Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CBX1 (chromobox 1)

Identity

Alias_nameschromobox homolog 1 (Drosophila HP1 beta)
chromobox homolog 1
Alias_symbol (synonym)HP1Hs-beta
M31
MOD1
CBX
HP1-BETA
Other aliasHP1Hsbeta
p25beta
HGNC (Hugo) CBX1
LocusID (NCBI) 10951
Atlas_Id 45621
Location 17q21.32  [Link to chromosome band 17q21]
Location_base_pair Starts at 46147414 and ends at 46178883 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CBX1 (17q21.32) / SSH2 (17q11.2)CBX1 (17q21.32) / SSRP1 (11q12.1)HNRNPM (19p13.2) / CBX1 (17q21.32)
RNF169 (11q13.4) / CBX1 (17q21.32)CBX1 17q21.32 / SSH2 17q11.2RNF169 11q13.4 / CBX1 17q21.32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CBX1   1551
Cards
Entrez_Gene (NCBI)CBX1  10951  chromobox 1
AliasesCBX; HP1-BETA; HP1Hs-beta; HP1Hsbeta; 
M31; MOD1; p25beta
GeneCards (Weizmann)CBX1
Ensembl hg19 (Hinxton)ENSG00000108468 [Gene_View]  chr17:46147414-46178883 [Contig_View]  CBX1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000108468 [Gene_View]  chr17:46147414-46178883 [Contig_View]  CBX1 [Vega]
ICGC DataPortalENSG00000108468
TCGA cBioPortalCBX1
AceView (NCBI)CBX1
Genatlas (Paris)CBX1
WikiGenes10951
SOURCE (Princeton)CBX1
Genetics Home Reference (NIH)CBX1
Genomic and cartography
GoldenPath hg19 (UCSC)CBX1  -     chr17:46147414-46178883 -  17q21.32   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CBX1  -     17q21.32   [Description]    (hg38-Dec_2013)
EnsemblCBX1 - 17q21.32 [CytoView hg19]  CBX1 - 17q21.32 [CytoView hg38]
Mapping of homologs : NCBICBX1 [Mapview hg19]  CBX1 [Mapview hg38]
OMIM604511   
Gene and transcription
Genbank (Entrez)AK312615 BC002609 BC021302 CB053834 CR456766
RefSeq transcript (Entrez)NM_001127228 NM_006807
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)CBX1
Cluster EST : UnigeneHs.77254 [ NCBI ]
CGAP (NCI)Hs.77254
Alternative Splicing GalleryENSG00000108468
Gene ExpressionCBX1 [ NCBI-GEO ]   CBX1 [ EBI - ARRAY_EXPRESS ]   CBX1 [ SEEK ]   CBX1 [ MEM ]
Gene Expression Viewer (FireBrowse)CBX1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10951
GTEX Portal (Tissue expression)CBX1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP83916   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP83916  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP83916
Splice isoforms : SwissVarP83916
PhosPhoSitePlusP83916
Domaine pattern : Prosite (Expaxy)CHROMO_1 (PS00598)    CHROMO_2 (PS50013)   
Domains : Interpro (EBI)Chromo/shadow_dom    Chromo_dom_subgr    Chromo_domain    Chromo_shadow_dom    Chromodomain-like    Chromodomain_CS   
Domain families : Pfam (Sanger)Chromo (PF00385)    Chromo_shadow (PF01393)   
Domain families : Pfam (NCBI)pfam00385    pfam01393   
Domain families : Smart (EMBL)CHROMO (SM00298)  ChSh (SM00300)  
Conserved Domain (NCBI)CBX1
DMDM Disease mutations10951
Blocks (Seattle)CBX1
PDB (SRS)2FMM    3F2U    3Q6S   
PDB (PDBSum)2FMM    3F2U    3Q6S   
PDB (IMB)2FMM    3F2U    3Q6S   
PDB (RSDB)2FMM    3F2U    3Q6S   
Structural Biology KnowledgeBase2FMM    3F2U    3Q6S   
SCOP (Structural Classification of Proteins)2FMM    3F2U    3Q6S   
CATH (Classification of proteins structures)2FMM    3F2U    3Q6S   
SuperfamilyP83916
Human Protein AtlasENSG00000108468
Peptide AtlasP83916
HPRD05149
IPIIPI00878669   IPI00001830   IPI00879132   IPI01014449   
Protein Interaction databases
DIP (DOE-UCLA)P83916
IntAct (EBI)P83916
FunCoupENSG00000108468
BioGRIDCBX1
STRING (EMBL)CBX1
ZODIACCBX1
Ontologies - Pathways
QuickGOP83916
Ontology : AmiGOchromosome, centromeric region  nuclear chromosome, telomeric region  nuclear chromosome, telomeric region  chromatin  female pronucleus  male pronucleus  chromatin binding  protein binding  nucleoplasm  nuclear heterochromatin  pericentric heterochromatin  spindle  chromocenter  enzyme binding  protein homodimerization activity  negative regulation of transcription, DNA-templated  histone methyltransferase binding  
Ontology : EGO-EBIchromosome, centromeric region  nuclear chromosome, telomeric region  nuclear chromosome, telomeric region  chromatin  female pronucleus  male pronucleus  chromatin binding  protein binding  nucleoplasm  nuclear heterochromatin  pericentric heterochromatin  spindle  chromocenter  enzyme binding  protein homodimerization activity  negative regulation of transcription, DNA-templated  histone methyltransferase binding  
NDEx NetworkCBX1
Atlas of Cancer Signalling NetworkCBX1
Wikipedia pathwaysCBX1
Orthology - Evolution
OrthoDB10951
GeneTree (enSembl)ENSG00000108468
Phylogenetic Trees/Animal Genes : TreeFamCBX1
HOVERGENP83916
HOGENOMP83916
Homologs : HomoloGeneCBX1
Homology/Alignments : Family Browser (UCSC)CBX1
Gene fusions - Rearrangements
Fusion : MitelmanCBX1/SSH2 [17q21.32/17q11.2]  
Fusion : MitelmanRNF169/CBX1 [11q13.4/17q21.32]  [t(11;17)(q13;q21)]  
Fusion: TCGACBX1 17q21.32 SSH2 17q11.2 BRCA
Fusion: TCGARNF169 11q13.4 CBX1 17q21.32 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCBX1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CBX1
dbVarCBX1
ClinVarCBX1
1000_GenomesCBX1 
Exome Variant ServerCBX1
ExAC (Exome Aggregation Consortium)CBX1 (select the gene name)
Genetic variants : HAPMAP10951
Genomic Variants (DGV)CBX1 [DGVbeta]
DECIPHER (Syndromes)17:46147414-46178883  ENSG00000108468
CONAN: Copy Number AnalysisCBX1 
Mutations
ICGC Data PortalCBX1 
TCGA Data PortalCBX1 
Broad Tumor PortalCBX1
OASIS PortalCBX1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCBX1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCBX1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CBX1
DgiDB (Drug Gene Interaction Database)CBX1
DoCM (Curated mutations)CBX1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CBX1 (select a term)
intoGenCBX1
Cancer3DCBX1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604511   
Orphanet
MedgenCBX1
Genetic Testing Registry CBX1
NextProtP83916 [Medical]
TSGene10951
GENETestsCBX1
Huge Navigator CBX1 [HugePedia]
snp3D : Map Gene to Disease10951
BioCentury BCIQCBX1
ClinGenCBX1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10951
Chemical/Pharm GKB GenePA26126
Clinical trialCBX1
Miscellaneous
canSAR (ICR)CBX1 (select the gene name)
Probes
Litterature
PubMed107 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCBX1
EVEXCBX1
GoPubMedCBX1
iHOPCBX1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:58:51 CET 2017

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