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CCND3 (cyclin D3)

Identity

Other alias-
HGNC (Hugo) CCND3
LocusID (NCBI) 896
Atlas_Id 955
Location 6p21.1  [Link to chromosome band 6p21]
Location_base_pair Starts at 41934933 and ends at 41941848 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCND3 (6p21.1) / C6orf89 (6p21.2)CCND3 (6p21.1) / GUCA1B (6p21.1)CCND3 (6p21.1) / IGH (14q32.33)
CCND3 (6p21.1) / LARP4B (10p15.3)GMDS (6p25.3) / CCND3 (6p21.1)IGH (14q32.33) / CCND3 (6p21.1)
IGHG1 (14q32.33) / CCND3 (6p21.1)IGL (22q11.22) / CCND3 (6p21.1)IGLV3-10 () / CCND3 (6p21.1)
Ig () / CCND3 (6p21.1)KCNMB4 (12q15) / CCND3 (6p21.1)TBC1D22B (6p21.2) / CCND3 (6p21.1)
CCND3 6p21.1 / C6orf89 6p21.2CCND3 6p21.1 / GUCA1B 6p21.1GMDS 6p25.3 / CCND3 6p21.1
TBC1D22B 6p21.2 / CCND3 6p21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 5 ]
  Multiple myeloma (published in 2004)
Multiple Myeloma
t(6;12)(p21;p13) CCND3/ETV6 in lymphoid malignancies
t(6;14)(p21;q32) IGH/CCND3
t(6;22)(p21;q11) IGL/CCND3


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 6 ]
  CCND3/C6orf89 (6p21)
CCND3/GUCA1B (6p21)
TBC1D22B/CCND3 (6p21)
t(6;6)(p21;p25) GMDS/CCND3
t(6;12)(p21;q15) KCNMB4/CCND3
t(6;14)(p21;q32) IGH/CCND3


External links

Nomenclature
HGNC (Hugo)CCND3   1585
LRG (Locus Reference Genomic)LRG_998
Cards
Entrez_Gene (NCBI)CCND3  896  cyclin D3
Aliases
GeneCards (Weizmann)CCND3
Ensembl hg19 (Hinxton)ENSG00000112576 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112576 [Gene_View]  ENSG00000112576 [Sequence]  chr6:41934933-41941848 [Contig_View]  CCND3 [Vega]
ICGC DataPortalENSG00000112576
TCGA cBioPortalCCND3
AceView (NCBI)CCND3
Genatlas (Paris)CCND3
WikiGenes896
SOURCE (Princeton)CCND3
Genetics Home Reference (NIH)CCND3
Genomic and cartography
GoldenPath hg38 (UCSC)CCND3  -     chr6:41934933-41941848 -  6p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CCND3  -     6p21.1   [Description]    (hg19-Feb_2009)
EnsemblCCND3 - 6p21.1 [CytoView hg19]  CCND3 - 6p21.1 [CytoView hg38]
Mapping of homologs : NCBICCND3 [Mapview hg19]  CCND3 [Mapview hg38]
OMIM123834   
Gene and transcription
Genbank (Entrez)AB209825 AK055519 AK057206 AK096276 AK097856
RefSeq transcript (Entrez)NM_001136017 NM_001136125 NM_001136126 NM_001287427 NM_001287434 NM_001760
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CCND3
Cluster EST : UnigeneHs.534307 [ NCBI ]
CGAP (NCI)Hs.534307
Alternative Splicing GalleryENSG00000112576
Gene ExpressionCCND3 [ NCBI-GEO ]   CCND3 [ EBI - ARRAY_EXPRESS ]   CCND3 [ SEEK ]   CCND3 [ MEM ]
Gene Expression Viewer (FireBrowse)CCND3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)896
GTEX Portal (Tissue expression)CCND3
Human Protein AtlasENSG00000112576-CCND3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP30281   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP30281  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP30281
Splice isoforms : SwissVarP30281
PhosPhoSitePlusP30281
Domaine pattern : Prosite (Expaxy)CYCLINS (PS00292)   
Domains : Interpro (EBI)Cyclin-like    Cyclin-like_sf    Cyclin_C-dom    Cyclin_D    Cyclin_N   
Domain families : Pfam (Sanger)Cyclin_C (PF02984)    Cyclin_N (PF00134)   
Domain families : Pfam (NCBI)pfam02984    pfam00134   
Domain families : Smart (EMBL)CYCLIN (SM00385)  Cyclin_C (SM01332)  
Conserved Domain (NCBI)CCND3
DMDM Disease mutations896
Blocks (Seattle)CCND3
PDB (SRS)3G33   
PDB (PDBSum)3G33   
PDB (IMB)3G33   
PDB (RSDB)3G33   
Structural Biology KnowledgeBase3G33   
SCOP (Structural Classification of Proteins)3G33   
CATH (Classification of proteins structures)3G33   
SuperfamilyP30281
Human Protein Atlas [tissue]ENSG00000112576-CCND3 [tissue]
Peptide AtlasP30281
HPRD00452
IPIIPI00025817   IPI00843804   IPI00514180   IPI00914637   IPI00940490   IPI00914619   IPI00966702   IPI01021614   IPI00968266   IPI00965274   IPI00968023   IPI00910362   
Protein Interaction databases
DIP (DOE-UCLA)P30281
IntAct (EBI)P30281
FunCoupENSG00000112576
BioGRIDCCND3
STRING (EMBL)CCND3
ZODIACCCND3
Ontologies - Pathways
QuickGOP30281
Ontology : AmiGOregulation of cyclin-dependent protein serine/threonine kinase activity  negative regulation of transcription by RNA polymerase II  mitotic cell cycle  cyclin-dependent protein kinase holoenzyme complex  cyclin-dependent protein kinase holoenzyme complex  positive regulation of protein phosphorylation  protein kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein binding  nucleus  nucleoplasm  cytoplasm  protein phosphorylation  regulation of mitotic nuclear division  signal transduction  positive regulation of cell proliferation  membrane  cyclin-dependent protein serine/threonine kinase regulator activity  protein kinase binding  protein kinase binding  T cell proliferation  positive regulation of cyclin-dependent protein serine/threonine kinase activity  positive regulation of cell cycle  regulation of insulin receptor signaling pathway  cell division  positive regulation of G1/S transition of mitotic cell cycle  
Ontology : EGO-EBIregulation of cyclin-dependent protein serine/threonine kinase activity  negative regulation of transcription by RNA polymerase II  mitotic cell cycle  cyclin-dependent protein kinase holoenzyme complex  cyclin-dependent protein kinase holoenzyme complex  positive regulation of protein phosphorylation  protein kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein binding  nucleus  nucleoplasm  cytoplasm  protein phosphorylation  regulation of mitotic nuclear division  signal transduction  positive regulation of cell proliferation  membrane  cyclin-dependent protein serine/threonine kinase regulator activity  protein kinase binding  protein kinase binding  T cell proliferation  positive regulation of cyclin-dependent protein serine/threonine kinase activity  positive regulation of cell cycle  regulation of insulin receptor signaling pathway  cell division  positive regulation of G1/S transition of mitotic cell cycle  
Pathways : KEGGCell cycle    p53 signaling pathway    PI3K-Akt signaling pathway    Wnt signaling pathway    Hippo signaling pathway    Focal adhesion    Jak-STAT signaling pathway    Measles    HTLV-I infection    Viral carcinogenesis   
NDEx NetworkCCND3
Atlas of Cancer Signalling NetworkCCND3
Wikipedia pathwaysCCND3
Orthology - Evolution
OrthoDB896
GeneTree (enSembl)ENSG00000112576
Phylogenetic Trees/Animal Genes : TreeFamCCND3
HOVERGENP30281
HOGENOMP30281
Homologs : HomoloGeneCCND3
Homology/Alignments : Family Browser (UCSC)CCND3
Gene fusions - Rearrangements
Fusion : MitelmanCCND3/C6orf89 [6p21.1/6p21.2]  
Fusion : MitelmanCCND3/GUCA1B [6p21.1/6p21.1]  [t(6;6)(p21;p21)]  
Fusion : MitelmanGMDS/CCND3 [6p25.3/6p21.1]  [t(6;6)(p21;p25)]  
Fusion : MitelmanIGH/CCND3 [14q32.33/6p21.1]  [t(11;14)(q13;q32)]  [t(14;16)(q32;q23)]  
[t(14;20)(q32;q12)]  [t(4;14)(p16;q32)]  [t(6;14)(p21;q32)]  
Fusion : MitelmanIGL/CCND3 [22q11.22/6p21.1]  [t(6;22)(p21;q11)]  
Fusion : MitelmanTBC1D22B/CCND3 [6p21.2/6p21.1]  [t(6;6)(p21;p21)]  
Fusion PortalCCND3 6p21.1 C6orf89 6p21.2 GBM
Fusion PortalCCND3 6p21.1 GUCA1B 6p21.1 BRCA
Fusion PortalGMDS 6p25.3 CCND3 6p21.1 PRAD
Fusion PortalTBC1D22B 6p21.2 CCND3 6p21.1 BRCA
Fusion : QuiverCCND3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCCND3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CCND3
dbVarCCND3
ClinVarCCND3
1000_GenomesCCND3 
Exome Variant ServerCCND3
ExAC (Exome Aggregation Consortium)ENSG00000112576
GNOMAD BrowserENSG00000112576
Varsome BrowserCCND3
Genetic variants : HAPMAP896
Genomic Variants (DGV)CCND3 [DGVbeta]
DECIPHERCCND3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCCND3 
Mutations
ICGC Data PortalCCND3 
TCGA Data PortalCCND3 
Broad Tumor PortalCCND3
OASIS PortalCCND3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCCND3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCCND3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CCND3
DgiDB (Drug Gene Interaction Database)CCND3
DoCM (Curated mutations)CCND3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CCND3 (select a term)
intoGenCCND3
Cancer3DCCND3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM123834   
Orphanet
DisGeNETCCND3
MedgenCCND3
Genetic Testing Registry CCND3
NextProtP30281 [Medical]
TSGene896
GENETestsCCND3
Target ValidationCCND3
Huge Navigator CCND3 [HugePedia]
snp3D : Map Gene to Disease896
BioCentury BCIQCCND3
ClinGenCCND3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD896
Chemical/Pharm GKB GenePA26152
Drug Sensitivity CCND3
Clinical trialCCND3
Miscellaneous
canSAR (ICR)CCND3 (select the gene name)
Probes
Litterature
PubMed182 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCCND3
EVEXCCND3
GoPubMedCCND3
iHOPCCND3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 10:56:27 CET 2018

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