CCNK (cyclin K)

2003-11-01  

Identity

HGNC
LOCATION
14q32.2
LOCUSID
ALIAS
CPR4,IDDHDF
FUSION GENES

Other Information

Locus ID:

NCBI: 8812
MIM: 603544
HGNC: 1596
Ensembl: ENSG00000090061

Variants:

dbSNP: 8812
ClinVar: 8812
TCGA: ENSG00000090061
COSMIC: CCNK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000090061ENST00000389879O75909
ENSG00000090061ENST00000389879A0A024R6K1
ENSG00000090061ENST00000555049G3V5E1
ENSG00000090061ENST00000555842G3V235
ENSG00000090061ENST00000557441G3V2Q3

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Transcription of the HIV genomeREACTOMER-HSA-167172
HIV elongation arrest and recoveryREACTOMER-HSA-167287
Formation of HIV elongation complex in the absence of HIV TatREACTOMER-HSA-167152
Pausing and recovery of HIV elongationREACTOMER-HSA-167290
Signal TransductionREACTOMER-HSA-162582
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerREACTOMER-HSA-2173793
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionREACTOMER-HSA-2173796
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Pre-transcription EventsREACTOMER-HSA-674695
RNA Polymerase II Transcription ElongationREACTOMER-HSA-75955
Formation of RNA Pol II elongation complexREACTOMER-HSA-112382
TP53 Regulates Transcription of DNA Repair GenesREACTOMER-HSA-6796648
RNA polymerase II transcribes snRNA genesREACTOMER-HSA-6807505

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD
PA443560Breast NeoplasmsDiseaseClinicalAnnotationassociatedPD
PA445113NeutropeniaDiseaseClinicalAnnotationassociatedPD
PA449165cyclophosphamideChemicalClinicalAnnotationassociatedPD
PA449476epirubicinChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
229882982012Interaction of cyclin-dependent kinase 12/CrkRS with cyclin K1 is required for the phosphorylation of the C-terminal domain of RNA polymerase II.40
209308492010Cyclin-dependent kinase 9-cyclin K functions in the replication stress response.39
257120992015Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex.31
118843992002P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA.27
225470582012Cyclin K-containing kinase complexes maintain self-renewal in murine embryonic stem cells.24
294749052018A Non-catalytic Function of SETD1A Regulates Cyclin K and the DNA Damage Response.24
119888472002Cyclin K as a direct transcriptional target of the p53 tumor suppressor.12
171693702007Crystal structure of human cyclin K, a positive regulator of cyclin-dependent kinase 9.12
265971752015Structures of the CDK12/CycK complex with AMP-PNP reveal a flexible C-terminal kinase extension important for ATP binding.8
204597412010Cyclin K and cyclin D1b are oncogenic in myeloma cells.7

Citation

Dessen P

CCNK (cyclin K)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/962/ccnk