Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CCNT1 (cyclin T1)

Identity

Alias (NCBI)CCNT
CYCT1
HIVE1
HGNC (Hugo) CCNT1
HGNC Alias symbCCNT
CYCT1
HGNC Previous nameHIVE1
HGNC Previous namehuman immunodeficiency virus type 1 (HIV-1) expression (elevated) 1
LocusID (NCBI) 904
Atlas_Id 47404
Location 12q13.11  [Link to chromosome band 12q13]
Location_base_pair Starts at 48688458 and ends at 48716707 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(4;11)(q21;q23) KMT2A::AFF1


External links

 

Nomenclature
HGNC (Hugo)CCNT1   1599
Cards
Entrez_Gene (NCBI)CCNT1    cyclin T1
AliasesCCNT; CYCT1; HIVE1
GeneCards (Weizmann)CCNT1
Ensembl hg19 (Hinxton)ENSG00000129315 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000129315 [Gene_View]  ENSG00000129315 [Sequence]  chr12:48688458-48716707 [Contig_View]  CCNT1 [Vega]
ICGC DataPortalENSG00000129315
TCGA cBioPortalCCNT1
AceView (NCBI)CCNT1
Genatlas (Paris)CCNT1
SOURCE (Princeton)CCNT1
Genetics Home Reference (NIH)CCNT1
Genomic and cartography
GoldenPath hg38 (UCSC)CCNT1  -     chr12:48688458-48716707 -  12q13.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CCNT1  -     12q13.11   [Description]    (hg19-Feb_2009)
GoldenPathCCNT1 - 12q13.11 [CytoView hg19]  CCNT1 - 12q13.11 [CytoView hg38]
ImmunoBaseENSG00000129315
Genome Data Viewer NCBICCNT1 [Mapview hg19]  
OMIM143055   
Gene and transcription
Genbank (Entrez)AF045161 AF048730 AK002085 AK290990 AL832083
RefSeq transcript (Entrez)NM_001240 NM_001277842
Consensus coding sequences : CCDS (NCBI)CCNT1
Gene ExpressionCCNT1 [ NCBI-GEO ]   CCNT1 [ EBI - ARRAY_EXPRESS ]   CCNT1 [ SEEK ]   CCNT1 [ MEM ]
Gene Expression Viewer (FireBrowse)CCNT1 [ Firebrowse - Broad ]
GenevisibleExpression of CCNT1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)904
GTEX Portal (Tissue expression)CCNT1
Human Protein AtlasENSG00000129315-CCNT1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60563   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60563  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60563
PhosPhoSitePlusO60563
Domains : Interpro (EBI)CCNT1    Cyclin-like    Cyclin-like_sf    Cyclin/Ssn8    Cyclin_N   
Domain families : Pfam (Sanger)Cyclin_N (PF00134)   
Domain families : Pfam (NCBI)pfam00134   
Domain families : Smart (EMBL)CYCLIN (SM00385)  
Conserved Domain (NCBI)CCNT1
PDB (RSDB)2PK2    3BLH    3BLQ    3BLR    3LQ5    3MI9    3MIA    3MY1    3TN8    3TNH    3TNI    4BCF    4BCG    4BCH    4BCI    4BCJ    4EC8    4EC9    4IMY    4OGR    4OR5    5L1Z    6CYT    6GZH   
PDB Europe2PK2    3BLH    3BLQ    3BLR    3LQ5    3MI9    3MIA    3MY1    3TN8    3TNH    3TNI    4BCF    4BCG    4BCH    4BCI    4BCJ    4EC8    4EC9    4IMY    4OGR    4OR5    5L1Z    6CYT    6GZH   
PDB (PDBSum)2PK2    3BLH    3BLQ    3BLR    3LQ5    3MI9    3MIA    3MY1    3TN8    3TNH    3TNI    4BCF    4BCG    4BCH    4BCI    4BCJ    4EC8    4EC9    4IMY    4OGR    4OR5    5L1Z    6CYT    6GZH   
PDB (IMB)2PK2    3BLH    3BLQ    3BLR    3LQ5    3MI9    3MIA    3MY1    3TN8    3TNH    3TNI    4BCF    4BCG    4BCH    4BCI    4BCJ    4EC8    4EC9    4IMY    4OGR    4OR5    5L1Z    6CYT    6GZH   
Structural Biology KnowledgeBase2PK2    3BLH    3BLQ    3BLR    3LQ5    3MI9    3MIA    3MY1    3TN8    3TNH    3TNI    4BCF    4BCG    4BCH    4BCI    4BCJ    4EC8    4EC9    4IMY    4OGR    4OR5    5L1Z    6CYT    6GZH   
SCOP (Structural Classification of Proteins)2PK2    3BLH    3BLQ    3BLR    3LQ5    3MI9    3MIA    3MY1    3TN8    3TNH    3TNI    4BCF    4BCG    4BCH    4BCI    4BCJ    4EC8    4EC9    4IMY    4OGR    4OR5    5L1Z    6CYT    6GZH   
CATH (Classification of proteins structures)2PK2    3BLH    3BLQ    3BLR    3LQ5    3MI9    3MIA    3MY1    3TN8    3TNH    3TNI    4BCF    4BCG    4BCH    4BCI    4BCJ    4EC8    4EC9    4IMY    4OGR    4OR5    5L1Z    6CYT    6GZH   
SuperfamilyO60563
AlphaFold pdb e-kbO60563   
Human Protein Atlas [tissue]ENSG00000129315-CCNT1 [tissue]
HPRD03938
Protein Interaction databases
DIP (DOE-UCLA)O60563
IntAct (EBI)O60563
BioGRIDCCNT1
STRING (EMBL)CCNT1
ZODIACCCNT1
Ontologies - Pathways
QuickGOO60563
Ontology : AmiGOregulation of cyclin-dependent protein serine/threonine kinase activity  transcription cis-regulatory region binding  DNA binding  chromatin binding  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  nucleolus  cytosol  regulation of transcription by RNA polymerase II  transcription by RNA polymerase II  protein phosphorylation  protein phosphorylation  cell cycle  cyclin/CDK positive transcription elongation factor complex  cyclin/CDK positive transcription elongation factor complex  cyclin/CDK positive transcription elongation factor complex  cyclin-dependent protein serine/threonine kinase regulator activity  protein kinase binding  positive regulation of DNA-templated transcription, elongation  positive regulation of transcription elongation from RNA polymerase II promoter  positive regulation by host of viral transcription  positive regulation by host of viral transcription  positive regulation of cyclin-dependent protein serine/threonine kinase activity  positive regulation of transcription by RNA polymerase II  cell division  cyclin-dependent protein serine/threonine kinase activator activity  RNA polymerase binding  P-TEFb complex  7SK snRNA binding  DNA-binding transcription factor binding  negative regulation of mRNA polyadenylation  phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter  phosphorylation of RNA polymerase II C-terminal domain serine 2 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter  
Ontology : EGO-EBIregulation of cyclin-dependent protein serine/threonine kinase activity  transcription cis-regulatory region binding  DNA binding  chromatin binding  protein binding  nucleus  nucleus  nucleoplasm  nucleoplasm  nucleolus  cytosol  regulation of transcription by RNA polymerase II  transcription by RNA polymerase II  protein phosphorylation  protein phosphorylation  cell cycle  cyclin/CDK positive transcription elongation factor complex  cyclin/CDK positive transcription elongation factor complex  cyclin/CDK positive transcription elongation factor complex  cyclin-dependent protein serine/threonine kinase regulator activity  protein kinase binding  positive regulation of DNA-templated transcription, elongation  positive regulation of transcription elongation from RNA polymerase II promoter  positive regulation by host of viral transcription  positive regulation by host of viral transcription  positive regulation of cyclin-dependent protein serine/threonine kinase activity  positive regulation of transcription by RNA polymerase II  cell division  cyclin-dependent protein serine/threonine kinase activator activity  RNA polymerase binding  P-TEFb complex  7SK snRNA binding  DNA-binding transcription factor binding  negative regulation of mRNA polyadenylation  phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter  phosphorylation of RNA polymerase II C-terminal domain serine 2 residues involved in positive regulation of transcription elongation from RNA polymerase II promoter  
NDEx NetworkCCNT1
Atlas of Cancer Signalling NetworkCCNT1
Wikipedia pathwaysCCNT1
Orthology - Evolution
OrthoDB904
GeneTree (enSembl)ENSG00000129315
Phylogenetic Trees/Animal Genes : TreeFamCCNT1
Homologs : HomoloGeneCCNT1
Homology/Alignments : Family Browser (UCSC)CCNT1
Gene fusions - Rearrangements
Fusion : QuiverCCNT1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCCNT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CCNT1
dbVarCCNT1
ClinVarCCNT1
MonarchCCNT1
1000_GenomesCCNT1 
Exome Variant ServerCCNT1
GNOMAD BrowserENSG00000129315
Varsome BrowserCCNT1
ACMGCCNT1 variants
VarityO60563
Genomic Variants (DGV)CCNT1 [DGVbeta]
DECIPHERCCNT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCCNT1 
Mutations
ICGC Data PortalCCNT1 
TCGA Data PortalCCNT1 
Broad Tumor PortalCCNT1
OASIS PortalCCNT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCCNT1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCCNT1
Mutations and Diseases : HGMDCCNT1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCCNT1
DgiDB (Drug Gene Interaction Database)CCNT1
DoCM (Curated mutations)CCNT1
CIViC (Clinical Interpretations of Variants in Cancer)CCNT1
Cancer3DCCNT1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM143055   
Orphanet
DisGeNETCCNT1
MedgenCCNT1
Genetic Testing Registry CCNT1
NextProtO60563 [Medical]
GENETestsCCNT1
Target ValidationCCNT1
Huge Navigator CCNT1 [HugePedia]
ClinGenCCNT1
Clinical trials, drugs, therapy
MyCancerGenomeCCNT1
Protein Interactions : CTDCCNT1
Pharm GKB GenePA26163
PharosO60563
Clinical trialCCNT1
Miscellaneous
canSAR (ICR)CCNT1
HarmonizomeCCNT1
ARCHS4CCNT1
DataMed IndexCCNT1
Probes
Litterature
PubMed381 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCCNT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jan 20 12:26:17 CET 2022

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