CCNG1 (cyclin G1)

2003-02-01  

Identity

HGNC
LOCATION
5q34
LOCUSID
ALIAS
CCNG
FUSION GENES

Other Information

Locus ID:

NCBI: 900
MIM: 601578
HGNC: 1592
Ensembl: ENSG00000113328

Variants:

dbSNP: 900
ClinVar: 900
TCGA: ENSG00000113328
COSMIC: CCNG1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113328ENST00000340828P51959
ENSG00000113328ENST00000393929P51959
ENSG00000113328ENST00000504553D6RD30
ENSG00000113328ENST00000510097D6RCC5
ENSG00000113328ENST00000510664E7ERZ1
ENSG00000113328ENST00000511490D6RGX3
ENSG00000113328ENST00000512163P51959

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
p53 signaling pathwayKEGGko04115
p53 signaling pathwayKEGGhsa04115
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Expression and DegradationREACTOMER-HSA-6806003
Regulation of TP53 DegradationREACTOMER-HSA-6804757

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
176166642007Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma.295
195842832009MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells.145
221053162012Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G(1) -modulated P53 activity.98
125565592003Cyclin G1 has growth inhibitory activity linked to the ARF-Mdm2-p53 and pRb tumor suppressor pathways.41
222715812012Cyclin G1-mediated epithelial-mesenchymal transition via phosphoinositide 3-kinase/Akt signaling facilitates liver cancer progression.38
266237192016The miR27b-CCNG1-P53-miR-508-5p axis regulates multidrug resistance of gastric cancer.28
254728772015Oleanolic acid suppresses the proliferation of lung carcinoma cells by miR-122/Cyclin G1/MEF2D axis.24
184080122008Cdk5-mediated phosphorylation of c-Myc on Ser-62 is essential in transcriptional activation of cyclin B1 by cyclin G1.23
150771712004The negative role of cyclin G in ATM-dependent p53 activation.22
178680902007Cyclin degradation for cancer therapy and chemoprevention.19

Citation

Dessen P

CCNG1 (cyclin G1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/959/ccng1