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CBR3 (carbonyl reductase 3)

Identity

Alias_namesmember 2
Alias_symbol (synonym)SDR21C2
Other aliasHEL-S-25
hCBR3
HGNC (Hugo) CBR3
LocusID (NCBI) 874
Atlas_Id 45951
Location 21q22.12  [Link to chromosome band 21q22]
Location_base_pair Starts at 36134965 and ends at 36146562 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DOPEY2 (21q22.12) / CBR3 (21q22.12)EVA1C (21q22.11) / CBR3 (21q22.12)C21orf63 CBR3 21q22.12
DOPEY2 21q22.12 / CBR3 21q22.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  DOPEY2/CBR3 (21q22)
EVA1C/CBR3 (21q22)


External links

Nomenclature
HGNC (Hugo)CBR3   1549
Cards
Entrez_Gene (NCBI)CBR3  874  carbonyl reductase 3
AliasesHEL-S-25; SDR21C2; hCBR3
GeneCards (Weizmann)CBR3
Ensembl hg19 (Hinxton)ENSG00000159231 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000159231 [Gene_View]  ENSG00000159231 [Sequence]  chr21:36134965-36146562 [Contig_View]  CBR3 [Vega]
ICGC DataPortalENSG00000159231
TCGA cBioPortalCBR3
AceView (NCBI)CBR3
Genatlas (Paris)CBR3
WikiGenes874
SOURCE (Princeton)CBR3
Genetics Home Reference (NIH)CBR3
Genomic and cartography
GoldenPath hg38 (UCSC)CBR3  -     chr21:36134965-36146562 +  21q22.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CBR3  -     21q22.12   [Description]    (hg19-Feb_2009)
EnsemblCBR3 - 21q22.12 [CytoView hg19]  CBR3 - 21q22.12 [CytoView hg38]
Mapping of homologs : NCBICBR3 [Mapview hg19]  CBR3 [Mapview hg38]
OMIM603608   
Gene and transcription
Genbank (Entrez)AB004850 AB004854 AB041012 AB124847 AJ000096
RefSeq transcript (Entrez)NM_001236
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CBR3
Cluster EST : UnigeneHs.154510 [ NCBI ]
CGAP (NCI)Hs.154510
Alternative Splicing GalleryENSG00000159231
Gene ExpressionCBR3 [ NCBI-GEO ]   CBR3 [ EBI - ARRAY_EXPRESS ]   CBR3 [ SEEK ]   CBR3 [ MEM ]
Gene Expression Viewer (FireBrowse)CBR3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)874
GTEX Portal (Tissue expression)CBR3
Human Protein AtlasENSG00000159231-CBR3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75828   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75828  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75828
Splice isoforms : SwissVarO75828
Catalytic activity : Enzyme1.1.1.184 [ Enzyme-Expasy ]   1.1.1.1841.1.1.184 [ IntEnz-EBI ]   1.1.1.184 [ BRENDA ]   1.1.1.184 [ KEGG ]   
PhosPhoSitePlusO75828
Domaine pattern : Prosite (Expaxy)ADH_SHORT (PS00061)   
Domains : Interpro (EBI)NAD(P)-bd_dom_sf    Sc_DH/Rdtase_CS    SDR_fam   
Domain families : Pfam (Sanger)adh_short (PF00106)   
Domain families : Pfam (NCBI)pfam00106   
Conserved Domain (NCBI)CBR3
DMDM Disease mutations874
Blocks (Seattle)CBR3
PDB (SRS)2HRB   
PDB (PDBSum)2HRB   
PDB (IMB)2HRB   
PDB (RSDB)2HRB   
Structural Biology KnowledgeBase2HRB   
SCOP (Structural Classification of Proteins)2HRB   
CATH (Classification of proteins structures)2HRB   
SuperfamilyO75828
Human Protein Atlas [tissue]ENSG00000159231-CBR3 [tissue]
Peptide AtlasO75828
HPRD07222
IPIIPI00290462   IPI00816567   
Protein Interaction databases
DIP (DOE-UCLA)O75828
IntAct (EBI)O75828
FunCoupENSG00000159231
BioGRIDCBR3
STRING (EMBL)CBR3
ZODIACCBR3
Ontologies - Pathways
QuickGOO75828
Ontology : AmiGO3-keto sterol reductase activity  carbonyl reductase (NADPH) activity  carbonyl reductase (NADPH) activity  carbonyl reductase (NADPH) activity  protein binding  extracellular space  nucleoplasm  cytosol  cytosol  xenobiotic metabolic process  phylloquinone catabolic process  cognition  oxidation-reduction process  NADPH binding  
Ontology : EGO-EBI3-keto sterol reductase activity  carbonyl reductase (NADPH) activity  carbonyl reductase (NADPH) activity  carbonyl reductase (NADPH) activity  protein binding  extracellular space  nucleoplasm  cytosol  cytosol  xenobiotic metabolic process  phylloquinone catabolic process  cognition  oxidation-reduction process  NADPH binding  
Pathways : KEGGArachidonic acid metabolism    Metabolism of xenobiotics by cytochrome P450   
NDEx NetworkCBR3
Atlas of Cancer Signalling NetworkCBR3
Wikipedia pathwaysCBR3
Orthology - Evolution
OrthoDB874
GeneTree (enSembl)ENSG00000159231
Phylogenetic Trees/Animal Genes : TreeFamCBR3
HOVERGENO75828
HOGENOMO75828
Homologs : HomoloGeneCBR3
Homology/Alignments : Family Browser (UCSC)CBR3
Gene fusions - Rearrangements
Fusion : MitelmanDOPEY2/CBR3 [21q22.12/21q22.12]  [t(21;21)(q22;q22)]  
Fusion : MitelmanEVA1C/CBR3 [21q22.11/21q22.12]  [t(21;21)(q22;q22)]  
Fusion PortalC21orf63 CBR3 21q22.12 PRAD
Fusion PortalDOPEY2 21q22.12 CBR3 21q22.12 LUAD
Fusion : QuiverCBR3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCBR3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CBR3
dbVarCBR3
ClinVarCBR3
1000_GenomesCBR3 
Exome Variant ServerCBR3
ExAC (Exome Aggregation Consortium)ENSG00000159231
GNOMAD BrowserENSG00000159231
Varsome BrowserCBR3
Genetic variants : HAPMAP874
Genomic Variants (DGV)CBR3 [DGVbeta]
DECIPHERCBR3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCBR3 
Mutations
ICGC Data PortalCBR3 
TCGA Data PortalCBR3 
Broad Tumor PortalCBR3
OASIS PortalCBR3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCBR3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCBR3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CBR3
DgiDB (Drug Gene Interaction Database)CBR3
DoCM (Curated mutations)CBR3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CBR3 (select a term)
intoGenCBR3
Cancer3DCBR3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603608   
Orphanet
DisGeNETCBR3
MedgenCBR3
Genetic Testing Registry CBR3
NextProtO75828 [Medical]
TSGene874
GENETestsCBR3
Target ValidationCBR3
Huge Navigator CBR3 [HugePedia]
snp3D : Map Gene to Disease874
BioCentury BCIQCBR3
ClinGenCBR3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD874
Chemical/Pharm GKB GenePA26122
Clinical trialCBR3
Miscellaneous
canSAR (ICR)CBR3 (select the gene name)
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCBR3
EVEXCBR3
GoPubMedCBR3
iHOPCBR3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Nov 6 10:55:57 CET 2018

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