Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CCL1 (C-C motif chemokine ligand 1)

Identity

Alias (NCBI)I-309
P500
SCYA1
SISe
TCA3
HGNC (Hugo) CCL1
HGNC Alias symbI-309
TCA3
P500
SISe
HGNC Alias nameinflammatory cytokine I-309
 T lymphocyte-secreted protein I-309
HGNC Previous nameSCYA1
HGNC Previous namesmall inducible cytokine A1 (I-309, homologous to mouse Tca-3)
 chemokine (C-C motif) ligand 1
LocusID (NCBI) 6346
Atlas_Id 53596
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 34360328 and ends at 34363233 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CCL1   10609
Cards
Entrez_Gene (NCBI)CCL1    C-C motif chemokine ligand 1
AliasesI-309; P500; SCYA1; SISe; 
TCA3
GeneCards (Weizmann)CCL1
Ensembl hg19 (Hinxton)ENSG00000108702 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108702 [Gene_View]  ENSG00000108702 [Sequence]  chr17:34360328-34363233 [Contig_View]  CCL1 [Vega]
ICGC DataPortalENSG00000108702
TCGA cBioPortalCCL1
AceView (NCBI)CCL1
Genatlas (Paris)CCL1
SOURCE (Princeton)CCL1
Genetics Home Reference (NIH)CCL1
Genomic and cartography
GoldenPath hg38 (UCSC)CCL1  -     chr17:34360328-34363233 -  17q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CCL1  -     17q12   [Description]    (hg19-Feb_2009)
GoldenPathCCL1 - 17q12 [CytoView hg19]  CCL1 - 17q12 [CytoView hg38]
ImmunoBaseENSG00000108702
Genome Data Viewer NCBICCL1 [Mapview hg19]  
OMIM182281   
Gene and transcription
Genbank (Entrez)AK312183 BC105073 BC105075 DA620119 M57502
RefSeq transcript (Entrez)NM_002981
Consensus coding sequences : CCDS (NCBI)CCL1
Gene ExpressionCCL1 [ NCBI-GEO ]   CCL1 [ EBI - ARRAY_EXPRESS ]   CCL1 [ SEEK ]   CCL1 [ MEM ]
Gene Expression Viewer (FireBrowse)CCL1 [ Firebrowse - Broad ]
GenevisibleExpression of CCL1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6346
GTEX Portal (Tissue expression)CCL1
Human Protein AtlasENSG00000108702-CCL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP22362   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP22362  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP22362
PhosPhoSitePlusP22362
Domaine pattern : Prosite (Expaxy)SMALL_CYTOKINES_CC (PS00472)   
Domains : Interpro (EBI)Chemokine_b/g/d    Chemokine_CC_CS    Chemokine_IL8-like_dom    Interleukin_8-like_sf   
Domain families : Pfam (Sanger)IL8 (PF00048)   
Domain families : Pfam (NCBI)pfam00048   
Domain families : Smart (EMBL)SCY (SM00199)  
Conserved Domain (NCBI)CCL1
PDB (RSDB)1EL0    4OIJ    4OIK   
PDB Europe1EL0    4OIJ    4OIK   
PDB (PDBSum)1EL0    4OIJ    4OIK   
PDB (IMB)1EL0    4OIJ    4OIK   
Structural Biology KnowledgeBase1EL0    4OIJ    4OIK   
SCOP (Structural Classification of Proteins)1EL0    4OIJ    4OIK   
CATH (Classification of proteins structures)1EL0    4OIJ    4OIK   
SuperfamilyP22362
AlphaFold pdb e-kbP22362   
Human Protein Atlas [tissue]ENSG00000108702-CCL1 [tissue]
HPRD01654
Protein Interaction databases
DIP (DOE-UCLA)P22362
IntAct (EBI)P22362
BioGRIDCCL1
STRING (EMBL)CCL1
ZODIACCCL1
Ontologies - Pathways
QuickGOP22362
Ontology : AmiGOmonocyte chemotaxis  extracellular region  extracellular space  extracellular space  cellular calcium ion homeostasis  chemotaxis  inflammatory response  signal transduction  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  chemokine activity  chemokine activity  viral process  neutrophil chemotaxis  positive regulation of interleukin-17 production  positive regulation of GTPase activity  CCR chemokine receptor binding  eosinophil chemotaxis  lymphocyte chemotaxis  positive regulation of inflammatory response  chemokine-mediated signaling pathway  positive regulation of ERK1 and ERK2 cascade  cellular response to interferon-gamma  cellular response to interleukin-1  cellular response to tumor necrosis factor  positive regulation of monocyte chemotaxis  
Ontology : EGO-EBImonocyte chemotaxis  extracellular region  extracellular space  extracellular space  cellular calcium ion homeostasis  chemotaxis  inflammatory response  signal transduction  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  chemokine activity  chemokine activity  viral process  neutrophil chemotaxis  positive regulation of interleukin-17 production  positive regulation of GTPase activity  CCR chemokine receptor binding  eosinophil chemotaxis  lymphocyte chemotaxis  positive regulation of inflammatory response  chemokine-mediated signaling pathway  positive regulation of ERK1 and ERK2 cascade  cellular response to interferon-gamma  cellular response to interleukin-1  cellular response to tumor necrosis factor  positive regulation of monocyte chemotaxis  
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway   
NDEx NetworkCCL1
Atlas of Cancer Signalling NetworkCCL1
Wikipedia pathwaysCCL1
Orthology - Evolution
OrthoDB6346
GeneTree (enSembl)ENSG00000108702
Phylogenetic Trees/Animal Genes : TreeFamCCL1
Homologs : HomoloGeneCCL1
Homology/Alignments : Family Browser (UCSC)CCL1
Gene fusions - Rearrangements
Fusion : QuiverCCL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCCL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CCL1
dbVarCCL1
ClinVarCCL1
MonarchCCL1
1000_GenomesCCL1 
Exome Variant ServerCCL1
GNOMAD BrowserENSG00000108702
Varsome BrowserCCL1
ACMGCCL1 variants
VarityP22362
Genomic Variants (DGV)CCL1 [DGVbeta]
DECIPHERCCL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCCL1 
Mutations
ICGC Data PortalCCL1 
TCGA Data PortalCCL1 
Broad Tumor PortalCCL1
OASIS PortalCCL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCCL1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCCL1
Mutations and Diseases : HGMDCCL1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCCL1
DgiDB (Drug Gene Interaction Database)CCL1
DoCM (Curated mutations)CCL1
CIViC (Clinical Interpretations of Variants in Cancer)CCL1
Cancer3DCCL1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM182281   
Orphanet
DisGeNETCCL1
MedgenCCL1
Genetic Testing Registry CCL1
NextProtP22362 [Medical]
GENETestsCCL1
Target ValidationCCL1
Huge Navigator CCL1 [HugePedia]
ClinGenCCL1
Clinical trials, drugs, therapy
MyCancerGenomeCCL1
Protein Interactions : CTDCCL1
Pharm GKB GenePA35542
PharosP22362
Clinical trialCCL1
Miscellaneous
canSAR (ICR)CCL1
HarmonizomeCCL1
DataMed IndexCCL1
Probes
Litterature
PubMed66 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCCL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:02:37 CEST 2021

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