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CCND2 (cyclin D2)

Identity

Other aliasKIAK0002
MPPH3
HGNC (Hugo) CCND2
LocusID (NCBI) 894
Atlas_Id 329
Location 12p13.32  [Link to chromosome band 12p13]
Location_base_pair Starts at 4273736 and ends at 4305356 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CCND2 (12p13.32) / AKAP3 (12p13.32)CCND2 (12p13.32) / CCND2 (12p13.32)CCND2 (12p13.32) / CREB5 (7p15.1)
CCND2 (12p13.32) / IGL (22q11.22)CCND2 (12p13.32) / KNDC1 (10q26.3)GCN1 (12q24.23) / CCND2 (12p13.32)
IGH (14q32.33) / CCND2 (12p13.32)IGHG1 (14q32.33) / CCND2 (12p13.32)IGK (14q32.33) / CCND2 (12p13.32)
IGL (22q11.22) / CCND2 (12p13.32)IGLV3-10 () / CCND2 (12p13.32)TRB () / CCND2 (12p13.32)
WDR62 (19q13.12) / CCND2 (12p13.32)GCN1L1 CCND2 12p13.32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Breakpoints

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 7 ]
  dic(9;12)(p13;p13) PAX5/ETV6
inv(16)(p13q24) CBFA2T3/GLIS2
t(5;7)(q35;q21) TLX3/CDK6
t(5;11)(q33;p13) CAPRIN1/PDGFRB
t(7;12)(q34;p13) TRB/CCND2::t(12;14)(p13;q11) TRA or TRD/CCND2
t(2;12)(p12;p13) IGK/CCND2::t(12;14)(p13;q32) IGH/CCND2::t(12;22)(p13;q11) IGL/CCND2
T-lineage acute lymphoblastic leukemia (T-ALL)


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  Testis: Germ cell tumors
Ovary: Sex cord-stromal tumors
Nervous system: Peripheral nerve sheath tumors


External links

Nomenclature
HGNC (Hugo)CCND2   1583
Cards
Entrez_Gene (NCBI)CCND2  894  cyclin D2
AliasesKIAK0002; MPPH3
GeneCards (Weizmann)CCND2
Ensembl hg19 (Hinxton)ENSG00000118971 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000118971 [Gene_View]  chr12:4273736-4305356 [Contig_View]  CCND2 [Vega]
ICGC DataPortalENSG00000118971
TCGA cBioPortalCCND2
AceView (NCBI)CCND2
Genatlas (Paris)CCND2
WikiGenes894
SOURCE (Princeton)CCND2
Genetics Home Reference (NIH)CCND2
Genomic and cartography
GoldenPath hg38 (UCSC)CCND2  -     chr12:4273736-4305356 +  12p13.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CCND2  -     12p13.32   [Description]    (hg19-Feb_2009)
EnsemblCCND2 - 12p13.32 [CytoView hg19]  CCND2 - 12p13.32 [CytoView hg38]
Mapping of homologs : NCBICCND2 [Mapview hg19]  CCND2 [Mapview hg38]
OMIM123833   615938   
Gene and transcription
Genbank (Entrez)AI055922 AK223577 AK291146 BC010958 BC014357
RefSeq transcript (Entrez)NM_001759
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CCND2
Cluster EST : UnigeneHs.376071 [ NCBI ]
CGAP (NCI)Hs.376071
Alternative Splicing GalleryENSG00000118971
Gene ExpressionCCND2 [ NCBI-GEO ]   CCND2 [ EBI - ARRAY_EXPRESS ]   CCND2 [ SEEK ]   CCND2 [ MEM ]
Gene Expression Viewer (FireBrowse)CCND2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)894
GTEX Portal (Tissue expression)CCND2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30279   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP30279  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30279
Splice isoforms : SwissVarP30279
PhosPhoSitePlusP30279
Domaine pattern : Prosite (Expaxy)CYCLINS (PS00292)   
Domains : Interpro (EBI)Cyclin-like    Cyclin_C-dom    Cyclin_D    Cyclin_N   
Domain families : Pfam (Sanger)Cyclin_C (PF02984)    Cyclin_N (PF00134)   
Domain families : Pfam (NCBI)pfam02984    pfam00134   
Domain families : Smart (EMBL)CYCLIN (SM00385)  Cyclin_C (SM01332)  
Conserved Domain (NCBI)CCND2
DMDM Disease mutations894
Blocks (Seattle)CCND2
SuperfamilyP30279
Human Protein AtlasENSG00000118971
Peptide AtlasP30279
HPRD00451
IPIIPI00025810   IPI01010530   
Protein Interaction databases
DIP (DOE-UCLA)P30279
IntAct (EBI)P30279
FunCoupENSG00000118971
BioGRIDCCND2
STRING (EMBL)CCND2
ZODIACCCND2
Ontologies - Pathways
QuickGOP30279
Ontology : AmiGOcyclin-dependent protein kinase holoenzyme complex  chromatin  positive regulation of protein phosphorylation  protein binding  nucleus  nucleoplasm  nucleolus  cytosol  cell cycle  long-term memory  positive regulation of cell proliferation  adult locomotory behavior  protein kinase binding  nuclear membrane  negative regulation of apoptotic process  positive regulation of cyclin-dependent protein serine/threonine kinase activity  cell division  cellular response to X-ray  cyclin D2-CDK4 complex  positive regulation of G1/S transition of mitotic cell cycle  
Ontology : EGO-EBIcyclin-dependent protein kinase holoenzyme complex  chromatin  positive regulation of protein phosphorylation  protein binding  nucleus  nucleoplasm  nucleolus  cytosol  cell cycle  long-term memory  positive regulation of cell proliferation  adult locomotory behavior  protein kinase binding  nuclear membrane  negative regulation of apoptotic process  positive regulation of cyclin-dependent protein serine/threonine kinase activity  cell division  cellular response to X-ray  cyclin D2-CDK4 complex  positive regulation of G1/S transition of mitotic cell cycle  
Pathways : BIOCARTACyclins and Cell Cycle Regulation [Genes]   
Pathways : KEGG   
NDEx NetworkCCND2
Atlas of Cancer Signalling NetworkCCND2
Wikipedia pathwaysCCND2
Orthology - Evolution
OrthoDB894
GeneTree (enSembl)ENSG00000118971
Phylogenetic Trees/Animal Genes : TreeFamCCND2
HOVERGENP30279
HOGENOMP30279
Homologs : HomoloGeneCCND2
Homology/Alignments : Family Browser (UCSC)CCND2
Gene fusions - Rearrangements
Fusion : MitelmanGCN1L1/12p13.32 [CCND2/t(12;12)(p13;q24)]  
Fusion : MitelmanIGH/CCND2 [14q32.33/12p13.32]  [t(12;14)(p13;q32)]  
Fusion : MitelmanIGK/CCND2 [2p11.2/12p13.32]  [t(2;12)(p11;p13)]  
Fusion : MitelmanIGL/CCND2 [22q11.22/12p13.32]  [t(12;22)(p13;q11)]  
Fusion : MitelmanTRB/CCND2 [-/12p13.32]  [t(7;12)(q34;p13)]  
Fusion: TCGAGCN1L1 CCND2 12p13.32 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCCND2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CCND2
dbVarCCND2
ClinVarCCND2
1000_GenomesCCND2 
Exome Variant ServerCCND2
ExAC (Exome Aggregation Consortium)CCND2 (select the gene name)
Genetic variants : HAPMAP894
Genomic Variants (DGV)CCND2 [DGVbeta]
DECIPHERCCND2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCCND2 
Mutations
ICGC Data PortalCCND2 
TCGA Data PortalCCND2 
Broad Tumor PortalCCND2
OASIS PortalCCND2 [ Somatic mutations - Copy number]
Cancer Gene: CensusCCND2 
Somatic Mutations in Cancer : COSMICCCND2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCCND2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CCND2
DgiDB (Drug Gene Interaction Database)CCND2
DoCM (Curated mutations)CCND2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CCND2 (select a term)
intoGenCCND2
Cancer3DCCND2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM123833    615938   
Orphanet11582   
MedgenCCND2
Genetic Testing Registry CCND2
NextProtP30279 [Medical]
TSGene894
GENETestsCCND2
Target ValidationCCND2
Huge Navigator CCND2 [HugePedia]
snp3D : Map Gene to Disease894
BioCentury BCIQCCND2
ClinGenCCND2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD894
Chemical/Pharm GKB GenePA26150
Drug Sensitivity CCND2
Clinical trialCCND2
Miscellaneous
canSAR (ICR)CCND2 (select the gene name)
Probes
Litterature
PubMed168 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCCND2
EVEXCCND2
GoPubMedCCND2
iHOPCCND2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 16:57:06 CEST 2017

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