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CCL18 (C-C motif chemokine ligand 18)

Identity

Alias_namesSCYA18
small inducible cytokine subfamily A (Cys-Cys), member 18, pulmonary and activation-regulated
chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
chemokine (C-C motif) ligand 18
Alias_symbol (synonym)DC-CK1
PARC
AMAC-1
DCCK1
MIP-4
CKb7
Other aliasAMAC1
HGNC (Hugo) CCL18
LocusID (NCBI) 6362
Atlas_Id 46358
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 36064272 and ends at 36071481 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CCL18   10616
Cards
Entrez_Gene (NCBI)CCL18  6362  C-C motif chemokine ligand 18
AliasesAMAC-1; AMAC1; CKb7; DC-CK1; 
DCCK1; MIP-4; PARC; SCYA18
GeneCards (Weizmann)CCL18
Ensembl hg19 (Hinxton)ENSG00000275385 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000275385 [Gene_View]  chr17:36064272-36071481 [Contig_View]  CCL18 [Vega]
ICGC DataPortalENSG00000275385
TCGA cBioPortalCCL18
AceView (NCBI)CCL18
Genatlas (Paris)CCL18
WikiGenes6362
SOURCE (Princeton)CCL18
Genetics Home Reference (NIH)CCL18
Genomic and cartography
GoldenPath hg38 (UCSC)CCL18  -     chr17:36064272-36071481 +  17q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CCL18  -     17q12   [Description]    (hg19-Feb_2009)
EnsemblCCL18 - 17q12 [CytoView hg19]  CCL18 - 17q12 [CytoView hg38]
Mapping of homologs : NCBICCL18 [Mapview hg19]  CCL18 [Mapview hg38]
OMIM603757   
Gene and transcription
Genbank (Entrez)AB000221 AB451458 BC069700 BC096124 BC096125
RefSeq transcript (Entrez)NM_002988
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_187614 NT_187661
Consensus coding sequences : CCDS (NCBI)CCL18
Cluster EST : UnigeneHs.143961 [ NCBI ]
CGAP (NCI)Hs.143961
Alternative Splicing GalleryENSG00000275385
Gene ExpressionCCL18 [ NCBI-GEO ]   CCL18 [ EBI - ARRAY_EXPRESS ]   CCL18 [ SEEK ]   CCL18 [ MEM ]
Gene Expression Viewer (FireBrowse)CCL18 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6362
GTEX Portal (Tissue expression)CCL18
Protein : pattern, domain, 3D structure
UniProt/SwissProtP55774   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP55774  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP55774
Splice isoforms : SwissVarP55774
PhosPhoSitePlusP55774
Domaine pattern : Prosite (Expaxy)SMALL_CYTOKINES_CC (PS00472)   
Domains : Interpro (EBI)Chemokine_CC_CS    Chemokine_IL8-like_dom   
Domain families : Pfam (Sanger)IL8 (PF00048)   
Domain families : Pfam (NCBI)pfam00048   
Domain families : Smart (EMBL)SCY (SM00199)  
Conserved Domain (NCBI)CCL18
DMDM Disease mutations6362
Blocks (Seattle)CCL18
PDB (SRS)4MHE   
PDB (PDBSum)4MHE   
PDB (IMB)4MHE   
PDB (RSDB)4MHE   
Structural Biology KnowledgeBase4MHE   
SCOP (Structural Classification of Proteins)4MHE   
CATH (Classification of proteins structures)4MHE   
SuperfamilyP55774
Human Protein AtlasENSG00000275385
Peptide AtlasP55774
HPRD04784
IPIIPI00026183   
Protein Interaction databases
DIP (DOE-UCLA)P55774
IntAct (EBI)P55774
FunCoupENSG00000275385
BioGRIDCCL18
STRING (EMBL)CCL18
ZODIACCCL18
Ontologies - Pathways
QuickGOP55774
Ontology : AmiGOmonocyte chemotaxis  protein binding  extracellular space  chemotaxis  inflammatory response  immune response  cell communication  signal transduction  G-protein coupled receptor signaling pathway  cell-cell signaling  chemokine activity  response to biotic stimulus  neutrophil chemotaxis  positive regulation of GTPase activity  CCR chemokine receptor binding  lymphocyte chemotaxis  chemokine-mediated signaling pathway  positive regulation of ERK1 and ERK2 cascade  cellular response to interferon-gamma  cellular response to interleukin-1  cellular response to tumor necrosis factor  
Ontology : EGO-EBImonocyte chemotaxis  protein binding  extracellular space  chemotaxis  inflammatory response  immune response  cell communication  signal transduction  G-protein coupled receptor signaling pathway  cell-cell signaling  chemokine activity  response to biotic stimulus  neutrophil chemotaxis  positive regulation of GTPase activity  CCR chemokine receptor binding  lymphocyte chemotaxis  chemokine-mediated signaling pathway  positive regulation of ERK1 and ERK2 cascade  cellular response to interferon-gamma  cellular response to interleukin-1  cellular response to tumor necrosis factor  
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway   
NDEx NetworkCCL18
Atlas of Cancer Signalling NetworkCCL18
Wikipedia pathwaysCCL18
Orthology - Evolution
OrthoDB6362
GeneTree (enSembl)ENSG00000275385
Phylogenetic Trees/Animal Genes : TreeFamCCL18
HOVERGENP55774
HOGENOMP55774
Homologs : HomoloGeneCCL18
Homology/Alignments : Family Browser (UCSC)CCL18
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCCL18 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CCL18
dbVarCCL18
ClinVarCCL18
1000_GenomesCCL18 
Exome Variant ServerCCL18
ExAC (Exome Aggregation Consortium)CCL18 (select the gene name)
Genetic variants : HAPMAP6362
Genomic Variants (DGV)CCL18 [DGVbeta]
DECIPHERCCL18 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCCL18 
Mutations
ICGC Data PortalCCL18 
TCGA Data PortalCCL18 
Broad Tumor PortalCCL18
OASIS PortalCCL18 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCCL18  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCCL18
BioMutasearch CCL18
DgiDB (Drug Gene Interaction Database)CCL18
DoCM (Curated mutations)CCL18 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CCL18 (select a term)
intoGenCCL18
Cancer3DCCL18(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603757   
Orphanet
MedgenCCL18
Genetic Testing Registry CCL18
NextProtP55774 [Medical]
TSGene6362
GENETestsCCL18
Huge Navigator CCL18 [HugePedia]
snp3D : Map Gene to Disease6362
BioCentury BCIQCCL18
ClinGenCCL18
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6362
Chemical/Pharm GKB GenePA35549
Clinical trialCCL18
Miscellaneous
canSAR (ICR)CCL18 (select the gene name)
Probes
Litterature
PubMed96 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCCL18
EVEXCCL18
GoPubMedCCL18
iHOPCCL18
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:09:16 CEST 2017

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