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CBX3 (chromobox 3)

Identity

Alias (NCBI)HECH
HP1-GAMMA
HP1Hs-gamma
HGNC (Hugo) CBX3
HGNC Alias symbHP1Hs-gamma
HGNC Alias nameHP1 gamma homolog (Drosophila)
HGNC Previous namechromobox homolog 3 (Drosophila HP1 gamma)
 chromobox homolog 3
LocusID (NCBI) 11335
Atlas_Id 936
Location 7p15.2  [Link to chromosome band 7p15]
Location_base_pair Starts at 26201745 and ends at 26213607 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C15orf57 (15q15.1) / CBX3 (7p15.2)CBX3 (7p15.2) / C15orf57 (15q15.1)CBX3 (7p15.2) / GARS (7p14.3)
CSNK1G1 (15q22.31) / CBX3 (7p15.2)DIS3L (15q22.31) / CBX3 (7p15.2)HNRNPA2B1 (7p15.2) / CBX3 (7p15.2)
TRA2A (7p15.3) / CBX3 (7p15.2)ZNF12 (7p22.1) / CBX3 (7p15.2)CBX3 7p15.2 / GARS 7p14.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  i(7)(q10)


External links

 

Nomenclature
HGNC (Hugo)CBX3   1553
Cards
Entrez_Gene (NCBI)CBX3    chromobox 3
AliasesHECH; HP1-GAMMA; HP1Hs-gamma
GeneCards (Weizmann)CBX3
Ensembl hg19 (Hinxton)ENSG00000122565 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000122565 [Gene_View]  ENSG00000122565 [Sequence]  chr7:26201745-26213607 [Contig_View]  CBX3 [Vega]
ICGC DataPortalENSG00000122565
TCGA cBioPortalCBX3
AceView (NCBI)CBX3
Genatlas (Paris)CBX3
SOURCE (Princeton)CBX3
Genetics Home Reference (NIH)CBX3
Genomic and cartography
GoldenPath hg38 (UCSC)CBX3  -     chr7:26201745-26213607 +  7p15.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CBX3  -     7p15.2   [Description]    (hg19-Feb_2009)
GoldenPathCBX3 - 7p15.2 [CytoView hg19]  CBX3 - 7p15.2 [CytoView hg38]
ImmunoBaseENSG00000122565
Genome Data Viewer NCBICBX3 [Mapview hg19]  
OMIM604477   
Gene and transcription
Genbank (Entrez)AB030905 AF086270 AF136630 AL542267 BC000954
RefSeq transcript (Entrez)NM_007276 NM_016587
Consensus coding sequences : CCDS (NCBI)CBX3
Gene ExpressionCBX3 [ NCBI-GEO ]   CBX3 [ EBI - ARRAY_EXPRESS ]   CBX3 [ SEEK ]   CBX3 [ MEM ]
Gene Expression Viewer (FireBrowse)CBX3 [ Firebrowse - Broad ]
GenevisibleExpression of CBX3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11335
GTEX Portal (Tissue expression)CBX3
Human Protein AtlasENSG00000122565-CBX3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13185   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13185  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13185
PhosPhoSitePlusQ13185
Domaine pattern : Prosite (Expaxy)CHROMO_1 (PS00598)    CHROMO_2 (PS50013)   
Domains : Interpro (EBI)CBX3    Chromo-like_dom_sf    Chromo/chromo_shadow_dom    Chromo_dom_subgr    Chromo_domain    Chromo_shadow_dom    Chromodomain_CS   
Domain families : Pfam (Sanger)Chromo (PF00385)    Chromo_shadow (PF01393)   
Domain families : Pfam (NCBI)pfam00385    pfam01393   
Domain families : Smart (EMBL)CHROMO (SM00298)  ChSh (SM00300)  
Conserved Domain (NCBI)CBX3
PDB (RSDB)2L11    3DM1    3KUP    3TZD    5T1I    6HW2   
PDB Europe2L11    3DM1    3KUP    3TZD    5T1I    6HW2   
PDB (PDBSum)2L11    3DM1    3KUP    3TZD    5T1I    6HW2   
PDB (IMB)2L11    3DM1    3KUP    3TZD    5T1I    6HW2   
Structural Biology KnowledgeBase2L11    3DM1    3KUP    3TZD    5T1I    6HW2   
SCOP (Structural Classification of Proteins)2L11    3DM1    3KUP    3TZD    5T1I    6HW2   
CATH (Classification of proteins structures)2L11    3DM1    3KUP    3TZD    5T1I    6HW2   
SuperfamilyQ13185
AlphaFold pdb e-kbQ13185   
Human Protein Atlas [tissue]ENSG00000122565-CBX3 [tissue]
HPRD05130
Protein Interaction databases
DIP (DOE-UCLA)Q13185
IntAct (EBI)Q13185
BioGRIDCBX3
STRING (EMBL)CBX3
ZODIACCBX3
Ontologies - Pathways
QuickGOQ13185
Ontology : AmiGOchromosome, centromeric region  condensed chromosome, centromeric region  chromosome, telomeric region  chromatin  euchromatin  heterochromatin  protein binding  nucleus  nuclear envelope  nuclear inner membrane  nucleoplasm  pericentric heterochromatin  spindle  chromatin remodeling  cellular response to DNA damage stimulus  transcription factor binding  enzyme binding  protein domain specific binding  identical protein binding  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  rhythmic process  negative regulation of G0 to G1 transition  RNA polymerase II transcription regulator complex  site of DNA damage  histone methyltransferase binding  
Ontology : EGO-EBIchromosome, centromeric region  condensed chromosome, centromeric region  chromosome, telomeric region  chromatin  euchromatin  heterochromatin  protein binding  nucleus  nuclear envelope  nuclear inner membrane  nucleoplasm  pericentric heterochromatin  spindle  chromatin remodeling  cellular response to DNA damage stimulus  transcription factor binding  enzyme binding  protein domain specific binding  identical protein binding  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  rhythmic process  negative regulation of G0 to G1 transition  RNA polymerase II transcription regulator complex  site of DNA damage  histone methyltransferase binding  
NDEx NetworkCBX3
Atlas of Cancer Signalling NetworkCBX3
Wikipedia pathwaysCBX3
Orthology - Evolution
OrthoDB11335
GeneTree (enSembl)ENSG00000122565
Phylogenetic Trees/Animal Genes : TreeFamCBX3
Homologs : HomoloGeneCBX3
Homology/Alignments : Family Browser (UCSC)CBX3
Gene fusions - Rearrangements
Fusion : MitelmanCBX3/C15orf57 [7p15.2/15q15.1]  
Fusion : MitelmanCBX3/GARS [7p15.2/7p14.3]  
Fusion Cancer (Beijing)C15orf57 [15q15.1]  -  CBX3 [7p15.2]  [FUSC000650]  [FUSC000650]  [FUSC000650]  [FUSC000650]  [FUSC000650]  [FUSC000650]  [FUSC000650]
Fusion : QuiverCBX3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCBX3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CBX3
dbVarCBX3
ClinVarCBX3
MonarchCBX3
1000_GenomesCBX3 
Exome Variant ServerCBX3
GNOMAD BrowserENSG00000122565
Varsome BrowserCBX3
ACMGCBX3 variants
VarityQ13185
Genomic Variants (DGV)CBX3 [DGVbeta]
DECIPHERCBX3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCBX3 
Mutations
ICGC Data PortalCBX3 
TCGA Data PortalCBX3 
Broad Tumor PortalCBX3
OASIS PortalCBX3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCBX3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCBX3
Mutations and Diseases : HGMDCBX3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCBX3
DgiDB (Drug Gene Interaction Database)CBX3
DoCM (Curated mutations)CBX3
CIViC (Clinical Interpretations of Variants in Cancer)CBX3
Cancer3DCBX3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604477   
Orphanet
DisGeNETCBX3
MedgenCBX3
Genetic Testing Registry CBX3
NextProtQ13185 [Medical]
GENETestsCBX3
Target ValidationCBX3
Huge Navigator CBX3 [HugePedia]
ClinGenCBX3
Clinical trials, drugs, therapy
MyCancerGenomeCBX3
Protein Interactions : CTDCBX3
Pharm GKB GenePA26128
PharosQ13185
Clinical trialCBX3
Miscellaneous
canSAR (ICR)CBX3
HarmonizomeCBX3
DataMed IndexCBX3
Probes
Litterature
PubMed228 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCBX3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:02:25 CEST 2021

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