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CCL8 (C-C motif chemokine ligand 8)

Identity

Alias_namesSCYA8
small inducible cytokine subfamily A (Cys-Cys), member 8 (monocyte chemotactic protein 2)
chemokine (C-C motif) ligand 8
Alias_symbol (synonym)MCP-2
HC14
Other aliasMCP2
SCYA10
HGNC (Hugo) CCL8
LocusID (NCBI) 6355
Atlas_Id 947
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 34319047 and ends at 34321402 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CCL8 (17q12) / ARL8B (3p26.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CCL8   10635
Cards
Entrez_Gene (NCBI)CCL8  6355  C-C motif chemokine ligand 8
AliasesHC14; MCP-2; MCP2; SCYA10; 
SCYA8
GeneCards (Weizmann)CCL8
Ensembl hg19 (Hinxton)ENSG00000108700 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108700 [Gene_View]  chr17:34319047-34321402 [Contig_View]  CCL8 [Vega]
ICGC DataPortalENSG00000108700
TCGA cBioPortalCCL8
AceView (NCBI)CCL8
Genatlas (Paris)CCL8
WikiGenes6355
SOURCE (Princeton)CCL8
Genetics Home Reference (NIH)CCL8
Genomic and cartography
GoldenPath hg38 (UCSC)CCL8  -     chr17:34319047-34321402 +  17q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CCL8  -     17q12   [Description]    (hg19-Feb_2009)
EnsemblCCL8 - 17q12 [CytoView hg19]  CCL8 - 17q12 [CytoView hg38]
Mapping of homologs : NCBICCL8 [Mapview hg19]  CCL8 [Mapview hg38]
OMIM602283   
Gene and transcription
Genbank (Entrez)BC126242 HQ258700 Y10802 Y16645
RefSeq transcript (Entrez)NM_005623
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CCL8
Cluster EST : UnigeneHs.271387 [ NCBI ]
CGAP (NCI)Hs.271387
Alternative Splicing GalleryENSG00000108700
Gene ExpressionCCL8 [ NCBI-GEO ]   CCL8 [ EBI - ARRAY_EXPRESS ]   CCL8 [ SEEK ]   CCL8 [ MEM ]
Gene Expression Viewer (FireBrowse)CCL8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6355
GTEX Portal (Tissue expression)CCL8
Protein : pattern, domain, 3D structure
UniProt/SwissProtP80075   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP80075  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP80075
Splice isoforms : SwissVarP80075
PhosPhoSitePlusP80075
Domaine pattern : Prosite (Expaxy)SMALL_CYTOKINES_CC (PS00472)   
Domains : Interpro (EBI)Chemokine_CC_CS    Chemokine_IL8-like_dom   
Domain families : Pfam (Sanger)IL8 (PF00048)   
Domain families : Pfam (NCBI)pfam00048   
Domain families : Smart (EMBL)SCY (SM00199)  
Conserved Domain (NCBI)CCL8
DMDM Disease mutations6355
Blocks (Seattle)CCL8
PDB (SRS)1ESR   
PDB (PDBSum)1ESR   
PDB (IMB)1ESR   
PDB (RSDB)1ESR   
Structural Biology KnowledgeBase1ESR   
SCOP (Structural Classification of Proteins)1ESR   
CATH (Classification of proteins structures)1ESR   
SuperfamilyP80075
Human Protein AtlasENSG00000108700
Peptide AtlasP80075
HPRD03791
IPIIPI00007524   
Protein Interaction databases
DIP (DOE-UCLA)P80075
IntAct (EBI)P80075
FunCoupENSG00000108700
BioGRIDCCL8
STRING (EMBL)CCL8
ZODIACCCL8
Ontologies - Pathways
QuickGOP80075
Ontology : AmiGOmonocyte chemotaxis  protein kinase activity  extracellular space  cell  protein phosphorylation  calcium ion transport  cellular calcium ion homeostasis  exocytosis  chemotaxis  inflammatory response  signal transduction  G-protein coupled receptor signaling pathway  cell-cell signaling  chemokine activity  heparin binding  response to virus  phospholipase activator activity  neutrophil chemotaxis  positive regulation of GTPase activity  positive regulation of myoblast differentiation  CCR chemokine receptor binding  lymphocyte chemotaxis  chemokine-mediated signaling pathway  positive regulation of ERK1 and ERK2 cascade  cellular response to interferon-gamma  cellular response to interleukin-1  cellular response to tumor necrosis factor  positive regulation of myoblast fusion  
Ontology : EGO-EBImonocyte chemotaxis  protein kinase activity  extracellular space  cell  protein phosphorylation  calcium ion transport  cellular calcium ion homeostasis  exocytosis  chemotaxis  inflammatory response  signal transduction  G-protein coupled receptor signaling pathway  cell-cell signaling  chemokine activity  heparin binding  response to virus  phospholipase activator activity  neutrophil chemotaxis  positive regulation of GTPase activity  positive regulation of myoblast differentiation  CCR chemokine receptor binding  lymphocyte chemotaxis  chemokine-mediated signaling pathway  positive regulation of ERK1 and ERK2 cascade  cellular response to interferon-gamma  cellular response to interleukin-1  cellular response to tumor necrosis factor  positive regulation of myoblast fusion  
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway   
NDEx NetworkCCL8
Atlas of Cancer Signalling NetworkCCL8
Wikipedia pathwaysCCL8
Orthology - Evolution
OrthoDB6355
GeneTree (enSembl)ENSG00000108700
Phylogenetic Trees/Animal Genes : TreeFamCCL8
HOVERGENP80075
HOGENOMP80075
Homologs : HomoloGeneCCL8
Homology/Alignments : Family Browser (UCSC)CCL8
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCCL8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CCL8
dbVarCCL8
ClinVarCCL8
1000_GenomesCCL8 
Exome Variant ServerCCL8
ExAC (Exome Aggregation Consortium)CCL8 (select the gene name)
Genetic variants : HAPMAP6355
Genomic Variants (DGV)CCL8 [DGVbeta]
DECIPHERCCL8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCCL8 
Mutations
ICGC Data PortalCCL8 
TCGA Data PortalCCL8 
Broad Tumor PortalCCL8
OASIS PortalCCL8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCCL8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCCL8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CCL8
DgiDB (Drug Gene Interaction Database)CCL8
DoCM (Curated mutations)CCL8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CCL8 (select a term)
intoGenCCL8
Cancer3DCCL8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602283   
Orphanet
MedgenCCL8
Genetic Testing Registry CCL8
NextProtP80075 [Medical]
TSGene6355
GENETestsCCL8
Target ValidationCCL8
Huge Navigator CCL8 [HugePedia]
snp3D : Map Gene to Disease6355
BioCentury BCIQCCL8
ClinGenCCL8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6355
Chemical/Pharm GKB GenePA35567
Clinical trialCCL8
Miscellaneous
canSAR (ICR)CCL8 (select the gene name)
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCCL8
EVEXCCL8
GoPubMedCCL8
iHOPCCL8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:00:59 CEST 2017

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