CCND2 (cyclin D2)

2003-02-01  

Identity

HGNC
LOCATION
12p13.32
LOCUSID
ALIAS
KIAK0002,MPPH3
FUSION GENES

Other Information

Locus ID:

NCBI: 894
MIM: 123833
HGNC: 1583
Ensembl: ENSG00000118971

Variants:

dbSNP: 894
ClinVar: 894
TCGA: ENSG00000118971
COSMIC: CCND2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000118971ENST00000261254P30279
ENSG00000118971ENST00000536537H0YGD4

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
p53 signaling pathwayKEGGko04115
Wnt signaling pathwayKEGGko04310
Hedgehog signaling pathwayKEGGko04340
Focal adhesionKEGGko04510
Jak-STAT signaling pathwayKEGGko04630
Cell cycleKEGGhsa04110
p53 signaling pathwayKEGGhsa04115
Wnt signaling pathwayKEGGhsa04310
Hedgehog signaling pathwayKEGGhsa04340
Focal adhesionKEGGhsa04510
Jak-STAT signaling pathwayKEGGhsa04630
MeaslesKEGGko05162
MeaslesKEGGhsa05162
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Prolactin signaling pathwayKEGGhsa04917
Prolactin signaling pathwayKEGGko04917
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
FoxO signaling pathwayKEGGhsa04068
Cell cycle - G1/S transitionKEGGhsa_M00692
Cell cycle - G1/S transitionKEGGM00692
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1 PhaseREACTOMER-HSA-69236
Cyclin D associated events in G1REACTOMER-HSA-69231

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
157558962005Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma.182
232665562013Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.172
244641002014Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes.111
204189482010MicroRNA let-7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2.87
146010572003DNA methylation of RASSF1A, HIN-1, RAR-beta, Cyclin D2 and Twist in in situ and invasive lobular breast carcinoma.77
218786502011miR-497 and miR-302b regulate ethanol-induced neuronal cell death through BCL2 protein and cyclin D2.57
155098062004FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism.54
192521332009Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach.51
174094092007Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer.47
223303402012Downregulation of microRNAs miR-1, -206 and -29 stabilizes PAX3 and CCND2 expression in rhabdomyosarcoma.45

Citation

Dessen P

CCND2 (cyclin D2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/329/ccnd2