Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CBX3 (chromobox 3)

Identity

Alias_nameschromobox homolog 3 (Drosophila HP1 gamma)
chromobox homolog 3
Alias_symbol (synonym)HP1Hs-gamma
Other aliasHECH
HP1-GAMMA
HGNC (Hugo) CBX3
LocusID (NCBI) 11335
Atlas_Id 936
Location 7p15.2  [Link to chromosome band 7p15]
Location_base_pair Starts at 26201211 and ends at 26213607 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
C15orf57 (15q15.1) / CBX3 (7p15.2)CBX3 (7p15.2) / C15orf57 (15q15.1)CBX3 (7p15.2) / GARS (7p14.3)
CSNK1G1 (15q22.31) / CBX3 (7p15.2)DIS3L (15q22.31) / CBX3 (7p15.2)HNRNPA2B1 (7p15.2) / CBX3 (7p15.2)
TRA2A (7p15.3) / CBX3 (7p15.2)ZNF12 (7p22.1) / CBX3 (7p15.2)CBX3 7p15.2 / GARS 7p14.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  i(7)(q10)


External links

Nomenclature
HGNC (Hugo)CBX3   1553
Cards
Entrez_Gene (NCBI)CBX3  11335  chromobox 3
AliasesHECH; HP1-GAMMA; HP1Hs-gamma
GeneCards (Weizmann)CBX3
Ensembl hg19 (Hinxton)ENSG00000122565 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000122565 [Gene_View]  chr7:26201211-26213607 [Contig_View]  CBX3 [Vega]
ICGC DataPortalENSG00000122565
TCGA cBioPortalCBX3
AceView (NCBI)CBX3
Genatlas (Paris)CBX3
WikiGenes11335
SOURCE (Princeton)CBX3
Genetics Home Reference (NIH)CBX3
Genomic and cartography
GoldenPath hg38 (UCSC)CBX3  -     chr7:26201211-26213607 +  7p15.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CBX3  -     7p15.2   [Description]    (hg19-Feb_2009)
EnsemblCBX3 - 7p15.2 [CytoView hg19]  CBX3 - 7p15.2 [CytoView hg38]
Mapping of homologs : NCBICBX3 [Mapview hg19]  CBX3 [Mapview hg38]
OMIM604477   
Gene and transcription
Genbank (Entrez)AB030905 AF086270 AF136630 AL542267 BC000954
RefSeq transcript (Entrez)NM_007276 NM_016587
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CBX3
Cluster EST : UnigeneHs.381189 [ NCBI ]
CGAP (NCI)Hs.381189
Alternative Splicing GalleryENSG00000122565
Gene ExpressionCBX3 [ NCBI-GEO ]   CBX3 [ EBI - ARRAY_EXPRESS ]   CBX3 [ SEEK ]   CBX3 [ MEM ]
Gene Expression Viewer (FireBrowse)CBX3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11335
GTEX Portal (Tissue expression)CBX3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13185   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13185  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13185
Splice isoforms : SwissVarQ13185
PhosPhoSitePlusQ13185
Domaine pattern : Prosite (Expaxy)CHROMO_1 (PS00598)    CHROMO_2 (PS50013)   
Domains : Interpro (EBI)Chromo/chromo_shadow_dom    Chromo_dom_subgr    Chromo_domain    Chromo_shadow_dom    Chromodomain-like    Chromodomain_CS   
Domain families : Pfam (Sanger)Chromo (PF00385)    Chromo_shadow (PF01393)   
Domain families : Pfam (NCBI)pfam00385    pfam01393   
Domain families : Smart (EMBL)CHROMO (SM00298)  ChSh (SM00300)  
Conserved Domain (NCBI)CBX3
DMDM Disease mutations11335
Blocks (Seattle)CBX3
PDB (SRS)2L11    3DM1    3KUP    3TZD    5T1I   
PDB (PDBSum)2L11    3DM1    3KUP    3TZD    5T1I   
PDB (IMB)2L11    3DM1    3KUP    3TZD    5T1I   
PDB (RSDB)2L11    3DM1    3KUP    3TZD    5T1I   
Structural Biology KnowledgeBase2L11    3DM1    3KUP    3TZD    5T1I   
SCOP (Structural Classification of Proteins)2L11    3DM1    3KUP    3TZD    5T1I   
CATH (Classification of proteins structures)2L11    3DM1    3KUP    3TZD    5T1I   
SuperfamilyQ13185
Human Protein AtlasENSG00000122565
Peptide AtlasQ13185
HPRD05130
IPIIPI00297579   IPI00917509   IPI00917646   
Protein Interaction databases
DIP (DOE-UCLA)Q13185
IntAct (EBI)Q13185
FunCoupENSG00000122565
BioGRIDCBX3
STRING (EMBL)CBX3
ZODIACCBX3
Ontologies - Pathways
QuickGOQ13185
Ontology : AmiGOchromosome, centromeric region  condensed chromosome, centromeric region  nuclear chromosome, telomeric region  chromatin  protein binding  nucleus  nuclear envelope  nuclear inner membrane  nuclear euchromatin  nuclear heterochromatin  spindle  chromatin remodeling  transcription, DNA-templated  covalent chromatin modification  enzyme binding  protein domain specific binding  nuclear pericentric heterochromatin  senescence-associated heterochromatin focus  identical protein binding  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  rhythmic process  cellular response to dexamethasone stimulus  histone methyltransferase binding  
Ontology : EGO-EBIchromosome, centromeric region  condensed chromosome, centromeric region  nuclear chromosome, telomeric region  chromatin  protein binding  nucleus  nuclear envelope  nuclear inner membrane  nuclear euchromatin  nuclear heterochromatin  spindle  chromatin remodeling  transcription, DNA-templated  covalent chromatin modification  enzyme binding  protein domain specific binding  nuclear pericentric heterochromatin  senescence-associated heterochromatin focus  identical protein binding  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  rhythmic process  cellular response to dexamethasone stimulus  histone methyltransferase binding  
NDEx NetworkCBX3
Atlas of Cancer Signalling NetworkCBX3
Wikipedia pathwaysCBX3
Orthology - Evolution
OrthoDB11335
GeneTree (enSembl)ENSG00000122565
Phylogenetic Trees/Animal Genes : TreeFamCBX3
HOVERGENQ13185
HOGENOMQ13185
Homologs : HomoloGeneCBX3
Homology/Alignments : Family Browser (UCSC)CBX3
Gene fusions - Rearrangements
Fusion : MitelmanCBX3/C15orf57 [7p15.2/15q15.1]  
Fusion : MitelmanCBX3/GARS [7p15.2/7p14.3]  [t(7;7)(p14;p15)]  
Fusion: TCGACBX3 7p15.2 GARS 7p14.3 BRCA
Fusion Cancer (Beijing)C15orf57 [15q15.1]  -  CBX3 [7p15.2]  [FUSC000650]  [FUSC000650]  [FUSC000650]  [FUSC000650]  [FUSC000650]  [FUSC000650]  [FUSC000650]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCBX3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CBX3
dbVarCBX3
ClinVarCBX3
1000_GenomesCBX3 
Exome Variant ServerCBX3
ExAC (Exome Aggregation Consortium)CBX3 (select the gene name)
Genetic variants : HAPMAP11335
Genomic Variants (DGV)CBX3 [DGVbeta]
DECIPHERCBX3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCBX3 
Mutations
ICGC Data PortalCBX3 
TCGA Data PortalCBX3 
Broad Tumor PortalCBX3
OASIS PortalCBX3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCBX3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCBX3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CBX3
DgiDB (Drug Gene Interaction Database)CBX3
DoCM (Curated mutations)CBX3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CBX3 (select a term)
intoGenCBX3
Cancer3DCBX3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604477   
Orphanet
MedgenCBX3
Genetic Testing Registry CBX3
NextProtQ13185 [Medical]
TSGene11335
GENETestsCBX3
Target ValidationCBX3
Huge Navigator CBX3 [HugePedia]
snp3D : Map Gene to Disease11335
BioCentury BCIQCBX3
ClinGenCBX3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11335
Chemical/Pharm GKB GenePA26128
Clinical trialCBX3
Miscellaneous
canSAR (ICR)CBX3 (select the gene name)
Probes
Litterature
PubMed137 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCBX3
EVEXCBX3
GoPubMedCBX3
iHOPCBX3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:26:53 CEST 2017

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