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CCL4 (C-C motif chemokine ligand 4)

Identity

Alias_namesLAG1
SCYA4
small inducible cytokine A4 (homologous to mouse Mip-1b)
chemokine (C-C motif) ligand 4
Alias_symbol (synonym)MIP-1-beta
Act-2
AT744.1
HGNC (Hugo) CCL4
LocusID (NCBI) 6351
Atlas_Id 945
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 34431220 and ends at 34433014 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CCL4 (17q12) / ALOX5AP (13q12.3)CCL4 (17q12) / MCL1 (1q21.3)CCL4 (17q12) / PRPF38A (1p32.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CCL4   10630
Cards
Entrez_Gene (NCBI)CCL4  6351  C-C motif chemokine ligand 4
AliasesACT2; AT744.1; G-26; HC21; 
LAG-1; LAG1; MIP-1-beta; MIP1B; MIP1B1; SCYA2; SCYA4
GeneCards (Weizmann)CCL4
Ensembl hg19 (Hinxton)ENSG00000275302 [Gene_View]  chr17:34431220-34433014 [Contig_View]  CCL4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000275302 [Gene_View]  chr17:34431220-34433014 [Contig_View]  CCL4 [Vega]
ICGC DataPortalENSG00000275302
TCGA cBioPortalCCL4
AceView (NCBI)CCL4
Genatlas (Paris)CCL4
WikiGenes6351
SOURCE (Princeton)CCL4
Genetics Home Reference (NIH)CCL4
Genomic and cartography
GoldenPath hg19 (UCSC)CCL4  -     chr17:34431220-34433014 +  17q12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CCL4  -     17q12   [Description]    (hg38-Dec_2013)
EnsemblCCL4 - 17q12 [CytoView hg19]  CCL4 - 17q12 [CytoView hg38]
Mapping of homologs : NCBICCL4 [Mapview hg19]  CCL4 [Mapview hg38]
OMIM182284   
Gene and transcription
Genbank (Entrez)AA362169 AY312578 AY766446 AY766448 BC027961
RefSeq transcript (Entrez)NM_002984
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_033066 NT_010783 NT_187614 NT_187661 NW_004929407
Consensus coding sequences : CCDS (NCBI)CCL4
Cluster EST : UnigeneHs.75703 [ NCBI ]
CGAP (NCI)Hs.75703
Alternative Splicing GalleryENSG00000275302
Gene ExpressionCCL4 [ NCBI-GEO ]   CCL4 [ EBI - ARRAY_EXPRESS ]   CCL4 [ SEEK ]   CCL4 [ MEM ]
Gene Expression Viewer (FireBrowse)CCL4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6351
GTEX Portal (Tissue expression)CCL4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13236   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP13236  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP13236
Splice isoforms : SwissVarP13236
PhosPhoSitePlusP13236
Domaine pattern : Prosite (Expaxy)SMALL_CYTOKINES_CC (PS00472)   
Domains : Interpro (EBI)Chemokine_CC_CS    Chemokine_IL8-like_dom   
Domain families : Pfam (Sanger)IL8 (PF00048)   
Domain families : Pfam (NCBI)pfam00048   
Domain families : Smart (EMBL)SCY (SM00199)  
Conserved Domain (NCBI)CCL4
DMDM Disease mutations6351
Blocks (Seattle)CCL4
PDB (SRS)1HUM    1HUN    1JE4    2FFK    2FIN    2X6L    3TN2    4RAL   
PDB (PDBSum)1HUM    1HUN    1JE4    2FFK    2FIN    2X6L    3TN2    4RAL   
PDB (IMB)1HUM    1HUN    1JE4    2FFK    2FIN    2X6L    3TN2    4RAL   
PDB (RSDB)1HUM    1HUN    1JE4    2FFK    2FIN    2X6L    3TN2    4RAL   
Structural Biology KnowledgeBase1HUM    1HUN    1JE4    2FFK    2FIN    2X6L    3TN2    4RAL   
SCOP (Structural Classification of Proteins)1HUM    1HUN    1JE4    2FFK    2FIN    2X6L    3TN2    4RAL   
CATH (Classification of proteins structures)1HUM    1HUN    1JE4    2FFK    2FIN    2X6L    3TN2    4RAL   
SuperfamilyP13236
Human Protein AtlasENSG00000275302
Peptide AtlasP13236
HPRD01657
Protein Interaction databases
DIP (DOE-UCLA)P13236
IntAct (EBI)P13236
FunCoupENSG00000275302
BioGRIDCCL4
STRING (EMBL)CCL4
ZODIACCCL4
Ontologies - Pathways
QuickGOP13236
Ontology : AmiGOmonocyte chemotaxis  cytokine activity  protein binding  extracellular region  extracellular space  movement of cell or subcellular component  inflammatory response  immune response  cell adhesion  establishment or maintenance of cell polarity  signal transduction  G-protein coupled receptor signaling pathway  cell-cell signaling  chemokine activity  response to virus  response to toxic substance  neutrophil chemotaxis  CCR1 chemokine receptor binding  CCR5 chemokine receptor binding  identical protein binding  positive regulation of GTPase activity  negative regulation by host of viral transcription  positive regulation of inflammatory response  positive regulation of calcium-mediated signaling  positive regulation of calcium ion transport  chemokine-mediated signaling pathway  positive regulation of ERK1 and ERK2 cascade  cellular response to interferon-gamma  cellular response to interleukin-1  cellular response to tumor necrosis factor  positive regulation of natural killer cell chemotaxis  
Ontology : EGO-EBImonocyte chemotaxis  cytokine activity  protein binding  extracellular region  extracellular space  movement of cell or subcellular component  inflammatory response  immune response  cell adhesion  establishment or maintenance of cell polarity  signal transduction  G-protein coupled receptor signaling pathway  cell-cell signaling  chemokine activity  response to virus  response to toxic substance  neutrophil chemotaxis  CCR1 chemokine receptor binding  CCR5 chemokine receptor binding  identical protein binding  positive regulation of GTPase activity  negative regulation by host of viral transcription  positive regulation of inflammatory response  positive regulation of calcium-mediated signaling  positive regulation of calcium ion transport  chemokine-mediated signaling pathway  positive regulation of ERK1 and ERK2 cascade  cellular response to interferon-gamma  cellular response to interleukin-1  cellular response to tumor necrosis factor  positive regulation of natural killer cell chemotaxis  
Pathways : BIOCARTAPertussis toxin-insensitive CCR5 Signaling in Macrophage [Genes]    Selective expression of chemokine receptors during T-cell polarization [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway    NF-kappa B signaling pathway    Toll-like receptor signaling pathway    Cytosolic DNA-sensing pathway    Salmonella infection   
NDEx NetworkCCL4
Atlas of Cancer Signalling NetworkCCL4
Wikipedia pathwaysCCL4
Orthology - Evolution
OrthoDB6351
GeneTree (enSembl)ENSG00000275302
Phylogenetic Trees/Animal Genes : TreeFamCCL4
HOVERGENP13236
HOGENOMP13236
Homologs : HomoloGeneCCL4
Homology/Alignments : Family Browser (UCSC)CCL4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCCL4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CCL4
dbVarCCL4
ClinVarCCL4
1000_GenomesCCL4 
Exome Variant ServerCCL4
ExAC (Exome Aggregation Consortium)CCL4 (select the gene name)
Genetic variants : HAPMAP6351
Genomic Variants (DGV)CCL4 [DGVbeta]
DECIPHER (Syndromes)17:34431220-34433014  ENSG00000275302
CONAN: Copy Number AnalysisCCL4 
Mutations
ICGC Data PortalCCL4 
TCGA Data PortalCCL4 
Broad Tumor PortalCCL4
OASIS PortalCCL4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCCL4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCCL4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CCL4
DgiDB (Drug Gene Interaction Database)CCL4
DoCM (Curated mutations)CCL4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CCL4 (select a term)
intoGenCCL4
Cancer3DCCL4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM182284   
Orphanet
MedgenCCL4
Genetic Testing Registry CCL4
NextProtP13236 [Medical]
TSGene6351
GENETestsCCL4
Huge Navigator CCL4 [HugePedia]
snp3D : Map Gene to Disease6351
BioCentury BCIQCCL4
ClinGenCCL4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6351
Chemical/Pharm GKB GenePA35562
Clinical trialCCL4
Miscellaneous
canSAR (ICR)CCL4 (select the gene name)
Probes
Litterature
PubMed187 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCCL4
EVEXCCL4
GoPubMedCCL4
iHOPCCL4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:33:10 CET 2016

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