CCKBR (cholecystokinin B receptor)

2003-10-01 Affiliation

Identity

HGNC

CCKBR

LOCATION

11p15.4

LOCUSID

887

ALIAS

CCK-B,CCK2R,GASR

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 887
MIM: 118445
HGNC: 1571
Ensembl: ENSG00000110148

Variants:

dbSNP: 887
ClinVar: 887
TCGA: ENSG00000110148
COSMIC: CCKBR

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000110148	ENST00000334619	P32239
ENSG00000110148	ENST00000525014	E9PPL7
ENSG00000110148	ENST00000525462	P32239
ENSG00000110148	ENST00000531712	E9PJ49
ENSG00000110148	ENST00000532715	E9PIC8

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Calcium signaling pathway	KEGG	ko04020
Neuroactive ligand-receptor interaction	KEGG	ko04080
Calcium signaling pathway	KEGG	hsa04020
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Gastric acid secretion	KEGG	ko04971
Gastric acid secretion	KEGG	hsa04971
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Peptide ligand-binding receptors	REACTOME	R-HSA-375276
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (q) signalling events	REACTOME	R-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA128406954	Weight gain	Disease	VariantAnnotation	associated	PD	20732371
PA166123368	schizoaffective disorder	Disease	VariantAnnotation	associated	PD	20732371
PA447216	Schizophrenia	Disease	VariantAnnotation	associated	PD	20732371
PA449061	clozapine	Chemical	VariantAnnotation	associated	PD	20732371
PA450688	olanzapine	Chemical	VariantAnnotation	associated	PD	20732371

References

Pubmed ID	Year	Title	Citations
19874574	2009	Genetical genomic determinants of alcohol consumption in rats and humans.	93
24623766	2014	Prefrontal cortical circuit for depression- and anxiety-related behaviors mediated by cholecystokinin: role of ΔFosB.	91
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
20201926	2010	Human variation in alcohol response is influenced by variation in neuronal signaling genes.	45
19086053	2009	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	34
20468064	2010	Association study of 182 candidate genes in anorexia nervosa.	30
14534299	2003	Heterodimerization of type A and B cholecystokinin receptors enhance signaling and promote cell growth.	26
19502590	2009	Signaling through cholesterol esterification: a new pathway for the cholecystokinin 2 receptor involved in cell growth and invasion.	24
11830556	2002	A misspliced form of the cholecystokinin-B/gastrin receptor in pancreatic carcinoma: role of reduced sellular U2AF35 and a suboptimal 3'-splicing site leading to retention of the fourth intron.	20

Citation

Dessen P

CCKBR (cholecystokinin B receptor)

Atlas Genet Cytogenet Oncol Haematol. 2003-10-01

Online version: http://atlasgeneticsoncology.org/gene/938/cckbr