom [organisation]   Caspase_ICE-type [organisation]   DEATH-like_dom [organisation]   Pept_C14_caspase [organisation]   Pept_C14_ICE_p20 [organisation]   Pept_C14_ICE_p20_AS [organisation]   Pept_C14_p10 [organisation]   Pept_C14A_p45_core [organisation]  
Related proteins : CluSTrP49662
Domain families : Pfam (Sanger)CARD (PF00619)    Peptidase_C14 (PF00656)   
Domain families : Pfam (NCBI)pfam00619    pfam00656   
Domain families : Smart (EMBL)CARD (SM00114)  CASc (SM00115)  
DMDM Disease mutations837
Blocks (Seattle)P49662
Human Protein AtlasENSG00000196954 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP49662
HPRD04047
IPIIPI00027725   IPI00941180   IPI00910956   IPI00383774   IPI00376080   IPI00974338   IPI00983433   
Protein Interaction databases
DIP (DOE-UCLA)P49662
IntAct (EBI)P49662
FunCoupENSG00000196954
BioGRIDCASP4
InParanoidP49662
Interologous Interaction database P49662
IntegromeDBCASP4
STRING (EMBL)CASP4
Ontologies - Pathways
Ontology : AmiGOcysteine-type endopeptidase activity  cytoplasm  mitochondrion  endoplasmic reticulum membrane  proteolysis  apoptotic process  regulation of apoptotic process  regulation of inflammatory response  IPAF inflammasome complex  NLRP3 inflammasome complex  AIM2 inflammasome complex  execution phase of apoptosis  
Ontology : EGO-EBIcysteine-type endopeptidase activity  cytoplasm  mitochondrion  endoplasmic reticulum membrane  proteolysis  apoptotic process  regulation of apoptotic process  regulation of inflammatory response  IPAF inflammasome complex  NLRP3 inflammasome complex  AIM2 inflammasome complex  execution phase of apoptosis  
Pathways : BIOCARTACaspase Cascade in Apoptosis [Genes]   
Protein Interaction DatabaseCASP4
Wikipedia pathwaysCASP4
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)CASP4
snp3D : Map Gene to Disease837
SNP (GeneSNP Utah)CASP4
SNP : HGBaseCASP4
Genetic variants : HAPMAPCASP4
Exome VariantCASP4
1000_GenomesCASP4 
ICGC programENSG00000196954 
Somatic Mutations in Cancer : COSMICCASP4 
CONAN: Copy Number AnalysisCASP4 
Mutations and Diseases : HGMDCASP4
Mutations and Diseases : intOGenCASP4
Genomic VariantsCASP4  CASP4 [DGVbeta]
dbVarCASP4
ClinVarCASP4
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM602664   
MedgenCASP4
GENETestsCASP4
Disease Genetic AssociationCASP4
Huge Navigator CASP4 [HugePedia]  CASP4 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneCASP4
Homology/Alignments : Family Browser (UCSC)CASP4
Phylogenetic Trees/Animal Genes : TreeFamCASP4
Chemical/Protein Interactions : CTD837
Chemical/Pharm GKB GenePA26088
Clinical trialCASP4
Cancer Resource (Charite)ENSG00000196954
Other databases
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
CoreMineCASP4
iHOPCASP4
OncoSearchCASP4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 22 18:42:29 CEST 2014

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