CCNA2 (cyclin A2)

Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CCNA2 (cyclin A2)

Identity

Alias_names	CCNA
	CCN1
Other alias
HGNC (Hugo)	CCNA2
LocusID (NCBI)	890
Atlas_Id	950
Location	4q27 [Link to chromosome band 4q27]
Location_base_pair	Starts at 121816444 and ends at 121824001 bp from pter ( according to hg38-Dec_2013)

Fusion genes
(updated 2017)

Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]

t(2;2)(p22;p22) LTBP1/BIRC6::del(2)(p22p22) LTBP1/BIRC6

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]

Head and Neck: Laryngeal tumors: an overview
t(2;2)(p22;p22) LTBP1/BIRC6::del(2)(p22p22) LTBP1/BIRC6

External links

	Nomenclature
HGNC (Hugo)	CCNA2 1578
	Cards
Entrez_Gene (NCBI)	CCNA2 890 cyclin A2
Aliases	CCN1; CCNA
GeneCards (Weizmann)	CCNA2
Ensembl hg19 (Hinxton)	ENSG00000145386 [Gene_View]
Ensembl hg38 (Hinxton)	ENSG00000145386 [Gene_View] ENSG00000145386 [Sequence] chr4:121816444-121824001 [Contig_View] CCNA2 [Vega]
ICGC DataPortal	ENSG00000145386
TCGA cBioPortal	CCNA2
AceView (NCBI)	CCNA2
Genatlas (Paris)	CCNA2
WikiGenes	890
SOURCE (Princeton)	CCNA2
Genetics Home Reference (NIH)	CCNA2
	Genomic and cartography
GoldenPath hg38 (UCSC)	CCNA2 - chr4:121816444-121824001 - 4q27 [Description] (hg38-Dec_2013)
GoldenPath hg19 (UCSC)	CCNA2 - 4q27 [Description] (hg19-Feb_2009)
Ensembl	CCNA2 - 4q27 [CytoView hg19] CCNA2 - 4q27 [CytoView hg38]
Mapping of homologs : NCBI	CCNA2 [Mapview hg19] CCNA2 [Mapview hg38]
OMIM	123835
	Gene and transcription
Genbank (Entrez)	AK291931 AW276578 BC104783 BC104787 BP363915
RefSeq transcript (Entrez)	NM_001237
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)	CCNA2
Cluster EST : Unigene	Hs.58974 [ NCBI ]
CGAP (NCI)	Hs.58974
Alternative Splicing Gallery	ENSG00000145386
Gene Expression	CCNA2 [ NCBI-GEO ] CCNA2 [ EBI - ARRAY_EXPRESS ] CCNA2 [ SEEK ] CCNA2 [ MEM ]
Gene Expression Viewer (FireBrowse)	CCNA2 [ Firebrowse - Broad ]
SOURCE (Princeton)	Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60]
Genevestigator	Expression in : [tissues] [cell-lines] [cancer] [perturbations]
BioGPS (Tissue expression)	890
GTEX Portal (Tissue expression)	CCNA2
Human Protein Atlas	ENSG00000145386-CCNA2 [pathology] [cell] [tissue]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	P20248 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction]
NextProt	P20248 [Sequence] [Exons] [Medical] [Publications]
With graphics : InterPro	P20248
Splice isoforms : SwissVar	P20248
PhosPhoSitePlus	P20248
Domaine pattern : Prosite (Expaxy)	CYCLINS (PS00292)
Domains : Interpro (EBI)	Cyclin-A_N Cyclin-like Cyclin-like_sf Cyclin_C-dom Cyclin_N
Domain families : Pfam (Sanger)	Cyclin_C (PF02984) Cyclin_N (PF00134) Cyclin_N2 (PF16500)
Domain families : Pfam (NCBI)	pfam02984 pfam00134 pfam16500
Domain families : Smart (EMBL)	CYCLIN (SM00385) Cyclin_C (SM01332)
Conserved Domain (NCBI)	CCNA2
DMDM Disease mutations	890
Blocks (Seattle)	CCNA2
PDB (SRS)	1E9H 1FIN 1FVV 1GY3 1H1P 1H1Q 1H1R 1H1S 1H24 1H25 1H26 1H27 1H28 1JST 1JSU 1OGU 1OI9 1OIU 1OIY 1OKV 1OKW 1OL1 1OL2 1P5E 1PKD 1QMZ 1URC 1VYW 2BKZ 2BPM 2C4G 2C5N 2C5O 2C5V 2C5X 2C6T 2CCH 2CCI 2CJM 2I40 2IW6 2IW8 2IW9 2UUE 2UZB 2UZD 2UZE 2UZL 2V22 2WEV 2WFY 2WHB 2WIH 2WIP 2WMA 2WMB 2WPA 2WXV 2X1N 3EID 3EJ1 3EOC 3F5X 4BCK 4BCM 4BCN 4BCP 4CFM 4CFN 4CFU 4CFV 4CFW 4CFX 4EOI 4EOJ 4EOK 4EOL 4EOM 4EON 4EOO 4EOP 4EOQ 4EOR 4EOS 4FX3 5CYI 5IF1 5LMK 5NEV
PDB (PDBSum)	1E9H 1FIN 1FVV 1GY3 1H1P 1H1Q 1H1R 1H1S 1H24 1H25 1H26 1H27 1H28 1JST 1JSU 1OGU 1OI9 1OIU 1OIY 1OKV 1OKW 1OL1 1OL2 1P5E 1PKD 1QMZ 1URC 1VYW 2BKZ 2BPM 2C4G 2C5N 2C5O 2C5V 2C5X 2C6T 2CCH 2CCI 2CJM 2I40 2IW6 2IW8 2IW9 2UUE 2UZB 2UZD 2UZE 2UZL 2V22 2WEV 2WFY 2WHB 2WIH 2WIP 2WMA 2WMB 2WPA 2WXV 2X1N 3EID 3EJ1 3EOC 3F5X 4BCK 4BCM 4BCN 4BCP 4CFM 4CFN 4CFU 4CFV 4CFW 4CFX 4EOI 4EOJ 4EOK 4EOL 4EOM 4EON 4EOO 4EOP 4EOQ 4EOR 4EOS 4FX3 5CYI 5IF1 5LMK 5NEV
PDB (IMB)	1E9H 1FIN 1FVV 1GY3 1H1P 1H1Q 1H1R 1H1S 1H24 1H25 1H26 1H27 1H28 1JST 1JSU 1OGU 1OI9 1OIU 1OIY 1OKV 1OKW 1OL1 1OL2 1P5E 1PKD 1QMZ 1URC 1VYW 2BKZ 2BPM 2C4G 2C5N 2C5O 2C5V 2C5X 2C6T 2CCH 2CCI 2CJM 2I40 2IW6 2IW8 2IW9 2UUE 2UZB 2UZD 2UZE 2UZL 2V22 2WEV 2WFY 2WHB 2WIH 2WIP 2WMA 2WMB 2WPA 2WXV 2X1N 3EID 3EJ1 3EOC 3F5X 4BCK 4BCM 4BCN 4BCP 4CFM 4CFN 4CFU 4CFV 4CFW 4CFX 4EOI 4EOJ 4EOK 4EOL 4EOM 4EON 4EOO 4EOP 4EOQ 4EOR 4EOS 4FX3 5CYI 5IF1 5LMK 5NEV
PDB (RSDB)	1E9H 1FIN 1FVV 1GY3 1H1P 1H1Q 1H1R 1H1S 1H24 1H25 1H26 1H27 1H28 1JST 1JSU 1OGU 1OI9 1OIU 1OIY 1OKV 1OKW 1OL1 1OL2 1P5E 1PKD 1QMZ 1URC 1VYW 2BKZ 2BPM 2C4G 2C5N 2C5O 2C5V 2C5X 2C6T 2CCH 2CCI 2CJM 2I40 2IW6 2IW8 2IW9 2UUE 2UZB 2UZD 2UZE 2UZL 2V22 2WEV 2WFY 2WHB 2WIH 2WIP 2WMA 2WMB 2WPA 2WXV 2X1N 3EID 3EJ1 3EOC 3F5X 4BCK 4BCM 4BCN 4BCP 4CFM 4CFN 4CFU 4CFV 4CFW 4CFX 4EOI 4EOJ 4EOK 4EOL 4EOM 4EON 4EOO 4EOP 4EOQ 4EOR 4EOS 4FX3 5CYI 5IF1 5LMK 5NEV
Structural Biology KnowledgeBase	1E9H 1FIN 1FVV 1GY3 1H1P 1H1Q 1H1R 1H1S 1H24 1H25 1H26 1H27 1H28 1JST 1JSU 1OGU 1OI9 1OIU 1OIY 1OKV 1OKW 1OL1 1OL2 1P5E 1PKD 1QMZ 1URC 1VYW 2BKZ 2BPM 2C4G 2C5N 2C5O 2C5V 2C5X 2C6T 2CCH 2CCI 2CJM 2I40 2IW6 2IW8 2IW9 2UUE 2UZB 2UZD 2UZE 2UZL 2V22 2WEV 2WFY 2WHB 2WIH 2WIP 2WMA 2WMB 2WPA 2WXV 2X1N 3EID 3EJ1 3EOC 3F5X 4BCK 4BCM 4BCN 4BCP 4CFM 4CFN 4CFU 4CFV 4CFW 4CFX 4EOI 4EOJ 4EOK 4EOL 4EOM 4EON 4EOO 4EOP 4EOQ 4EOR 4EOS 4FX3 5CYI 5IF1 5LMK 5NEV
SCOP (Structural Classification of Proteins)	1E9H 1FIN 1FVV 1GY3 1H1P 1H1Q 1H1R 1H1S 1H24 1H25 1H26 1H27 1H28 1JST 1JSU 1OGU 1OI9 1OIU 1OIY 1OKV 1OKW 1OL1 1OL2 1P5E 1PKD 1QMZ 1URC 1VYW 2BKZ 2BPM 2C4G 2C5N 2C5O 2C5V 2C5X 2C6T 2CCH 2CCI 2CJM 2I40 2IW6 2IW8 2IW9 2UUE 2UZB 2UZD 2UZE 2UZL 2V22 2WEV 2WFY 2WHB 2WIH 2WIP 2WMA 2WMB 2WPA 2WXV 2X1N 3EID 3EJ1 3EOC 3F5X 4BCK 4BCM 4BCN 4BCP 4CFM 4CFN 4CFU 4CFV 4CFW 4CFX 4EOI 4EOJ 4EOK 4EOL 4EOM 4EON 4EOO 4EOP 4EOQ 4EOR 4EOS 4FX3 5CYI 5IF1 5LMK 5NEV
CATH (Classification of proteins structures)	1E9H 1FIN 1FVV 1GY3 1H1P 1H1Q 1H1R 1H1S 1H24 1H25 1H26 1H27 1H28 1JST 1JSU 1OGU 1OI9 1OIU 1OIY 1OKV 1OKW 1OL1 1OL2 1P5E 1PKD 1QMZ 1URC 1VYW 2BKZ 2BPM 2C4G 2C5N 2C5O 2C5V 2C5X 2C6T 2CCH 2CCI 2CJM 2I40 2IW6 2IW8 2IW9 2UUE 2UZB 2UZD 2UZE 2UZL 2V22 2WEV 2WFY 2WHB 2WIH 2WIP 2WMA 2WMB 2WPA 2WXV 2X1N 3EID 3EJ1 3EOC 3F5X 4BCK 4BCM 4BCN 4BCP 4CFM 4CFN 4CFU 4CFV 4CFW 4CFX 4EOI 4EOJ 4EOK 4EOL 4EOM 4EON 4EOO 4EOP 4EOQ 4EOR 4EOS 4FX3 5CYI 5IF1 5LMK 5NEV
Superfamily	P20248
Human Protein Atlas [tissue]	ENSG00000145386-CCNA2 [tissue]
Peptide Atlas	P20248
HPRD	00453
IPI	IPI00022865
	Protein Interaction databases
DIP (DOE-UCLA)	P20248
IntAct (EBI)	P20248
FunCoup	ENSG00000145386
BioGRID	CCNA2
STRING (EMBL)	CCNA2
ZODIAC	CCNA2
	Ontologies - Pathways
QuickGO	P20248
Ontology : AmiGO	regulation of cyclin-dependent protein serine/threonine kinase activity G2/M transition of mitotic cell cycle G2/M transition of mitotic cell cycle mitotic cell cycle cyclin-dependent protein kinase holoenzyme complex cyclin-dependent protein kinase holoenzyme complex female pronucleus male pronucleus protein kinase activity protein binding nucleus nucleus nucleoplasm nucleoplasm cytoplasm cytoplasm cytosol regulation of mitotic nuclear division Ras protein signal transduction positive regulation of cell proliferation viral process cyclin-dependent protein serine/threonine kinase regulator activity histone phosphorylation protein deubiquitination protein kinase binding protein kinase binding protein domain specific binding animal organ regeneration response to glucagon cellular response to platelet-derived growth factor stimulus cellular response to leptin stimulus cell cycle G1/S phase transition positive regulation of cell cycle positive regulation of transcription, DNA-templated positive regulation of fibroblast proliferation cell division regulation of cell cycle cellular response to cocaine cellular response to luteinizing hormone stimulus cellular response to estradiol stimulus cellular response to hypoxia cellular response to nitric oxide cochlea development cyclin A2-CDK2 complex cyclin A2-CDK2 complex cyclin-dependent protein kinase activity cellular response to insulin-like growth factor stimulus
Ontology : EGO-EBI	regulation of cyclin-dependent protein serine/threonine kinase activity G2/M transition of mitotic cell cycle G2/M transition of mitotic cell cycle mitotic cell cycle cyclin-dependent protein kinase holoenzyme complex cyclin-dependent protein kinase holoenzyme complex female pronucleus male pronucleus protein kinase activity protein binding nucleus nucleus nucleoplasm nucleoplasm cytoplasm cytoplasm cytosol regulation of mitotic nuclear division Ras protein signal transduction positive regulation of cell proliferation viral process cyclin-dependent protein serine/threonine kinase regulator activity histone phosphorylation protein deubiquitination protein kinase binding protein kinase binding protein domain specific binding animal organ regeneration response to glucagon cellular response to platelet-derived growth factor stimulus cellular response to leptin stimulus cell cycle G1/S phase transition positive regulation of cell cycle positive regulation of transcription, DNA-templated positive regulation of fibroblast proliferation cell division regulation of cell cycle cellular response to cocaine cellular response to luteinizing hormone stimulus cellular response to estradiol stimulus cellular response to hypoxia cellular response to nitric oxide cochlea development cyclin A2-CDK2 complex cyclin A2-CDK2 complex cyclin-dependent protein kinase activity cellular response to insulin-like growth factor stimulus
Pathways : KEGG	Cell cycle Progesterone-mediated oocyte maturation Hepatitis B Epstein-Barr virus infection Viral carcinogenesis
NDEx Network	CCNA2
Atlas of Cancer Signalling Network	CCNA2
Wikipedia pathways	CCNA2
	Orthology - Evolution
OrthoDB	890
GeneTree (enSembl)	ENSG00000145386
Phylogenetic Trees/Animal Genes : TreeFam	CCNA2
HOVERGEN	P20248
HOGENOM	P20248
Homologs : HomoloGene	CCNA2
Homology/Alignments : Family Browser (UCSC)	CCNA2
	Gene fusions - Rearrangements
Fusion : Quiver	CCNA2
	Polymorphisms : SNP and Copy number variants
NCBI Variation Viewer	CCNA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)	CCNA2
dbVar	CCNA2
ClinVar	CCNA2
1000_Genomes	CCNA2
Exome Variant Server	CCNA2
ExAC (Exome Aggregation Consortium)	ENSG00000145386
GNOMAD Browser	ENSG00000145386
Varsome Browser	CCNA2
Genetic variants : HAPMAP	890
Genomic Variants (DGV)	CCNA2 [DGVbeta]
DECIPHER	CCNA2 [patients] [syndromes] [variants] [genes]
CONAN: Copy Number Analysis	CCNA2
	Mutations
ICGC Data Portal	CCNA2
TCGA Data Portal	CCNA2
Broad Tumor Portal	CCNA2
OASIS Portal	CCNA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMIC	CCNA2 [overview] [genome browser] [tissue] [distribution]
Mutations and Diseases : HGMD	CCNA2
LOVD (Leiden Open Variation Database)	Whole genome datasets
LOVD (Leiden Open Variation Database)	LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)	LOVD 3.0 shared installation
BioMuta	search CCNA2
DgiDB (Drug Gene Interaction Database)	CCNA2
DoCM (Curated mutations)	CCNA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)	CCNA2 (select a term)
intoGen	CCNA2
Cancer3D	CCNA2(select the gene name)
Impact of mutations	[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
	Diseases
OMIM	123835
Orphanet
DisGeNET	CCNA2
Medgen	CCNA2
Genetic Testing Registry	CCNA2
NextProt	P20248 [Medical]
TSGene	890
GENETests	CCNA2
Target Validation	CCNA2
Huge Navigator	CCNA2 [HugePedia]
snp3D : Map Gene to Disease	890
BioCentury BCIQ	CCNA2
ClinGen	CCNA2
	Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD	890
Chemical/Pharm GKB Gene	PA94
Clinical trial	CCNA2
	Miscellaneous
canSAR (ICR)	CCNA2 (select the gene name)
	Probes
	Litterature
PubMed	304 Pubmed reference(s) in Entrez
GeneRIFs	Gene References Into Functions (Entrez)
CoreMine	CCNA2
EVEX	CCNA2
GoPubMed	CCNA2
iHOP	CCNA2

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

indexed on : Mon Aug 27 11:13:43 CEST 2018

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Atlas of Genetics and Cytogenetics in Oncology and Haematology

CCNA2 (cyclin A2)

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to How to contribute