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CCNE1 (cyclin E1)

Identity

Alias_namesCCNE
Other aliaspCCNE1
HGNC (Hugo) CCNE1
LocusID (NCBI) 898
Atlas_Id 956
Location 19q12  [Link to chromosome band 19q12]
Location_base_pair Starts at 29811994 and ends at 29824317 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CCNE1 (19q12) / HIGD1A (3p22.1)IGH (14q32.33) / CCNE1 (19q12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Thyroid: Anaplastic (undifferentiated) carcinoma


External links

Nomenclature
HGNC (Hugo)CCNE1   1589
Cards
Entrez_Gene (NCBI)CCNE1  898  cyclin E1
AliasesCCNE; pCCNE1
GeneCards (Weizmann)CCNE1
Ensembl hg19 (Hinxton)ENSG00000105173 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105173 [Gene_View]  chr19:29811994-29824317 [Contig_View]  CCNE1 [Vega]
ICGC DataPortalENSG00000105173
TCGA cBioPortalCCNE1
AceView (NCBI)CCNE1
Genatlas (Paris)CCNE1
WikiGenes898
SOURCE (Princeton)CCNE1
Genetics Home Reference (NIH)CCNE1
Genomic and cartography
GoldenPath hg38 (UCSC)CCNE1  -     chr19:29811994-29824317 +  19q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CCNE1  -     19q12   [Description]    (hg19-Feb_2009)
EnsemblCCNE1 - 19q12 [CytoView hg19]  CCNE1 - 19q12 [CytoView hg38]
Mapping of homologs : NCBICCNE1 [Mapview hg19]  CCNE1 [Mapview hg38]
OMIM123837   
Gene and transcription
Genbank (Entrez)AK291549 AU137789 BC035498 BE645164 BQ018270
RefSeq transcript (Entrez)NM_001238 NM_001322259 NM_001322261 NM_001322262 NM_057182
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CCNE1
Cluster EST : UnigeneHs.244723 [ NCBI ]
CGAP (NCI)Hs.244723
Alternative Splicing GalleryENSG00000105173
Gene ExpressionCCNE1 [ NCBI-GEO ]   CCNE1 [ EBI - ARRAY_EXPRESS ]   CCNE1 [ SEEK ]   CCNE1 [ MEM ]
Gene Expression Viewer (FireBrowse)CCNE1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)898
GTEX Portal (Tissue expression)CCNE1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP24864   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP24864  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP24864
Splice isoforms : SwissVarP24864
PhosPhoSitePlusP24864
Domaine pattern : Prosite (Expaxy)CYCLINS (PS00292)   
Domains : Interpro (EBI)Cyclin-like    Cyclin_C-dom    Cyclin_E    Cyclin_N   
Domain families : Pfam (Sanger)Cyclin_C (PF02984)    Cyclin_N (PF00134)   
Domain families : Pfam (NCBI)pfam02984    pfam00134   
Domain families : Smart (EMBL)CYCLIN (SM00385)  Cyclin_C (SM01332)  
Conserved Domain (NCBI)CCNE1
DMDM Disease mutations898
Blocks (Seattle)CCNE1
PDB (SRS)1W98    5L2W   
PDB (PDBSum)1W98    5L2W   
PDB (IMB)1W98    5L2W   
PDB (RSDB)1W98    5L2W   
Structural Biology KnowledgeBase1W98    5L2W   
SCOP (Structural Classification of Proteins)1W98    5L2W   
CATH (Classification of proteins structures)1W98    5L2W   
SuperfamilyP24864
Human Protein AtlasENSG00000105173
Peptide AtlasP24864
HPRD00455
IPIIPI00031077   IPI01012689   IPI00376965   IPI00216040   
Protein Interaction databases
DIP (DOE-UCLA)P24864
IntAct (EBI)P24864
FunCoupENSG00000105173
BioGRIDCCNE1
STRING (EMBL)CCNE1
ZODIACCCNE1
Ontologies - Pathways
QuickGOP24864
Ontology : AmiGOG1/S transition of mitotic cell cycle  G1/S transition of mitotic cell cycle  regulation of transcription involved in G1/S transition of mitotic cell cycle  negative regulation of transcription from RNA polymerase II promoter  telomere maintenance  transcription coactivator activity  protein binding  nucleus  nucleoplasm  nucleoplasm  cytosol  DNA replication initiation  protein phosphorylation  synapsis  Wnt signaling pathway  kinase activity  cyclin-dependent protein serine/threonine kinase regulator activity  protein kinase binding  androgen receptor signaling pathway  regulation of protein kinase activity  positive regulation of transcription, DNA-templated  androgen receptor binding  cell division  regulation of cell cycle  cyclin E1-CDK2 complex  regulation of cellular protein localization  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  G1/S transition of mitotic cell cycle  regulation of transcription involved in G1/S transition of mitotic cell cycle  negative regulation of transcription from RNA polymerase II promoter  telomere maintenance  transcription coactivator activity  protein binding  nucleus  nucleoplasm  nucleoplasm  cytosol  DNA replication initiation  protein phosphorylation  synapsis  Wnt signaling pathway  kinase activity  cyclin-dependent protein serine/threonine kinase regulator activity  protein kinase binding  androgen receptor signaling pathway  regulation of protein kinase activity  positive regulation of transcription, DNA-templated  androgen receptor binding  cell division  regulation of cell cycle  cyclin E1-CDK2 complex  regulation of cellular protein localization  
Pathways : BIOCARTA [Genes]   
Pathways : KEGG   
NDEx NetworkCCNE1
Atlas of Cancer Signalling NetworkCCNE1
Wikipedia pathwaysCCNE1
Orthology - Evolution
OrthoDB898
GeneTree (enSembl)ENSG00000105173
Phylogenetic Trees/Animal Genes : TreeFamCCNE1
HOVERGENP24864
HOGENOMP24864
Homologs : HomoloGeneCCNE1
Homology/Alignments : Family Browser (UCSC)CCNE1
Gene fusions - Rearrangements
Fusion : MitelmanIGH/CCNE1 [14q32.33/19q12]  [t(14;19)(q32;q12)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCCNE1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CCNE1
dbVarCCNE1
ClinVarCCNE1
1000_GenomesCCNE1 
Exome Variant ServerCCNE1
ExAC (Exome Aggregation Consortium)CCNE1 (select the gene name)
Genetic variants : HAPMAP898
Genomic Variants (DGV)CCNE1 [DGVbeta]
DECIPHERCCNE1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCCNE1 
Mutations
ICGC Data PortalCCNE1 
TCGA Data PortalCCNE1 
Broad Tumor PortalCCNE1
OASIS PortalCCNE1 [ Somatic mutations - Copy number]
Cancer Gene: CensusCCNE1 
Somatic Mutations in Cancer : COSMICCCNE1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCCNE1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CCNE1
DgiDB (Drug Gene Interaction Database)CCNE1
DoCM (Curated mutations)CCNE1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CCNE1 (select a term)
intoGenCCNE1
Cancer3DCCNE1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM123837   
Orphanet
MedgenCCNE1
Genetic Testing Registry CCNE1
NextProtP24864 [Medical]
TSGene898
GENETestsCCNE1
Target ValidationCCNE1
Huge Navigator CCNE1 [HugePedia]
snp3D : Map Gene to Disease898
BioCentury BCIQCCNE1
ClinGenCCNE1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD898
Chemical/Pharm GKB GenePA96
Clinical trialCCNE1
Miscellaneous
canSAR (ICR)CCNE1 (select the gene name)
Probes
Litterature
PubMed377 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCCNE1
EVEXCCNE1
GoPubMedCCNE1
iHOPCCNE1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:27:12 CEST 2017

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