CBFA2T2 (CBFA2/RUNX1 partner transcriptional co-repressor 2)

2003-02-01  

Identity

HGNC
LOCATION
20q11.22
LOCUSID
ALIAS
EHT,MTGR1,ZMYND3,p85
FUSION GENES

Other Information

Locus ID:

NCBI: 9139
MIM: 603672
HGNC: 1536
Ensembl: ENSG00000078699

Variants:

dbSNP: 9139
ClinVar: 9139
TCGA: ENSG00000078699
COSMIC: CBFA2T2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000078699ENST00000342704O43439
ENSG00000078699ENST00000344201O43439
ENSG00000078699ENST00000346541O43439
ENSG00000078699ENST00000359606O43439
ENSG00000078699ENST00000375279O43439
ENSG00000078699ENST00000397800O43439
ENSG00000078699ENST00000492345O43439
ENSG00000078699ENST00000543126Q68DC6

Expression (GTEx)

0
5
10
15
20
25

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
205206372010CBFA2T2 and C20orf112: two novel fusion partners of RUNX1 in acute myeloid leukemia.13
272812182016Co-repressor CBFA2T2 regulates pluripotency and germline development.11
272704372016Myeloid translocation genes differentially regulate colorectal cancer programs.5
224431752012The leukemia associated nuclear corepressor ETO homologue genes MTG16 and MTGR1 are regulated differently in hematopoietic cells.4
185861232008Transcriptional repression by leukaemia-associated ETO family members can be independent of oligomerization and coexpressed hSIN3B and N-CoR.3
190266872009Loss of function genetic screens reveal MTGR1 as an intracellular repressor of beta1 integrin-dependent neurite outgrowth.2

Citation

Dessen P

CBFA2T2 (CBFA2/RUNX1 partner transcriptional co-repressor 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/934/cbfa2t2