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CASP5 (caspase 5, apoptosis-related cysteine peptidase)

Identity

Other namesICE(rel)III
ICEREL-III
ICH-3
HGNC (Hugo) CASP5
LocusID (NCBI) 838
Location 11q22.3
Location_base_pair Starts at 104864967 and ends at 104893895 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CASP5   1506
Cards
Entrez_Gene (NCBI)CASP5  838  caspase 5, apoptosis-related cysteine peptidase
GeneCards (Weizmann)CASP5
Ensembl hg19 (Hinxton)ENSG00000137757 [Gene_View]  chr11:104864967-104893895 [Contig_View]  CASP5 [Vega]
Ensembl hg38 (Hinxton)ENSG00000137757 [Gene_View]  chr11:104864967-104893895 [Contig_View]  CASP5 [Vega]
ICGC DataPortalENSG00000137757
cBioPortalCASP5
AceView (NCBI)CASP5
Genatlas (Paris)CASP5
WikiGenes838
SOURCE (Princeton)CASP5
Genomic and cartography
GoldenPath hg19 (UCSC)CASP5  -     chr11:104864967-104893895 -  11q22.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CASP5  -     11q22.3   [Description]    (hg38-Dec_2013)
EnsemblCASP5 - 11q22.3 [CytoView hg19]  CASP5 - 11q22.3 [CytoView hg38]
Mapping of homologs : NCBICASP5 [Mapview hg19]  CASP5 [Mapview hg38]
OMIM602665   
Gene and transcription
Genbank (Entrez)AK296660 BC074994 BC113406 DQ228672 DQ228673
RefSeq transcript (Entrez)NM_001136109 NM_001136110 NM_001136112 NM_004347
RefSeq genomic (Entrez)AC_000143 NC_000011 NC_018922 NT_033899 NW_001838042 NW_004929381
Consensus coding sequences : CCDS (NCBI)CASP5
Cluster EST : UnigeneHs.213327 [ NCBI ]
CGAP (NCI)Hs.213327
Alternative Splicing : Fast-db (Paris)GSHG0006140
Alternative Splicing GalleryENSG00000137757
Gene ExpressionCASP5 [ NCBI-GEO ]     CASP5 [ SEEK ]   CASP5 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51878 (Uniprot)
NextProtP51878  [Medical]
With graphics : InterProP51878
Splice isoforms : SwissVarP51878 (Swissvar)
Catalytic activity : Enzyme3.4.22.58 [ Enzyme-Expasy ]   3.4.22.583.4.22.58 [ IntEnz-EBI ]   3.4.22.58 [ BRENDA ]   3.4.22.58 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)CARD (PS50209)    CASPASE_CYS (PS01122)    CASPASE_HIS (PS01121)    CASPASE_P10 (PS50207)    CASPASE_P20 (PS50208)   
Domains : Interpro (EBI)CARD    Caspase-like_dom    Caspase_ICE-type    DEATH-like_dom    Pept_C14_caspase    Pept_C14_ICE_p20    Pept_C14_ICE_p20_AS    Pept_C14_p10    Pept_C14A_p45_core   
Related proteins : CluSTrP51878
Domain families : Pfam (Sanger)CARD (PF00619)    Peptidase_C14 (PF00656)   
Domain families : Pfam (NCBI)pfam00619    pfam00656   
Domain families : Smart (EMBL)CARD (SM00114)  CASc (SM00115)  
DMDM Disease mutations838
Blocks (Seattle)P51878
Human Protein AtlasENSG00000137757
Peptide AtlasP51878
HPRD04048
IPIIPI00942522   IPI00914557   IPI00914544   IPI00020978   IPI00979949   IPI00784640   IPI00784770   IPI00872124   IPI00873979   
Protein Interaction databases
DIP (DOE-UCLA)P51878
IntAct (EBI)P51878
FunCoupENSG00000137757
BioGRIDCASP5
IntegromeDBCASP5
STRING (EMBL)CASP5
Ontologies - Pathways
QuickGOP51878
Ontology : AmiGOcysteine-type endopeptidase activity  cytoplasm  proteolysis  apoptotic process  cysteine-type peptidase activity  substantia nigra development  regulation of apoptotic process  regulation of inflammatory response  cellular response to mechanical stimulus  IPAF inflammasome complex  NLRP1 inflammasome complex  NLRP3 inflammasome complex  AIM2 inflammasome complex  execution phase of apoptosis  
Ontology : EGO-EBIcysteine-type endopeptidase activity  cytoplasm  proteolysis  apoptotic process  cysteine-type peptidase activity  substantia nigra development  regulation of apoptotic process  regulation of inflammatory response  cellular response to mechanical stimulus  IPAF inflammasome complex  NLRP1 inflammasome complex  NLRP3 inflammasome complex  AIM2 inflammasome complex  execution phase of apoptosis  
Pathways : KEGGNOD-like receptor signaling pathway   
Protein Interaction DatabaseCASP5
DoCM (Curated mutations)CASP5
Wikipedia pathwaysCASP5
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerCASP5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CASP5
dbVarCASP5
ClinVarCASP5
1000_GenomesCASP5 
Exome Variant ServerCASP5
SNP (GeneSNP Utah)CASP5
SNP : HGBaseCASP5
Genetic variants : HAPMAPCASP5
Genomic VariantsCASP5  CASP5 [DGVbeta]
Mutations
ICGC Data PortalENSG00000137757 
Somatic Mutations in Cancer : COSMICCASP5 
CONAN: Copy Number AnalysisCASP5 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)11:104864967-104893895
Mutations and Diseases : HGMDCASP5
OMIM602665   
MedgenCASP5
NextProtP51878 [Medical]
GENETestsCASP5
Disease Genetic AssociationCASP5
Huge Navigator CASP5 [HugePedia]  CASP5 [HugeCancerGEM]
snp3D : Map Gene to Disease838
DGIdb (Drug Gene Interaction db)CASP5
General knowledge
Homologs : HomoloGeneCASP5
Homology/Alignments : Family Browser (UCSC)CASP5
Phylogenetic Trees/Animal Genes : TreeFamCASP5
Chemical/Protein Interactions : CTD838
Chemical/Pharm GKB GenePA26089
Clinical trialCASP5
Cancer Resource (Charite)ENSG00000137757
Other databases
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
CoreMineCASP5
GoPubMedCASP5
iHOPCASP5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 20:37:48 CET 2014

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