Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CAV2 (caveolin 2)

Identity

Alias_symbol (synonym)CAV
Other alias
HGNC (Hugo) CAV2
LocusID (NCBI) 858
Atlas_Id 933
Location 7q31.2  [Link to chromosome band 7q31]
Location_base_pair Starts at 116499601 and ends at 116508541 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CAV2 (7q31.2) / FAM13B (5q31.2)CAV2 (7q31.2) / FAM189B (1q22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CAV2   1528
Cards
Entrez_Gene (NCBI)CAV2  858  caveolin 2
AliasesCAV
GeneCards (Weizmann)CAV2
Ensembl hg19 (Hinxton)ENSG00000105971 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105971 [Gene_View]  chr7:116499601-116508541 [Contig_View]  CAV2 [Vega]
ICGC DataPortalENSG00000105971
TCGA cBioPortalCAV2
AceView (NCBI)CAV2
Genatlas (Paris)CAV2
WikiGenes858
SOURCE (Princeton)CAV2
Genetics Home Reference (NIH)CAV2
Genomic and cartography
GoldenPath hg38 (UCSC)CAV2  -     chr7:116499601-116508541 +  7q31.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CAV2  -     7q31.2   [Description]    (hg19-Feb_2009)
EnsemblCAV2 - 7q31.2 [CytoView hg19]  CAV2 - 7q31.2 [CytoView hg38]
Mapping of homologs : NCBICAV2 [Mapview hg19]  CAV2 [Mapview hg38]
OMIM601048   
Gene and transcription
Genbank (Entrez)AA878149 AA883287 AB451285 AB451417 AF035752
RefSeq transcript (Entrez)NM_001206747 NM_001206748 NM_001233 NM_198212
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CAV2
Cluster EST : UnigeneHs.603096 [ NCBI ]
CGAP (NCI)Hs.603096
Alternative Splicing GalleryENSG00000105971
Gene ExpressionCAV2 [ NCBI-GEO ]   CAV2 [ EBI - ARRAY_EXPRESS ]   CAV2 [ SEEK ]   CAV2 [ MEM ]
Gene Expression Viewer (FireBrowse)CAV2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)858
GTEX Portal (Tissue expression)CAV2
Human Protein AtlasENSG00000105971-CAV2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51636   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51636  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51636
Splice isoforms : SwissVarP51636
PhosPhoSitePlusP51636
Domaine pattern : Prosite (Expaxy)CAVEOLIN (PS01210)   
Domains : Interpro (EBI)CAV-2    Caveolin    Caveolin_CS   
Domain families : Pfam (Sanger)Caveolin (PF01146)   
Domain families : Pfam (NCBI)pfam01146   
Conserved Domain (NCBI)CAV2
DMDM Disease mutations858
Blocks (Seattle)CAV2
SuperfamilyP51636
Human Protein Atlas [tissue]ENSG00000105971-CAV2 [tissue]
Peptide AtlasP51636
HPRD03029
IPIIPI00019870   IPI00759514   IPI00386526   IPI01018255   
Protein Interaction databases
DIP (DOE-UCLA)P51636
IntAct (EBI)P51636
FunCoupENSG00000105971
BioGRIDCAV2
STRING (EMBL)CAV2
ZODIACCAV2
Ontologies - Pathways
QuickGOP51636
Ontology : AmiGOGolgi membrane  negative regulation of endothelial cell proliferation  positive regulation of endothelial cell proliferation  acrosomal membrane  protein binding  intracellular  nucleus  Golgi apparatus  plasma membrane  integral component of plasma membrane  caveola  focal adhesion  vesicle fusion  mitochondrion organization  endoplasmic reticulum organization  regulation of mitotic nuclear division  insulin receptor signaling pathway  vesicle organization  receptor-mediated endocytosis of virus by host cell  protein kinase binding  transport vesicle  negative regulation of transforming growth factor beta receptor signaling pathway  protein binding, bridging  extrinsic component of cytoplasmic side of plasma membrane  cytoplasmic vesicle  protein complex scaffold  protein homodimerization activity  protein complex  positive regulation of MAPK cascade  positive regulation of GTPase activity  positive regulation by host of viral release from host cell  positive regulation by host of viral process  membrane raft  protein heterodimerization activity  vesicle docking  perinuclear region of cytoplasm  skeletal muscle fiber development  protein oligomerization  positive regulation of dopamine receptor signaling pathway  caveola assembly  caveola assembly  scaffold protein binding  
Ontology : EGO-EBIGolgi membrane  negative regulation of endothelial cell proliferation  positive regulation of endothelial cell proliferation  acrosomal membrane  protein binding  intracellular  nucleus  Golgi apparatus  plasma membrane  integral component of plasma membrane  caveola  focal adhesion  vesicle fusion  mitochondrion organization  endoplasmic reticulum organization  regulation of mitotic nuclear division  insulin receptor signaling pathway  vesicle organization  receptor-mediated endocytosis of virus by host cell  protein kinase binding  transport vesicle  negative regulation of transforming growth factor beta receptor signaling pathway  protein binding, bridging  extrinsic component of cytoplasmic side of plasma membrane  cytoplasmic vesicle  protein complex scaffold  protein homodimerization activity  protein complex  positive regulation of MAPK cascade  positive regulation of GTPase activity  positive regulation by host of viral release from host cell  positive regulation by host of viral process  membrane raft  protein heterodimerization activity  vesicle docking  perinuclear region of cytoplasm  skeletal muscle fiber development  protein oligomerization  positive regulation of dopamine receptor signaling pathway  caveola assembly  caveola assembly  scaffold protein binding  
Pathways : KEGGEndocytosis    Focal adhesion    Bacterial invasion of epithelial cells    Proteoglycans in cancer   
NDEx NetworkCAV2
Atlas of Cancer Signalling NetworkCAV2
Wikipedia pathwaysCAV2
Orthology - Evolution
OrthoDB858
GeneTree (enSembl)ENSG00000105971
Phylogenetic Trees/Animal Genes : TreeFamCAV2
HOVERGENP51636
HOGENOMP51636
Homologs : HomoloGeneCAV2
Homology/Alignments : Family Browser (UCSC)CAV2
Gene fusions - Rearrangements
Tumor Fusion PortalCAV2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCAV2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CAV2
dbVarCAV2
ClinVarCAV2
1000_GenomesCAV2 
Exome Variant ServerCAV2
ExAC (Exome Aggregation Consortium)ENSG00000105971
GNOMAD BrowserENSG00000105971
Genetic variants : HAPMAP858
Genomic Variants (DGV)CAV2 [DGVbeta]
DECIPHERCAV2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCAV2 
Mutations
ICGC Data PortalCAV2 
TCGA Data PortalCAV2 
Broad Tumor PortalCAV2
OASIS PortalCAV2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCAV2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCAV2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CAV2
DgiDB (Drug Gene Interaction Database)CAV2
DoCM (Curated mutations)CAV2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CAV2 (select a term)
intoGenCAV2
Cancer3DCAV2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601048   
Orphanet
DisGeNETCAV2
MedgenCAV2
Genetic Testing Registry CAV2
NextProtP51636 [Medical]
TSGene858
GENETestsCAV2
Target ValidationCAV2
Huge Navigator CAV2 [HugePedia]
snp3D : Map Gene to Disease858
BioCentury BCIQCAV2
ClinGenCAV2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD858
Chemical/Pharm GKB GenePA26108
Clinical trialCAV2
Miscellaneous
canSAR (ICR)CAV2 (select the gene name)
Probes
Litterature
PubMed98 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCAV2
EVEXCAV2
GoPubMedCAV2
iHOPCAV2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:06:06 CET 2017

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