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CCNB1IP1 (cyclin B1 interacting protein 1)

Identity

Alias_namesC14orf18
chromosome 14 open reading frame 18
cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
Alias_symbol (synonym)HEI10
Other alias
HGNC (Hugo) CCNB1IP1
LocusID (NCBI) 57820
Atlas_Id 952
Location 14q11.2  [Link to chromosome band 14q11]
Location_base_pair Starts at 20311368 and ends at 20333312 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCNB1IP1 (14q11.2) / ARF3 (12q13.12)CCNB1IP1 (14q11.2) / HMGA2 (12q14.3)CCNB1IP1 (14q11.2) / RASGRF2 (5q14.1)
CCNB1IP1 (14q11.2) / SZT2 (1p34.2)HMGA2 (12q14.3) / CCNB1IP1 (14q11.2)PVT1 (8q24.21) / CCNB1IP1 (14q11.2)
HMGA2 12q14.3 CCNB1IP1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Uterus: Leiomyoma
Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)CCNB1IP1   19437
Cards
Entrez_Gene (NCBI)CCNB1IP1  57820  cyclin B1 interacting protein 1
AliasesC14orf18; HEI10
GeneCards (Weizmann)CCNB1IP1
Ensembl hg19 (Hinxton)ENSG00000100814 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100814 [Gene_View]  chr14:20311368-20333312 [Contig_View]  CCNB1IP1 [Vega]
ICGC DataPortalENSG00000100814
TCGA cBioPortalCCNB1IP1
AceView (NCBI)CCNB1IP1
Genatlas (Paris)CCNB1IP1
WikiGenes57820
SOURCE (Princeton)CCNB1IP1
Genetics Home Reference (NIH)CCNB1IP1
Genomic and cartography
GoldenPath hg38 (UCSC)CCNB1IP1  -     chr14:20311368-20333312 -  14q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CCNB1IP1  -     14q11.2   [Description]    (hg19-Feb_2009)
EnsemblCCNB1IP1 - 14q11.2 [CytoView hg19]  CCNB1IP1 - 14q11.2 [CytoView hg38]
Mapping of homologs : NCBICCNB1IP1 [Mapview hg19]  CCNB1IP1 [Mapview hg38]
OMIM608249   
Gene and transcription
Genbank (Entrez)AA101731 AF216381 AI301662 AK026233 AK225253
RefSeq transcript (Entrez)NM_021178 NM_182849 NM_182851 NM_182852
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CCNB1IP1
Cluster EST : UnigeneHs.741214 "[ NCBI ]
CGAP (NCI)Hs.741214
Alternative Splicing GalleryENSG00000100814
Gene ExpressionCCNB1IP1 [ NCBI-GEO ]   CCNB1IP1 [ EBI - ARRAY_EXPRESS ]   CCNB1IP1 [ SEEK ]   CCNB1IP1 [ MEM ]
Gene Expression Viewer (FireBrowse)CCNB1IP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57820
GTEX Portal (Tissue expression)CCNB1IP1
Human Protein AtlasENSG00000100814-CCNB1IP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NPC3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NPC3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NPC3
Splice isoforms : SwissVarQ9NPC3
PhosPhoSitePlusQ9NPC3
Domains : Interpro (EBI)Znf_RING   
Domain families : Pfam (Sanger)zf-RING_5 (PF14634)   
Domain families : Pfam (NCBI)pfam14634   
Conserved Domain (NCBI)CCNB1IP1
DMDM Disease mutations57820
Blocks (Seattle)CCNB1IP1
SuperfamilyQ9NPC3
Human Protein Atlas [tissue]ENSG00000100814-CCNB1IP1 [tissue]
Peptide AtlasQ9NPC3
HPRD07000
IPIIPI00009603   IPI01025777   IPI01025438   IPI01025661   IPI01025251   IPI01025374   IPI01025150   
Protein Interaction databases
DIP (DOE-UCLA)Q9NPC3
IntAct (EBI)Q9NPC3
FunCoupENSG00000100814
BioGRIDCCNB1IP1
STRING (EMBL)CCNB1IP1
ZODIACCCNB1IP1
Ontologies - Pathways
QuickGOQ9NPC3
Ontology : AmiGOsynaptonemal complex  blastocyst formation  protein binding  reciprocal meiotic recombination  reciprocal meiotic recombination  spermatid development  zinc ion binding  protein ubiquitination  protein ubiquitination  chiasma assembly  ubiquitin protein ligase activity  
Ontology : EGO-EBIsynaptonemal complex  blastocyst formation  protein binding  reciprocal meiotic recombination  reciprocal meiotic recombination  spermatid development  zinc ion binding  protein ubiquitination  protein ubiquitination  chiasma assembly  ubiquitin protein ligase activity  
NDEx NetworkCCNB1IP1
Atlas of Cancer Signalling NetworkCCNB1IP1
Wikipedia pathwaysCCNB1IP1
Orthology - Evolution
OrthoDB57820
GeneTree (enSembl)ENSG00000100814
Phylogenetic Trees/Animal Genes : TreeFamCCNB1IP1
HOVERGENQ9NPC3
HOGENOMQ9NPC3
Homologs : HomoloGeneCCNB1IP1
Homology/Alignments : Family Browser (UCSC)CCNB1IP1
Gene fusions - Rearrangements
Fusion : MitelmanHMGA2/CCNB1IP1 [12q14.3/14q11.2]  [t(12;14)(q14;q11)]  
Fusion : MitelmanPVT1/CCNB1IP1 [8q24.21/14q11.2]  [t(8;14)(q24;q11)]  
Fusion: Tumor Portal CCNB1IP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCCNB1IP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CCNB1IP1
dbVarCCNB1IP1
ClinVarCCNB1IP1
1000_GenomesCCNB1IP1 
Exome Variant ServerCCNB1IP1
ExAC (Exome Aggregation Consortium)ENSG00000100814
GNOMAD BrowserENSG00000100814
Genetic variants : HAPMAP57820
Genomic Variants (DGV)CCNB1IP1 [DGVbeta]
DECIPHERCCNB1IP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCCNB1IP1 
Mutations
ICGC Data PortalCCNB1IP1 
TCGA Data PortalCCNB1IP1 
Broad Tumor PortalCCNB1IP1
OASIS PortalCCNB1IP1 [ Somatic mutations - Copy number]
Cancer Gene: CensusCCNB1IP1 
Somatic Mutations in Cancer : COSMICCCNB1IP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCCNB1IP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CCNB1IP1
DgiDB (Drug Gene Interaction Database)CCNB1IP1
DoCM (Curated mutations)CCNB1IP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CCNB1IP1 (select a term)
intoGenCCNB1IP1
Cancer3DCCNB1IP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608249   
Orphanet
MedgenCCNB1IP1
Genetic Testing Registry CCNB1IP1
NextProtQ9NPC3 [Medical]
TSGene57820
GENETestsCCNB1IP1
Target ValidationCCNB1IP1
Huge Navigator CCNB1IP1 [HugePedia]
snp3D : Map Gene to Disease57820
BioCentury BCIQCCNB1IP1
ClinGenCCNB1IP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57820
Chemical/Pharm GKB GenePA134863884
Clinical trialCCNB1IP1
Miscellaneous
canSAR (ICR)CCNB1IP1 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCCNB1IP1
EVEXCCNB1IP1
GoPubMedCCNB1IP1
iHOPCCNB1IP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 12:43:33 CET 2017

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