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CCL4 (chemokine (C-C motif) ligand 4)

Identity

Other namesACT2
AT744.1
G-26
HC21
LAG-1
LAG1
MIP-1-beta
MIP1B
MIP1B1
SCYA2
SCYA4
HGNC (Hugo) CCL4
LocusID (NCBI) 6351
Location 17q12
Location_base_pair Starts at 34431220 and ends at 34433014 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CCL4   10630
Cards
Entrez_Gene (NCBI)CCL4  6351  chemokine (C-C motif) ligand 4
GeneCards (Weizmann)CCL4
Ensembl (Hinxton) [Gene_View]  chr17:34431220-34433014 [Contig_View]  CCL4 [Vega]
cBioPortalCCL4
AceView (NCBI)CCL4
Genatlas (Paris)CCL4
WikiGenes6351
SOURCE (Princeton)NM_002984
Genomic and cartography
GoldenPath (UCSC)CCL4  -  17q12   chr17:34431220-34433014 +  17q12   [Description]    (hg19-Feb_2009)
EnsemblCCL4 - 17q12 [CytoView]
Mapping of homologs : NCBICCL4 [Mapview]
OMIM182284   
Gene and transcription
Genbank (Entrez)AA362169 AY312578 AY766446 AY766448 BC027961
RefSeq transcript (Entrez)NM_002984
RefSeq genomic (Entrez)AC_000149 NC_000017 NC_018928 NG_033066 NT_010783 NT_187614 NT_187661 NW_001838432 NW_004929407
Consensus coding sequences : CCDS (NCBI)CCL4
Cluster EST : UnigeneHs.75703 [ NCBI ]
CGAP (NCI)Hs.75703
Alternative Splicing : Fast-db (Paris)GSHG0012421
Gene ExpressionCCL4 [ NCBI-GEO ]     CCL4 [ SEEK ]   CCL4 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13236 (Uniprot)
NextProtP13236  [Medical]
With graphics : InterProP13236
Splice isoforms : SwissVarP13236 (Swissvar)
Domaine pattern : Prosite (Expaxy)SMALL_CYTOKINES_CC (PS00472)   
Domains : Interpro (EBI)Chemokine_CC_CS [organisation]   Chemokine_IL8-like_dom [organisation]  
Related proteins : CluSTrP13236
Domain families : Pfam (Sanger)IL8 (PF00048)   
Domain families : Pfam (NCBI)pfam00048   
Domain families : Smart (EMBL)SCY (SM00199)  
DMDM Disease mutations6351
Blocks (Seattle)P13236
PDB (SRS)1HUM    1HUN    1JE4    2FFK    2FIN    2X6L    3TN2   
PDB (PDBSum)1HUM    1HUN    1JE4    2FFK    2FIN    2X6L    3TN2   
PDB (IMB)1HUM    1HUN    1JE4    2FFK    2FIN    2X6L    3TN2   
PDB (RSDB)1HUM    1HUN    1JE4    2FFK    2FIN    2X6L    3TN2   
Peptide AtlasP13236
HPRD01657
Protein Interaction databases
DIP (DOE-UCLA)P13236
IntAct (EBI)P13236
BioGRIDCCL4
InParanoidP13236
Interologous Interaction database P13236
IntegromeDBCCL4
STRING (EMBL)CCL4
Ontologies - Pathways
Ontology : AmiGOcytokine activity  protein binding  extracellular region  extracellular space  cellular component movement  inflammatory response  immune response  cell adhesion  establishment or maintenance of cell polarity  signal transduction  cell-cell signaling  chemokine activity  response to virus  response to toxic substance  CCR1 chemokine receptor binding  CCR5 chemokine receptor binding  identical protein binding  negative regulation by host of viral transcription  positive regulation of calcium-mediated signaling  positive regulation of calcium ion transport  cell chemotaxis  cell chemotaxis  positive regulation of natural killer cell chemotaxis  
Ontology : EGO-EBIcytokine activity  protein binding  extracellular region  extracellular space  cellular component movement  inflammatory response  immune response  cell adhesion  establishment or maintenance of cell polarity  signal transduction  cell-cell signaling  chemokine activity  response to virus  response to toxic substance  CCR1 chemokine receptor binding  CCR5 chemokine receptor binding  identical protein binding  negative regulation by host of viral transcription  positive regulation of calcium-mediated signaling  positive regulation of calcium ion transport  cell chemotaxis  cell chemotaxis  positive regulation of natural killer cell chemotaxis  
Pathways : BIOCARTAPertussis toxin-insensitive CCR5 Signaling in Macrophage [Genes]    Selective expression of chemokine receptors during T-cell polarization [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway    NF-kappa B signaling pathway    Toll-like receptor signaling pathway    Cytosolic DNA-sensing pathway    Salmonella infection   
Protein Interaction DatabaseCCL4
Wikipedia pathwaysCCL4
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)CCL4
snp3D : Map Gene to Disease6351
SNP (GeneSNP Utah)CCL4
SNP : HGBaseCCL4
Genetic variants : HAPMAPCCL4
Exome VariantCCL4
1000_GenomesCCL4 
Somatic Mutations in Cancer : COSMICCCL4 
CONAN: Copy Number AnalysisCCL4 
Mutations and Diseases : HGMDCCL4
Genomic VariantsCCL4  CCL4 [DGVbeta]
dbVarCCL4
ClinVarCCL4
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM182284   
MedgenCCL4
GENETestsCCL4
Disease Genetic AssociationCCL4
Huge Navigator CCL4 [HugePedia]  CCL4 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneCCL4
Homology/Alignments : Family Browser (UCSC)CCL4
Phylogenetic Trees/Animal Genes : TreeFamCCL4
Chemical/Protein Interactions : CTD6351
Chemical/Pharm GKB GenePA35562
Clinical trialCCL4
Other databases
Probes
Litterature
PubMed164 Pubmed reference(s) in Entrez
CoreMineCCL4
iHOPCCL4
OncoSearchCCL4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 30 13:46:44 CEST 2014

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