CASP5 (caspase 5)

2003-08-01  

Identity

HGNC
CASP5
LOCATION
11q22.3
LOCUSID
838
ALIAS
ICE(rel)III,ICEREL-III,ICH-3

Other Information

Locus ID:

NCBI: 838
MIM: 602665
HGNC: 1506
Ensembl: ENSG00000137757

Variants:

dbSNP: 838
ClinVar: 838
TCGA: ENSG00000137757
COSMIC: CASP5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137757ENST00000260315P51878
ENSG00000137757ENST00000393141P51878
ENSG00000137757ENST00000418434P51878
ENSG00000137757ENST00000438448H7C0P5
ENSG00000137757ENST00000444749P51878
ENSG00000137757ENST00000456094C9JF14
ENSG00000137757ENST00000456200P51878
ENSG00000137757ENST00000526056P51878
ENSG00000137757ENST00000531367P51878

Expression (GTEx)

0
1
2
3
4
5
6
7
8
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621

References

Pubmed IDYearTitleCitations
121914862002The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.1466
265083692015Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes.66
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
261739882015NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5.53
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
190748852008Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.25
206353892011Common alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancer.25
194148602009Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studies.19
184304582008Mutational analysis of caspase 1, 4, and 5 genes in common human cancers.18
208555362010Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma.18

Citation

Dessen P

CASP5 (caspase 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/922/casp5