CASP6 (caspase 6, apoptosis-related cysteine peptidase)

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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret
Donations are also welcome

CASP6 (caspase 6, apoptosis-related cysteine peptidase)

Identity

Other names	MCH2
HGNC (Hugo)	CASP6
LocusID (NCBI)	839
Location	4q25
Location_base_pair	Starts at 110609785 and ends at 110624629 bp from pter ( according to hg19-Feb_2009)
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

External links

	Nomenclature
HGNC (Hugo)	CASP6 1507
	Cards
Entrez_Gene (NCBI)	CASP6 839 caspase 6, apoptosis-related cysteine peptidase
GeneCards (Weizmann)	CASP6
Ensembl hg19 (Hinxton)	ENSG00000138794 [Gene_View] chr4:110609785-110624629 [Contig_View] CASP6 [Vega]
Ensembl hg38 (Hinxton)	ENSG00000138794 [Gene_View] chr4:110609785-110624629 [Contig_View] CASP6 [Vega]
ICGC DataPortal	ENSG00000138794
cBioPortal	CASP6
AceView (NCBI)	CASP6
Genatlas (Paris)	CASP6
WikiGenes	839
SOURCE (Princeton)	CASP6
	Genomic and cartography
GoldenPath hg19 (UCSC)	CASP6 - chr4:110609785-110624629 - 4q25 [Description] (hg19-Feb_2009)
GoldenPath hg38 (UCSC)	CASP6 - 4q25 [Description] (hg38-Dec_2013)
Ensembl	CASP6 - 4q25 [CytoView hg19] CASP6 - 4q25 [CytoView hg38]
Mapping of homologs : NCBI	CASP6 [Mapview hg19] CASP6 [Mapview hg38]
OMIM	601532
	Gene and transcription
Genbank (Entrez)	BC000305 BC004460 BM837197 DQ894589 EU176306
RefSeq transcript (Entrez)	NM_001226 NM_032992
RefSeq genomic (Entrez)	AC_000136 NC_000004 NC_018915 NG_029187 NT_016354 NW_001838915 NW_004929320
Consensus coding sequences : CCDS (NCBI)	CASP6
Cluster EST : Unigene	Hs.654616 [ NCBI ]
CGAP (NCI)	Hs.654616
Alternative Splicing : Fast-db (Paris)	GSHG0023468
Alternative Splicing Gallery	ENSG00000138794
Gene Expression	CASP6 [ NCBI-GEO ] CASP6 [ SEEK ] CASP6 [ MEM ]
SOURCE (Princeton)	Expression in : [Normal Tissue Atlas] [carcinoma Classsification] [NCI60]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	P55212 (Uniprot)
NextProt	P55212 [Medical]
With graphics : InterPro	P55212
Splice isoforms : SwissVar	P55212 (Swissvar)
Catalytic activity : Enzyme	3.4.22.59 [ Enzyme-Expasy ] 3.4.22.59 3.4.22.59 [ IntEnz-EBI ] 3.4.22.59 [ BRENDA ] 3.4.22.59 [ KEGG ]
Domaine pattern : Prosite (Expaxy)	CASPASE_CYS (PS01122) CASPASE_HIS (PS01121) CASPASE_P10 (PS50207) CASPASE_P20 (PS50208)
Domains : Interpro (EBI)	Caspase-like_dom Pept_C14_caspase Pept_C14_ICE_p20 Pept_C14_ICE_p20_AS Pept_C14_p10 Pept_C14A_p45_core
Related proteins : CluSTr	P55212
Domain families : Pfam (Sanger)	Peptidase_C14 (PF00656)
Domain families : Pfam (NCBI)	pfam00656
Domain families : Smart (EMBL)	CASc (SM00115)
DMDM Disease mutations	839
Blocks (Seattle)	P55212
PDB (SRS)	1MI9 2WDP 3K7E 3NKF 3NR2 3OD5 3P45 3P4U 3QNW 3S70 3S8E 3V6L 3V6M 4EJF 4FXO 4HVA 4IYR 4N5D 4N6G 4N7J 4N7M 4NBK 4NBL 4NBN
PDB (PDBSum)	1MI9 2WDP 3K7E 3NKF 3NR2 3OD5 3P45 3P4U 3QNW 3S70 3S8E 3V6L 3V6M 4EJF 4FXO 4HVA 4IYR 4N5D 4N6G 4N7J 4N7M 4NBK 4NBL 4NBN
PDB (IMB)	1MI9 2WDP 3K7E 3NKF 3NR2 3OD5 3P45 3P4U 3QNW 3S70 3S8E 3V6L 3V6M 4EJF 4FXO 4HVA 4IYR 4N5D 4N6G 4N7J 4N7M 4NBK 4NBL 4NBN
PDB (RSDB)	1MI9 2WDP 3K7E 3NKF 3NR2 3OD5 3P45 3P4U 3QNW 3S70 3S8E 3V6L 3V6M 4EJF 4FXO 4HVA 4IYR 4N5D 4N6G 4N7J 4N7M 4NBK 4NBL 4NBN
Human Protein Atlas	ENSG00000138794
Peptide Atlas	P55212
HPRD	03321
IPI	IPI00023876 IPI00217208 IPI00966630 IPI00966602
	Protein Interaction databases
DIP (DOE-UCLA)	P55212
IntAct (EBI)	P55212
FunCoup	ENSG00000138794
BioGRID	CASP6
IntegromeDB	CASP6
STRING (EMBL)	CASP6
	Ontologies - Pathways
QuickGO	P55212
Ontology : AmiGO	cysteine-type endopeptidase activity cysteine-type endopeptidase activity protein binding nucleoplasm cytosol cytosol proteolysis apoptotic process apoptotic process cellular component disassembly involved in execution phase of apoptosis cysteine-type peptidase activity epithelial cell differentiation identical protein binding
Ontology : EGO-EBI	cysteine-type endopeptidase activity cysteine-type endopeptidase activity protein binding nucleoplasm cytosol cytosol proteolysis apoptotic process apoptotic process cellular component disassembly involved in execution phase of apoptosis cysteine-type peptidase activity epithelial cell differentiation identical protein binding
Pathways : BIOCARTA	Induction of apoptosis through DR3 and DR4/5 Death Receptors [Genes] Role of Mitochondria in Apoptotic Signaling [Genes] Caspase Cascade in Apoptosis [Genes] HIV-I Nef: negative effector of Fas and TNF [Genes] Apoptotic Signaling in Response to DNA Damage [Genes] FAS signaling pathway ( CD95 ) [Genes]
Pathways : KEGG	Apoptosis
Protein Interaction Database	CASP6
DoCM (Curated mutations)	CASP6
Wikipedia pathways	CASP6
	Gene fusion - rearrangements
	Polymorphisms : SNP, variants
NCBI Variation Viewer	CASP6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)	CASP6
dbVar	CASP6
ClinVar	CASP6
1000_Genomes	CASP6
Exome Variant Server	CASP6
SNP (GeneSNP Utah)	CASP6
SNP : HGBase	CASP6
Genetic variants : HAPMAP	CASP6
Genomic Variants (DGV)	CASP6 [DGVbeta]
	Mutations
ICGC Data Portal	ENSG00000138794
Somatic Mutations in Cancer : COSMIC	CASP6
CONAN: Copy Number Analysis	CASP6
LOVD (Leiden Open Variation Database)	Whole genome datasets
LOVD (Leiden Open Variation Database)	LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)	LOVD 3.0 shared installation
Impact of mutations	[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor]
	Diseases
DECIPHER (Syndromes)	4:110609785-110624629
Mutations and Diseases : HGMD	CASP6
OMIM	601532
Medgen	CASP6
NextProt	P55212 [Medical]
GENETests	CASP6
Disease Genetic Association	CASP6
Huge Navigator	CASP6 [HugePedia] CASP6 [HugeCancerGEM]
snp3D : Map Gene to Disease	839
DGIdb (Drug Gene Interaction db)	CASP6
	General knowledge
Homologs : HomoloGene	CASP6
Homology/Alignments : Family Browser (UCSC)	CASP6
Phylogenetic Trees/Animal Genes : TreeFam	CASP6
Chemical/Protein Interactions : CTD	839
Chemical/Pharm GKB Gene	PA26090
Clinical trial	CASP6
Cancer Resource (Charite)	ENSG00000138794
	Other databases
	Probes
	Litterature
PubMed	122 Pubmed reference(s) in Entrez
CoreMine	CASP6
GoPubMed	CASP6
iHOP	CASP6

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S

Updated	12-2014	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Feb 14 15:01:46 CET 2015

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