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CASP5 (caspase 5)

Identity

Other namesICE(rel)III
ICEREL-III
ICH-3
HGNC (Hugo) CASP5
LocusID (NCBI) 838
Atlas_Id 922
Location 11q22.3  [Link to chromosome band 11q22]
Location_base_pair Starts at 104864967 and ends at 104893895 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CASP5   1506
Cards
Entrez_Gene (NCBI)CASP5  838  caspase 5
AliasesICE(rel)III; ICEREL-III; ICH-3
GeneCards (Weizmann)CASP5
Ensembl hg19 (Hinxton)ENSG00000137757 [Gene_View]  chr11:104864967-104893895 [Contig_View]  CASP5 [Vega]
Ensembl hg38 (Hinxton)ENSG00000137757 [Gene_View]  chr11:104864967-104893895 [Contig_View]  CASP5 [Vega]
ICGC DataPortalENSG00000137757
TCGA cBioPortalCASP5
AceView (NCBI)CASP5
Genatlas (Paris)CASP5
WikiGenes838
SOURCE (Princeton)CASP5
Genomic and cartography
GoldenPath hg19 (UCSC)CASP5  -     chr11:104864967-104893895 -  11q22.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CASP5  -     11q22.3   [Description]    (hg38-Dec_2013)
EnsemblCASP5 - 11q22.3 [CytoView hg19]  CASP5 - 11q22.3 [CytoView hg38]
Mapping of homologs : NCBICASP5 [Mapview hg19]  CASP5 [Mapview hg38]
OMIM602665   
Gene and transcription
Genbank (Entrez)AK296660 BC074994 BC113406 DQ228672 DQ228673
RefSeq transcript (Entrez)NM_001136109 NM_001136110 NM_001136112 NM_004347
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_033899 NW_004929381
Consensus coding sequences : CCDS (NCBI)CASP5
Cluster EST : UnigeneHs.213327 [ NCBI ]
CGAP (NCI)Hs.213327
Alternative Splicing GalleryENSG00000137757
Gene ExpressionCASP5 [ NCBI-GEO ]   CASP5 [ EBI - ARRAY_EXPRESS ]   CASP5 [ SEEK ]   CASP5 [ MEM ]
Gene Expression Viewer (FireBrowse)CASP5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)838
GTEX Portal (Tissue expression)CASP5
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51878 (Uniprot)
NextProtP51878  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51878
Splice isoforms : SwissVarP51878 (Swissvar)
Catalytic activity : Enzyme3.4.22.58 [ Enzyme-Expasy ]   3.4.22.583.4.22.58 [ IntEnz-EBI ]   3.4.22.58 [ BRENDA ]   3.4.22.58 [ KEGG ]   
PhosPhoSitePlusP51878
Domaine pattern : Prosite (Expaxy)CARD (PS50209)    CASPASE_CYS (PS01122)    CASPASE_HIS (PS01121)    CASPASE_P10 (PS50207)    CASPASE_P20 (PS50208)   
Domains : Interpro (EBI)CARD    Caspase-like_dom    Caspase_cys_AS    Caspase_his_AS    DEATH-like_dom    Pept_C14_p10    Pept_C14_p20    Pept_C14A    Pept_C14A_HD   
Domain families : Pfam (Sanger)CARD (PF00619)   
Domain families : Pfam (NCBI)pfam00619   
Domain families : Smart (EMBL)CARD (SM00114)  CASc (SM00115)  
DMDM Disease mutations838
Blocks (Seattle)CASP5
SuperfamilyP51878
Human Protein AtlasENSG00000137757
Peptide AtlasP51878
HPRD04048
IPIIPI00942522   IPI00914557   IPI00914544   IPI00020978   IPI00979949   IPI00784640   IPI00784770   IPI00872124   IPI00873979   
Protein Interaction databases
DIP (DOE-UCLA)P51878
IntAct (EBI)P51878
FunCoupENSG00000137757
BioGRIDCASP5
STRING (EMBL)CASP5
ZODIACCASP5
Ontologies - Pathways
QuickGOP51878
Ontology : AmiGOproteolysis  apoptotic process  cysteine-type peptidase activity  substantia nigra development  ectopic germ cell programmed cell death  regulation of apoptotic process  positive regulation of interleukin-1 beta secretion  regulation of inflammatory response  pyroptosis  cellular response to mechanical stimulus  IPAF inflammasome complex  NLRP1 inflammasome complex  NLRP3 inflammasome complex  cysteine-type endopeptidase activity involved in apoptotic process  AIM2 inflammasome complex  
Ontology : EGO-EBIproteolysis  apoptotic process  cysteine-type peptidase activity  substantia nigra development  ectopic germ cell programmed cell death  regulation of apoptotic process  positive regulation of interleukin-1 beta secretion  regulation of inflammatory response  pyroptosis  cellular response to mechanical stimulus  IPAF inflammasome complex  NLRP1 inflammasome complex  NLRP3 inflammasome complex  cysteine-type endopeptidase activity involved in apoptotic process  AIM2 inflammasome complex  
Pathways : KEGGNOD-like receptor signaling pathway   
NDEx NetworkCASP5
Atlas of Cancer Signalling NetworkCASP5
Wikipedia pathwaysCASP5
Orthology - Evolution
OrthoDB838
GeneTree (enSembl)ENSG00000137757
Phylogenetic Trees/Animal Genes : TreeFamCASP5
Homologs : HomoloGeneCASP5
Homology/Alignments : Family Browser (UCSC)CASP5
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerCASP5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CASP5
dbVarCASP5
ClinVarCASP5
1000_GenomesCASP5 
Exome Variant ServerCASP5
ExAC (Exome Aggregation Consortium)CASP5 (select the gene name)
Genetic variants : HAPMAP838
Genomic Variants (DGV)CASP5 [DGVbeta]
Mutations
ICGC Data PortalCASP5 
TCGA Data PortalCASP5 
Broad Tumor PortalCASP5
OASIS PortalCASP5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCASP5 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CASP5
DgiDB (Drug Gene Interaction Database)CASP5
DoCM (Curated mutations)CASP5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CASP5 (select a term)
intoGenCASP5
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)11:104864967-104893895  ENSG00000137757
CONAN: Copy Number AnalysisCASP5 
Mutations and Diseases : HGMDCASP5
OMIM602665   
MedgenCASP5
Genetic Testing Registry CASP5
NextProtP51878 [Medical]
TSGene838
GENETestsCASP5
Huge Navigator CASP5 [HugePedia]
snp3D : Map Gene to Disease838
BioCentury BCIQCASP5
ClinGenCASP5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD838
Chemical/Pharm GKB GenePA26089
Clinical trialCASP5
Miscellaneous
canSAR (ICR)CASP5 (select the gene name)
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCASP5
EVEXCASP5
GoPubMedCASP5
iHOPCASP5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 19 18:40:15 CEST 2016

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