Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CCL3 (C-C motif chemokine ligand 3)

Identity

Alias_namesSCYA3
small inducible cytokine A3 (homologous to mouse Mip-1a)
chemokine (C-C motif) ligand 3
Alias_symbol (synonym)G0S19-1
LD78ALPHA
MIP-1-alpha
Other aliasMIP1A
HGNC (Hugo) CCL3
LocusID (NCBI) 6348
Atlas_Id 944
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 36088256 and ends at 36090160 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  Multiple Myeloma in 2017


External links

Nomenclature
HGNC (Hugo)CCL3   10627
Cards
Entrez_Gene (NCBI)CCL3  6348  C-C motif chemokine ligand 3
AliasesG0S19-1; LD78ALPHA; MIP-1-alpha; MIP1A; 
SCYA3
GeneCards (Weizmann)CCL3
Ensembl hg19 (Hinxton)ENSG00000277632 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000277632 [Gene_View]  chr17:36088256-36090160 [Contig_View]  CCL3 [Vega]
ICGC DataPortalENSG00000277632
TCGA cBioPortalCCL3
AceView (NCBI)CCL3
Genatlas (Paris)CCL3
WikiGenes6348
SOURCE (Princeton)CCL3
Genetics Home Reference (NIH)CCL3
Genomic and cartography
GoldenPath hg38 (UCSC)CCL3  -     chr17:36088256-36090160 -  17q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CCL3  -     17q12   [Description]    (hg19-Feb_2009)
EnsemblCCL3 - 17q12 [CytoView hg19]  CCL3 - 17q12 [CytoView hg38]
Mapping of homologs : NCBICCL3 [Mapview hg19]  CCL3 [Mapview hg38]
OMIM182283   609423   
Gene and transcription
Genbank (Entrez)AF043339 BC071834 BC171831 BC171891 BX103455
RefSeq transcript (Entrez)NM_002983
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_027730 NT_187614 NT_187661
Consensus coding sequences : CCDS (NCBI)CCL3
Cluster EST : UnigeneHs.514107 [ NCBI ]
CGAP (NCI)Hs.514107
Alternative Splicing GalleryENSG00000277632
Gene ExpressionCCL3 [ NCBI-GEO ]   CCL3 [ EBI - ARRAY_EXPRESS ]   CCL3 [ SEEK ]   CCL3 [ MEM ]
Gene Expression Viewer (FireBrowse)CCL3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6348
GTEX Portal (Tissue expression)CCL3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP10147   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP10147  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP10147
Splice isoforms : SwissVarP10147
PhosPhoSitePlusP10147
Domaine pattern : Prosite (Expaxy)SMALL_CYTOKINES_CC (PS00472)   
Domains : Interpro (EBI)Chemokine_CC_CS    Chemokine_IL8-like_dom   
Domain families : Pfam (Sanger)IL8 (PF00048)   
Domain families : Pfam (NCBI)pfam00048   
Domain families : Smart (EMBL)SCY (SM00199)  
Conserved Domain (NCBI)CCL3
DMDM Disease mutations6348
Blocks (Seattle)CCL3
PDB (SRS)1B50    1B53    2X69    2X6G    3FPU    3H44    3KBX    4RA8    4ZKB    5COR    5D65   
PDB (PDBSum)1B50    1B53    2X69    2X6G    3FPU    3H44    3KBX    4RA8    4ZKB    5COR    5D65   
PDB (IMB)1B50    1B53    2X69    2X6G    3FPU    3H44    3KBX    4RA8    4ZKB    5COR    5D65   
PDB (RSDB)1B50    1B53    2X69    2X6G    3FPU    3H44    3KBX    4RA8    4ZKB    5COR    5D65   
Structural Biology KnowledgeBase1B50    1B53    2X69    2X6G    3FPU    3H44    3KBX    4RA8    4ZKB    5COR    5D65   
SCOP (Structural Classification of Proteins)1B50    1B53    2X69    2X6G    3FPU    3H44    3KBX    4RA8    4ZKB    5COR    5D65   
CATH (Classification of proteins structures)1B50    1B53    2X69    2X6G    3FPU    3H44    3KBX    4RA8    4ZKB    5COR    5D65   
SuperfamilyP10147
Human Protein AtlasENSG00000277632
Peptide AtlasP10147
HPRD01656
IPIIPI00019426   
Protein Interaction databases
DIP (DOE-UCLA)P10147
IntAct (EBI)P10147
FunCoupENSG00000277632
BioGRIDCCL3
STRING (EMBL)CCL3
ZODIACCCL3
Ontologies - Pathways
QuickGOP10147
Ontology : AmiGOMAPK cascade  MAPK cascade  osteoblast differentiation  cell activation  monocyte chemotaxis  monocyte chemotaxis  protein kinase activity  calcium-dependent protein kinase C activity  protein binding  extracellular region  extracellular region  extracellular space  intracellular  cytoplasm  cytosol  calcium ion transport  cellular calcium ion homeostasis  exocytosis  chemotaxis  inflammatory response  cytoskeleton organization  G-protein coupled receptor signaling pathway  cell-cell signaling  behavior  chemokine activity  regulation of cell shape  response to toxic substance  positive regulation of gene expression  negative regulation of gene expression  T cell chemotaxis  release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  phospholipase activator activity  kinase activity  calcium-mediated signaling  signaling  positive regulation of cell migration  negative regulation of bone mineralization  neutrophil chemotaxis  lipopolysaccharide-mediated signaling pathway  CCR1 chemokine receptor binding  CCR5 chemokine receptor binding  positive regulation of tumor necrosis factor production  chemoattractant activity  identical protein binding  eosinophil degranulation  protein kinase B signaling  positive regulation of neuron apoptotic process  positive regulation of GTPase activity  astrocyte cell migration  negative regulation by host of viral transcription  negative regulation of osteoclast differentiation  eosinophil chemotaxis  macrophage chemotaxis  lymphocyte chemotaxis  positive regulation of interleukin-1 beta secretion  positive regulation of inflammatory response  positive regulation of calcium-mediated signaling  positive chemotaxis  positive regulation of protein kinase B signaling  positive regulation of calcium ion transport  regulation of sensory perception of pain  chemokine-mediated signaling pathway  positive regulation of ERK1 and ERK2 cascade  response to cholesterol  cellular response to interferon-gamma  cellular response to interleukin-1  cellular response to tumor necrosis factor  cellular response to organic cyclic compound  granulocyte chemotaxis  positive regulation of calcium ion import  positive regulation of natural killer cell chemotaxis  
Ontology : EGO-EBIMAPK cascade  MAPK cascade  osteoblast differentiation  cell activation  monocyte chemotaxis  monocyte chemotaxis  protein kinase activity  calcium-dependent protein kinase C activity  protein binding  extracellular region  extracellular region  extracellular space  intracellular  cytoplasm  cytosol  calcium ion transport  cellular calcium ion homeostasis  exocytosis  chemotaxis  inflammatory response  cytoskeleton organization  G-protein coupled receptor signaling pathway  cell-cell signaling  behavior  chemokine activity  regulation of cell shape  response to toxic substance  positive regulation of gene expression  negative regulation of gene expression  T cell chemotaxis  release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  phospholipase activator activity  kinase activity  calcium-mediated signaling  signaling  positive regulation of cell migration  negative regulation of bone mineralization  neutrophil chemotaxis  lipopolysaccharide-mediated signaling pathway  CCR1 chemokine receptor binding  CCR5 chemokine receptor binding  positive regulation of tumor necrosis factor production  chemoattractant activity  identical protein binding  eosinophil degranulation  protein kinase B signaling  positive regulation of neuron apoptotic process  positive regulation of GTPase activity  astrocyte cell migration  negative regulation by host of viral transcription  negative regulation of osteoclast differentiation  eosinophil chemotaxis  macrophage chemotaxis  lymphocyte chemotaxis  positive regulation of interleukin-1 beta secretion  positive regulation of inflammatory response  positive regulation of calcium-mediated signaling  positive chemotaxis  positive regulation of protein kinase B signaling  positive regulation of calcium ion transport  regulation of sensory perception of pain  chemokine-mediated signaling pathway  positive regulation of ERK1 and ERK2 cascade  response to cholesterol  cellular response to interferon-gamma  cellular response to interleukin-1  cellular response to tumor necrosis factor  cellular response to organic cyclic compound  granulocyte chemotaxis  positive regulation of calcium ion import  positive regulation of natural killer cell chemotaxis  
Pathways : BIOCARTASelective expression of chemokine receptors during T-cell polarization [Genes]    Erythrocyte Differentiation Pathway [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway    Toll-like receptor signaling pathway    Salmonella infection    Chagas disease (American trypanosomiasis)    Rheumatoid arthritis   
NDEx NetworkCCL3
Atlas of Cancer Signalling NetworkCCL3
Wikipedia pathwaysCCL3
Orthology - Evolution
OrthoDB6348
GeneTree (enSembl)ENSG00000277632
Phylogenetic Trees/Animal Genes : TreeFamCCL3
HOVERGENP10147
HOGENOMP10147
Homologs : HomoloGeneCCL3
Homology/Alignments : Family Browser (UCSC)CCL3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCCL3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CCL3
dbVarCCL3
ClinVarCCL3
1000_GenomesCCL3 
Exome Variant ServerCCL3
ExAC (Exome Aggregation Consortium)CCL3 (select the gene name)
Genetic variants : HAPMAP6348
Genomic Variants (DGV)CCL3 [DGVbeta]
DECIPHERCCL3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCCL3 
Mutations
ICGC Data PortalCCL3 
TCGA Data PortalCCL3 
Broad Tumor PortalCCL3
OASIS PortalCCL3 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDCCL3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CCL3
DgiDB (Drug Gene Interaction Database)CCL3
DoCM (Curated mutations)CCL3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CCL3 (select a term)
intoGenCCL3
Cancer3DCCL3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM182283    609423   
Orphanet
MedgenCCL3
Genetic Testing Registry CCL3
NextProtP10147 [Medical]
TSGene6348
GENETestsCCL3
Target ValidationCCL3
Huge Navigator CCL3 [HugePedia]
snp3D : Map Gene to Disease6348
BioCentury BCIQCCL3
ClinGenCCL3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6348
Chemical/Pharm GKB GenePA35559
Clinical trialCCL3
Miscellaneous
canSAR (ICR)CCL3 (select the gene name)
Probes
Litterature
PubMed250 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCCL3
EVEXCCL3
GoPubMedCCL3
iHOPCCL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 16:57:04 CEST 2017

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