CCL19 (C-C motif chemokine ligand 19)

2007-02-01 Affiliation

Identity

HGNC

CCL19

LOCATION

9p13.3

LOCUSID

6363

ALIAS

CKb11,ELC,MIP-3b,MIP3B,SCYA19

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6363
MIM: 602227
HGNC: 10617
Ensembl: ENSG00000172724

Variants:

dbSNP: 6363
ClinVar: 6363
TCGA: ENSG00000172724
COSMIC: CCL19

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000172724	ENST00000311925	Q99731
ENSG00000172724	ENST00000311925	Q6IBD6
ENSG00000172724	ENST00000378800	Q5VZ75

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Chemokine signaling pathway	KEGG	ko04062
Chemokine signaling pathway	KEGG	hsa04062
NF-kappa B signaling pathway	KEGG	hsa04064
NF-kappa B signaling pathway	KEGG	ko04064
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Peptide ligand-binding receptors	REACTOME	R-HSA-375276
Chemokine receptors bind chemokines	REACTOME	R-HSA-380108
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594
Interleukin-10 signaling	REACTOME	R-HSA-6783783

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
12949249	2003	Many chemokines including CCL20/MIP-3alpha display antimicrobial activity.	154
17881634	2007	CCR7 ligands CCL19 and CCL21 increase permissiveness of resting memory CD4+ T cells to HIV-1 infection: a novel model of HIV-1 latency.	120
17703412	2007	Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.	100
14592837	2004	CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2.	60
11869682	2002	Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus.	57
11929789	2002	The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes.	48
17825430	2007	CCL19 is constitutively expressed in the CNS, up-regulated in neuroinflammation, active and also inactive multiple sclerosis lesions.	43
16081805	2005	CC chemokine ligand 19 secreted by mature dendritic cells increases naive T cell scanning behavior and their response to rare cognate antigen.	29
17469160	2007	Plasmacytoid dendritic cells in inflamed muscle of patients with juvenile dermatomyositis.	29
17182562	2007	Multiple NF-kappaB and IFN regulatory factor family transcription factors regulate CCL19 gene expression in human monocyte-derived dendritic cells.	27

Citation

Dessen P

CCL19 (C-C motif chemokine ligand 19)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43862/ccl19