Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CCNA2 (cyclin A2)

Identity

Alias_namesCCNA
CCN1
Other alias
HGNC (Hugo) CCNA2
LocusID (NCBI) 890
Atlas_Id 950
Location 4q27  [Link to chromosome band 4q27]
Location_base_pair Starts at 121816444 and ends at 121824001 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(2;2)(p22;p22) LTBP1/BIRC6::del(2)(p22p22) LTBP1/BIRC6

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Head and Neck: Laryngeal tumors: an overview
t(2;2)(p22;p22) LTBP1/BIRC6::del(2)(p22p22) LTBP1/BIRC6

External links

Nomenclature
HGNC (Hugo)CCNA2   1578
Cards
Entrez_Gene (NCBI)CCNA2  890  cyclin A2
AliasesCCN1; CCNA
GeneCards (Weizmann)CCNA2
Ensembl hg19 (Hinxton)ENSG00000145386 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000145386 [Gene_View]  chr4:121816444-121824001 [Contig_View]  CCNA2 [Vega]
ICGC DataPortalENSG00000145386
TCGA cBioPortalCCNA2
AceView (NCBI)CCNA2
Genatlas (Paris)CCNA2
WikiGenes890
SOURCE (Princeton)CCNA2
Genetics Home Reference (NIH)CCNA2
Genomic and cartography
GoldenPath hg38 (UCSC)CCNA2  -     chr4:121816444-121824001 -  4q27   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CCNA2  -     4q27   [Description]    (hg19-Feb_2009)
EnsemblCCNA2 - 4q27 [CytoView hg19]  CCNA2 - 4q27 [CytoView hg38]
Mapping of homologs : NCBICCNA2 [Mapview hg19]  CCNA2 [Mapview hg38]
OMIM123835   
Gene and transcription
Genbank (Entrez)AK291931 AW276578 BC104783 BC104787 BP363915
RefSeq transcript (Entrez)NM_001237
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CCNA2
Cluster EST : UnigeneHs.58974 [ NCBI ]
CGAP (NCI)Hs.58974
Alternative Splicing GalleryENSG00000145386
Gene ExpressionCCNA2 [ NCBI-GEO ]   CCNA2 [ EBI - ARRAY_EXPRESS ]   CCNA2 [ SEEK ]   CCNA2 [ MEM ]
Gene Expression Viewer (FireBrowse)CCNA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)890
GTEX Portal (Tissue expression)CCNA2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20248   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20248  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20248
Splice isoforms : SwissVarP20248
PhosPhoSitePlusP20248
Domaine pattern : Prosite (Expaxy)CYCLINS (PS00292)   
Domains : Interpro (EBI)Cyclin-A_N    Cyclin-like    Cyclin_A2_chordates    Cyclin_C-dom    Cyclin_N   
Domain families : Pfam (Sanger)Cyclin_C (PF02984)    Cyclin_N (PF00134)    Cyclin_N2 (PF16500)   
Domain families : Pfam (NCBI)pfam02984    pfam00134    pfam16500   
Domain families : Smart (EMBL)CYCLIN (SM00385)  Cyclin_C (SM01332)  
Conserved Domain (NCBI)CCNA2
DMDM Disease mutations890
Blocks (Seattle)CCNA2
PDB (SRS)###############################################################################################################################################################################################################################################################   
PDB (PDBSum)###############################################################################################################################################################################################################################################################   
PDB (IMB)###############################################################################################################################################################################################################################################################   
PDB (RSDB)###############################################################################################################################################################################################################################################################   
Structural Biology KnowledgeBase###############################################################################################################################################################################################################################################################   
SCOP (Structural Classification of Proteins)###############################################################################################################################################################################################################################################################   
CATH (Classification of proteins structures)###############################################################################################################################################################################################################################################################   
SuperfamilyP20248
Human Protein AtlasENSG00000145386
Peptide AtlasP20248
HPRD00453
IPIIPI00022865   
Protein Interaction databases
DIP (DOE-UCLA)P20248
IntAct (EBI)P20248
FunCoupENSG00000145386
BioGRIDCCNA2
STRING (EMBL)CCNA2
ZODIACCCNA2
Ontologies - Pathways
QuickGOP20248
Ontology : AmiGOregulation of cyclin-dependent protein serine/threonine kinase activity  G2/M transition of mitotic cell cycle  cyclin-dependent protein kinase holoenzyme complex  female pronucleus  male pronucleus  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  Ras protein signal transduction  regulation of G2/M transition of mitotic cell cycle  viral process  histone phosphorylation  protein deubiquitination  protein kinase binding  protein domain specific binding  animal organ regeneration  response to glucagon  cellular response to platelet-derived growth factor stimulus  cellular response to leptin stimulus  cell cycle G1/S phase transition  positive regulation of transcription, DNA-templated  positive regulation of fibroblast proliferation  cell division  cellular response to cocaine  cellular response to luteinizing hormone stimulus  cellular response to estradiol stimulus  cellular response to hypoxia  cellular response to nitric oxide  cochlea development  cyclin A2-CDK2 complex  cyclin-dependent protein kinase activity  cellular response to insulin-like growth factor stimulus  
Ontology : EGO-EBIregulation of cyclin-dependent protein serine/threonine kinase activity  G2/M transition of mitotic cell cycle  cyclin-dependent protein kinase holoenzyme complex  female pronucleus  male pronucleus  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  Ras protein signal transduction  regulation of G2/M transition of mitotic cell cycle  viral process  histone phosphorylation  protein deubiquitination  protein kinase binding  protein domain specific binding  animal organ regeneration  response to glucagon  cellular response to platelet-derived growth factor stimulus  cellular response to leptin stimulus  cell cycle G1/S phase transition  positive regulation of transcription, DNA-templated  positive regulation of fibroblast proliferation  cell division  cellular response to cocaine  cellular response to luteinizing hormone stimulus  cellular response to estradiol stimulus  cellular response to hypoxia  cellular response to nitric oxide  cochlea development  cyclin A2-CDK2 complex  cyclin-dependent protein kinase activity  cellular response to insulin-like growth factor stimulus  
Pathways : KEGGCell cycle    Progesterone-mediated oocyte maturation    Hepatitis B    Epstein-Barr virus infection    Viral carcinogenesis   
NDEx NetworkCCNA2
Atlas of Cancer Signalling NetworkCCNA2
Wikipedia pathwaysCCNA2
Orthology - Evolution
OrthoDB890
GeneTree (enSembl)ENSG00000145386
Phylogenetic Trees/Animal Genes : TreeFamCCNA2
HOVERGENP20248
HOGENOMP20248
Homologs : HomoloGeneCCNA2
Homology/Alignments : Family Browser (UCSC)CCNA2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCCNA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CCNA2
dbVarCCNA2
ClinVarCCNA2
1000_GenomesCCNA2 
Exome Variant ServerCCNA2
ExAC (Exome Aggregation Consortium)CCNA2 (select the gene name)
Genetic variants : HAPMAP890
Genomic Variants (DGV)CCNA2 [DGVbeta]
DECIPHERCCNA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCCNA2 
Mutations
ICGC Data PortalCCNA2 
TCGA Data PortalCCNA2 
Broad Tumor PortalCCNA2
OASIS PortalCCNA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCCNA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCCNA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CCNA2
DgiDB (Drug Gene Interaction Database)CCNA2
DoCM (Curated mutations)CCNA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CCNA2 (select a term)
intoGenCCNA2
Cancer3DCCNA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM123835   
Orphanet
MedgenCCNA2
Genetic Testing Registry CCNA2
NextProtP20248 [Medical]
TSGene890
GENETestsCCNA2
Target ValidationCCNA2
Huge Navigator CCNA2 [HugePedia]
snp3D : Map Gene to Disease890
BioCentury BCIQCCNA2
ClinGenCCNA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD890
Chemical/Pharm GKB GenePA94
Clinical trialCCNA2
Miscellaneous
canSAR (ICR)CCNA2 (select the gene name)
Probes
Litterature
PubMed284 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCCNA2
EVEXCCNA2
GoPubMedCCNA2
iHOPCCNA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 13:49:02 CEST 2017
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