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CASTOR1 (cytosolic arginine sensor for mTORC1 subunit 1)

Identity

Alias_namesGATSL3
GATS protein-like 3
GATS protein like 3
Other alias
HGNC (Hugo) CASTOR1
LocusID (NCBI) 652968
Atlas_Id 79060
Location 22q12.2  [Link to chromosome band 22q12]
Location_base_pair Starts at 30285118 and ends at 30289627 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CASTOR1   34423
Cards
Entrez_Gene (NCBI)CASTOR1  652968  cytosolic arginine sensor for mTORC1 subunit 1
AliasesGATSL3
GeneCards (Weizmann)CASTOR1
Ensembl hg19 (Hinxton)ENSG00000239282 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000239282 [Gene_View]  chr22:30285118-30289627 [Contig_View]  CASTOR1 [Vega]
ICGC DataPortalENSG00000239282
TCGA cBioPortalCASTOR1
AceView (NCBI)CASTOR1
Genatlas (Paris)CASTOR1
WikiGenes652968
SOURCE (Princeton)CASTOR1
Genetics Home Reference (NIH)CASTOR1
Genomic and cartography
GoldenPath hg38 (UCSC)CASTOR1  -     chr22:30285118-30289627 -  22q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CASTOR1  -     22q12.2   [Description]    (hg19-Feb_2009)
EnsemblCASTOR1 - 22q12.2 [CytoView hg19]  CASTOR1 - 22q12.2 [CytoView hg38]
Mapping of homologs : NCBICASTOR1 [Mapview hg19]  CASTOR1 [Mapview hg38]
OMIM617034   
Gene and transcription
Genbank (Entrez)AK055587 AK309436 AK310246 BC021927 CR456449
RefSeq transcript (Entrez)NM_001037666
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CASTOR1
Cluster EST : UnigeneHs.444950 [ NCBI ]
CGAP (NCI)Hs.444950
Alternative Splicing GalleryENSG00000239282
Gene ExpressionCASTOR1 [ NCBI-GEO ]   CASTOR1 [ EBI - ARRAY_EXPRESS ]   CASTOR1 [ SEEK ]   CASTOR1 [ MEM ]
Gene Expression Viewer (FireBrowse)CASTOR1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)652968
GTEX Portal (Tissue expression)CASTOR1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8WTX7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8WTX7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8WTX7
Splice isoforms : SwissVarQ8WTX7
PhosPhoSitePlusQ8WTX7
Domains : Interpro (EBI)GATS-like    GATS-like_ACT_dom    GATSL3   
Domain families : Pfam (Sanger)ACT_7 (PF13840)   
Domain families : Pfam (NCBI)pfam13840   
Conserved Domain (NCBI)CASTOR1
DMDM Disease mutations652968
Blocks (Seattle)CASTOR1
PDB (SRS)5GS9    5I2C   
PDB (PDBSum)5GS9    5I2C   
PDB (IMB)5GS9    5I2C   
PDB (RSDB)5GS9    5I2C   
Structural Biology KnowledgeBase5GS9    5I2C   
SCOP (Structural Classification of Proteins)5GS9    5I2C   
CATH (Classification of proteins structures)5GS9    5I2C   
SuperfamilyQ8WTX7
Human Protein AtlasENSG00000239282
Peptide AtlasQ8WTX7
IPIIPI00871376   IPI00878961   IPI00880152   IPI00879981   IPI00878204   IPI00878008   
Protein Interaction databases
DIP (DOE-UCLA)Q8WTX7
IntAct (EBI)Q8WTX7
FunCoupENSG00000239282
BioGRIDCASTOR1
STRING (EMBL)CASTOR1
ZODIACCASTOR1
Ontologies - Pathways
QuickGOQ8WTX7
Ontology : AmiGOprotein binding  cytosol  arginine binding  identical protein binding  identical protein binding  GATOR2 complex  cellular response to L-arginine  negative regulation of TORC1 signaling  
Ontology : EGO-EBIprotein binding  cytosol  arginine binding  identical protein binding  identical protein binding  GATOR2 complex  cellular response to L-arginine  negative regulation of TORC1 signaling  
NDEx NetworkCASTOR1
Atlas of Cancer Signalling NetworkCASTOR1
Wikipedia pathwaysCASTOR1
Orthology - Evolution
OrthoDB652968
GeneTree (enSembl)ENSG00000239282
Phylogenetic Trees/Animal Genes : TreeFamCASTOR1
HOVERGENQ8WTX7
HOGENOMQ8WTX7
Homologs : HomoloGeneCASTOR1
Homology/Alignments : Family Browser (UCSC)CASTOR1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCASTOR1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CASTOR1
dbVarCASTOR1
ClinVarCASTOR1
1000_GenomesCASTOR1 
Exome Variant ServerCASTOR1
ExAC (Exome Aggregation Consortium)CASTOR1 (select the gene name)
Genetic variants : HAPMAP652968
Genomic Variants (DGV)CASTOR1 [DGVbeta]
DECIPHERCASTOR1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCASTOR1 
Mutations
ICGC Data PortalCASTOR1 
TCGA Data PortalCASTOR1 
Broad Tumor PortalCASTOR1
OASIS PortalCASTOR1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDCASTOR1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CASTOR1
DgiDB (Drug Gene Interaction Database)CASTOR1
DoCM (Curated mutations)CASTOR1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CASTOR1 (select a term)
intoGenCASTOR1
Cancer3DCASTOR1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617034   
Orphanet
MedgenCASTOR1
Genetic Testing Registry CASTOR1
NextProtQ8WTX7 [Medical]
TSGene652968
GENETestsCASTOR1
Target ValidationCASTOR1
Huge Navigator CASTOR1 [HugePedia]
snp3D : Map Gene to Disease652968
BioCentury BCIQCASTOR1
ClinGenCASTOR1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD652968
Chemical/Pharm GKB GenePA164720260
Clinical trialCASTOR1
Miscellaneous
canSAR (ICR)CASTOR1 (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCASTOR1
EVEXCASTOR1
GoPubMedCASTOR1
iHOPCASTOR1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:03:55 CEST 2017

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