CCNE2 (cyclin E2)

2003-02-01  

Identity

HGNC
LOCATION
8q22.1
LOCUSID
ALIAS
CYCE2
FUSION GENES

Other Information

Locus ID:

NCBI: 9134
MIM: 603775
HGNC: 1590
Ensembl: ENSG00000175305

Variants:

dbSNP: 9134
ClinVar: 9134
TCGA: ENSG00000175305
COSMIC: CCNE2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175305ENST00000308108O96020
ENSG00000175305ENST00000308108A0A024R9B0
ENSG00000175305ENST00000396133Q8WUE3
ENSG00000175305ENST00000519889E5RHN2
ENSG00000175305ENST00000520509O96020
ENSG00000175305ENST00000520509A0A024R9B0
ENSG00000175305ENST00000521809E5RK20
ENSG00000175305ENST00000524224H0YBQ2

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
p53 signaling pathwayKEGGko04115
Prostate cancerKEGGko05215
Small cell lung cancerKEGGko05222
Cell cycleKEGGhsa04110
p53 signaling pathwayKEGGhsa04115
Pathways in cancerKEGGhsa05200
Prostate cancerKEGGhsa05215
Small cell lung cancerKEGGhsa05222
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Hepatitis BKEGGhsa05161
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Cell cycle - G1/S transitionKEGGhsa_M00692
Cell cycle - G1/S transitionKEGGM00692
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Association of TriC/CCT with target proteins during biosynthesisREACTOMER-HSA-390471
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G1/S DNA Damage CheckpointsREACTOMER-HSA-69615
p53-Dependent G1/S DNA damage checkpointREACTOMER-HSA-69580
p53-Dependent G1 DNA Damage ResponseREACTOMER-HSA-69563
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G0 and Early G1REACTOMER-HSA-1538133
G1/S TransitionREACTOMER-HSA-69206
Cyclin E associated events during G1/S transitionREACTOMER-HSA-69202
SCF(Skp2)-mediated degradation of p27/p21REACTOMER-HSA-187577
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexesREACTOMER-HSA-69200
S PhaseREACTOMER-HSA-69242
Cyclin A:Cdk2-associated events at S phase entryREACTOMER-HSA-69656
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
DNA Damage/Telomere Stress Induced SenescenceREACTOMER-HSA-2559586
TP53 Regulates Transcription of Cell Cycle GenesREACTOMER-HSA-6791312
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestREACTOMER-HSA-6804116

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
385059212024Downregulation of miR-503-5p Promotes the Development of Pancreatic Cancer by Targeting Cyclin E2.0
385059212024Downregulation of miR-503-5p Promotes the Development of Pancreatic Cancer by Targeting Cyclin E2.0
350059882022Screening Differential CircRNAs Expression Profiles Reveals the Regulatory Role of the has_circTPT1_003-has-miR-218-5p-CCNE2/SMC4 Signaling Axis in Bladder Carcinoma Progression.1
350416432022Genome-wide chromatin contacts of super-enhancer-associated lncRNA identify LINC01013 as a regulator of fibrosis in the aortic valve.3
350059882022Screening Differential CircRNAs Expression Profiles Reveals the Regulatory Role of the has_circTPT1_003-has-miR-218-5p-CCNE2/SMC4 Signaling Axis in Bladder Carcinoma Progression.1
350416432022Genome-wide chromatin contacts of super-enhancer-associated lncRNA identify LINC01013 as a regulator of fibrosis in the aortic valve.3
337285852021SP1-induced overexpression of LINC00520 facilitates non-small cell lung cancer progression through miR-577/CCNE2 pathway and predicts poor prognosis.9
341289732021Vascular endothelial cell-derived exosomal miR-30a-5p inhibits lung adenocarcinoma malignant progression by targeting CCNE2.9
345213012021E2F transcription factor 1 (E2F1) promotes the transforming growth factor TGF-β1 induced human cardiac fibroblasts differentiation through promoting the transcription of CCNE2 gene.0
337285852021SP1-induced overexpression of LINC00520 facilitates non-small cell lung cancer progression through miR-577/CCNE2 pathway and predicts poor prognosis.9
341289732021Vascular endothelial cell-derived exosomal miR-30a-5p inhibits lung adenocarcinoma malignant progression by targeting CCNE2.9
345213012021E2F transcription factor 1 (E2F1) promotes the transforming growth factor TGF-β1 induced human cardiac fibroblasts differentiation through promoting the transcription of CCNE2 gene.0
316891222020Nicotine-upregulated miR-30a arrests cell cycle in G1 phase by directly targeting CCNE2 in human periodontal ligament cells.5
321417022020Antibiotic tigecycline inhibits cell proliferation, migration and invasion via down-regulating CCNE2 in pancreatic ductal adenocarcinoma.16
324877792020CARM1 promotes non-small cell lung cancer progression through upregulating CCNE2 expression.14

Citation

Dessen P

CCNE2 (cyclin E2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/957/ccne2