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CCL3 (C-C motif chemokine ligand 3)

Identity

Alias (NCBI)G0S19-1
LD78ALPHA
MIP-1-alpha
MIP1A
SCYA3
HGNC (Hugo) CCL3
HGNC Alias symbG0S19-1
LD78ALPHA
MIP-1-alpha
HGNC Previous nameSCYA3
HGNC Previous namesmall inducible cytokine A3 (homologous to mouse Mip-1a)
 chemokine (C-C motif) ligand 3
LocusID (NCBI) 6348
Atlas_Id 944
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 36088256 and ends at 36090143 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  Multiple Myeloma


External links

 

Nomenclature
HGNC (Hugo)CCL3   10627
Cards
Entrez_Gene (NCBI)CCL3    C-C motif chemokine ligand 3
AliasesG0S19-1; LD78ALPHA; MIP-1-alpha; MIP1A; 
SCYA3
GeneCards (Weizmann)CCL3
Ensembl hg19 (Hinxton)ENSG00000277632 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000277632 [Gene_View]  ENSG00000277632 [Sequence]  chr17:36088256-36090143 [Contig_View]  CCL3 [Vega]
ICGC DataPortalENSG00000277632
TCGA cBioPortalCCL3
AceView (NCBI)CCL3
Genatlas (Paris)CCL3
SOURCE (Princeton)CCL3
Genetics Home Reference (NIH)CCL3
Genomic and cartography
GoldenPath hg38 (UCSC)CCL3  -     chr17:36088256-36090143 -  17q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CCL3  -     17q12   [Description]    (hg19-Feb_2009)
GoldenPathCCL3 - 17q12 [CytoView hg19]  CCL3 - 17q12 [CytoView hg38]
ImmunoBaseENSG00000277632
Genome Data Viewer NCBICCL3 [Mapview hg19]  
OMIM182283   609423   
Gene and transcription
Genbank (Entrez)AF043339 BC071834 BC171831 BC171891 BX103455
RefSeq transcript (Entrez)NM_002983
Consensus coding sequences : CCDS (NCBI)CCL3
Gene ExpressionCCL3 [ NCBI-GEO ]   CCL3 [ EBI - ARRAY_EXPRESS ]   CCL3 [ SEEK ]   CCL3 [ MEM ]
Gene Expression Viewer (FireBrowse)CCL3 [ Firebrowse - Broad ]
GenevisibleExpression of CCL3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6348
GTEX Portal (Tissue expression)CCL3
Human Protein AtlasENSG00000277632-CCL3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10147   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP10147  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP10147
PhosPhoSitePlusP10147
Domaine pattern : Prosite (Expaxy)SMALL_CYTOKINES_CC (PS00472)   
Domains : Interpro (EBI)Chemokine_b/g/d    Chemokine_CC_CS    Chemokine_IL8-like_dom    Interleukin_8-like_sf   
Domain families : Pfam (Sanger)IL8 (PF00048)   
Domain families : Pfam (NCBI)pfam00048   
Domain families : Smart (EMBL)SCY (SM00199)  
Conserved Domain (NCBI)CCL3
PDB (RSDB)1B50    1B53    2X69    2X6G    3FPU    3H44    3KBX    4RA8    4ZKB    5COR    5D65   
PDB Europe1B50    1B53    2X69    2X6G    3FPU    3H44    3KBX    4RA8    4ZKB    5COR    5D65   
PDB (PDBSum)1B50    1B53    2X69    2X6G    3FPU    3H44    3KBX    4RA8    4ZKB    5COR    5D65   
PDB (IMB)1B50    1B53    2X69    2X6G    3FPU    3H44    3KBX    4RA8    4ZKB    5COR    5D65   
Structural Biology KnowledgeBase1B50    1B53    2X69    2X6G    3FPU    3H44    3KBX    4RA8    4ZKB    5COR    5D65   
SCOP (Structural Classification of Proteins)1B50    1B53    2X69    2X6G    3FPU    3H44    3KBX    4RA8    4ZKB    5COR    5D65   
CATH (Classification of proteins structures)1B50    1B53    2X69    2X6G    3FPU    3H44    3KBX    4RA8    4ZKB    5COR    5D65   
SuperfamilyP10147
AlphaFold pdb e-kbP10147   
Human Protein Atlas [tissue]ENSG00000277632-CCL3 [tissue]
HPRD01656
Protein Interaction databases
DIP (DOE-UCLA)P10147
IntAct (EBI)P10147
BioGRIDCCL3
STRING (EMBL)CCL3
ZODIACCCL3
Ontologies - Pathways
QuickGOP10147
Ontology : AmiGOMAPK cascade  MAPK cascade  osteoblast differentiation  cell activation  monocyte chemotaxis  monocyte chemotaxis  monocyte chemotaxis  protein kinase activity  calcium-dependent protein kinase C activity  protein binding  extracellular region  extracellular region  extracellular space  extracellular space  cytoplasm  cytosol  protein phosphorylation  calcium ion transport  cellular calcium ion homeostasis  exocytosis  chemotaxis  inflammatory response  inflammatory response  cytoskeleton organization  G protein-coupled receptor signaling pathway  cell-cell signaling  chemokine activity  chemokine activity  regulation of cell shape  response to toxic substance  positive regulation of gene expression  negative regulation of gene expression  T cell chemotaxis  release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  phospholipase activator activity  kinase activity  cytokine-mediated signaling pathway  calcium-mediated signaling  signaling  positive regulation of cell migration  negative regulation of bone mineralization  neutrophil chemotaxis  neutrophil chemotaxis  lipopolysaccharide-mediated signaling pathway  CCR1 chemokine receptor binding  CCR5 chemokine receptor binding  positive regulation of interleukin-1 beta production  positive regulation of tumor necrosis factor production  chemoattractant activity  identical protein binding  eosinophil degranulation  protein kinase B signaling  positive regulation of neuron apoptotic process  positive regulation of GTPase activity  astrocyte cell migration  negative regulation by host of viral transcription  negative regulation of osteoclast differentiation  CCR chemokine receptor binding  eosinophil chemotaxis  macrophage chemotaxis  lymphocyte chemotaxis  lymphocyte chemotaxis  positive regulation of inflammatory response  regulation of behavior  positive regulation of calcium-mediated signaling  positive chemotaxis  positive regulation of protein kinase B signaling  positive regulation of calcium ion transport  regulation of sensory perception of pain  chemokine-mediated signaling pathway  positive regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  response to cholesterol  cellular response to interferon-gamma  cellular response to interferon-gamma  cellular response to interleukin-1  cellular response to interleukin-1  cellular response to tumor necrosis factor  cellular response to tumor necrosis factor  cellular response to organic cyclic compound  granulocyte chemotaxis  positive regulation of calcium ion import  positive regulation of microglial cell activation  positive regulation of microglial cell migration  positive regulation of natural killer cell chemotaxis  
Ontology : EGO-EBIMAPK cascade  MAPK cascade  osteoblast differentiation  cell activation  monocyte chemotaxis  monocyte chemotaxis  monocyte chemotaxis  protein kinase activity  calcium-dependent protein kinase C activity  protein binding  extracellular region  extracellular region  extracellular space  extracellular space  cytoplasm  cytosol  protein phosphorylation  calcium ion transport  cellular calcium ion homeostasis  exocytosis  chemotaxis  inflammatory response  inflammatory response  cytoskeleton organization  G protein-coupled receptor signaling pathway  cell-cell signaling  chemokine activity  chemokine activity  regulation of cell shape  response to toxic substance  positive regulation of gene expression  negative regulation of gene expression  T cell chemotaxis  release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  phospholipase activator activity  kinase activity  cytokine-mediated signaling pathway  calcium-mediated signaling  signaling  positive regulation of cell migration  negative regulation of bone mineralization  neutrophil chemotaxis  neutrophil chemotaxis  lipopolysaccharide-mediated signaling pathway  CCR1 chemokine receptor binding  CCR5 chemokine receptor binding  positive regulation of interleukin-1 beta production  positive regulation of tumor necrosis factor production  chemoattractant activity  identical protein binding  eosinophil degranulation  protein kinase B signaling  positive regulation of neuron apoptotic process  positive regulation of GTPase activity  astrocyte cell migration  negative regulation by host of viral transcription  negative regulation of osteoclast differentiation  CCR chemokine receptor binding  eosinophil chemotaxis  macrophage chemotaxis  lymphocyte chemotaxis  lymphocyte chemotaxis  positive regulation of inflammatory response  regulation of behavior  positive regulation of calcium-mediated signaling  positive chemotaxis  positive regulation of protein kinase B signaling  positive regulation of calcium ion transport  regulation of sensory perception of pain  chemokine-mediated signaling pathway  positive regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  response to cholesterol  cellular response to interferon-gamma  cellular response to interferon-gamma  cellular response to interleukin-1  cellular response to interleukin-1  cellular response to tumor necrosis factor  cellular response to tumor necrosis factor  cellular response to organic cyclic compound  granulocyte chemotaxis  positive regulation of calcium ion import  positive regulation of microglial cell activation  positive regulation of microglial cell migration  positive regulation of natural killer cell chemotaxis  
Pathways : BIOCARTASelective expression of chemokine receptors during T-cell polarization [Genes]    Erythrocyte Differentiation Pathway [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway    Toll-like receptor signaling pathway    Salmonella infection    Chagas disease (American trypanosomiasis)    Rheumatoid arthritis   
NDEx NetworkCCL3
Atlas of Cancer Signalling NetworkCCL3
Wikipedia pathwaysCCL3
Orthology - Evolution
OrthoDB6348
GeneTree (enSembl)ENSG00000277632
Phylogenetic Trees/Animal Genes : TreeFamCCL3
Homologs : HomoloGeneCCL3
Homology/Alignments : Family Browser (UCSC)CCL3
Gene fusions - Rearrangements
Fusion : QuiverCCL3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCCL3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CCL3
dbVarCCL3
ClinVarCCL3
MonarchCCL3
1000_GenomesCCL3 
Exome Variant ServerCCL3
GNOMAD BrowserENSG00000277632
Varsome BrowserCCL3
ACMGCCL3 variants
VarityP10147
Genomic Variants (DGV)CCL3 [DGVbeta]
DECIPHERCCL3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCCL3 
Mutations
ICGC Data PortalCCL3 
TCGA Data PortalCCL3 
Broad Tumor PortalCCL3
OASIS PortalCCL3 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDCCL3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCCL3
DgiDB (Drug Gene Interaction Database)CCL3
DoCM (Curated mutations)CCL3
CIViC (Clinical Interpretations of Variants in Cancer)CCL3
Cancer3DCCL3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM182283    609423   
Orphanet
DisGeNETCCL3
MedgenCCL3
Genetic Testing Registry CCL3
NextProtP10147 [Medical]
GENETestsCCL3
Target ValidationCCL3
Huge Navigator CCL3 [HugePedia]
ClinGenCCL3
Clinical trials, drugs, therapy
MyCancerGenomeCCL3
Protein Interactions : CTDCCL3
Pharm GKB GenePA35559
PharosP10147
Clinical trialCCL3
Miscellaneous
canSAR (ICR)CCL3
HarmonizomeCCL3
DataMed IndexCCL3
Probes
Litterature
PubMed283 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCCL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:02:41 CEST 2021

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