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CCNA2 (cyclin A2)

Identity

Alias (NCBI)CCN1
CCNA
HGNC (Hugo) CCNA2
HGNC Previous nameCCNA
 CCN1
LocusID (NCBI) 890
Atlas_Id 950
Location 4q27  [Link to chromosome band 4q27]
Location_base_pair Starts at 121816444 and ends at 121823883 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(2;2)(p22;p22) LTBP1/BIRC6::del(2)(p22p22) LTBP1/BIRC6

External links

 

Nomenclature
HGNC (Hugo)CCNA2   1578
Cards
Entrez_Gene (NCBI)CCNA2    cyclin A2
AliasesCCN1; CCNA
GeneCards (Weizmann)CCNA2
Ensembl hg19 (Hinxton)ENSG00000145386 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000145386 [Gene_View]  ENSG00000145386 [Sequence]  chr4:121816444-121823883 [Contig_View]  CCNA2 [Vega]
ICGC DataPortalENSG00000145386
TCGA cBioPortalCCNA2
AceView (NCBI)CCNA2
Genatlas (Paris)CCNA2
SOURCE (Princeton)CCNA2
Genetics Home Reference (NIH)CCNA2
Genomic and cartography
GoldenPath hg38 (UCSC)CCNA2  -     chr4:121816444-121823883 -  4q27   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CCNA2  -     4q27   [Description]    (hg19-Feb_2009)
GoldenPathCCNA2 - 4q27 [CytoView hg19]  CCNA2 - 4q27 [CytoView hg38]
ImmunoBaseENSG00000145386
Genome Data Viewer NCBICCNA2 [Mapview hg19]  
OMIM123835   
Gene and transcription
Genbank (Entrez)AK291931 AW276578 BC104783 BC104787 BP363915
RefSeq transcript (Entrez)NM_001237
Consensus coding sequences : CCDS (NCBI)CCNA2
Gene ExpressionCCNA2 [ NCBI-GEO ]   CCNA2 [ EBI - ARRAY_EXPRESS ]   CCNA2 [ SEEK ]   CCNA2 [ MEM ]
Gene Expression Viewer (FireBrowse)CCNA2 [ Firebrowse - Broad ]
GenevisibleExpression of CCNA2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)890
GTEX Portal (Tissue expression)CCNA2
Human Protein AtlasENSG00000145386-CCNA2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20248   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20248  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20248
PhosPhoSitePlusP20248
Domaine pattern : Prosite (Expaxy)CYCLINS (PS00292)   
Domains : Interpro (EBI)Cyclin    Cyclin-A_N    Cyclin-like    Cyclin-like_sf    Cyclin_C-dom    Cyclin_N   
Domain families : Pfam (Sanger)Cyclin_C (PF02984)    Cyclin_N (PF00134)    Cyclin_N2 (PF16500)   
Domain families : Pfam (NCBI)pfam02984    pfam00134    pfam16500   
Domain families : Smart (EMBL)CYCLIN (SM00385)  Cyclin_C (SM01332)  
Conserved Domain (NCBI)CCNA2
PDB (RSDB)1E9H    1FIN    1FVV    1GY3    1H1P    1H1Q    1H1R    1H1S    1H24    1H25    1H26    1H27    1H28    1JST    1JSU    1OGU    1OI9    1OIU    1OIY    1OKV    1OKW    1OL1    1OL2    1P5E    1PKD    1QMZ    1URC    1VYW    2BKZ    2BPM    2C4G    2C5N    2C5O    2C5V    2C5X    2C6T    2CCH    2CCI    2CJM    2I40    2IW6    2IW8    2IW9    2UUE    2UZB    2UZD    2UZE    2UZL    2V22    2WEV    2WFY    2WHB    2WIH    2WIP    2WMA    2WMB    2WPA    2WXV    2X1N    3EID    3EJ1    3EOC    3F5X    4BCK    4BCM    4BCN    4BCP    4CFM    4CFN    4CFU    4CFV    4CFW    4CFX    4EOI    4EOJ    4EOK    4EOL    4EOM    4EON    4EOO    4EOP    4EOQ    4EOR    4EOS    4FX3    5CYI    5IF1    5LMK    5NEV    6ATH    6GVA    6P3W    6Q6G    6Q6H    6RIJ   
PDB Europe1E9H    1FIN    1FVV    1GY3    1H1P    1H1Q    1H1R    1H1S    1H24    1H25    1H26    1H27    1H28    1JST    1JSU    1OGU    1OI9    1OIU    1OIY    1OKV    1OKW    1OL1    1OL2    1P5E    1PKD    1QMZ    1URC    1VYW    2BKZ    2BPM    2C4G    2C5N    2C5O    2C5V    2C5X    2C6T    2CCH    2CCI    2CJM    2I40    2IW6    2IW8    2IW9    2UUE    2UZB    2UZD    2UZE    2UZL    2V22    2WEV    2WFY    2WHB    2WIH    2WIP    2WMA    2WMB    2WPA    2WXV    2X1N    3EID    3EJ1    3EOC    3F5X    4BCK    4BCM    4BCN    4BCP    4CFM    4CFN    4CFU    4CFV    4CFW    4CFX    4EOI    4EOJ    4EOK    4EOL    4EOM    4EON    4EOO    4EOP    4EOQ    4EOR    4EOS    4FX3    5CYI    5IF1    5LMK    5NEV    6ATH    6GVA    6P3W    6Q6G    6Q6H    6RIJ   
PDB (PDBSum)1E9H    1FIN    1FVV    1GY3    1H1P    1H1Q    1H1R    1H1S    1H24    1H25    1H26    1H27    1H28    1JST    1JSU    1OGU    1OI9    1OIU    1OIY    1OKV    1OKW    1OL1    1OL2    1P5E    1PKD    1QMZ    1URC    1VYW    2BKZ    2BPM    2C4G    2C5N    2C5O    2C5V    2C5X    2C6T    2CCH    2CCI    2CJM    2I40    2IW6    2IW8    2IW9    2UUE    2UZB    2UZD    2UZE    2UZL    2V22    2WEV    2WFY    2WHB    2WIH    2WIP    2WMA    2WMB    2WPA    2WXV    2X1N    3EID    3EJ1    3EOC    3F5X    4BCK    4BCM    4BCN    4BCP    4CFM    4CFN    4CFU    4CFV    4CFW    4CFX    4EOI    4EOJ    4EOK    4EOL    4EOM    4EON    4EOO    4EOP    4EOQ    4EOR    4EOS    4FX3    5CYI    5IF1    5LMK    5NEV    6ATH    6GVA    6P3W    6Q6G    6Q6H    6RIJ   
PDB (IMB)1E9H    1FIN    1FVV    1GY3    1H1P    1H1Q    1H1R    1H1S    1H24    1H25    1H26    1H27    1H28    1JST    1JSU    1OGU    1OI9    1OIU    1OIY    1OKV    1OKW    1OL1    1OL2    1P5E    1PKD    1QMZ    1URC    1VYW    2BKZ    2BPM    2C4G    2C5N    2C5O    2C5V    2C5X    2C6T    2CCH    2CCI    2CJM    2I40    2IW6    2IW8    2IW9    2UUE    2UZB    2UZD    2UZE    2UZL    2V22    2WEV    2WFY    2WHB    2WIH    2WIP    2WMA    2WMB    2WPA    2WXV    2X1N    3EID    3EJ1    3EOC    3F5X    4BCK    4BCM    4BCN    4BCP    4CFM    4CFN    4CFU    4CFV    4CFW    4CFX    4EOI    4EOJ    4EOK    4EOL    4EOM    4EON    4EOO    4EOP    4EOQ    4EOR    4EOS    4FX3    5CYI    5IF1    5LMK    5NEV    6ATH    6GVA    6P3W    6Q6G    6Q6H    6RIJ   
Structural Biology KnowledgeBase1E9H    1FIN    1FVV    1GY3    1H1P    1H1Q    1H1R    1H1S    1H24    1H25    1H26    1H27    1H28    1JST    1JSU    1OGU    1OI9    1OIU    1OIY    1OKV    1OKW    1OL1    1OL2    1P5E    1PKD    1QMZ    1URC    1VYW    2BKZ    2BPM    2C4G    2C5N    2C5O    2C5V    2C5X    2C6T    2CCH    2CCI    2CJM    2I40    2IW6    2IW8    2IW9    2UUE    2UZB    2UZD    2UZE    2UZL    2V22    2WEV    2WFY    2WHB    2WIH    2WIP    2WMA    2WMB    2WPA    2WXV    2X1N    3EID    3EJ1    3EOC    3F5X    4BCK    4BCM    4BCN    4BCP    4CFM    4CFN    4CFU    4CFV    4CFW    4CFX    4EOI    4EOJ    4EOK    4EOL    4EOM    4EON    4EOO    4EOP    4EOQ    4EOR    4EOS    4FX3    5CYI    5IF1    5LMK    5NEV    6ATH    6GVA    6P3W    6Q6G    6Q6H    6RIJ   
SCOP (Structural Classification of Proteins)1E9H    1FIN    1FVV    1GY3    1H1P    1H1Q    1H1R    1H1S    1H24    1H25    1H26    1H27    1H28    1JST    1JSU    1OGU    1OI9    1OIU    1OIY    1OKV    1OKW    1OL1    1OL2    1P5E    1PKD    1QMZ    1URC    1VYW    2BKZ    2BPM    2C4G    2C5N    2C5O    2C5V    2C5X    2C6T    2CCH    2CCI    2CJM    2I40    2IW6    2IW8    2IW9    2UUE    2UZB    2UZD    2UZE    2UZL    2V22    2WEV    2WFY    2WHB    2WIH    2WIP    2WMA    2WMB    2WPA    2WXV    2X1N    3EID    3EJ1    3EOC    3F5X    4BCK    4BCM    4BCN    4BCP    4CFM    4CFN    4CFU    4CFV    4CFW    4CFX    4EOI    4EOJ    4EOK    4EOL    4EOM    4EON    4EOO    4EOP    4EOQ    4EOR    4EOS    4FX3    5CYI    5IF1    5LMK    5NEV    6ATH    6GVA    6P3W    6Q6G    6Q6H    6RIJ   
CATH (Classification of proteins structures)1E9H    1FIN    1FVV    1GY3    1H1P    1H1Q    1H1R    1H1S    1H24    1H25    1H26    1H27    1H28    1JST    1JSU    1OGU    1OI9    1OIU    1OIY    1OKV    1OKW    1OL1    1OL2    1P5E    1PKD    1QMZ    1URC    1VYW    2BKZ    2BPM    2C4G    2C5N    2C5O    2C5V    2C5X    2C6T    2CCH    2CCI    2CJM    2I40    2IW6    2IW8    2IW9    2UUE    2UZB    2UZD    2UZE    2UZL    2V22    2WEV    2WFY    2WHB    2WIH    2WIP    2WMA    2WMB    2WPA    2WXV    2X1N    3EID    3EJ1    3EOC    3F5X    4BCK    4BCM    4BCN    4BCP    4CFM    4CFN    4CFU    4CFV    4CFW    4CFX    4EOI    4EOJ    4EOK    4EOL    4EOM    4EON    4EOO    4EOP    4EOQ    4EOR    4EOS    4FX3    5CYI    5IF1    5LMK    5NEV    6ATH    6GVA    6P3W    6Q6G    6Q6H    6RIJ   
SuperfamilyP20248
AlphaFold pdb e-kbP20248   
Human Protein Atlas [tissue]ENSG00000145386-CCNA2 [tissue]
HPRD00453
Protein Interaction databases
DIP (DOE-UCLA)P20248
IntAct (EBI)P20248
BioGRIDCCNA2
STRING (EMBL)CCNA2
ZODIACCCNA2
Ontologies - Pathways
QuickGOP20248
Ontology : AmiGOregulation of cyclin-dependent protein serine/threonine kinase activity  G2/M transition of mitotic cell cycle  cyclin-dependent protein kinase holoenzyme complex  cyclin-dependent protein kinase holoenzyme complex  female pronucleus  male pronucleus  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytoplasm  cytosol  regulation of DNA replication  Ras protein signal transduction  cyclin-dependent protein serine/threonine kinase regulator activity  cyclin-dependent protein serine/threonine kinase regulator activity  histone phosphorylation  protein deubiquitination  protein kinase binding  protein domain specific binding  animal organ regeneration  response to glucagon  cellular response to platelet-derived growth factor stimulus  cellular response to leptin stimulus  mitotic cell cycle phase transition  cell cycle G1/S phase transition  positive regulation of transcription, DNA-templated  positive regulation of fibroblast proliferation  cell division  cellular response to cocaine  cellular response to luteinizing hormone stimulus  cellular response to estradiol stimulus  cellular response to hypoxia  cellular response to nitric oxide  cochlea development  cyclin A2-CDK2 complex  cyclin A2-CDK2 complex  cellular response to insulin-like growth factor stimulus  
Ontology : EGO-EBIregulation of cyclin-dependent protein serine/threonine kinase activity  G2/M transition of mitotic cell cycle  cyclin-dependent protein kinase holoenzyme complex  cyclin-dependent protein kinase holoenzyme complex  female pronucleus  male pronucleus  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytoplasm  cytosol  regulation of DNA replication  Ras protein signal transduction  cyclin-dependent protein serine/threonine kinase regulator activity  cyclin-dependent protein serine/threonine kinase regulator activity  histone phosphorylation  protein deubiquitination  protein kinase binding  protein domain specific binding  animal organ regeneration  response to glucagon  cellular response to platelet-derived growth factor stimulus  cellular response to leptin stimulus  mitotic cell cycle phase transition  cell cycle G1/S phase transition  positive regulation of transcription, DNA-templated  positive regulation of fibroblast proliferation  cell division  cellular response to cocaine  cellular response to luteinizing hormone stimulus  cellular response to estradiol stimulus  cellular response to hypoxia  cellular response to nitric oxide  cochlea development  cyclin A2-CDK2 complex  cyclin A2-CDK2 complex  cellular response to insulin-like growth factor stimulus  
Pathways : KEGGCell cycle    Progesterone-mediated oocyte maturation    Hepatitis B    Epstein-Barr virus infection    Viral carcinogenesis   
NDEx NetworkCCNA2
Atlas of Cancer Signalling NetworkCCNA2
Wikipedia pathwaysCCNA2
Orthology - Evolution
OrthoDB890
GeneTree (enSembl)ENSG00000145386
Phylogenetic Trees/Animal Genes : TreeFamCCNA2
Homologs : HomoloGeneCCNA2
Homology/Alignments : Family Browser (UCSC)CCNA2
Gene fusions - Rearrangements
Fusion : QuiverCCNA2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCCNA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CCNA2
dbVarCCNA2
ClinVarCCNA2
MonarchCCNA2
1000_GenomesCCNA2 
Exome Variant ServerCCNA2
GNOMAD BrowserENSG00000145386
Varsome BrowserCCNA2
ACMGCCNA2 variants
VarityP20248
Genomic Variants (DGV)CCNA2 [DGVbeta]
DECIPHERCCNA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCCNA2 
Mutations
ICGC Data PortalCCNA2 
TCGA Data PortalCCNA2 
Broad Tumor PortalCCNA2
OASIS PortalCCNA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCCNA2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCCNA2
Mutations and Diseases : HGMDCCNA2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCCNA2
DgiDB (Drug Gene Interaction Database)CCNA2
DoCM (Curated mutations)CCNA2
CIViC (Clinical Interpretations of Variants in Cancer)CCNA2
Cancer3DCCNA2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM123835   
Orphanet
DisGeNETCCNA2
MedgenCCNA2
Genetic Testing Registry CCNA2
NextProtP20248 [Medical]
GENETestsCCNA2
Target ValidationCCNA2
Huge Navigator CCNA2 [HugePedia]
ClinGenCCNA2
Clinical trials, drugs, therapy
MyCancerGenomeCCNA2
Protein Interactions : CTDCCNA2
Pharm GKB GenePA94
PharosP20248
Clinical trialCCNA2
Miscellaneous
canSAR (ICR)CCNA2
HarmonizomeCCNA2
DataMed IndexCCNA2
Probes
Litterature
PubMed347 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCCNA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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