CASTOR1 (cytosolic arginine sensor for mTORC1 subunit 1)

2021-06-01  

Identity

HGNC
CASTOR1
LOCATION
22q12.2
LOCUSID
652968
ALIAS
GATSL3

Other Information

Locus ID:

NCBI: 652968
MIM: 617034
HGNC: 34423
Ensembl: ENSG00000239282

Variants:

dbSNP: 652968
ClinVar: 652968
TCGA: ENSG00000239282
COSMIC: CASTOR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000239282ENST00000404953B7WPJ3
ENSG00000239282ENST00000407689Q8WTX7
ENSG00000239282ENST00000415484F8WD52
ENSG00000239282ENST00000421236F2Z3I9
ENSG00000239282ENST00000425691F2Z2C1
ENSG00000239282ENST00000440704H7C2U7
ENSG00000239282ENST00000440839F2Z3I9

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
244495722014Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study.0
269720532016The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway.0
274872102016Mechanism of arginine sensing by CASTOR1 upstream of mTORC1.0
301329782018CASTOR1 suppresses the progression of lung adenocarcinoma and predicts poor prognosis.0
305033382019Crystal structures of arginine sensor CASTOR1 in arginine-bound and ligand free states.0
313052632019Kaposi sarcoma-associated herpesvirus miRNAs suppress CASTOR1-mediated mTORC1 inhibition to promote tumorigenesis.0
316591012019Seeking mTORC1 Inhibitors Through Molecular Dynamics Simulation of Arginine Analogs Inhibiting CASTOR1.0

Citation

Dessen P

CASTOR1 (cytosolic arginine sensor for mTORC1 subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58240/castor1