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CASP4 (caspase 4)

Identity

Other namesICE(rel)II
ICEREL-II
ICH-2
Mih1
Mih1/TX
TX
HGNC (Hugo) CASP4
LocusID (NCBI) 837
Atlas_Id 921
Location 11q22.3  [Link to chromosome band 11q22]
Location_base_pair Starts at 104813594 and ends at 104839325 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CASP4 (11q22.3) / PIK3R4 (3q22.1)MEGF6 (1p36.32) / CASP4 (11q22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CASP4   1505
Cards
Entrez_Gene (NCBI)CASP4  837  caspase 4
AliasesICE(rel)II; ICEREL-II; ICH-2; Mih1; 
Mih1/TX; TX
GeneCards (Weizmann)CASP4
Ensembl hg19 (Hinxton)ENSG00000196954 [Gene_View]  chr11:104813594-104839325 [Contig_View]  CASP4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000196954 [Gene_View]  chr11:104813594-104839325 [Contig_View]  CASP4 [Vega]
ICGC DataPortalENSG00000196954
TCGA cBioPortalCASP4
AceView (NCBI)CASP4
Genatlas (Paris)CASP4
WikiGenes837
SOURCE (Princeton)CASP4
Genomic and cartography
GoldenPath hg19 (UCSC)CASP4  -     chr11:104813594-104839325 -  11q22.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CASP4  -     11q22.3   [Description]    (hg38-Dec_2013)
EnsemblCASP4 - 11q22.3 [CytoView hg19]  CASP4 - 11q22.3 [CytoView hg38]
Mapping of homologs : NCBICASP4 [Mapview hg19]  CASP4 [Mapview hg38]
OMIM602664   
Gene and transcription
Genbank (Entrez)AI128358 AK057094 AK225751 AK296081 AK304222
RefSeq transcript (Entrez)NM_001225 NM_033306 NM_033307
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_033899 NW_004929381
Consensus coding sequences : CCDS (NCBI)CASP4
Cluster EST : UnigeneHs.138378 [ NCBI ]
CGAP (NCI)Hs.138378
Alternative Splicing GalleryENSG00000196954
Gene ExpressionCASP4 [ NCBI-GEO ]   CASP4 [ EBI - ARRAY_EXPRESS ]   CASP4 [ SEEK ]   CASP4 [ MEM ]
Gene Expression Viewer (FireBrowse)CASP4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)837
GTEX Portal (Tissue expression)CASP4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49662 (Uniprot)
NextProtP49662  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49662
Splice isoforms : SwissVarP49662 (Swissvar)
PhosPhoSitePlusP49662
Domaine pattern : Prosite (Expaxy)CARD (PS50209)    CASPASE_CYS (PS01122)    CASPASE_HIS (PS01121)    CASPASE_P10 (PS50207)    CASPASE_P20 (PS50208)   
Domains : Interpro (EBI)CARD    Caspase-like_dom    Caspase_cys_AS    Caspase_his_AS    DEATH-like_dom    Pept_C14_p10    Pept_C14_p20    Pept_C14A_HD   
Domain families : Pfam (Sanger)CARD (PF00619)   
Domain families : Pfam (NCBI)pfam00619   
Domain families : Smart (EMBL)CARD (SM00114)  CASc (SM00115)  
DMDM Disease mutations837
Blocks (Seattle)CASP4
SuperfamilyP49662
Human Protein AtlasENSG00000196954
Peptide AtlasP49662
HPRD04047
IPIIPI00027725   IPI00941180   IPI00910956   IPI00383774   IPI00376080   IPI00974338   IPI00983433   
Protein Interaction databases
DIP (DOE-UCLA)P49662
IntAct (EBI)P49662
FunCoupENSG00000196954
BioGRIDCASP4
STRING (EMBL)CASP4
ZODIACCASP4
Ontologies - Pathways
QuickGOP49662
Ontology : AmiGOextracellular region  mitochondrion  endoplasmic reticulum  endoplasmic reticulum membrane  proteolysis  apoptotic process  inflammatory response  regulation of apoptotic process  innate immune response  regulation of inflammatory response  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  IPAF inflammasome complex  NLRP3 inflammasome complex  cysteine-type endopeptidase activity involved in apoptotic process  AIM2 inflammasome complex  intrinsic apoptotic signaling pathway  cellular response to beta-amyloid  
Ontology : EGO-EBIextracellular region  mitochondrion  endoplasmic reticulum  endoplasmic reticulum membrane  proteolysis  apoptotic process  inflammatory response  regulation of apoptotic process  innate immune response  regulation of inflammatory response  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  IPAF inflammasome complex  NLRP3 inflammasome complex  cysteine-type endopeptidase activity involved in apoptotic process  AIM2 inflammasome complex  intrinsic apoptotic signaling pathway  cellular response to beta-amyloid  
Pathways : BIOCARTACaspase Cascade in Apoptosis [Genes]   
NDEx Network
Atlas of Cancer Signalling NetworkCASP4
Wikipedia pathwaysCASP4
Orthology - Evolution
OrthoDB837
GeneTree (enSembl)ENSG00000196954
Phylogenetic Trees/Animal Genes : TreeFamCASP4
Homologs : HomoloGeneCASP4
Homology/Alignments : Family Browser (UCSC)CASP4
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerCASP4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CASP4
dbVarCASP4
ClinVarCASP4
1000_GenomesCASP4 
Exome Variant ServerCASP4
ExAC (Exome Aggregation Consortium)CASP4 (select the gene name)
Genetic variants : HAPMAP837
Genomic Variants (DGV)CASP4 [DGVbeta]
Mutations
ICGC Data PortalCASP4 
TCGA Data PortalCASP4 
Broad Tumor PortalCASP4
OASIS PortalCASP4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCASP4 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CASP4
DgiDB (Drug Gene Interaction Database)CASP4
DoCM (Curated mutations)CASP4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CASP4 (select a term)
intoGenCASP4
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)11:104813594-104839325  ENSG00000196954
CONAN: Copy Number AnalysisCASP4 
Mutations and Diseases : HGMDCASP4
OMIM602664   
MedgenCASP4
Genetic Testing Registry CASP4
NextProtP49662 [Medical]
TSGene837
GENETestsCASP4
Huge Navigator CASP4 [HugePedia]
snp3D : Map Gene to Disease837
BioCentury BCIQCASP4
ClinGenCASP4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD837
Chemical/Pharm GKB GenePA26088
Clinical trialCASP4
Miscellaneous
canSAR (ICR)CASP4 (select the gene name)
Probes
Litterature
PubMed65 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCASP4
EVEXCASP4
GoPubMedCASP4
iHOPCASP4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 9 18:59:55 CEST 2016

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