CCL7 (C-C motif chemokine ligand 7)

2003-06-01 Affiliation

Identity

HGNC

CCL7

LOCATION

17q12

LOCUSID

6354

ALIAS

FIC,MARC,MCP-3,MCP3,NC28,SCYA6,SCYA7

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 6354
MIM: 158106
HGNC: 10634
Ensembl: ENSG00000108688

Variants:

dbSNP: 6354
ClinVar: 6354
TCGA: ENSG00000108688
COSMIC: CCL7

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000108688	ENST00000378569	P80098
ENSG00000108688	ENST00000394627	A8MVH1
ENSG00000108688	ENST00000394630	A8MX17

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Chemokine signaling pathway	KEGG	ko04062
Chemokine signaling pathway	KEGG	hsa04062
IL-17 signaling pathway	KEGG	ko04657
IL-17 signaling pathway	KEGG	hsa04657

References

Pubmed ID	Year	Title	Citations
17364026	2007	Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites.	416
20570966	2010	Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.	130
17703412	2007	Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.	100
18660381	2008	Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx.	77
26756352	2016	Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity.	60
18469140	2008	Synergy between coproduced CC and CXC chemokines in monocyte chemotaxis through receptor-mediated events.	52
19937793	2010	Tumor-stromal crosstalk in invasion of oral squamous cell carcinoma: a pivotal role of CCL7.	44
19424580	2009	Tumor-associated macrophage/microglia infiltration in human gliomas is correlated with MCP-3, but not MCP-1.	37
16002730	2005	A non-glycosaminoglycan-binding variant of CC chemokine ligand 7 (monocyte chemoattractant protein-3) antagonizes chemokine-mediated inflammation.	34
20628624	2010	Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".	29

Citation

Dessen P

CCL7 (C-C motif chemokine ligand 7)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/946/ccl7