CASS4 (Cas scaffold protein family member 4)

2013-04-01  

Identity

HGNC
LOCATION
20q13.31
LOCUSID
ALIAS
C20orf32,CAS4,HEFL,HEPL
FUSION GENES

Other Information

Locus ID:

NCBI: 57091
MIM: 618888
HGNC: 15878
Ensembl: ENSG00000087589

Variants:

dbSNP: 57091
ClinVar: 57091
TCGA: ENSG00000087589
COSMIC: CASS4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000087589ENST00000360314Q9NQ75
ENSG00000087589ENST00000434344Q9NQ75

Expression (GTEx)

0
5
10
15
20

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
182562812008A novel Cas family member, HEPL, regulates FAK and cell spreading.27
261190912015Embryonal Fyn-associated substrate (EFS) and CASS4: The lesser-known CAS protein family members.3
230019262013Overexpression and cytoplasmic accumulation of Hepl is associated with clinicopathological parameters and poor prognosis in non-small cell lung cancer.2
276772882016Overexpression of CASS4 promotes invasion in non-small cell lung cancer by activating the AKT signaling pathway and inhibiting E-cadherin expression.0
297899682018Exploring the mechanistic insights of Cas scaffolding protein family member 4 with protein tyrosine kinase 2 in Alzheimer's disease by evaluating protein interactions through molecular docking and dynamic simulations.0

Citation

Dessen P

CASS4 (Cas scaffold protein family member 4)

Atlas Genet Cytogenet Oncol Haematol. 2013-04-01

Online version: http://atlasgeneticsoncology.org/gene/53239/cass4