CBX1 (chromobox 1)

2007-02-01  

Identity

HGNC
CBX1
LOCATION
17q21.32
LOCUSID
10951
ALIAS
CBX,HP1-BETA,HP1Hs-beta,HP1Hsbeta,M31,MOD1,p25beta
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10951
MIM: 604511
HGNC: 1551
Ensembl: ENSG00000108468

Variants:

dbSNP: 10951
ClinVar: 10951
TCGA: ENSG00000108468
COSMIC: CBX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108468ENST00000225603P83916
ENSG00000108468ENST00000225603Q6IBN6
ENSG00000108468ENST00000393408P83916
ENSG00000108468ENST00000393408Q6IBN6
ENSG00000108468ENST00000402583B5MD17
ENSG00000108468ENST00000444685C9JWS9
ENSG00000108468ENST00000495350K7ELA4
ENSG00000108468ENST00000581003J3KS05

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
125605552003Maintenance of stable heterochromatin domains by dynamic HP1 binding.191
184383992008HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response.178
158998592005In vivo HP1 targeting causes large-scale chromatin condensation and enhanced histone lysine methylation.61
145859932003Human heterochromatin protein 1 isoforms HP1(Hsalpha) and HP1(Hsbeta) interfere with hTERT-telomere interactions and correlate with changes in cell growth and response to ionizing radiation.40
237077592013A method for systematic mapping of protein lysine methylation identifies functions for HP1β in DNA damage response.35
182396892008Regulation of an inducible promoter by an HP1beta-HP1gamma switch.29
185905782008Phosphorylation at Ser473 regulates heterochromatin protein 1 binding and corepressor function of TIF1beta/KAP1.26
270904912016Dynamic and flexible H3K9me3 bridging via HP1β dimerization establishes a plastic state of condensed chromatin.26
119599142002Isoform-specific interaction of HP1 with human TAFII130.25
227150962012Kruppel-associated Box (KRAB)-associated co-repressor (KAP-1) Ser-473 phosphorylation regulates heterochromatin protein 1β (HP1-β) mobilization and DNA repair in heterochromatin.24

Citation

Dessen P

CBX1 (chromobox 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45621/cbx1