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CAV2 (caveolin 2)

Identity

Alias (NCBI)CAV
HGNC (Hugo) CAV2
HGNC Alias symbCAV
LocusID (NCBI) 858
Atlas_Id 933
Location 7q31.2  [Link to chromosome band 7q31]
Location_base_pair Starts at 116499738 and ends at 116508541 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CAV2 (7q31.2) / FAM13B (5q31.2)CAV2 (7q31.2) / FAM189B (1q22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CAV2   1528
Cards
Entrez_Gene (NCBI)CAV2    caveolin 2
AliasesCAV
GeneCards (Weizmann)CAV2
Ensembl hg19 (Hinxton)ENSG00000105971 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105971 [Gene_View]  ENSG00000105971 [Sequence]  chr7:116499738-116508541 [Contig_View]  CAV2 [Vega]
ICGC DataPortalENSG00000105971
TCGA cBioPortalCAV2
AceView (NCBI)CAV2
Genatlas (Paris)CAV2
SOURCE (Princeton)CAV2
Genetics Home Reference (NIH)CAV2
Genomic and cartography
GoldenPath hg38 (UCSC)CAV2  -     chr7:116499738-116508541 +  7q31.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CAV2  -     7q31.2   [Description]    (hg19-Feb_2009)
GoldenPathCAV2 - 7q31.2 [CytoView hg19]  CAV2 - 7q31.2 [CytoView hg38]
ImmunoBaseENSG00000105971
Genome Data Viewer NCBICAV2 [Mapview hg19]  
OMIM601048   
Gene and transcription
Genbank (Entrez)AA878149 AA883287 AB451285 AB451417 AF035752
RefSeq transcript (Entrez)NM_001206747 NM_001206748 NM_001233 NM_198212
Consensus coding sequences : CCDS (NCBI)CAV2
Gene ExpressionCAV2 [ NCBI-GEO ]   CAV2 [ EBI - ARRAY_EXPRESS ]   CAV2 [ SEEK ]   CAV2 [ MEM ]
Gene Expression Viewer (FireBrowse)CAV2 [ Firebrowse - Broad ]
GenevisibleExpression of CAV2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)858
GTEX Portal (Tissue expression)CAV2
Human Protein AtlasENSG00000105971-CAV2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51636   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51636  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51636
PhosPhoSitePlusP51636
Domaine pattern : Prosite (Expaxy)CAVEOLIN (PS01210)   
Domains : Interpro (EBI)CAV-2    Caveolin    Caveolin_CS   
Domain families : Pfam (Sanger)Caveolin (PF01146)   
Domain families : Pfam (NCBI)pfam01146   
Conserved Domain (NCBI)CAV2
SuperfamilyP51636
AlphaFold pdb e-kbP51636   
Human Protein Atlas [tissue]ENSG00000105971-CAV2 [tissue]
HPRD03029
Protein Interaction databases
DIP (DOE-UCLA)P51636
IntAct (EBI)P51636
BioGRIDCAV2
STRING (EMBL)CAV2
ZODIACCAV2
Ontologies - Pathways
QuickGOP51636
Ontology : AmiGOGolgi membrane  negative regulation of endothelial cell proliferation  negative regulation of endothelial cell proliferation  positive regulation of endothelial cell proliferation  acrosomal membrane  caveolar macromolecular signaling complex  protein binding  nucleus  Golgi apparatus  Golgi apparatus  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  caveola  focal adhesion  focal adhesion  vesicle fusion  mitochondrion organization  endoplasmic reticulum organization  regulation of mitotic nuclear division  insulin receptor signaling pathway  insulin receptor signaling pathway  vesicle organization  receptor-mediated endocytosis of virus by host cell  protein kinase binding  transport vesicle  cell differentiation  negative regulation of transforming growth factor beta receptor signaling pathway  protein-macromolecule adaptor activity  extrinsic component of cytoplasmic side of plasma membrane  cytoplasmic vesicle  cytoplasmic vesicle  protein-containing complex  sarcolemma  protein homodimerization activity  positive regulation of MAPK cascade  positive regulation of MAPK cascade  positive regulation of GTPase activity  positive regulation by host of viral release from host cell  positive regulation by host of viral process  membrane raft  protein heterodimerization activity  vesicle docking  perinuclear region of cytoplasm  perinuclear region of cytoplasm  skeletal muscle fiber development  regulation of cytosolic calcium ion concentration  molecular adaptor activity  positive regulation of dopamine receptor signaling pathway  caveola assembly  caveola assembly  caveola assembly  basement membrane organization  scaffold protein binding  
Ontology : EGO-EBIGolgi membrane  negative regulation of endothelial cell proliferation  negative regulation of endothelial cell proliferation  positive regulation of endothelial cell proliferation  acrosomal membrane  caveolar macromolecular signaling complex  protein binding  nucleus  Golgi apparatus  Golgi apparatus  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  caveola  focal adhesion  focal adhesion  vesicle fusion  mitochondrion organization  endoplasmic reticulum organization  regulation of mitotic nuclear division  insulin receptor signaling pathway  insulin receptor signaling pathway  vesicle organization  receptor-mediated endocytosis of virus by host cell  protein kinase binding  transport vesicle  cell differentiation  negative regulation of transforming growth factor beta receptor signaling pathway  protein-macromolecule adaptor activity  extrinsic component of cytoplasmic side of plasma membrane  cytoplasmic vesicle  cytoplasmic vesicle  protein-containing complex  sarcolemma  protein homodimerization activity  positive regulation of MAPK cascade  positive regulation of MAPK cascade  positive regulation of GTPase activity  positive regulation by host of viral release from host cell  positive regulation by host of viral process  membrane raft  protein heterodimerization activity  vesicle docking  perinuclear region of cytoplasm  perinuclear region of cytoplasm  skeletal muscle fiber development  regulation of cytosolic calcium ion concentration  molecular adaptor activity  positive regulation of dopamine receptor signaling pathway  caveola assembly  caveola assembly  caveola assembly  basement membrane organization  scaffold protein binding  
Pathways : KEGGEndocytosis    Focal adhesion    Bacterial invasion of epithelial cells    Proteoglycans in cancer   
NDEx NetworkCAV2
Atlas of Cancer Signalling NetworkCAV2
Wikipedia pathwaysCAV2
Orthology - Evolution
OrthoDB858
GeneTree (enSembl)ENSG00000105971
Phylogenetic Trees/Animal Genes : TreeFamCAV2
Homologs : HomoloGeneCAV2
Homology/Alignments : Family Browser (UCSC)CAV2
Gene fusions - Rearrangements
Fusion : QuiverCAV2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCAV2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CAV2
dbVarCAV2
ClinVarCAV2
MonarchCAV2
1000_GenomesCAV2 
Exome Variant ServerCAV2
GNOMAD BrowserENSG00000105971
Varsome BrowserCAV2
ACMGCAV2 variants
VarityP51636
Genomic Variants (DGV)CAV2 [DGVbeta]
DECIPHERCAV2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCAV2 
Mutations
ICGC Data PortalCAV2 
TCGA Data PortalCAV2 
Broad Tumor PortalCAV2
OASIS PortalCAV2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCAV2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCAV2
Mutations and Diseases : HGMDCAV2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCAV2
DgiDB (Drug Gene Interaction Database)CAV2
DoCM (Curated mutations)CAV2
CIViC (Clinical Interpretations of Variants in Cancer)CAV2
Cancer3DCAV2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601048   
Orphanet
DisGeNETCAV2
MedgenCAV2
Genetic Testing Registry CAV2
NextProtP51636 [Medical]
GENETestsCAV2
Target ValidationCAV2
Huge Navigator CAV2 [HugePedia]
ClinGenCAV2
Clinical trials, drugs, therapy
MyCancerGenomeCAV2
Protein Interactions : CTDCAV2
Pharm GKB GenePA26108
PharosP51636
Clinical trialCAV2
Miscellaneous
canSAR (ICR)CAV2
HarmonizomeCAV2
DataMed IndexCAV2
Probes
Litterature
PubMed117 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCAV2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:02:22 CEST 2021

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