CCDC170 (coiled-coil domain containing 170)

2010-12-01  

Identity

HGNC
CCDC170
LOCATION
6q25.1
LOCUSID
80129
ALIAS
C6orf97,bA282P11.1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 80129
HGNC: 21177
Ensembl: ENSG00000120262

Variants:

dbSNP: 80129
ClinVar: 80129
TCGA: ENSG00000120262
COSMIC: CCDC170

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120262ENST00000239374Q8IYT3

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
206614392010Ancestry-shift refinement mapping of the C6orf97-ESR1 breast cancer susceptibility locus.54
250996792014Recurrent ESR1-CCDC170 rearrangements in an aggressive subset of oestrogen receptor-positive breast cancers.50
269282282016Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170.45
253700372015C6ORF97-ESR1 breast cancer susceptibility locus: influence on progression and survival in breast cancer patients.13
269115902016Genome-wide association study using family-based cohorts identifies the WLS and CCDC170/ESR1 loci as associated with bone mineral density.12
286874972017The Protein Encoded by the CCDC170 Breast Cancer Gene Functions to Organize the Golgi-Microtubule Network.8
202009782010Replication of previous genome-wide association studies of bone mineral density in premenopausal American women.7
244818792014Association of ESR1 and C6orf97 gene polymorphism with osteoporosis in postmenopausal women.5
306010662019Association of RMND1/CCDC170-ESR1 single nucleotide polymorphisms with hip fracture and osteoporosis in postmenopausal women.2
253389832014Current evidence on the association between rs3757318 of C6orf97 and breast cancer risk: a meta-analysis.1

Citation

Dessen P

CCDC170 (coiled-coil domain containing 170)

Atlas Genet Cytogenet Oncol Haematol. 2010-12-01

Online version: http://atlasgeneticsoncology.org/gene/51782/ccdc170