Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

CCNA1 (cyclin A1)

Written2012-05Immacolata Vocca, Gianmarco Muzi, Francesca Pentimalli, Antonio Giordano
INT-CROM, National Cancer Institute, 'Pascale Foundation', - Cancer Research Center, Via Ammiraglio Bianco 83013, Mercogliano, Avellino, Italy (IV, FP, AG); Department of Human Pathology, Oncology, University of Siena, Siena, Italy (GM, AG); Sbarro Institute for Cancer Research, Molecular Medicine, College of Science, Technology, Temple University Philadelphia, PA, USA (AG)

(Note : for Links provided by Atlas : click)


HGNC Alias symbCT146
LocusID (NCBI) 8900
Atlas_Id 949
Location 13q13.3  [Link to chromosome band 13q13]
Location_base_pair Starts at 36432495 and ends at 36442870 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping CCNA1.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)


  Exons are represented by solid dark rectangles.
Description The CCNA1 gene is located at chromosome 13q12.3-q13 (Yang et al., 1997) and made up of 9 exons and 8 introns that extend over ~ 13 kb (Müller et al., 1999).
Transcription 2,1 kb mRNA; coding region is from 130 to 1527 bp (Yang et al., 1997). The cyclin A1 promoter does not possess a TATA box, whereas the region upstream of the transcriptional start site region contains four GC boxes, with multiple -binding sites important for the regulation of cyclin A1 expression (Müller et al., 1999). Three different transcript variants exist: isoform "a" is the longest transcript and encodes the longest isoform; isoform "b" has an alternate in-frame splice site in the 5' coding region resulting in a protein that is 1 amino acid shorter than isoform "a"; isoform "c" contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, resulting in a 44 aa shorter N-terminus compared to isoform "a".
Pseudogene None described.


  Schematic diagram of human cyclin A1. The positions of the cyclin box (with the two cyclin box folds) and the polyalanine sequence are shown. Numbers represent the amino acids positions.
Description MW: 52 kDa. Amino acids (aa): 465 full-length isoform a (464 aa isoform b; 421 aa isoform c). Cyclin A1 is a member of the highly conserved cyclin family whose members are able to control the progression of cells through the cell cycle by activating cyclin-dependent kinases (CDKs). Within the protein the cyclin box is a region of protein sequence homology that is common to all members of the cyclin family and is required for interaction with the CDK partner.
Expression Cyclin A1 expression is tissue-specific and high levels of expression are restricted to testis; a lower expression is reported in other human cell lines and in healthy brain. Cyclin A1 is also expressed in several myeloid leukemia cell lines and various other tumour types (Yang et al., 1997; Wegiel et al., 2008). Cyclin A1 is expressed at low levels in G0 phase and increases in early G1, S and G2/M phases (Yang et al., 1997; Yang et al., 1999).
Localisation Mammalian cyclin A1 is primarily localized in the nuclei of spermatocytes in mouse and human (Liu et al., 1998; Liao et al., 2004). Cyclin A1 has an important role in the development of acute myeloid leukemia (AML): its localization in normal hematopoietic cells is nuclear, whereas in leukemic cells from AML patients and cell lines, it is predominantly cytoplasmic (Ekberg et al., 2004).
Function Cyclin A1 belongs to the A-type cyclin family of proteins originally identified as 60 kDa polypeptides associated to CDK2 and interacting with viral proteins (Giordano et al., 1989; Giordano et al., 1991). Cyclin A family members are characterized by a typical periodicity in protein abundance through the cell division cycle functioning as activating subunits of enzymatic complexes, together with cyclin-dependent kinases (CDKs) (Lapenna and Giordano, 2009). Cyclin A2, also known as cyclin A, is the major A-type cyclin in mammals. Cyclin A1 primarily functions in the meiotic cell cycle, but it also seems to contribute to G1/S cell cycle progression in somatic cells (Ji et al., 2005). Human cyclin A1 interacts with CDK2 in vitro and in vivo (Yang et al., 1997) and the resulting complex is essential for spermatogenesis and contributes to leukemogenesis, although its molecular functions remain largely unclear. Male knockout mice lacking cyclin A1 are infertile owing to a cell cycle arrest before the first meiotic division (Liu et al., 1998). Cyclin A1 interacts also with E2F1 and the retinoblastoma protein (Yang et al., 1999), with GPS2 (Diederichs et al., 2004), binds to and activates B-MYB in leukemic blasts (Müller-Tidow et al., 2001). Moreover the cyclin A1-CDK2 complex regulates DNA double-strand break repair following radiation damage (Müller-Tidow et al., 2004) by competing with CDK2-cyclin A2 for the binding to Ku70, a pivotal player in the non-homologous end-joining double strand break repair pathway, and inhibiting apoptosis through modulating RB functions in leukemia cells (Ji et al., 2007). Consistently, cyclin A1 knockout mice and Xenopus embryos show defects in the DNA repair process and are more prone to undergo apoptosis (Müller-Tidow et al., 2004; Cho et al., 2006). Finally, following exposure to DNA damaging agents, cyclin A1 is strongly upregulated and localizes to the nucleus. Inhibition of this upregulation, through roscovitine treatment, resulted in a significant decrease of DNA repair and an increase of DNA damage over time (Federico et al., 2010).
Homology The percentage of identity below represents identity over an aligned protein region using pairwise alignment function of ClustalW software:
Bos taurus: 87%
Rattus norvegicus: 85%
Mus musculus: 84%
Xenopus tropicalis: 60%
Xenopus laevis: 59%
Danio rerio: 53%


Germinal None.
Somatic Some mutations in the CCNA1 gene have been found in several tumor types. No insertions, nonsense substitutions or deletions have been described, whereas, some substitutions leading to missense (P50L in skin; A429V in stomach; C452Y in ovary) or silent mutations (Y107Y in stomach; L122L in lung; A391A in ovary) have been reported and were obtained from the Sanger Institute Catalogue Of Somatic Mutations In Cancer web site (Bamford et al., 2004).

Implicated in

Entity Leukemias
Note Cyclin A1 is expressed in the majority of myeloid and undifferentiated hematological malignancies as well as in normal hematopoietic progenitor cells (Krämer et al., 1998). It has an important role in the development of acute myeloid leukemia (AML): overexpression of murine cyclin A1 in the myeloid lineage of transgenic mice leads to abnormal myelopoiesis in the first months after birth and to the development of AML at a low frequency over the course of 7-14 months. This indicates that cyclin A1 overexpression results in abnormal myelopoiesis and is necessary to induce transformation thus contributing to leukemogenesis (Liao et al., 2001). Cyclin A1 expression is an independent prognostic factor in predicting overall survival and disease-free survival in AML patients (Ekberg et al., 2005) and high expression levels of both cyclin A2 and A1 are associated with good prognosis in the same patients (Nakamaki et al., 2003). Its localization in normal hematopoietic cells is nuclear, whereas in leukemic cells from AML patients and cell lines, it is predominantly cytoplasmic (Ekberg et al., 2004). The frequency of cyclin A1 overexpression is also high in acute promyelocytic leukemia (APL) as a consequence of the APL-associated aberrant fusion proteins (PML-retinoic acid receptor alpha [PML-RAR alpha] or PLZF-RAR alpha) (Müller et al., 2000). Cyclin A1 is highly expressed in lymphoblastic leukemic cell lines and in childhood acute lymphoblastic leukemia (ALL) patients and its expression correlates with patient age and with a poorer event-free survival (Holm et al., 2006). Interestingly, in human promyelocytic leukemia cells HL60, cyclin A1 expression is regulated by a miR34b-CREB axis, which seems to be crucial for myeloid transformation (Pigazzi et al., 2009).
Disease AML is a relatively rare cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and do not mature, thereby interfering with the production of normal blood cells. APL is a subtype of AML characterized by a chromosomal translocation involving the retinoic acid receptor alpha (RARα or RARA) gene and is unique, compared to other forms of AML, in its responsiveness to all trans retinoic acid (ATRA) therapy. In ALL, malignant, immature white blood cells continuously multiply and are overproduced in the bone marrow. ALL causes damage and death by crowding out normal cells in the bone marrow, and by spreading to other organs.
Entity Prostate cancer
Note Cyclin A1 promotes cell survival in response to growth factors through PI3K/Akt signaling (Wegiel et al., 2008). Also, cyclin A1 mediates VEGF expression in cooperation with Rb- and androgen-dependent pathways (Wegiel et al., 2005). In particular, cyclin A1, by interacting with AR, binds to VEGF and MMP2 promoters and increases their expression, thus contributing to prostate cancer invasion (Wegiel et al., 2008).
Disease Prostate cancer is a slow-growing cancer that develops in the prostate. Cancer cells can metastasize from the prostate to secondary sites, particularly the bones and lymph nodes. Treatment options are primarily surgery, radiation therapy, stereotactic radiosurgery and proton therapy.
Prognosis Many prostate cancers are successfully cured and most patients will ultimately die from causes other than the disease itself.
Entity Testicular cancer
Note Cyclin A1 is highly expressed in aggressive testicular germ cell tumors (Müller-Tidow et al., 2003). Among the different histological subtypes of testicular tumors, embryonal cell carcinomas and immature teratomas expressed the highest levels of cyclin A1, whereas intermediate levels were expressed in seminomas and yolk sac tumors. Cyclin A1 expression was very low in mature teratomas.
Disease Testicular cancer is a common cancer in males that develops in testicles. If it is diagnosed early, in the great majority of cases it can be treated by surgery, radiation and/or chemotherapy.
Entity Cervical cancer
Note Ectopic expression of miR-372 suppresses cell growth and induces arrest in the S/G2 phases of cell cycle in HeLa cells by targeting CDK2 and cyclin A1 (Tian et al., 2011). Also, it seems that in invasive cervical cancer the integrated form of HPV might affect CCNA1 promoter methylation (Yanatatsaneejit et al., 2011). In human cervical cancer cells, down-regulation of pSrcY416 inhibits cell proliferation by increasing the cell population in the G0-G1 phase and causes the up-regulation of p21Cip1 and p27Kip1 and the decrease of cyclin A1, cyclin E, and CDK-6, cyclin B and CDK-2 (Kong et al., 2011). Also, overexpressed Notch1 results in significant growth inhibition of human cervical carcinoma cells, which is related to a decrease of cyclin A1, cyclin E and pRb protein expression (Wang et al., 2007). The CCNA1 gene is never methylated in normal cervices and rarely in low-grade squamous intraepithelial lesions, whereas its methylation frequency increases with the severity of cervical lesions (Yang et al., 2010). In human papillomavirus-associated cervical cancer, promoter hypermethylation is also specific to the invasive phenotype in comparison with other histopathological stages during multistep carcinogenesis (Kitkumthorn et al., 2006).
Disease Cervical cancer is a malignant neoplasm of the cervix. In almost all cases, human papillomavirus (HPV) infection is a necessary factor in the development of this cancer. Treatment includes surgery in early stages and chemotherapy and radiotherapy in advanced stages of the disease.
Prognosis It is usually a slow-growing cancer, in some cases there might be no obvious symptoms until the cancer is in its advanced stages.
Entity Head and neck squamous cell carcinoma (HNSCC)
Note Methylation of CCNA1 is an important risk factors for HNSCC development since the cyclin A1 promoter is methylated in salivary rinses from HNSCC patients (Sun et al., 2012). The CCNA1 promoter is methylated in 45% of tumours but in none of the normal tissues and this methylation is inversely related to p53 mutational status in primary tumors (Tokumaru et al., 2004). In another study, cyclin A1 promoter methylation is associated with human papillomavirus 16 induced HNSCC, independently of p53 mutation (Weiss et al., 2011).
Disease HNSCC refers to the squamous cell carcinomas of the oral cavity, pharynx and larynx. The major risk factor for head and neck cancer is chronic exposure of epithelia to tobacco smoke and alcohol, UV light, some chemicals and human papillomavirus.
Prognosis HNSCC are frequently aggressive; patients are at a higher risk of developing another cancer in the head and neck area. These cancers are highly curable if detected early, surgery and radiotherapy are the main modality of treatment. Chemotherapy, acting as a radio-sensitizer, increases survival in locally advanced disease. Recently, inhibition of epidermal growth factor receptor (EGFR) has proved a successful therapeutic strategy.
Entity Bladder cancer
Note The CCNA1 promoter has been found hypermethylated in urine sediments from bladder cancer patients (Yu et al., 2007). Also, in another study, the CCNA1 gene displays high frequency of methylation in bladder cancer samples and no methylation in normal uroepithelium, indicating a potential role of cyclin A1 in the pathogenesis and spread of bladder cancer (Brait et al., 2008). Interestingly, the deubiquitinating enzyme USP2a can bind cyclin A1 and consequently blocks its ubiquitination and degradation. Enforced expression of USP2a resulted in cyclin A1 accumulation and increased cell proliferation in bladder cancer cells (Kim et al., 2012).
Disease Bladder cancer is a cancer of the urothelium. Treatment options for people with bladder cancer are surgery, chemotherapy, biological therapy, and radiation therapy.
Entity Breast cancer
Note Six1 overexpression in mammary cells induces genomic instability and malignant transformation that is dependent on upregulation of its transcriptional target cyclin A1 (Coletta et al., 2004). Consistently, in another study, the tumor suppressor miR-185, by inhibiting the expression of Six1 and consequently of its transcriptional targets c-myc and Cyclin A1, sensitizes cancer cells to apoptosis (Imam et al., 2010). Also, in the malignant breast cancer cell line MDA-MB-231, the dysregulation of activating transcription factor-3 by TGFβ1 activates cyclin A1 and MMP-13 leading to cell invasion and metastasis (Kwok et al., 2009). The histone demethylase JMJD2B is regulated by both ERalpha and HIF-1alpha driving breast cancer cell proliferation in normoxia and hypoxia, and epigenetically regulates the expression of cell cycle genes such as CCND1, CCNA1, and WEE1 (Yang et al., 2010). On the contrary, the dietary supplement BreastDefend inhibits proliferation and invasive behavior of the highly metastatic MDA-MB-231 cell line by downregulating the expression of CCNA1 and CDK6 genes (Jiang et al., 2011). Bisphenol A promotes mammary carcinogenesis by stimulating the DNA methylation of genes related to development of most or all tumor types, including the CCNA1 gene (Qin et al., 2012).
Disease Breast cancer is a type of cancer originating from breast tissue. The size, stage, rate of growth and other characteristics of the tumor determine the kinds of treatment which may include surgery, hormonal, therapy and chemotherapy, radiation and/or immunotherapy.
Entity Other cancers
Note Some studies indicate a potential tumor suppressor role for cyclin A1 in nasopharyngeal carcinomas, colon carcinomas, oral carcinomas, melanomas, and hepatocellular carcinomas (Yanatatsaneejit et al., 2008; Xu et al., 2004; Shaw et al., 2006; Garrido et al., 2012; Yu et al., 2003). Also, Cyclin A1 mediates apoptosis, G2/M arrest, and mitotic catastrophe in renal, ovarian, and lung carcinoma cells through an inappropriate activation of CDK1 (Rivera et al., 2006). Other studies show that cyclin A1 is overexpressed in human hepatocellular carcinoma (Studach et al., 2012) and correlates with a poor outcome in ependymomas (Lukashova-v Zangen et al., 2007).
The information contained herein was partially compiled using Proteinquest, a software able to automatically parse the scientific literature to extract relevant data.


The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website.
Bamford S, Dawson E, Forbes S, Clements J, Pettett R, Dogan A, Flanagan A, Teague J, Futreal PA, Stratton MR, Wooster R.
Br J Cancer. 2004 Jul 19;91(2):355-8.
PMID 15188009
Aberrant promoter methylation of multiple genes during pathogenesis of bladder cancer.
Brait M, Begum S, Carvalho AL, Dasgupta S, Vettore AL, Czerniak B, Caballero OL, Westra WH, Sidransky D, Hoque MO.
Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2786-94.
PMID 18843024
Induction of cell apoptosis in non-small cell lung cancer cells by cyclin A1 small interfering RNA.
Cho NH, Choi YP, Moon DS, Kim H, Kang S, Ding O, Rha SY, Yang YJ, Cho SH.
Cancer Sci. 2006 Oct;97(10):1082-92.
PMID 16984381
The Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1.
Coletta RD, Christensen K, Reichenberger KJ, Lamb J, Micomonaco D, Huang L, Wolf DM, Muller-Tidow C, Golub TR, Kawakami K, Ford HL.
Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6478-83. Epub 2004 Apr 26.
PMID 15123840
Identification of interaction partners and substrates of the cyclin A1-CDK2 complex.
Diederichs S, Baumer N, Ji P, Metzelder SK, Idos GE, Cauvet T, Wang W, Moller M, Pierschalski S, Gromoll J, Schrader MG, Koeffler HP, Berdel WE, Serve H, Muller-Tidow C.
J Biol Chem. 2004 Aug 6;279(32):33727-41. Epub 2004 May 24.
PMID 15159402
Expression of cyclin A1 and cell cycle proteins in hematopoietic cells and acute myeloid leukemia and links to patient outcome.
Ekberg J, Holm C, Jalili S, Richter J, Anagnostaki L, Landberg G, Persson JL.
Eur J Haematol. 2005 Aug;75(2):106-15.
PMID 16004607
Regulation of the cyclin A1 protein is associated with its differential subcellular localization in hematopoietic and leukemic cells.
Ekberg J, Landberg G, Holm C, Richter J, Wolgemuth DJ, Persson JL.
Oncogene. 2004 Dec 2;23(56):9082-9.
PMID 15489899
R-Roscovitine (Seliciclib) prevents DNA damage-induced cyclin A1 upregulation and hinders non-homologous end-joining (NHEJ) DNA repair.
Federico M, Symonds CE, Bagella L, Rizzolio F, Fanale D, Russo A, Giordano A.
Mol Cancer. 2010 Aug 4;9:208.
PMID 20684776
MHC class I molecules act as tumor suppressor genes regulating the cell cycle gene expression, invasion and intrinsic tumorigenicity of melanoma cells.
Garrido C, Paco L, Romero I, Berruguilla E, Stefansky J, Collado A, Algarra I, Garrido F, Garcia-Lora AM.
Carcinogenesis. 2012 Mar;33(3):687-93. Epub 2012 Jan 4.
PMID 22219178
Cell cycle regulation of histone H1 kinase activity associated with the adenoviral protein E1A.
Giordano A, Lee JH, Scheppler JA, Herrmann C, Harlow E, Deuschle U, Beach D, Franza BR Jr.
Science. 1991 Sep 13;253(5025):1271-5.
PMID 1653969
Cyclin A1 expression and associations with disease characteristics in childhood acute lymphoblastic leukemia.
Holm C, Ora I, Brunhoff C, Anagnostaki L, Landberg G, Persson JL.
Leuk Res. 2006 Mar;30(3):254-61. Epub 2005 Sep 22.
PMID 16182364
MicroRNA-185 suppresses tumor growth and progression by targeting the Six1 oncogene in human cancers.
Imam JS, Buddavarapu K, Lee-Chang JS, Ganapathy S, Camosy C, Chen Y, Rao MK.
Oncogene. 2010 Sep 2;29(35):4971-9. Epub 2010 Jul 5.
PMID 20603620
Cyclin A1, the alternative A-type cyclin, contributes to G1/S cell cycle progression in somatic cells.
Ji P, Agrawal S, Diederichs S, Baumer N, Becker A, Cauvet T, Kowski S, Beger C, Welte K, Berdel WE, Serve H, Muller-Tidow C.
Oncogene. 2005 Apr 14;24(16):2739-44.
PMID 15829981
DNA damage response involves modulation of Ku70 and Rb functions by cyclin A1 in leukemia cells.
Ji P, Baumer N, Yin T, Diederichs S, Zhang F, Beger C, Welte K, Fulda S, Berdel WE, Serve H, Muller-Tidow C.
Int J Cancer. 2007 Aug 15;121(4):706-13.
PMID 17455244
Suppression of proliferation and invasive behavior of human metastatic breast cancer cells by dietary supplement BreastDefend.
Jiang J, Wojnowski R, Jedinak A, Sliva D.
Integr Cancer Ther. 2011 Jun;10(2):192-200. Epub 2010 Oct 6.
PMID 20926736
The ubiquitin-specific protease USP2a enhances tumor progression by targeting cyclin A1 in bladder cancer.
Kim J, Kim WJ, Liu Z, Loda M, Freeman MR.
Cell Cycle. 2012 Mar 15;11(6):1123-30. Epub 2012 Mar 15.
PMID 22370483
Cyclin A1 promoter hypermethylation in human papillomavirus-associated cervical cancer.
Kitkumthorn N, Yanatatsanajit P, Kiatpongsan S, Phokaew C, Triratanachat S, Trivijitsilp P, Termrungruanglert W, Tresukosol D, Niruthisard S, Mutirangura A.
BMC Cancer. 2006 Mar 8;6:55.
PMID 16524460
Down-regulation of phospho-non-receptor Src tyrosine kinases contributes to growth inhibition of cervical cancer cells.
Kong L, Deng Z, Zhao Y, Wang Y, Sarkar FH, Zhang Y.
Med Oncol. 2011 Dec;28(4):1495-506. Epub 2010 Jun 8.
PMID 20532678
Cyclin A1 is predominantly expressed in hematological malignancies with myeloid differentiation.
Kramer A, Hochhaus A, Saussele S, Reichert A, Willer A, Hehlmann R.
Leukemia. 1998 Jun;12(6):893-8.
PMID 9639417
Transforming growth factor-beta1 regulation of ATF-3 and identification of ATF-3 target genes in breast cancer cells.
Kwok S, Rittling SR, Partridge NC, Benson CS, Thiyagaraj M, Srinivasan N, Selvamurugan N.
J Cell Biochem. 2009 Oct 1;108(2):408-14.
PMID 19582787
Cell cycle kinases as therapeutic targets for cancer.
Lapenna S, Giordano A.
Nat Rev Drug Discov. 2009 Jul;8(7):547-66. (REVIEW)
PMID 19568282
Elevated levels and distinct patterns of expression of A-type cyclins and their associated cyclin-dependent kinases in male germ cell tumors.
Liao C, Li SQ, Wang X, Muhlrad S, Bjartell A, Wolgemuth DJ.
Int J Cancer. 2004 Feb 20;108(5):654-64.
PMID 14696091
Altered myelopoiesis and the development of acute myeloid leukemia in transgenic mice overexpressing cyclin A1.
Liao C, Wang XY, Wei HQ, Li SQ, Merghoub T, Pandolfi PP, Wolgemuth DJ.
Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6853-8. Epub 2001 May 29.
PMID 11381140
Cyclin A1 is required for meiosis in the male mouse.
Liu D, Matzuk MM, Sung WK, Guo Q, Wang P, Wolgemuth DJ.
Nat Genet. 1998 Dec;20(4):377-80.
PMID 9843212
Ependymoma gene expression profiles associated with histological subtype, proliferation, and patient survival.
Lukashova-v Zangen I, Kneitz S, Monoranu CM, Rutkowski S, Hinkes B, Vince GH, Huang B, Roggendorf W.
Acta Neuropathol. 2007 Mar;113(3):325-37. Epub 2007 Jan 31.
PMID 17265049
The aberrant fusion proteins PML-RAR alpha and PLZF-RAR alpha contribute to the overexpression of cyclin A1 in acute promyelocytic leukemia.
Muller C, Yang R, Park DJ, Serve H, Berdel WE, Koeffler HP.
Blood. 2000 Dec 1;96(12):3894-9.
PMID 11090075
The cyclin A1-CDK2 complex regulates DNA double-strand break repair.
Muller-Tidow C, Ji P, Diederichs S, Potratz J, Baumer N, Kohler G, Cauvet T, Choudary C, van der Meer T, Chan WY, Nieduszynski C, Colledge WH, Carrington M, Koeffler HP, Restle A, Wiesmuller L, Sobczak-Thepot J, Berdel WE, Serve H.
Mol Cell Biol. 2004 Oct;24(20):8917-28.
PMID 15456866
Elevated levels of cyclin A1 and A (A2) mRNA in acute myeloid leukaemia are associated with increased survival.
Nakamaki T, Hamano Y, Hisatake J, Yokoyama A, Kawakami K, Tomoyasu S, Honma Y, Koeffler P.
Br J Haematol. 2003 Oct;123(1):72-80.
PMID 14510945
miR-34b targets cyclic AMP-responsive element binding protein in acute myeloid leukemia.
Pigazzi M, Manara E, Baron E, Basso G.
Cancer Res. 2009 Mar 15;69(6):2471-8. Epub 2009 Mar 3.
PMID 19258499
Effects of bisphenol A exposure on the proliferation and senescence of normal human mammary epithelial cells.
Qin XY, Fukuda T, Yang L, Zaha H, Akanuma H, Zeng Q, Yoshinaga J, Sone H.
Cancer Biol Ther. 2012 Mar;13(5):296-306. Epub 2012 Mar 1.
PMID 22258036
Cyclin A1 is a p53-induced gene that mediates apoptosis, G2/M arrest, and mitotic catastrophe in renal, ovarian, and lung carcinoma cells.
Rivera A, Mavila A, Bayless KJ, Davis GE, Maxwell SA.
Cell Mol Life Sci. 2006 Jun;63(12):1425-39.
PMID 16799873
Promoter methylation of P16, RARbeta, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencing.
Shaw RJ, Liloglou T, Rogers SN, Brown JS, Vaughan ED, Lowe D, Field JK, Risk JM.
Br J Cancer. 2006 Feb 27;94(4):561-8.
PMID 16449996
A subset of Suz12/PRC2 target genes is activated during HBV replication and liver carcinogenesis associated with hepatitis B virus X protein.
Studach LL, Menne S, Cairo S, Buendia MA, Hullinger RL, Lefrancois L, Merle P, Andrisani OM.
Hepatology. 2012 Apr 13. doi: 10.1002/hep.25781. [Epub ahead of print]
PMID 22505317
Comparison of promoter hypermethylation pattern in salivary rinses collected with and without an exfoliating brush from patients with HNSCC.
Sun W, Zaboli D, Liu Y, Arnaoutakis D, Khan T, Wang H, Koch W, Khan Z, Califano JA.
PLoS One. 2012;7(3):e33642. Epub 2012 Mar 16.
PMID 22438973
MicroRNA-372 is down-regulated and targets cyclin-dependent kinase 2 (CDK2) and cyclin A1 in human cervical cancer, which may contribute to tumorigenesis.
Tian RQ, Wang XH, Hou LJ, Jia WH, Yang Q, Li YX, Liu M, Li X, Tang H.
J Biol Chem. 2011 Jul 22;286(29):25556-63. Epub 2011 Jun 6.
PMID 21646351
Inverse correlation between cyclin A1 hypermethylation and p53 mutation in head and neck cancer identified by reversal of epigenetic silencing.
Tokumaru Y, Yamashita K, Osada M, Nomoto S, Sun DI, Xiao Y, Hoque MO, Westra WH, Califano JA, Sidransky D.
Cancer Res. 2004 Sep 1;64(17):5982-7.
PMID 15342377
Overexpressed active Notch1 induces cell growth arrest of HeLa cervical carcinoma cells.
Wang L, Qin H, Chen B, Xin X, Li J, Han H.
Int J Gynecol Cancer. 2007 Nov-Dec;17(6):1283-92. Epub 2007 Apr 8.
PMID 17425682
Multiple cellular mechanisms related to cyclin A1 in prostate cancer invasion and metastasis.
Wegiel B, Bjartell A, Tuomela J, Dizeyi N, Tinzl M, Helczynski L, Nilsson E, Otterbein LE, Harkonen P, Persson JL.
J Natl Cancer Inst. 2008 Jul 16;100(14):1022-36. Epub 2008 Jul 8.
PMID 18612129
Promoter methylation of cyclin A1 is associated with human papillomavirus 16 induced head and neck squamous cell carcinoma independently of p53 mutation.
Weiss D, Basel T, Sachse F, Braeuninger A, Rudack C.
Mol Carcinog. 2011 Sep;50(9):680-8. doi: 10.1002/mc.20798. Epub 2011 May 11.
PMID 21563216
Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis.
Xu XL, Yu J, Zhang HY, Sun MH, Gu J, Du X, Shi DR, Wang P, Yang ZH, Zhu JD.
World J Gastroenterol. 2004 Dec 1;10(23):3441-54.
PMID 15526363
Human papillomavirus's physical state and cyclin A1 promoter methylation in cervical cancer.
Yanatatsaneejit P, Mutirangura A, Kitkumthorn N.
Int J Gynecol Cancer. 2011 Jul;21(5):902-6.
PMID 21412159
The histone demethylase JMJD2B is regulated by estrogen receptor alpha and hypoxia, and is a key mediator of estrogen induced growth.
Yang J, Jubb AM, Pike L, Buffa FM, Turley H, Baban D, Leek R, Gatter KC, Ragoussis J, Harris AL.
Cancer Res. 2010 Aug 15;70(16):6456-66. Epub 2010 Aug 3.
PMID 20682797
Gene promoter methylation patterns throughout the process of cervical carcinogenesis.
Yang N, Nijhuis ER, Volders HH, Eijsink JJ, Lendvai A, Zhang B, Hollema H, Schuuring E, Wisman GB, van der Zee AG.
Cell Oncol. 2010;32(1-2):131-43.
PMID 20208141
Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines.
Yang R, Morosetti R, Koeffler HP.
Cancer Res. 1997 Mar 1;57(5):913-20.
PMID 9041194
Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins.
Yang R, Muller C, Huynh V, Fung YK, Yee AS, Koeffler HP.
Mol Cell Biol. 1999 Mar;19(3):2400-7.
PMID 10022926
Methylation profiling of twenty four genes and the concordant methylation behaviours of nineteen genes that may contribute to hepatocellular carcinogenesis.
Yu J, Zhang HY, Ma ZZ, Lu W, Wang YF, Zhu JD.
Cell Res. 2003 Oct;13(5):319-33.
PMID 14672555
A novel set of DNA methylation markers in urine sediments for sensitive/specific detection of bladder cancer.
Yu J, Zhu T, Wang Z, Zhang H, Qian Z, Xu H, Gao B, Wang W, Gu L, Meng J, Wang J, Feng X, Li Y, Yao X, Zhu J.
Clin Cancer Res. 2007 Dec 15;13(24):7296-304.
PMID 18094410


This paper should be referenced as such :
Vocca, I ; Muzi, G ; Pentimalli, F ; Giordano, A
CCNA1 (cyclin A1)
Atlas Genet Cytogenet Oncol Haematol. 2012;16(11):775-781.
Free journal version : [ pdf ]   [ DOI ]

External links


HGNC (Hugo)CCNA1   1577
Entrez_Gene (NCBI)CCNA1    cyclin A1
GeneCards (Weizmann)CCNA1
Ensembl hg19 (Hinxton)ENSG00000133101 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000133101 [Gene_View]  ENSG00000133101 [Sequence]  chr13:36432495-36442870 [Contig_View]  CCNA1 [Vega]
ICGC DataPortalENSG00000133101
TCGA cBioPortalCCNA1
Genatlas (Paris)CCNA1
SOURCE (Princeton)CCNA1
Genetics Home Reference (NIH)CCNA1
Genomic and cartography
GoldenPath hg38 (UCSC)CCNA1  -     chr13:36432495-36442870 +  13q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CCNA1  -     13q13.3   [Description]    (hg19-Feb_2009)
GoldenPathCCNA1 - 13q13.3 [CytoView hg19]  CCNA1 - 13q13.3 [CytoView hg38]
Genome Data Viewer NCBICCNA1 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AA553454 AK225146 AK301897 AK314261 AK316392
RefSeq transcript (Entrez)NM_001111045 NM_001111046 NM_001111047 NM_003914
Consensus coding sequences : CCDS (NCBI)CCNA1
Gene ExpressionCCNA1 [ NCBI-GEO ]   CCNA1 [ EBI - ARRAY_EXPRESS ]   CCNA1 [ SEEK ]   CCNA1 [ MEM ]
Gene Expression Viewer (FireBrowse)CCNA1 [ Firebrowse - Broad ]
GenevisibleExpression of CCNA1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8900
GTEX Portal (Tissue expression)CCNA1
Human Protein AtlasENSG00000133101-CCNA1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP78396   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP78396  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP78396
Domaine pattern : Prosite (Expaxy)CYCLINS (PS00292)   
Domains : Interpro (EBI)Cyclin    Cyclin-like    Cyclin-like_sf    Cyclin_C-dom    Cyclin_N   
Domain families : Pfam (Sanger)Cyclin_C (PF02984)    Cyclin_N (PF00134)   
Domain families : Pfam (NCBI)pfam02984    pfam00134   
Domain families : Smart (EMBL)CYCLIN (SM00385)  Cyclin_C (SM01332)  
Conserved Domain (NCBI)CCNA1
AlphaFold pdb e-kbP78396   
Human Protein Atlas [tissue]ENSG00000133101-CCNA1 [tissue]
Protein Interaction databases
IntAct (EBI)P78396
Complex Portal (EBI)P78396 CPX-2003 Cyclin A1-CDK1 complex
P78396 CPX-2005 Cyclin A1-CDK2 complex
Ontologies - Pathways
Ontology : AmiGOregulation of cyclin-dependent protein serine/threonine kinase activity  regulation of transcription involved in G1/S transition of mitotic cell cycle  cyclin-dependent protein kinase holoenzyme complex  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  male meiosis I  spermatogenesis  microtubule cytoskeleton  cyclin-dependent protein serine/threonine kinase regulator activity  protein deubiquitination  mitotic cell cycle phase transition  cell division  cyclin A1-CDK2 complex  cyclin A2-CDK2 complex  cyclin A2-CDK2 complex  
Ontology : EGO-EBIregulation of cyclin-dependent protein serine/threonine kinase activity  regulation of transcription involved in G1/S transition of mitotic cell cycle  cyclin-dependent protein kinase holoenzyme complex  protein binding  nucleus  nucleoplasm  cytoplasm  cytosol  male meiosis I  spermatogenesis  microtubule cytoskeleton  cyclin-dependent protein serine/threonine kinase regulator activity  protein deubiquitination  mitotic cell cycle phase transition  cell division  cyclin A1-CDK2 complex  cyclin A2-CDK2 complex  cyclin A2-CDK2 complex  
Pathways : BIOCARTACyclins and Cell Cycle Regulation [Genes]    Cell Cycle: G1/S Check Point [Genes]    E2F1 Destruction Pathway [Genes]   
Pathways : KEGGCell cycle    Progesterone-mediated oocyte maturation    Hepatitis B    Epstein-Barr virus infection    Pathways in cancer    Transcriptional misregulation in cancer    Viral carcinogenesis    Acute myeloid leukemia   
REACTOMEP78396 [protein]
REACTOME PathwaysR-HSA-69656 [pathway]   
NDEx NetworkCCNA1
Atlas of Cancer Signalling NetworkCCNA1
Wikipedia pathwaysCCNA1
Orthology - Evolution
GeneTree (enSembl)ENSG00000133101
Phylogenetic Trees/Animal Genes : TreeFamCCNA1
Homologs : HomoloGeneCCNA1
Homology/Alignments : Family Browser (UCSC)CCNA1
Gene fusions - Rearrangements
Fusion : QuiverCCNA1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCCNA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CCNA1
Exome Variant ServerCCNA1
GNOMAD BrowserENSG00000133101
Varsome BrowserCCNA1
ACMGCCNA1 variants
Genomic Variants (DGV)CCNA1 [DGVbeta]
DECIPHERCCNA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCCNA1 
ICGC Data PortalCCNA1 
TCGA Data PortalCCNA1 
Broad Tumor PortalCCNA1
OASIS PortalCCNA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCCNA1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCCNA1
Mutations and Diseases : HGMDCCNA1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
DgiDB (Drug Gene Interaction Database)CCNA1
DoCM (Curated mutations)CCNA1
CIViC (Clinical Interpretations of Variants in Cancer)CCNA1
NCG (London)CCNA1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Genetic Testing Registry CCNA1
NextProtP78396 [Medical]
Target ValidationCCNA1
Huge Navigator CCNA1 [HugePedia]
Clinical trials, drugs, therapy
Protein Interactions : CTDCCNA1
Pharm GKB GenePA26147
Clinical trialCCNA1
DataMed IndexCCNA1
PubMed149 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Oct 8 21:14:17 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us