Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CCNE1 (cyclin E1)

Identity

Alias (NCBI)CCNE
pCCNE1
HGNC (Hugo) CCNE1
HGNC Alias namecyclin Es
 cyclin Et
HGNC Previous nameCCNE
LocusID (NCBI) 898
Atlas_Id 956
Location 19q12  [Link to chromosome band 19q12]
Location_base_pair Starts at 29811991 and ends at 29824312 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCNE1 (19q12) / HIGD1A (3p22.1)IGH (14q32.33) / CCNE1 (19q12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CCNE1   1589
Cards
Entrez_Gene (NCBI)CCNE1    cyclin E1
AliasesCCNE; pCCNE1
GeneCards (Weizmann)CCNE1
Ensembl hg19 (Hinxton)ENSG00000105173 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105173 [Gene_View]  ENSG00000105173 [Sequence]  chr19:29811991-29824312 [Contig_View]  CCNE1 [Vega]
ICGC DataPortalENSG00000105173
TCGA cBioPortalCCNE1
AceView (NCBI)CCNE1
Genatlas (Paris)CCNE1
SOURCE (Princeton)CCNE1
Genetics Home Reference (NIH)CCNE1
Genomic and cartography
GoldenPath hg38 (UCSC)CCNE1  -     chr19:29811991-29824312 +  19q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CCNE1  -     19q12   [Description]    (hg19-Feb_2009)
GoldenPathCCNE1 - 19q12 [CytoView hg19]  CCNE1 - 19q12 [CytoView hg38]
ImmunoBaseENSG00000105173
Genome Data Viewer NCBICCNE1 [Mapview hg19]  
OMIM123837   
Gene and transcription
Genbank (Entrez)AK291549 AU137789 BC035498 BE645164 BQ018270
RefSeq transcript (Entrez)NM_001238 NM_001322259 NM_001322261 NM_001322262 NM_057182
Consensus coding sequences : CCDS (NCBI)CCNE1
Gene ExpressionCCNE1 [ NCBI-GEO ]   CCNE1 [ EBI - ARRAY_EXPRESS ]   CCNE1 [ SEEK ]   CCNE1 [ MEM ]
Gene Expression Viewer (FireBrowse)CCNE1 [ Firebrowse - Broad ]
GenevisibleExpression of CCNE1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)898
GTEX Portal (Tissue expression)CCNE1
Human Protein AtlasENSG00000105173-CCNE1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP24864   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP24864  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP24864
PhosPhoSitePlusP24864
Domaine pattern : Prosite (Expaxy)CYCLINS (PS00292)   
Domains : Interpro (EBI)Cyclin    Cyclin-like    Cyclin-like_sf    Cyclin_C-dom    Cyclin_E    Cyclin_N   
Domain families : Pfam (Sanger)Cyclin_C (PF02984)    Cyclin_N (PF00134)   
Domain families : Pfam (NCBI)pfam02984    pfam00134   
Domain families : Smart (EMBL)CYCLIN (SM00385)  Cyclin_C (SM01332)  
Conserved Domain (NCBI)CCNE1
PDB (RSDB)1W98    5L2W   
PDB Europe1W98    5L2W   
PDB (PDBSum)1W98    5L2W   
PDB (IMB)1W98    5L2W   
Structural Biology KnowledgeBase1W98    5L2W   
SCOP (Structural Classification of Proteins)1W98    5L2W   
CATH (Classification of proteins structures)1W98    5L2W   
SuperfamilyP24864
AlphaFold pdb e-kbP24864   
Human Protein Atlas [tissue]ENSG00000105173-CCNE1 [tissue]
HPRD00455
Protein Interaction databases
DIP (DOE-UCLA)P24864
IntAct (EBI)P24864
BioGRIDCCNE1
STRING (EMBL)CCNE1
ZODIACCCNE1
Ontologies - Pathways
QuickGOP24864
Ontology : AmiGOregulation of cyclin-dependent protein serine/threonine kinase activity  G1/S transition of mitotic cell cycle  G1/S transition of mitotic cell cycle  G1/S transition of mitotic cell cycle  G1/S transition of mitotic cell cycle  regulation of transcription involved in G1/S transition of mitotic cell cycle  negative regulation of transcription by RNA polymerase II  cyclin-dependent protein kinase holoenzyme complex  telomere maintenance  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  centrosome  cytosol  DNA replication initiation  protein phosphorylation  homologous chromosome pairing at meiosis  Wnt signaling pathway  kinase activity  cyclin-dependent protein serine/threonine kinase regulator activity  protein kinase binding  mitotic cell cycle phase transition  cell division  cyclin E1-CDK2 complex  cyclin E1-CDK2 complex  positive regulation of mesenchymal stem cell proliferation  regulation of cellular protein localization  
Ontology : EGO-EBIregulation of cyclin-dependent protein serine/threonine kinase activity  G1/S transition of mitotic cell cycle  G1/S transition of mitotic cell cycle  G1/S transition of mitotic cell cycle  G1/S transition of mitotic cell cycle  regulation of transcription involved in G1/S transition of mitotic cell cycle  negative regulation of transcription by RNA polymerase II  cyclin-dependent protein kinase holoenzyme complex  telomere maintenance  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  cytoplasm  centrosome  cytosol  DNA replication initiation  protein phosphorylation  homologous chromosome pairing at meiosis  Wnt signaling pathway  kinase activity  cyclin-dependent protein serine/threonine kinase regulator activity  protein kinase binding  mitotic cell cycle phase transition  cell division  cyclin E1-CDK2 complex  cyclin E1-CDK2 complex  positive regulation of mesenchymal stem cell proliferation  regulation of cellular protein localization  
Pathways : BIOCARTACyclins and Cell Cycle Regulation [Genes]    Influence of Ras and Rho proteins on G1 to S Transition [Genes]    Cell Cycle: G1/S Check Point [Genes]    Regulation of p27 Phosphorylation during Cell Cycle Progression [Genes]    p53 Signaling Pathway [Genes]    E2F1 Destruction Pathway [Genes]    CDK Regulation of DNA Replication [Genes]    Cyclin E Destruction Pathway [Genes]   
Pathways : KEGGCell cycle    Oocyte meiosis    p53 signaling pathway    PI3K-Akt signaling pathway    Hepatitis B    Measles    Pathways in cancer    Viral carcinogenesis    MicroRNAs in cancer    Prostate cancer    Small cell lung cancer   
NDEx NetworkCCNE1
Atlas of Cancer Signalling NetworkCCNE1
Wikipedia pathwaysCCNE1
Orthology - Evolution
OrthoDB898
GeneTree (enSembl)ENSG00000105173
Phylogenetic Trees/Animal Genes : TreeFamCCNE1
Homologs : HomoloGeneCCNE1
Homology/Alignments : Family Browser (UCSC)CCNE1
Gene fusions - Rearrangements
Fusion : MitelmanIGH/CCNE1 [14q32.33/19q12]  
Fusion : QuiverCCNE1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCCNE1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CCNE1
dbVarCCNE1
ClinVarCCNE1
MonarchCCNE1
1000_GenomesCCNE1 
Exome Variant ServerCCNE1
GNOMAD BrowserENSG00000105173
Varsome BrowserCCNE1
ACMGCCNE1 variants
VarityP24864
Genomic Variants (DGV)CCNE1 [DGVbeta]
DECIPHERCCNE1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCCNE1 
Mutations
ICGC Data PortalCCNE1 
TCGA Data PortalCCNE1 
Broad Tumor PortalCCNE1
OASIS PortalCCNE1 [ Somatic mutations - Copy number]
Cancer Gene: CensusCCNE1 
Somatic Mutations in Cancer : COSMICCCNE1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCCNE1
Mutations and Diseases : HGMDCCNE1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCCNE1
DgiDB (Drug Gene Interaction Database)CCNE1
DoCM (Curated mutations)CCNE1
CIViC (Clinical Interpretations of Variants in Cancer)CCNE1
Cancer3DCCNE1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM123837   
Orphanet
DisGeNETCCNE1
MedgenCCNE1
Genetic Testing Registry CCNE1
NextProtP24864 [Medical]
GENETestsCCNE1
Target ValidationCCNE1
Huge Navigator CCNE1 [HugePedia]
ClinGenCCNE1
Clinical trials, drugs, therapy
MyCancerGenomeCCNE1
Protein Interactions : CTDCCNE1
Pharm GKB GenePA96
PharosP24864
Clinical trialCCNE1
Miscellaneous
canSAR (ICR)CCNE1
HarmonizomeCCNE1
DataMed IndexCCNE1
Probes
Litterature
PubMed464 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCCNE1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:02:45 CEST 2021

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