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CASP8 (caspase 8, apoptosis-related cysteine peptidase)

Identity

Other namesALPS2B
CAP4
Casp-8
FLICE
FLJ17672
MACH
MCH5
MGC78473
HGNC (Hugo) CASP8
Location 2q33.1
Location_base_pair Starts at 201806411 and ends at 201860679 bp from pter ( according to hg18-March_2006)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CASP8   1509
Entrez_Gene (NCBI)CASP8  841  caspase 8, apoptosis-related cysteine peptidase
Cards
GeneCards (Weizmann)CASP8
Ensembl (Hinxton)ENSG00000064012 [Gene_View]  CASP8 [Vega]
AceView (NCBI)CASP8
Genatlas (Paris)CASP8
euGene (Indiana)841
SOURCE (Stanford)NM_001080124 NM_001080125 NM_001228 NM_033355 NM_033356 NM_033358
Gene Expression (Array Express) ENSG00000064012
Genomic and cartography
GoldenPath (UCSC)CASP8  -  2q33.1   chr2:201806411-201860679 +  2q33.1   [Description]    (hg18-March_2006)
EnsemblCASP8 - 2q33.1 [CytoView]
Mapping of homologs : NCBICASP8 [Mapview]
OMIM114480   114550   211980   601763   607271   
Gene and transcription
Gene : Genbank (Entrez)AA312258 AB451282 AB451414 AF009620 AF380342
Reference sequence (RefSeq transcript) :SRSNM_001080124 NM_001080125 NM_001228 NM_033355 NM_033356 NM_033358
Reference transcript : EntrezNM_001080124 NM_001080125 NM_001228 NM_033355 NM_033356 NM_033358
RefSeq genomic : SRSAC_000045 AC_000134 NC_000002 NG_007497 NT_005403 NW_001838863 NW_921618
RefSeq genomic : EntrezAC_000045 AC_000134 NC_000002 NG_007497 NT_005403 NW_001838863 NW_921618
Consensus coding sequences : CCDS NCBICASP8
Cluster EST : UnigeneHs.599762 [ SRS ] Hs.599762 [ NCBI ]
Alternative Splicing : Fast-db (Paris)14342
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtQ14790 (SRS) Q14790 (Expasy) Q14790 (Uniprot)
With graphics : InterProQ14790
Splice isoforms : VarSplice FASTAQ14790(VarSplice FASTA)
Domaine pattern : Prosite (SRS)CASPASE_CYS (PS01122)    CASPASE_HIS (PS01121)    CASPASE_P10 (PS50207)    CASPASE_P20 (PS50208)    DED (PS50168)   
Domain pattern : Prosite (Expaxy)CASPASE_CYS (PS01122)    CASPASE_HIS (PS01121)    CASPASE_P10 (PS50207)    CASPASE_P20 (PS50208)    DED (PS50168)   
Domains : Interpro (SRS)DEATH-like    DED    Pept_C14_cat    Pept_C14_ICE_p20    Pept_C14_ICE_p20_AS    Pept_C14_p10    Pept_C14_p45    Pept_C14_p45_core   
Domains : Interpro (EBI)DEATH-like    DED    Pept_C14_cat    Pept_C14_ICE_p20    Pept_C14_ICE_p20_AS    Pept_C14_p10    Pept_C14_p45    Pept_C14_p45_core   
Related proteins : CluSTrQ14790
Domain families : Pfam SRSDED (PF01335)    Peptidase_C14 (PF00656)   
Domain families : Pfam SangerDED (PF01335)    Peptidase_C14 (PF00656)   
Domain families : Pfam NCBIpfam01335    pfam00656   
Domain families : Smart EMBLCASc (SM00115)  DED (SM00031)  
Blocks (Seattle)Q14790
Crystal structure of protein : PDB SRS1F9E    1I4E    1QDU    1QTN    2C2Z    2FUN    2K7Z    3H11   
Crystal structure of protein : PDBSum1F9E    1I4E    1QDU    1QTN    2C2Z    2FUN    2K7Z    3H11   
Crystal structure of protein : IMB1F9E    1I4E    1QDU    1QTN    2C2Z    2FUN    2K7Z    3H11   
Crystal structure of protein : PDB RSDB1F9E    1I4E    1QDU    1QTN    2C2Z    2FUN    2K7Z    3H11   
HPRD03459
Protein Interaction databases
DIP (DOE-UCLA)Q14790
IntAct (EBI)Q14790
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBICASP8
SNP : GeneSNP UtahCASP8
SNP : HGBaseCASP8
Genetic variants : HAPMAPCASP8
Somatic Mutations in Cancer : COSMICCASP8 
Mutations and Diseases : HGMDCASP8
Hereditary diseases : OMIM114480    114550    211980    601763    607271   
Hereditary diseases : GENETests114480    114550    211980    601763    607271   
Diseases : Genetic AssociationCASP8
General knowledge
Homologs : HomoloGeneCASP8
Homology/Alignments : Family Browser UCSCCASP8
Phylogenetic Trees/Animal Genes : TreeFamCASP8
Catalytic activity : Enzyme3.4.22.61 [ Enzyme-Expasy ]   3.4.22.61 [ Enzyme-SRS ]   3.4.22.61 [ IntEnz-EBI ]   3.4.22.61 [ BRENDA ]   3.4.22.61 [ KEGG ]   
Chemical/Protein Interactions : CTD841
Keywords Ontology : AmiGOangiogenesis  neural tube formation  cysteine-type endopeptidase activity  nucleus  cytoplasm  mitochondrion  mitochondrial outer membrane  cytosol  cytoskeleton  heart development  peptidase activity  induction of apoptosis by extracellular signals  induction of apoptosis by extracellular signals  activation of pro-apoptotic gene products  macrophage differentiation  Noc1p-Noc2p complex  death-inducing signaling complex  response to tumor necrosis factor  identical protein binding  regulation of apoptosis  positive regulation of I-kappaB kinase/NF-kappaB cascade  membrane raft  protein heterooligomerization  proteolysis involved in cellular protein catabolic process  
Keywords Ontology : EGO-EBIangiogenesis  neural tube formation  cysteine-type endopeptidase activity  nucleus  cytoplasm  mitochondrion  mitochondrial outer membrane  cytosol  cytoskeleton  heart development  peptidase activity  induction of apoptosis by extracellular signals  induction of apoptosis by extracellular signals  activation of pro-apoptotic gene products  macrophage differentiation  Noc1p-Noc2p complex  death-inducing signaling complex  response to tumor necrosis factor  identical protein binding  regulation of apoptosis  positive regulation of I-kappaB kinase/NF-kappaB cascade  membrane raft  protein heterooligomerization  proteolysis involved in cellular protein catabolic process  
Pathways : BIOCARTAHIV-I Nef: negative effector of Fas and TNF [Genes]    Caspase Cascade in Apoptosis [Genes]    Ceramide Signaling Pathway [Genes]    D4-GDI Signaling Pathway [Genes]    Induction of apoptosis through DR3 and DR4/5 Death Receptors [Genes]    FAS signaling pathway ( CD95 ) [Genes]    Role of Mitochondria in Apoptotic Signaling [Genes]    SODD/TNFR1 Signaling Pathway [Genes]    TNFR1 Signaling Pathway [Genes]   
Pathways : KEGGNeurodegenerative DisordersMAPK signaling pathwayApoptosisToll-like receptor signaling pathwayHuntington's diseaseDentatorubropallidoluysian atrophy (DRPLA)
Other databases
Probes
Probes : ImagenesCASP8 Related clones (RZPD - Berlin)
Literature
PubMed387 Pubmed reference(s) in Entrez
PubGeneCASP8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated03-2009Dessen P

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indexed on : Sat Feb 27 10:39:39 CET 2010
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