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CCNK (cyclin K)

Identity

Alias_symbol (synonym)CPR4
Other alias
HGNC (Hugo) CCNK
LocusID (NCBI) 8812
Atlas_Id 962
Location 14q32.2  [Link to chromosome band 14q32]
Location_base_pair Starts at 99481402 and ends at 99511515 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CCNK (14q32.2) / ATP13A1 (19p13.11)CCNK (14q32.2) / CCDC171 (9p22.3)CCNK (14q32.2) / MICB (6p21.33)
CITED4 (1p34.2) / CCNK (14q32.2)EML1 (14q32.2) / CCNK (14q32.2)IQSEC3 (12p13.33) / CCNK (14q32.2)
YY1 (14q32.2) / CCNK (14q32.2)CCNK 14q32.2 C9orf93EML1 14q32.2 / CCNK 14q32.2
YY1 14q32.2 / CCNK 14q32.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CCNK   1596
Cards
Entrez_Gene (NCBI)CCNK  8812  cyclin K
AliasesCPR4
GeneCards (Weizmann)CCNK
Ensembl hg19 (Hinxton)ENSG00000090061 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000090061 [Gene_View]  chr14:99481402-99511515 [Contig_View]  CCNK [Vega]
ICGC DataPortalENSG00000090061
TCGA cBioPortalCCNK
AceView (NCBI)CCNK
Genatlas (Paris)CCNK
WikiGenes8812
SOURCE (Princeton)CCNK
Genetics Home Reference (NIH)CCNK
Genomic and cartography
GoldenPath hg38 (UCSC)CCNK  -     chr14:99481402-99511515 +  14q32.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CCNK  -     14q32.2   [Description]    (hg19-Feb_2009)
EnsemblCCNK - 14q32.2 [CytoView hg19]  CCNK - 14q32.2 [CytoView hg38]
Mapping of homologs : NCBICCNK [Mapview hg19]  CCNK [Mapview hg38]
OMIM603544   
Gene and transcription
Genbank (Entrez)AB209373 AK311075 BC015935 BG503760 BM505592
RefSeq transcript (Entrez)NM_001099402 NM_003858
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CCNK
Cluster EST : UnigeneHs.510409 [ NCBI ]
CGAP (NCI)Hs.510409
Alternative Splicing GalleryENSG00000090061
Gene ExpressionCCNK [ NCBI-GEO ]   CCNK [ EBI - ARRAY_EXPRESS ]   CCNK [ SEEK ]   CCNK [ MEM ]
Gene Expression Viewer (FireBrowse)CCNK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8812
GTEX Portal (Tissue expression)CCNK
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75909   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75909  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75909
Splice isoforms : SwissVarO75909
PhosPhoSitePlusO75909
Domains : Interpro (EBI)Cyclin-like    Cyclin_C-dom    Cyclin_N   
Domain families : Pfam (Sanger)Cyclin_C (PF02984)    Cyclin_N (PF00134)   
Domain families : Pfam (NCBI)pfam02984    pfam00134   
Domain families : Smart (EMBL)CYCLIN (SM00385)  Cyclin_C (SM01332)  
Conserved Domain (NCBI)CCNK
DMDM Disease mutations8812
Blocks (Seattle)CCNK
PDB (SRS)2I53    4CXA    4NST    4UN0    5ACB    5EFQ   
PDB (PDBSum)2I53    4CXA    4NST    4UN0    5ACB    5EFQ   
PDB (IMB)2I53    4CXA    4NST    4UN0    5ACB    5EFQ   
PDB (RSDB)2I53    4CXA    4NST    4UN0    5ACB    5EFQ   
Structural Biology KnowledgeBase2I53    4CXA    4NST    4UN0    5ACB    5EFQ   
SCOP (Structural Classification of Proteins)2I53    4CXA    4NST    4UN0    5ACB    5EFQ   
CATH (Classification of proteins structures)2I53    4CXA    4NST    4UN0    5ACB    5EFQ   
SuperfamilyO75909
Human Protein AtlasENSG00000090061
Peptide AtlasO75909
IPIIPI00915260   IPI00783214   IPI00939644   IPI00953526   IPI00411579   IPI01026246   IPI01026566   IPI00431127   
Protein Interaction databases
DIP (DOE-UCLA)O75909
IntAct (EBI)O75909
FunCoupENSG00000090061
BioGRIDCCNK
STRING (EMBL)CCNK
ZODIACCCNK
Ontologies - Pathways
QuickGOO75909
Ontology : AmiGOregulation of cyclin-dependent protein serine/threonine kinase activity  cyclin K-CDK12 complex  cyclin K-CDK13 complex  protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  protein phosphorylation  cellular response to DNA damage stimulus  cell cycle  RNA polymerase II carboxy-terminal domain kinase activity  cyclin-dependent protein serine/threonine kinase regulator activity  protein kinase binding  snRNA transcription from RNA polymerase II promoter  negative regulation by host of viral genome replication  positive regulation of cyclin-dependent protein serine/threonine kinase activity  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  cell division  negative regulation of cell cycle arrest  positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues  
Ontology : EGO-EBIregulation of cyclin-dependent protein serine/threonine kinase activity  cyclin K-CDK12 complex  cyclin K-CDK13 complex  protein serine/threonine kinase activity  cyclin-dependent protein serine/threonine kinase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  protein phosphorylation  cellular response to DNA damage stimulus  cell cycle  RNA polymerase II carboxy-terminal domain kinase activity  cyclin-dependent protein serine/threonine kinase regulator activity  protein kinase binding  snRNA transcription from RNA polymerase II promoter  negative regulation by host of viral genome replication  positive regulation of cyclin-dependent protein serine/threonine kinase activity  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  cell division  negative regulation of cell cycle arrest  positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues  
NDEx NetworkCCNK
Atlas of Cancer Signalling NetworkCCNK
Wikipedia pathwaysCCNK
Orthology - Evolution
OrthoDB8812
GeneTree (enSembl)ENSG00000090061
Phylogenetic Trees/Animal Genes : TreeFamCCNK
HOVERGENO75909
HOGENOMO75909
Homologs : HomoloGeneCCNK
Homology/Alignments : Family Browser (UCSC)CCNK
Gene fusions - Rearrangements
Fusion : MitelmanCCNK/CCDC171 [14q32.2/9p22.3]  
Fusion : MitelmanEML1/CCNK [14q32.2/14q32.2]  [t(14;14)(q32;q32)]  
Fusion : MitelmanYY1/CCNK [14q32.2/14q32.2]  [t(14;14)(q32;q32)]  
Fusion: TCGACCNK 14q32.2 C9orf93 BRCA
Fusion: TCGAEML1 14q32.2 CCNK 14q32.2 BRCA
Fusion: TCGAYY1 14q32.2 CCNK 14q32.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCCNK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CCNK
dbVarCCNK
ClinVarCCNK
1000_GenomesCCNK 
Exome Variant ServerCCNK
ExAC (Exome Aggregation Consortium)CCNK (select the gene name)
Genetic variants : HAPMAP8812
Genomic Variants (DGV)CCNK [DGVbeta]
DECIPHERCCNK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCCNK 
Mutations
ICGC Data PortalCCNK 
TCGA Data PortalCCNK 
Broad Tumor PortalCCNK
OASIS PortalCCNK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCCNK  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCCNK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CCNK
DgiDB (Drug Gene Interaction Database)CCNK
DoCM (Curated mutations)CCNK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CCNK (select a term)
intoGenCCNK
Cancer3DCCNK(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603544   
Orphanet
MedgenCCNK
Genetic Testing Registry CCNK
NextProtO75909 [Medical]
TSGene8812
GENETestsCCNK
Target ValidationCCNK
Huge Navigator CCNK [HugePedia]
snp3D : Map Gene to Disease8812
BioCentury BCIQCCNK
ClinGenCCNK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8812
Chemical/Pharm GKB GenePA26161
Clinical trialCCNK
Miscellaneous
canSAR (ICR)CCNK (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCCNK
EVEXCCNK
GoPubMedCCNK
iHOPCCNK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 13:49:04 CEST 2017

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