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CCL17 (C-C motif chemokine ligand 17)

Identity

Alias (NCBI)A-152E5.3
ABCD-2
SCYA17
TARC
HGNC (Hugo) CCL17
HGNC Alias symbTARC
ABCD-2
HGNC Previous nameSCYA17
HGNC Previous namesmall inducible cytokine subfamily A (Cys-Cys), member 17
 chemokine (C-C motif) ligand 17
LocusID (NCBI) 6361
Atlas_Id 49742
Location 16q21  [Link to chromosome band 16q21]
Location_base_pair Starts at 57404767 and ends at 57416063 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MICALL2 (7p22.3) / CCL17 (16q21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CCL17   10615
Cards
Entrez_Gene (NCBI)CCL17    C-C motif chemokine ligand 17
AliasesA-152E5.3; ABCD-2; SCYA17; TARC
GeneCards (Weizmann)CCL17
Ensembl hg19 (Hinxton)ENSG00000102970 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000102970 [Gene_View]  ENSG00000102970 [Sequence]  chr16:57404767-57416063 [Contig_View]  CCL17 [Vega]
ICGC DataPortalENSG00000102970
TCGA cBioPortalCCL17
AceView (NCBI)CCL17
Genatlas (Paris)CCL17
SOURCE (Princeton)CCL17
Genetics Home Reference (NIH)CCL17
Genomic and cartography
GoldenPath hg38 (UCSC)CCL17  -     chr16:57404767-57416063 +  16q21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CCL17  -     16q21   [Description]    (hg19-Feb_2009)
GoldenPathCCL17 - 16q21 [CytoView hg19]  CCL17 - 16q21 [CytoView hg38]
ImmunoBaseENSG00000102970
Genome Data Viewer NCBICCL17 [Mapview hg19]  
OMIM601520   
Gene and transcription
Genbank (Entrez)BC069107 BC112066 BC112068 BE061171 D43767
RefSeq transcript (Entrez)NM_002987
Consensus coding sequences : CCDS (NCBI)CCL17
Gene ExpressionCCL17 [ NCBI-GEO ]   CCL17 [ EBI - ARRAY_EXPRESS ]   CCL17 [ SEEK ]   CCL17 [ MEM ]
Gene Expression Viewer (FireBrowse)CCL17 [ Firebrowse - Broad ]
GenevisibleExpression of CCL17 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6361
GTEX Portal (Tissue expression)CCL17
Human Protein AtlasENSG00000102970-CCL17 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92583   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92583  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92583
PhosPhoSitePlusQ92583
Domaine pattern : Prosite (Expaxy)SMALL_CYTOKINES_CC (PS00472)   
Domains : Interpro (EBI)Chemokine_b/g/d    Chemokine_CC_CS    Chemokine_IL8-like_dom    Interleukin_8-like_sf   
Domain families : Pfam (Sanger)IL8 (PF00048)   
Domain families : Pfam (NCBI)pfam00048   
Domain families : Smart (EMBL)SCY (SM00199)  
Conserved Domain (NCBI)CCL17
PDB (RSDB)1NR2    1NR4    5WK3   
PDB Europe1NR2    1NR4    5WK3   
PDB (PDBSum)1NR2    1NR4    5WK3   
PDB (IMB)1NR2    1NR4    5WK3   
Structural Biology KnowledgeBase1NR2    1NR4    5WK3   
SCOP (Structural Classification of Proteins)1NR2    1NR4    5WK3   
CATH (Classification of proteins structures)1NR2    1NR4    5WK3   
SuperfamilyQ92583
AlphaFold pdb e-kbQ92583   
Human Protein Atlas [tissue]ENSG00000102970-CCL17 [tissue]
HPRD03309
Protein Interaction databases
DIP (DOE-UCLA)Q92583
IntAct (EBI)Q92583
BioGRIDCCL17
STRING (EMBL)CCL17
ZODIACCCL17
Ontologies - Pathways
QuickGOQ92583
Ontology : AmiGOmonocyte chemotaxis  signaling receptor binding  protein binding  extracellular region  extracellular space  chemotaxis  inflammatory response  G protein-coupled receptor signaling pathway  cell-cell signaling  multicellular organism development  chemokine activity  neutrophil chemotaxis  CCR4 chemokine receptor binding  positive regulation of GTPase activity  negative regulation of myoblast differentiation  CCR chemokine receptor binding  lymphocyte chemotaxis  chemokine-mediated signaling pathway  positive regulation of ERK1 and ERK2 cascade  cellular response to interferon-gamma  cellular response to interleukin-1  cellular response to tumor necrosis factor  
Ontology : EGO-EBImonocyte chemotaxis  signaling receptor binding  protein binding  extracellular region  extracellular space  chemotaxis  inflammatory response  G protein-coupled receptor signaling pathway  cell-cell signaling  multicellular organism development  chemokine activity  neutrophil chemotaxis  CCR4 chemokine receptor binding  positive regulation of GTPase activity  negative regulation of myoblast differentiation  CCR chemokine receptor binding  lymphocyte chemotaxis  chemokine-mediated signaling pathway  positive regulation of ERK1 and ERK2 cascade  cellular response to interferon-gamma  cellular response to interleukin-1  cellular response to tumor necrosis factor  
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway   
NDEx NetworkCCL17
Atlas of Cancer Signalling NetworkCCL17
Wikipedia pathwaysCCL17
Orthology - Evolution
OrthoDB6361
GeneTree (enSembl)ENSG00000102970
Phylogenetic Trees/Animal Genes : TreeFamCCL17
Homologs : HomoloGeneCCL17
Homology/Alignments : Family Browser (UCSC)CCL17
Gene fusions - Rearrangements
Fusion : QuiverCCL17
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCCL17 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CCL17
dbVarCCL17
ClinVarCCL17
MonarchCCL17
1000_GenomesCCL17 
Exome Variant ServerCCL17
GNOMAD BrowserENSG00000102970
Varsome BrowserCCL17
ACMGCCL17 variants
VarityQ92583
Genomic Variants (DGV)CCL17 [DGVbeta]
DECIPHERCCL17 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCCL17 
Mutations
ICGC Data PortalCCL17 
TCGA Data PortalCCL17 
Broad Tumor PortalCCL17
OASIS PortalCCL17 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCCL17  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCCL17
Mutations and Diseases : HGMDCCL17
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCCL17
DgiDB (Drug Gene Interaction Database)CCL17
DoCM (Curated mutations)CCL17
CIViC (Clinical Interpretations of Variants in Cancer)CCL17
Cancer3DCCL17
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601520   
Orphanet
DisGeNETCCL17
MedgenCCL17
Genetic Testing Registry CCL17
NextProtQ92583 [Medical]
GENETestsCCL17
Target ValidationCCL17
Huge Navigator CCL17 [HugePedia]
ClinGenCCL17
Clinical trials, drugs, therapy
MyCancerGenomeCCL17
Protein Interactions : CTDCCL17
Pharm GKB GenePA35548
PharosQ92583
Clinical trialCCL17
Miscellaneous
canSAR (ICR)CCL17
HarmonizomeCCL17
DataMed IndexCCL17
Probes
Litterature
PubMed149 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCCL17
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:02:38 CEST 2021

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