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CCL11 (C-C motif chemokine ligand 11)

Identity

Alias_namesSCYA11
small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin)
chemokine (C-C motif) ligand 11
Alias_symbol (synonym)eotaxin
MGC22554
Other alias
HGNC (Hugo) CCL11
LocusID (NCBI) 6356
Atlas_Id 939
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 32612687 and ends at 32615199 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
RPL19 (17q12) / CCL11 (17q12)RPL19 17q12 / CCL11 17q12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CCL11   10610
Cards
Entrez_Gene (NCBI)CCL11  6356  C-C motif chemokine ligand 11
AliasesSCYA11
GeneCards (Weizmann)CCL11
Ensembl hg19 (Hinxton)ENSG00000172156 [Gene_View]  chr17:32612687-32615199 [Contig_View]  CCL11 [Vega]
Ensembl hg38 (Hinxton)ENSG00000172156 [Gene_View]  chr17:32612687-32615199 [Contig_View]  CCL11 [Vega]
ICGC DataPortalENSG00000172156
TCGA cBioPortalCCL11
AceView (NCBI)CCL11
Genatlas (Paris)CCL11
WikiGenes6356
SOURCE (Princeton)CCL11
Genetics Home Reference (NIH)CCL11
Genomic and cartography
GoldenPath hg19 (UCSC)CCL11  -     chr17:32612687-32615199 +  17q12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CCL11  -     17q12   [Description]    (hg38-Dec_2013)
EnsemblCCL11 - 17q12 [CytoView hg19]  CCL11 - 17q12 [CytoView hg38]
Mapping of homologs : NCBICCL11 [Mapview hg19]  CCL11 [Mapview hg38]
OMIM600807   601156   609423   
Gene and transcription
Genbank (Entrez)AI446061 BC017850 BF197516 CR457421 DQ891969
RefSeq transcript (Entrez)NM_002986
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_012212 NT_010783 NW_004929407
Consensus coding sequences : CCDS (NCBI)CCL11
Cluster EST : UnigeneHs.54460 [ NCBI ]
CGAP (NCI)Hs.54460
Alternative Splicing GalleryENSG00000172156
Gene ExpressionCCL11 [ NCBI-GEO ]   CCL11 [ EBI - ARRAY_EXPRESS ]   CCL11 [ SEEK ]   CCL11 [ MEM ]
Gene Expression Viewer (FireBrowse)CCL11 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6356
GTEX Portal (Tissue expression)CCL11
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51671   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51671  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51671
Splice isoforms : SwissVarP51671
PhosPhoSitePlusP51671
Domaine pattern : Prosite (Expaxy)SMALL_CYTOKINES_CC (PS00472)   
Domains : Interpro (EBI)Chemokine_CC_CS    Chemokine_IL8-like_dom   
Domain families : Pfam (Sanger)IL8 (PF00048)   
Domain families : Pfam (NCBI)pfam00048   
Domain families : Smart (EMBL)SCY (SM00199)  
Conserved Domain (NCBI)CCL11
DMDM Disease mutations6356
Blocks (Seattle)CCL11
PDB (SRS)1EOT    2EOT    2MPM   
PDB (PDBSum)1EOT    2EOT    2MPM   
PDB (IMB)1EOT    2EOT    2MPM   
PDB (RSDB)1EOT    2EOT    2MPM   
Structural Biology KnowledgeBase1EOT    2EOT    2MPM   
SCOP (Structural Classification of Proteins)1EOT    2EOT    2MPM   
CATH (Classification of proteins structures)1EOT    2EOT    2MPM   
SuperfamilyP51671
Human Protein AtlasENSG00000172156
Peptide AtlasP51671
HPRD03098
IPIIPI00019945   
Protein Interaction databases
DIP (DOE-UCLA)P51671
IntAct (EBI)P51671
FunCoupENSG00000172156
BioGRIDCCL11
STRING (EMBL)CCL11
ZODIACCCL11
Ontologies - Pathways
QuickGOP51671
Ontology : AmiGOpositive regulation of endothelial cell proliferation  chronic inflammatory response  monocyte chemotaxis  mast cell chemotaxis  protein binding  extracellular region  extracellular region  extracellular space  intracellular  protein phosphorylation  cellular calcium ion homeostasis  chemotaxis  inflammatory response  cytoskeleton organization  actin filament organization  cell adhesion  signal transduction  G-protein coupled receptor signaling pathway  chemokine activity  regulation of cell shape  response to radiation  response to virus  positive regulation of cell migration  neutrophil chemotaxis  positive regulation of actin filament polymerization  response to interleukin-13  positive regulation of GTPase activity  positive regulation of angiogenesis  CCR chemokine receptor binding  eosinophil chemotaxis  lymphocyte chemotaxis  positive regulation of inflammatory response  branching involved in mammary gland duct morphogenesis  mammary duct terminal end bud growth  chemokine-mediated signaling pathway  ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  response to interleukin-4  cellular response to interferon-gamma  cellular response to interleukin-1  cellular response to tumor necrosis factor  
Ontology : EGO-EBIpositive regulation of endothelial cell proliferation  chronic inflammatory response  monocyte chemotaxis  mast cell chemotaxis  protein binding  extracellular region  extracellular region  extracellular space  intracellular  protein phosphorylation  cellular calcium ion homeostasis  chemotaxis  inflammatory response  cytoskeleton organization  actin filament organization  cell adhesion  signal transduction  G-protein coupled receptor signaling pathway  chemokine activity  regulation of cell shape  response to radiation  response to virus  positive regulation of cell migration  neutrophil chemotaxis  positive regulation of actin filament polymerization  response to interleukin-13  positive regulation of GTPase activity  positive regulation of angiogenesis  CCR chemokine receptor binding  eosinophil chemotaxis  lymphocyte chemotaxis  positive regulation of inflammatory response  branching involved in mammary gland duct morphogenesis  mammary duct terminal end bud growth  chemokine-mediated signaling pathway  ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  response to interleukin-4  cellular response to interferon-gamma  cellular response to interleukin-1  cellular response to tumor necrosis factor  
Pathways : BIOCARTAThe Role of Eosinophils in the Chemokine Network of Allergy [Genes]    CCR3 signaling in Eosinophils [Genes]    IL 5 Signaling Pathway [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway    Asthma   
NDEx NetworkCCL11
Atlas of Cancer Signalling NetworkCCL11
Wikipedia pathwaysCCL11
Orthology - Evolution
OrthoDB6356
GeneTree (enSembl)ENSG00000172156
Phylogenetic Trees/Animal Genes : TreeFamCCL11
HOVERGENP51671
HOGENOMP51671
Homologs : HomoloGeneCCL11
Homology/Alignments : Family Browser (UCSC)CCL11
Gene fusions - Rearrangements
Fusion: TCGARPL19 17q12 CCL11 17q12 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCCL11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CCL11
dbVarCCL11
ClinVarCCL11
1000_GenomesCCL11 
Exome Variant ServerCCL11
ExAC (Exome Aggregation Consortium)CCL11 (select the gene name)
Genetic variants : HAPMAP6356
Genomic Variants (DGV)CCL11 [DGVbeta]
DECIPHER (Syndromes)17:32612687-32615199  ENSG00000172156
CONAN: Copy Number AnalysisCCL11 
Mutations
ICGC Data PortalCCL11 
TCGA Data PortalCCL11 
Broad Tumor PortalCCL11
OASIS PortalCCL11 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCCL11  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCCL11
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CCL11
DgiDB (Drug Gene Interaction Database)CCL11
DoCM (Curated mutations)CCL11 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CCL11 (select a term)
intoGenCCL11
Cancer3DCCL11(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600807    601156    609423   
Orphanet
MedgenCCL11
Genetic Testing Registry CCL11
NextProtP51671 [Medical]
TSGene6356
GENETestsCCL11
Huge Navigator CCL11 [HugePedia]
snp3D : Map Gene to Disease6356
BioCentury BCIQCCL11
ClinGenCCL11
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6356
Chemical/Pharm GKB GenePA35543
Clinical trialCCL11
Miscellaneous
canSAR (ICR)CCL11 (select the gene name)
Probes
Litterature
PubMed169 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCCL11
EVEXCCL11
GoPubMedCCL11
iHOPCCL11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 12:59:03 CET 2017

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