CASP8 (caspase 8, apoptosis-related cysteine peptidase)

Identity

Other names	ALPS2B
	CAP4
	FLICE
	FLJ17672
	MACH
	MCH5
	MGC78473
HGNC	CASP8
Location	2q33-q34
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	CASP8   1509
Entrez_Gene	CASP8  841  caspase 8, apoptosis-related cysteine peptidase
	Cards
GeneCards	CASP8
Ensembl	CASP8 [Search_View]   ENSG00000064012 [Gene_View]
Genatlas	CASP8
GeneLynx	CASP8
eGenome	CASP8
euGene	841
	Genomic and cartography
GoldenPath	CASP8  -     chr2:201806411-201860679 +  2q33.1   [Description]    (hg18-March_2006)
Ensembl	CASP8 - 2q33.1 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	CASP8
	Gene and transcription
Genbank	AA312258 [ ENTREZ ]
Genbank	AF009620 [ ENTREZ ]
Genbank	AF380342 [ ENTREZ ]
Genbank	AF422926 [ ENTREZ ]
Genbank	AF422927 [ ENTREZ ]
RefSeq	NM_001080124 [ SRS ]    NM_001080124 [ ENTREZ ]
RefSeq	NM_001080125 [ SRS ]    NM_001080125 [ ENTREZ ]
RefSeq	NM_001228 [ SRS ]    NM_001228 [ ENTREZ ]
RefSeq	NM_033355 [ SRS ]    NM_033355 [ ENTREZ ]
RefSeq	NM_033356 [ SRS ]    NM_033356 [ ENTREZ ]
RefSeq	NM_033358 [ SRS ]    NM_033358 [ ENTREZ ]
RefSeq	AC_000045 [ SRS ]    AC_000045 [ ENTREZ ]
RefSeq	AC_000134 [ SRS ]    AC_000134 [ ENTREZ ]
RefSeq	NC_000002 [ SRS ]    NC_000002 [ ENTREZ ]
RefSeq	NG_007497 [ SRS ]    NG_007497 [ ENTREZ ]
RefSeq	NT_005403 [ SRS ]    NT_005403 [ ENTREZ ]
RefSeq	NW_001838863 [ SRS ]    NW_001838863 [ ENTREZ ]
RefSeq	NW_921618 [ SRS ]    NW_921618 [ ENTREZ ]
AceView	CASP8 AceView - NCBI
Unigene	Hs.655983 [ SRS ]    Hs.655983 [ NCBI ]     HS655983 [ spliceNest ]
Fast-db	14342 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q14790 [ SRS]    Q14790 [ EXPASY ]     Q14790 [ INTERPRO ]     Q14790 [ UNIPROT ]
Prosite	PS01122 CASPASE_CYS [ SRS ]    PS01122 CASPASE_CYS [ Expasy ]
Prosite	PS01121 CASPASE_HIS [ SRS ]    PS01121 CASPASE_HIS [ Expasy ]
Prosite	PS50207 CASPASE_P10 [ SRS ]    PS50207 CASPASE_P10 [ Expasy ]
Prosite	PS50208 CASPASE_P20 [ SRS ]    PS50208 CASPASE_P20 [ Expasy ]
Prosite	PS50168 DED [ SRS ]    PS50168 DED [ Expasy ]
Interpro	IPR011029 DEATH_like [ SRS ]    IPR011029 DEATH_like [ EBI ]
Interpro	IPR001875 DED [ SRS ]    IPR001875 DED [ EBI ]
Interpro	IPR011600 Pept_C14_cat [ SRS ]    IPR011600 Pept_C14_cat [ EBI ]
Interpro	IPR001309 Pept_C14_ICE_p20 [ SRS ]    IPR001309 Pept_C14_ICE_p20 [ EBI ]
Interpro	IPR016129 Pept_C14_ICE_p20_AS [ SRS ]    IPR016129 Pept_C14_ICE_p20_AS [ EBI ]
Interpro	IPR002138 Pept_C14_p10 [ SRS ]    IPR002138 Pept_C14_p10 [ EBI ]
Interpro	IPR002398 Pept_C14_p45 [ SRS ]    IPR002398 Pept_C14_p45 [ EBI ]
Interpro	IPR015917 Pept_C14_p45_core [ SRS ]    IPR015917 Pept_C14_p45_core [ EBI ]
CluSTr	Q14790
Pfam	PF01335 DED [ SRS ]    PF01335 DED [ Sanger ]    pfam01335 [ NCBI-CDD ]
Pfam	PF00656 Peptidase_C14 [ SRS ]    PF00656 Peptidase_C14 [ Sanger ]    pfam00656 [ NCBI-CDD ]
Smart	SM00115 CASc [EMBL]
Smart	SM00031 DED [EMBL]
Blocks	Q14790
PDB	1F9E [ SRS ]    1F9E [ PdbSum ],   1F9E [ IMB ]   1F9E [ RSDB ]
PDB	1I4E [ SRS ]    1I4E [ PdbSum ],   1I4E [ IMB ]   1I4E [ RSDB ]
PDB	1QDU [ SRS ]    1QDU [ PdbSum ],   1QDU [ IMB ]   1QDU [ RSDB ]
PDB	1QTN [ SRS ]    1QTN [ PdbSum ],   1QTN [ IMB ]   1QTN [ RSDB ]
PDB	2C2Z [ SRS ]    2C2Z [ PdbSum ],   2C2Z [ IMB ]   2C2Z [ RSDB ]
PDB	2FUN [ SRS ]    2FUN [ PdbSum ],   2FUN [ IMB ]   2FUN [ RSDB ]
HPRD	03459
	Protein Interaction databases
DIP	Q14790
IntAct	Q14790
	Polymorphism : SNP, mutations, diseases
OMIM	114480;114550;211980;601763;607271    [ map ]
GENECLINICS	114480;114550;211980;601763;607271
SNP	CASP8 [dbSNP-NCBI]
SNP	NM_001080124 [SNP-NCI]
SNP	NM_001080125 [SNP-NCI]
SNP	NM_001228 [SNP-NCI]
SNP	NM_033355 [SNP-NCI]
SNP	NM_033356 [SNP-NCI]
SNP	NM_033358 [SNP-NCI]
SNP	CASP8 [GeneSNPs - Utah]  CASP8] [HGBASE - SRS]
HAPMAP	CASP8 [HAPMAP]
COSMIC	CASP8 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	CASP8
	General knowledge
Family Browser	CASP8 [UCSC Family Browser]
SOURCE	NM_001080124
SOURCE	NM_001080125
SOURCE	NM_001228
SOURCE	NM_033355
SOURCE	NM_033356
SOURCE	NM_033358
SMD	Hs.655983
SAGE	Hs.655983
Enzyme	3.4.22.61 [ Enzyme-Expasy ]   3.4.22.61 [ Enzyme-SRS ]   3.4.22.61 [ IntEnz-EBI ]   3.4.22.61 [ BRENDA ]   3.4.22.61 [ KEGG ]   3.4.22.61 [ WIT ]
GO	cytoplasm [Amigo]  cytoplasm
GO	mitochondrion [Amigo]  mitochondrion
GO	cytosol [Amigo]  cytosol
GO	cytoskeleton [Amigo]  cytoskeleton
GO	proteolysis [Amigo]  proteolysis
GO	cysteine-type peptidase activity [Amigo]  cysteine-type peptidase activity
GO	induction of apoptosis by extracellular signals [Amigo]  induction of apoptosis by extracellular signals
GO	activation of pro-apoptotic gene products [Amigo]  activation of pro-apoptotic gene products
GO	caspase activity [Amigo]  caspase activity
GO	caspase activity [Amigo]  caspase activity
GO	identical protein binding [Amigo]  identical protein binding
GO	regulation of apoptosis [Amigo]  regulation of apoptosis
GO	positive regulation of I-kappaB kinase/NF-kappaB cascade [Amigo]  positive regulation of I-kappaB kinase/NF-kappaB cascade
BIOCARTA	HIV-I Nef: negative effector of Fas and TNF    [Genes]
BIOCARTA	Caspase Cascade in Apoptosis    [Genes]
BIOCARTA	Ceramide Signaling Pathway    [Genes]
BIOCARTA	D4-GDI Signaling Pathway    [Genes]
BIOCARTA	Induction of apoptosis through DR3 and DR4/5 Death Receptors    [Genes]
BIOCARTA	FAS signaling pathway ( CD95 )    [Genes]
BIOCARTA	Role of Mitochondria in Apoptotic Signaling    [Genes]
BIOCARTA	SODD/TNFR1 Signaling Pathway    [Genes]
BIOCARTA	TNFR1 Signaling Pathway    [Genes]
KEGG	Neurodegenerative Disorders
KEGG	MAPK signaling pathway
KEGG	Apoptosis
KEGG	Toll-like receptor signaling pathway
KEGG	Huntington's disease
KEGG	Dentatorubropallidoluysian atrophy (DRPLA)
PubGene	CASP8
TreeFam	CASP8
CTD	841 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	CASP8 Related clones (RZPD - Berlin)
	PubMed
PubMed	298 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:03:15 2008