CCL18 (C-C motif chemokine ligand 18)

2007-02-01  

Identity

HGNC
CCL18
LOCATION
17q12
LOCUSID
6362
ALIAS
AMAC-1,AMAC1,CKb7,DC-CK1,DCCK1,MIP-4,PARC,SCYA18

Other Information

Locus ID:

NCBI: 6362
MIM: 603757
HGNC: 10616
Ensembl: ENSG00000275385

Variants:

dbSNP: 6362
ClinVar: 6362
TCGA: ENSG00000275385
COSMIC: CCL18

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000275385ENST00000616054P55774

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062

References

Pubmed IDYearTitleCitations
248236382014A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis.180
214817942011CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3.169
129492492003Many chemokines including CCL20/MIP-3alpha display antimicrobial activity.154
164152742006A vicious circle of alveolar macrophages and fibroblasts perpetuates pulmonary fibrosis via CCL18.133
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
174691632007CCL18 as an indicator of pulmonary fibrotic activity in idiopathic interstitial pneumonias and systemic sclerosis.56
128050862003Pulmonary and activation-regulated chemokine stimulates collagen production in lung fibroblasts.42
179091042007CC chemokine ligand-5 (CCL5/RANTES) and CC chemokine ligand-18 (CCL18/PARC) are specific markers of refractory unstable angina pectoris and are transiently raised during severe ischemic symptoms.41
239995002013Identification of human CCR8 as a CCL18 receptor.38

Citation

Dessen P

CCL18 (C-C motif chemokine ligand 18)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46358/ccl18