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CCL21 (C-C motif chemokine ligand 21)

Identity

Alias_namesSCYA21
small inducible cytokine subfamily A (Cys-Cys), member 21
chemokine (C-C motif) ligand 21
Alias_symbol (synonym)SLC
exodus-2
TCA4
CKb9
6Ckine
ECL
Other alias
HGNC (Hugo) CCL21
LocusID (NCBI) 6366
Atlas_Id 943
Location 9p13.3  [Link to chromosome band 9p13]
Location_base_pair Starts at 34709005 and ends at 34710167 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CCL21 (9p13.3) / GEMIN5 (5q33.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CCL21   10620
Cards
Entrez_Gene (NCBI)CCL21  6366  C-C motif chemokine ligand 21
Aliases6Ckine; CKb9; ECL; SCYA21; 
SLC; TCA4
GeneCards (Weizmann)CCL21
Ensembl hg19 (Hinxton)ENSG00000137077 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137077 [Gene_View]  chr9:34709005-34710167 [Contig_View]  CCL21 [Vega]
ICGC DataPortalENSG00000137077
TCGA cBioPortalCCL21
AceView (NCBI)CCL21
Genatlas (Paris)CCL21
WikiGenes6366
SOURCE (Princeton)CCL21
Genetics Home Reference (NIH)CCL21
Genomic and cartography
GoldenPath hg38 (UCSC)CCL21  -     chr9:34709005-34710167 -  9p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CCL21  -     9p13.3   [Description]    (hg19-Feb_2009)
EnsemblCCL21 - 9p13.3 [CytoView hg19]  CCL21 - 9p13.3 [CytoView hg38]
Mapping of homologs : NCBICCL21 [Mapview hg19]  CCL21 [Mapview hg38]
OMIM602737   
Gene and transcription
Genbank (Entrez)AB002409 AF001979 AK311901 AY358887 BC027918
RefSeq transcript (Entrez)NM_002989
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CCL21
Cluster EST : UnigeneHs.57907 [ NCBI ]
CGAP (NCI)Hs.57907
Alternative Splicing GalleryENSG00000137077
Gene ExpressionCCL21 [ NCBI-GEO ]   CCL21 [ EBI - ARRAY_EXPRESS ]   CCL21 [ SEEK ]   CCL21 [ MEM ]
Gene Expression Viewer (FireBrowse)CCL21 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6366
GTEX Portal (Tissue expression)CCL21
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00585   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00585  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00585
Splice isoforms : SwissVarO00585
PhosPhoSitePlusO00585
Domains : Interpro (EBI)CCL21    Chemokine_CC_DCCL    Chemokine_IL8-like_dom   
Domain families : Pfam (Sanger)IL8 (PF00048)   
Domain families : Pfam (NCBI)pfam00048   
Domain families : Smart (EMBL)SCY (SM00199)  
Conserved Domain (NCBI)CCL21
DMDM Disease mutations6366
Blocks (Seattle)CCL21
PDB (SRS)2L4N    5EKI   
PDB (PDBSum)2L4N    5EKI   
PDB (IMB)2L4N    5EKI   
PDB (RSDB)2L4N    5EKI   
Structural Biology KnowledgeBase2L4N    5EKI   
SCOP (Structural Classification of Proteins)2L4N    5EKI   
CATH (Classification of proteins structures)2L4N    5EKI   
SuperfamilyO00585
Human Protein AtlasENSG00000137077
Peptide AtlasO00585
HPRD04113
IPIIPI00012174   IPI00641478   
Protein Interaction databases
DIP (DOE-UCLA)O00585
IntAct (EBI)O00585
FunCoupENSG00000137077
BioGRIDCCL21
STRING (EMBL)CCL21
ZODIACCCL21
Ontologies - Pathways
QuickGOO00585
Ontology : AmiGOestablishment of T cell polarity  immunological synapse formation  positive regulation of cell-matrix adhesion  dendritic cell chemotaxis  monocyte chemotaxis  positive regulation of dendritic cell antigen processing and presentation  extracellular region  extracellular space  cell  inflammatory response  inflammatory response  immune response  G-protein coupled receptor signaling pathway  cell-cell signaling  chemokine activity  positive regulation of glycoprotein biosynthetic process  positive regulation of actin filament polymerization  positive regulation of pseudopodium assembly  T cell costimulation  ruffle organization  CCR7 chemokine receptor binding  positive regulation of cell adhesion mediated by integrin  response to prostaglandin E  mesangial cell-matrix adhesion  chemokine receptor binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of phosphatidylinositol 3-kinase activity  positive regulation of protein kinase activity  positive regulation of JNK cascade  CCR chemokine receptor binding  lymphocyte chemotaxis  positive regulation of receptor-mediated endocytosis  cell maturation  positive regulation of chemotaxis  release of sequestered calcium ion into cytosol  positive regulation of filopodium assembly  positive regulation of protein kinase B signaling  cell chemotaxis  chemokine-mediated signaling pathway  positive regulation of ERK1 and ERK2 cascade  cellular response to interferon-gamma  cellular response to interleukin-1  cellular response to tumor necrosis factor  positive regulation of neutrophil chemotaxis  activation of GTPase activity  dendritic cell dendrite assembly  negative regulation of leukocyte tethering or rolling  negative regulation of leukocyte apoptotic process  positive regulation of cell motility  positive regulation of T cell migration  positive regulation of myeloid dendritic cell chemotaxis  negative regulation of dendritic cell dendrite assembly  
Ontology : EGO-EBIestablishment of T cell polarity  immunological synapse formation  positive regulation of cell-matrix adhesion  dendritic cell chemotaxis  monocyte chemotaxis  positive regulation of dendritic cell antigen processing and presentation  extracellular region  extracellular space  cell  inflammatory response  inflammatory response  immune response  G-protein coupled receptor signaling pathway  cell-cell signaling  chemokine activity  positive regulation of glycoprotein biosynthetic process  positive regulation of actin filament polymerization  positive regulation of pseudopodium assembly  T cell costimulation  ruffle organization  CCR7 chemokine receptor binding  positive regulation of cell adhesion mediated by integrin  response to prostaglandin E  mesangial cell-matrix adhesion  chemokine receptor binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of phosphatidylinositol 3-kinase activity  positive regulation of protein kinase activity  positive regulation of JNK cascade  CCR chemokine receptor binding  lymphocyte chemotaxis  positive regulation of receptor-mediated endocytosis  cell maturation  positive regulation of chemotaxis  release of sequestered calcium ion into cytosol  positive regulation of filopodium assembly  positive regulation of protein kinase B signaling  cell chemotaxis  chemokine-mediated signaling pathway  positive regulation of ERK1 and ERK2 cascade  cellular response to interferon-gamma  cellular response to interleukin-1  cellular response to tumor necrosis factor  positive regulation of neutrophil chemotaxis  activation of GTPase activity  dendritic cell dendrite assembly  negative regulation of leukocyte tethering or rolling  negative regulation of leukocyte apoptotic process  positive regulation of cell motility  positive regulation of T cell migration  positive regulation of myeloid dendritic cell chemotaxis  negative regulation of dendritic cell dendrite assembly  
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway    NF-kappa B signaling pathway   
NDEx NetworkCCL21
Atlas of Cancer Signalling NetworkCCL21
Wikipedia pathwaysCCL21
Orthology - Evolution
OrthoDB6366
GeneTree (enSembl)ENSG00000137077
Phylogenetic Trees/Animal Genes : TreeFamCCL21
HOVERGENO00585
HOGENOMO00585
Homologs : HomoloGeneCCL21
Homology/Alignments : Family Browser (UCSC)CCL21
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCCL21 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CCL21
dbVarCCL21
ClinVarCCL21
1000_GenomesCCL21 
Exome Variant ServerCCL21
ExAC (Exome Aggregation Consortium)CCL21 (select the gene name)
Genetic variants : HAPMAP6366
Genomic Variants (DGV)CCL21 [DGVbeta]
DECIPHERCCL21 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCCL21 
Mutations
ICGC Data PortalCCL21 
TCGA Data PortalCCL21 
Broad Tumor PortalCCL21
OASIS PortalCCL21 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCCL21  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCCL21
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CCL21
DgiDB (Drug Gene Interaction Database)CCL21
DoCM (Curated mutations)CCL21 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CCL21 (select a term)
intoGenCCL21
Cancer3DCCL21(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602737   
Orphanet
MedgenCCL21
Genetic Testing Registry CCL21
NextProtO00585 [Medical]
TSGene6366
GENETestsCCL21
Huge Navigator CCL21 [HugePedia]
snp3D : Map Gene to Disease6366
BioCentury BCIQCCL21
ClinGenCCL21
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6366
Chemical/Pharm GKB GenePA35552
Clinical trialCCL21
Miscellaneous
canSAR (ICR)CCL21 (select the gene name)
Probes
Litterature
PubMed132 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCCL21
EVEXCCL21
GoPubMedCCL21
iHOPCCL21
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:09:17 CEST 2017

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