| Nomenclature | | HGNC | CASP8 1509 |
| Entrez_Gene | CASP8 841 caspase 8, apoptosis-related cysteine peptidase |
| Cards |
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| GeneCards | CASP8 |
| Ensembl | CASP8 [Search_View] ENSG00000064012 [Gene_View] |
| Genatlas | CASP8 |
| GeneLynx | CASP8 |
| eGenome | CASP8 |
| euGene | 841 |
| Genomic and cartography |
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| GoldenPath | CASP8 - chr2:201806411-201860679 + 2q33.1 [Description] (hg18-March_2006) |
| Ensembl | CASP8 - 2q33.1 [CytoView] |
| NCBI | Mapview |
| OMIM | Disease map [OMIM] |
| HomoloGene | CASP8 |
| Gene and transcription | | Genbank | AA312258 [ ENTREZ ] |
| Genbank | AF009620 [ ENTREZ ] |
| Genbank | AF380342 [ ENTREZ ] |
| Genbank | AF422926 [ ENTREZ ] |
| Genbank | AF422927 [ ENTREZ ] |
| RefSeq | NM_001080124 [ SRS ] NM_001080124 [ ENTREZ ] |
| RefSeq | NM_001080125 [ SRS ] NM_001080125 [ ENTREZ ] |
| RefSeq | NM_001228 [ SRS ] NM_001228 [ ENTREZ ] |
| RefSeq | NM_033355 [ SRS ] NM_033355 [ ENTREZ ] |
| RefSeq | NM_033356 [ SRS ] NM_033356 [ ENTREZ ] |
| RefSeq | NM_033358 [ SRS ] NM_033358 [ ENTREZ ] |
| RefSeq | AC_000045 [ SRS ] AC_000045 [ ENTREZ ] |
| RefSeq | AC_000134 [ SRS ] AC_000134 [ ENTREZ ] |
| RefSeq | NC_000002 [ SRS ] NC_000002 [ ENTREZ ] |
| RefSeq | NG_007497 [ SRS ] NG_007497 [ ENTREZ ] |
| RefSeq | NT_005403 [ SRS ] NT_005403 [ ENTREZ ] |
| RefSeq | NW_001838863 [ SRS ] NW_001838863 [ ENTREZ ] |
| RefSeq | NW_921618 [ SRS ] NW_921618 [ ENTREZ ] |
| AceView | CASP8 AceView - NCBI |
| Unigene | Hs.655983 [ SRS ] Hs.655983 [ NCBI ]
HS655983 [ spliceNest ] |
| Fast-db | 14342 (alternative variants) |
| Protein : pattern, domain, 3D structure |
|---|
| SwissProt | Q14790 [ SRS] Q14790 [ EXPASY ] Q14790 [ INTERPRO ] Q14790 [ UNIPROT ] |
| Prosite | PS01122 CASPASE_CYS [ SRS ] PS01122 CASPASE_CYS [ Expasy ] |
| Prosite | PS01121 CASPASE_HIS [ SRS ] PS01121 CASPASE_HIS [ Expasy ] |
| Prosite | PS50207 CASPASE_P10 [ SRS ] PS50207 CASPASE_P10 [ Expasy ] |
| Prosite | PS50208 CASPASE_P20 [ SRS ] PS50208 CASPASE_P20 [ Expasy ] |
| Prosite | PS50168 DED [ SRS ] PS50168 DED [ Expasy ] |
| Interpro | IPR011029 DEATH_like [ SRS ] IPR011029 DEATH_like [ EBI ] |
| Interpro | IPR001875 DED [ SRS ] IPR001875 DED [ EBI ] |
| Interpro | IPR011600 Pept_C14_cat [ SRS ] IPR011600 Pept_C14_cat [ EBI ] |
| Interpro | IPR001309 Pept_C14_ICE_p20 [ SRS ] IPR001309 Pept_C14_ICE_p20 [ EBI ] |
| Interpro | IPR016129 Pept_C14_ICE_p20_AS [ SRS ] IPR016129 Pept_C14_ICE_p20_AS [ EBI ] |
| Interpro | IPR002138 Pept_C14_p10 [ SRS ] IPR002138 Pept_C14_p10 [ EBI ] |
| Interpro | IPR002398 Pept_C14_p45 [ SRS ] IPR002398 Pept_C14_p45 [ EBI ] |
| Interpro | IPR015917 Pept_C14_p45_core [ SRS ] IPR015917 Pept_C14_p45_core [ EBI ] |
| CluSTr | Q14790 |
| Pfam | PF01335 DED [ SRS ] PF01335 DED [ Sanger ] pfam01335 [ NCBI-CDD ] |
| Pfam | PF00656 Peptidase_C14 [ SRS ] PF00656 Peptidase_C14 [ Sanger ] pfam00656 [ NCBI-CDD ] |
| Smart | SM00115 CASc [EMBL] |
| Smart | SM00031 DED [EMBL] |
| Blocks | Q14790 |
| PDB | 1F9E [ SRS ] 1F9E [ PdbSum ], 1F9E [ IMB ] 1F9E [ RSDB ] |
| PDB | 1I4E [ SRS ] 1I4E [ PdbSum ], 1I4E [ IMB ] 1I4E [ RSDB ] |
| PDB | 1QDU [ SRS ] 1QDU [ PdbSum ], 1QDU [ IMB ] 1QDU [ RSDB ] |
| PDB | 1QTN [ SRS ] 1QTN [ PdbSum ], 1QTN [ IMB ] 1QTN [ RSDB ] |
| PDB | 2C2Z [ SRS ] 2C2Z [ PdbSum ], 2C2Z [ IMB ] 2C2Z [ RSDB ] |
| PDB | 2FUN [ SRS ] 2FUN [ PdbSum ], 2FUN [ IMB ] 2FUN [ RSDB ] |
| HPRD | 03459 |
| Protein Interaction databases |
|---|
| DIP | Q14790 |
| IntAct | Q14790 |
| Polymorphism : SNP, mutations, diseases |
|---|
| OMIM | 114480;114550;211980;601763;607271 [ map ] |
| GENECLINICS | 114480;114550;211980;601763;607271 |
| SNP | CASP8 [dbSNP-NCBI] |
| SNP | NM_001080124 [SNP-NCI] |
| SNP | NM_001080125 [SNP-NCI] |
| SNP | NM_001228 [SNP-NCI] |
| SNP | NM_033355 [SNP-NCI] |
| SNP | NM_033356 [SNP-NCI] |
| SNP | NM_033358 [SNP-NCI] |
| SNP | CASP8 [GeneSNPs - Utah] CASP8] [HGBASE - SRS] |
| HAPMAP | CASP8 [HAPMAP] |
| COSMIC | CASP8 [Somatic mutation (COSMIC-CGP-Sanger)] |
| HGMD | CASP8 |
| General knowledge |
|---|
| Family Browser | CASP8 [UCSC Family Browser] |
| SOURCE | NM_001080124 |
| SOURCE | NM_001080125 |
| SOURCE | NM_001228 |
| SOURCE | NM_033355 |
| SOURCE | NM_033356 |
| SOURCE | NM_033358 |
| SMD | Hs.655983 |
| SAGE | Hs.655983 |
| Enzyme | 3.4.22.61 [ Enzyme-Expasy ] 3.4.22.61 [ Enzyme-SRS ] 3.4.22.61 [ IntEnz-EBI ] 3.4.22.61 [ BRENDA ] 3.4.22.61 [ KEGG ] 3.4.22.61 [ WIT ] |
| GO | cytoplasm [Amigo] cytoplasm |
| GO | mitochondrion [Amigo] mitochondrion |
| GO | cytosol [Amigo] cytosol |
| GO | cytoskeleton [Amigo] cytoskeleton |
| GO | proteolysis [Amigo] proteolysis |
| GO | cysteine-type peptidase activity [Amigo] cysteine-type peptidase activity |
| GO | induction of apoptosis by extracellular signals [Amigo] induction of apoptosis by extracellular signals |
| GO | activation of pro-apoptotic gene products [Amigo] activation of pro-apoptotic gene products |
| GO | caspase activity [Amigo] caspase activity |
| GO | caspase activity [Amigo] caspase activity |
| GO | identical protein binding [Amigo] identical protein binding |
| GO | regulation of apoptosis [Amigo] regulation of apoptosis |
| GO | positive regulation of I-kappaB kinase/NF-kappaB cascade [Amigo] positive regulation of I-kappaB kinase/NF-kappaB cascade |
| BIOCARTA | HIV-I Nef: negative effector of Fas and TNF [Genes] |
| BIOCARTA | Caspase Cascade in Apoptosis [Genes] |
| BIOCARTA | Ceramide Signaling Pathway [Genes] |
| BIOCARTA | D4-GDI Signaling Pathway [Genes] |
| BIOCARTA | Induction of apoptosis through DR3 and DR4/5 Death Receptors [Genes] |
| BIOCARTA | FAS signaling pathway ( CD95 ) [Genes] |
| BIOCARTA | Role of Mitochondria in Apoptotic Signaling [Genes] |
| BIOCARTA | SODD/TNFR1 Signaling Pathway [Genes] |
| BIOCARTA | TNFR1 Signaling Pathway [Genes] |
| KEGG | Neurodegenerative Disorders |
| KEGG | MAPK signaling pathway |
| KEGG | Apoptosis |
| KEGG | Toll-like receptor signaling pathway |
| KEGG | Huntington's disease |
| KEGG | Dentatorubropallidoluysian atrophy (DRPLA) |
| PubGene | CASP8 |
| TreeFam | CASP8 |
| CTD | 841 [Comparative ToxicoGenomics Database] |
| Other databases |
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| Probes |
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| Probe | CASP8 Related clones (RZPD - Berlin) |
| PubMed |
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| PubMed | 298 Pubmed reference(s) in LocusLink |