Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CCL5 (C-C motif chemokine ligand 5)

Identity

Alias (NCBI)D17S136E
RANTES
SCYA5
SIS-delta
SISd
TCP228
eoCP
HGNC (Hugo) CCL5
HGNC Alias symbRANTES
SISd
TCP228
MGC17164
HGNC Alias nameT-cell specific protein p288
 T-cell specific RANTES protein
 SIS-delta
 regulated upon activation, normally T-expressed, and presumably secreted
 beta-chemokine RANTES
 small inducible cytokine subfamily A (Cys-Cys), member 5
HGNC Previous nameD17S136E
 SCYA5
HGNC Previous namesmall inducible cytokine A5 (RANTES)
 chemokine (C-C motif) ligand 5
LocusID (NCBI) 6352
Atlas_Id 45956
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 35871491 and ends at 35880360 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  Subcutaneous panniculitis-like T-cell lymphoma

External links

Nomenclature
HGNC (Hugo)CCL5   10632
Cards
Entrez_Gene (NCBI)CCL5  6352  C-C motif chemokine ligand 5
AliasesD17S136E; RANTES; SCYA5; SIS-delta; 
SISd; TCP228; eoCP
GeneCards (Weizmann)CCL5
Ensembl hg19 (Hinxton)ENSG00000271503 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000271503 [Gene_View]  ENSG00000271503 [Sequence]  chr17:35871491-35880360 [Contig_View]  CCL5 [Vega]
ICGC DataPortalENSG00000271503
TCGA cBioPortalCCL5
AceView (NCBI)CCL5
Genatlas (Paris)CCL5
WikiGenes6352
SOURCE (Princeton)CCL5
Genetics Home Reference (NIH)CCL5
Genomic and cartography
GoldenPath hg38 (UCSC)CCL5  -     chr17:35871491-35880360 -  17q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CCL5  -     17q12   [Description]    (hg19-Feb_2009)
GoldenPathCCL5 - 17q12 [CytoView hg19]  CCL5 - 17q12 [CytoView hg38]
ImmunoBaseENSG00000271503
genome Data Viewer NCBICCL5 [Mapview hg19]  
OMIM187011   
Gene and transcription
Genbank (Entrez)AA443491 AA486131 AF043341 AF266753 AK312212
RefSeq transcript (Entrez)NM_001278736 NM_002985
RefSeq genomic (Entrez)NC_000017 NG_015990 NT_187614
Consensus coding sequences : CCDS (NCBI)CCL5
Alternative Splicing GalleryENSG00000271503
Gene ExpressionCCL5 [ NCBI-GEO ]   CCL5 [ EBI - ARRAY_EXPRESS ]   CCL5 [ SEEK ]   CCL5 [ MEM ]
Gene Expression Viewer (FireBrowse)CCL5 [ Firebrowse - Broad ]
GenevisibleExpression of CCL5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6352
GTEX Portal (Tissue expression)CCL5
Human Protein AtlasENSG00000271503-CCL5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13501   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP13501  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP13501
Splice isoforms : SwissVarP13501
PhosPhoSitePlusP13501
Domaine pattern : Prosite (Expaxy)SMALL_CYTOKINES_CC (PS00472)   
Domains : Interpro (EBI)Chemokine_b/g/d    Chemokine_CC_CS    Chemokine_IL8-like_dom    Interleukin_8-like_sf   
Domain families : Pfam (Sanger)IL8 (PF00048)   
Domain families : Pfam (NCBI)pfam00048   
Domain families : Smart (EMBL)SCY (SM00199)  
Conserved Domain (NCBI)CCL5
DMDM Disease mutations6352
Blocks (Seattle)CCL5
PDB (RSDB)1B3A    1EQT    1HRJ    1RTN    1RTO    1U4L    1U4M    1U4P    1U4R    2L9H    2VXW    5CMD    5COY    5DNF    5L2U    5UIW    6AEZ    6C6D    6FGP   
PDB Europe1B3A    1EQT    1HRJ    1RTN    1RTO    1U4L    1U4M    1U4P    1U4R    2L9H    2VXW    5CMD    5COY    5DNF    5L2U    5UIW    6AEZ    6C6D    6FGP   
PDB (PDBSum)1B3A    1EQT    1HRJ    1RTN    1RTO    1U4L    1U4M    1U4P    1U4R    2L9H    2VXW    5CMD    5COY    5DNF    5L2U    5UIW    6AEZ    6C6D    6FGP   
PDB (IMB)1B3A    1EQT    1HRJ    1RTN    1RTO    1U4L    1U4M    1U4P    1U4R    2L9H    2VXW    5CMD    5COY    5DNF    5L2U    5UIW    6AEZ    6C6D    6FGP   
Structural Biology KnowledgeBase1B3A    1EQT    1HRJ    1RTN    1RTO    1U4L    1U4M    1U4P    1U4R    2L9H    2VXW    5CMD    5COY    5DNF    5L2U    5UIW    6AEZ    6C6D    6FGP   
SCOP (Structural Classification of Proteins)1B3A    1EQT    1HRJ    1RTN    1RTO    1U4L    1U4M    1U4P    1U4R    2L9H    2VXW    5CMD    5COY    5DNF    5L2U    5UIW    6AEZ    6C6D    6FGP   
CATH (Classification of proteins structures)1B3A    1EQT    1HRJ    1RTN    1RTO    1U4L    1U4M    1U4P    1U4R    2L9H    2VXW    5CMD    5COY    5DNF    5L2U    5UIW    6AEZ    6C6D    6FGP   
SuperfamilyP13501
Human Protein Atlas [tissue]ENSG00000271503-CCL5 [tissue]
Peptide AtlasP13501
HPRD01751
IPIIPI00009309   
Protein Interaction databases
DIP (DOE-UCLA)P13501
IntAct (EBI)P13501
FunCoupENSG00000271503
BioGRIDCCL5
STRING (EMBL)CCL5
ZODIACCCL5
Ontologies - Pathways
QuickGOP13501
Ontology : AmiGOMAPK cascade  dendritic cell chemotaxis  monocyte chemotaxis  monocyte chemotaxis  regulation of chronic inflammatory response  phosphatidylinositol phospholipase C activity  protein kinase activity  protein binding  extracellular region  extracellular space  cytoplasm  calcium ion transport  cellular calcium ion homeostasis  exocytosis  chemotaxis  inflammatory response  inflammatory response  leukocyte cell-cell adhesion  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway  cell-cell signaling  chemokine activity  chemokine activity  chemokine activity  response to virus  response to toxic substance  positive regulation of activation of Janus kinase activity  positive regulation of macrophage chemotaxis  positive regulation of T cell chemotaxis  positive regulation of T cell chemotaxis  positive regulation of phosphatidylinositol 3-kinase signaling  positive regulation of smooth muscle cell migration  phospholipase activator activity  cytokine-mediated signaling pathway  receptor signaling protein tyrosine kinase activator activity  positive regulation of cell migration  neutrophil chemotaxis  positive regulation of cellular biosynthetic process  activation of phospholipase D activity  lipopolysaccharide-mediated signaling pathway  CCR1 chemokine receptor binding  CCR1 chemokine receptor binding  CCR1 chemokine receptor binding  CCR4 chemokine receptor binding  CCR5 chemokine receptor binding  positive regulation of cell-cell adhesion mediated by integrin  positive regulation of homotypic cell-cell adhesion  chemoattractant activity  positive regulation of T cell proliferation  neutrophil activation  positive regulation of phosphorylation  chemokine receptor binding  positive regulation of tyrosine phosphorylation of STAT protein  identical protein binding  protein homodimerization activity  protein kinase B signaling  positive regulation of GTPase activity  protein self-association  negative regulation by host of viral transcription  cellular response to fibroblast growth factor stimulus  positive regulation of viral genome replication  negative regulation of viral genome replication  positive regulation of innate immune response  negative regulation of G protein-coupled receptor signaling pathway  positive regulation of cell adhesion  positive regulation of translational initiation  positive regulation of JAK-STAT cascade  chemokine receptor antagonist activity  CCR chemokine receptor binding  eosinophil chemotaxis  macrophage chemotaxis  lymphocyte chemotaxis  positive regulation of smooth muscle cell proliferation  positive regulation of epithelial cell proliferation  regulation of insulin secretion  regulation of T cell activation  positive chemotaxis  positive regulation of calcium ion transport  positive regulation of protein tyrosine kinase activity  chemokine-mediated signaling pathway  chemokine-mediated signaling pathway  chemokine-mediated signaling pathway  negative regulation of chemokine-mediated signaling pathway  negative regulation of T cell apoptotic process  positive regulation of T cell apoptotic process  positive regulation of ERK1 and ERK2 cascade  cellular response to interferon-gamma  cellular response to interferon-gamma  cellular response to interleukin-1  cellular response to interleukin-1  cellular response to tumor necrosis factor  cellular response to tumor necrosis factor  cellular response to organic cyclic compound  positive regulation of monocyte chemotaxis  regulation of neuron death  negative regulation of macrophage apoptotic process  positive regulation of T cell migration  positive regulation of natural killer cell chemotaxis  
Ontology : EGO-EBIMAPK cascade  dendritic cell chemotaxis  monocyte chemotaxis  monocyte chemotaxis  regulation of chronic inflammatory response  phosphatidylinositol phospholipase C activity  protein kinase activity  protein binding  extracellular region  extracellular space  cytoplasm  calcium ion transport  cellular calcium ion homeostasis  exocytosis  chemotaxis  inflammatory response  inflammatory response  leukocyte cell-cell adhesion  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway  G protein-coupled receptor signaling pathway  cell-cell signaling  chemokine activity  chemokine activity  chemokine activity  response to virus  response to toxic substance  positive regulation of activation of Janus kinase activity  positive regulation of macrophage chemotaxis  positive regulation of T cell chemotaxis  positive regulation of T cell chemotaxis  positive regulation of phosphatidylinositol 3-kinase signaling  positive regulation of smooth muscle cell migration  phospholipase activator activity  cytokine-mediated signaling pathway  receptor signaling protein tyrosine kinase activator activity  positive regulation of cell migration  neutrophil chemotaxis  positive regulation of cellular biosynthetic process  activation of phospholipase D activity  lipopolysaccharide-mediated signaling pathway  CCR1 chemokine receptor binding  CCR1 chemokine receptor binding  CCR1 chemokine receptor binding  CCR4 chemokine receptor binding  CCR5 chemokine receptor binding  positive regulation of cell-cell adhesion mediated by integrin  positive regulation of homotypic cell-cell adhesion  chemoattractant activity  positive regulation of T cell proliferation  neutrophil activation  positive regulation of phosphorylation  chemokine receptor binding  positive regulation of tyrosine phosphorylation of STAT protein  identical protein binding  protein homodimerization activity  protein kinase B signaling  positive regulation of GTPase activity  protein self-association  negative regulation by host of viral transcription  cellular response to fibroblast growth factor stimulus  positive regulation of viral genome replication  negative regulation of viral genome replication  positive regulation of innate immune response  negative regulation of G protein-coupled receptor signaling pathway  positive regulation of cell adhesion  positive regulation of translational initiation  positive regulation of JAK-STAT cascade  chemokine receptor antagonist activity  CCR chemokine receptor binding  eosinophil chemotaxis  macrophage chemotaxis  lymphocyte chemotaxis  positive regulation of smooth muscle cell proliferation  positive regulation of epithelial cell proliferation  regulation of insulin secretion  regulation of T cell activation  positive chemotaxis  positive regulation of calcium ion transport  positive regulation of protein tyrosine kinase activity  chemokine-mediated signaling pathway  chemokine-mediated signaling pathway  chemokine-mediated signaling pathway  negative regulation of chemokine-mediated signaling pathway  negative regulation of T cell apoptotic process  positive regulation of T cell apoptotic process  positive regulation of ERK1 and ERK2 cascade  cellular response to interferon-gamma  cellular response to interferon-gamma  cellular response to interleukin-1  cellular response to interleukin-1  cellular response to tumor necrosis factor  cellular response to tumor necrosis factor  cellular response to organic cyclic compound  positive regulation of monocyte chemotaxis  regulation of neuron death  negative regulation of macrophage apoptotic process  positive regulation of T cell migration  positive regulation of natural killer cell chemotaxis  
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway    Toll-like receptor signaling pathway    NOD-like receptor signaling pathway    Cytosolic DNA-sensing pathway    TNF signaling pathway    Prion diseases    Epithelial cell signaling in Helicobacter pylori infection    Chagas disease (American trypanosomiasis)    Influenza A    Herpes simplex infection    Rheumatoid arthritis   
NDEx NetworkCCL5
Atlas of Cancer Signalling NetworkCCL5
Wikipedia pathwaysCCL5
Orthology - Evolution
OrthoDB6352
GeneTree (enSembl)ENSG00000271503
Phylogenetic Trees/Animal Genes : TreeFamCCL5
HOGENOMP13501
Homologs : HomoloGeneCCL5
Homology/Alignments : Family Browser (UCSC)CCL5
Gene fusions - Rearrangements
Fusion : QuiverCCL5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCCL5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CCL5
dbVarCCL5
ClinVarCCL5
1000_GenomesCCL5 
Exome Variant ServerCCL5
GNOMAD BrowserENSG00000271503
Varsome BrowserCCL5
Genetic variants : HAPMAP6352
Genomic Variants (DGV)CCL5 [DGVbeta]
DECIPHERCCL5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCCL5 
Mutations
ICGC Data PortalCCL5 
TCGA Data PortalCCL5 
Broad Tumor PortalCCL5
OASIS PortalCCL5 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDCCL5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)TBsLVD Tuberculosis susceptibility Locus Variation Database
BioMutasearch CCL5
DgiDB (Drug Gene Interaction Database)CCL5
DoCM (Curated mutations)CCL5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CCL5 (select a term)
intoGenCCL5
Cancer3DCCL5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM187011   
Orphanet
DisGeNETCCL5
MedgenCCL5
Genetic Testing Registry CCL5
NextProtP13501 [Medical]
TSGene6352
GENETestsCCL5
Target ValidationCCL5
Huge Navigator CCL5 [HugePedia]
snp3D : Map Gene to Disease6352
BioCentury BCIQCCL5
ClinGenCCL5
Clinical trials, drugs, therapy
Protein Interactions : CTD6352
Pharm GKB GenePA35564
Clinical trialCCL5
Miscellaneous
canSAR (ICR)CCL5 (select the gene name)
HarmonizomeCCL5
DataMed IndexCCL5
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCCL5
EVEXCCL5
GoPubMedCCL5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 15:06:30 CEST 2020
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