CCNT2 (cyclin T2)

2006-10-01  

Identity

HGNC
LOCATION
2q21.3
LOCUSID
ALIAS
CYCT2
FUSION GENES

Other Information

Locus ID:

NCBI: 905
MIM: 603862
HGNC: 1600
Ensembl: ENSG00000082258

Variants:

dbSNP: 905
ClinVar: 905
TCGA: ENSG00000082258
COSMIC: CCNT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000082258ENST00000264157O60583
ENSG00000082258ENST00000295238O60583
ENSG00000082258ENST00000417175F8WDY7
ENSG00000082258ENST00000419781F2Z2C9
ENSG00000082258ENST00000438691H7C411
ENSG00000082258ENST00000446247C9JUL2
ENSG00000082258ENST00000452521H7BZ27
ENSG00000082258ENST00000452839F2Z2C9

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Transcription of the HIV genomeREACTOMER-HSA-167172
HIV elongation arrest and recoveryREACTOMER-HSA-167287
Formation of HIV elongation complex in the absence of HIV TatREACTOMER-HSA-167152
Pausing and recovery of HIV elongationREACTOMER-HSA-167290
Signal TransductionREACTOMER-HSA-162582
Signaling by TGF-beta Receptor ComplexREACTOMER-HSA-170834
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimerREACTOMER-HSA-2173793
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionREACTOMER-HSA-2173796
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Pre-transcription EventsREACTOMER-HSA-674695
RNA Polymerase II Transcription ElongationREACTOMER-HSA-75955
Formation of RNA Pol II elongation complexREACTOMER-HSA-112382
TP53 Regulates Transcription of DNA Repair GenesREACTOMER-HSA-6796648
RNA polymerase II transcribes snRNA genesREACTOMER-HSA-6807505

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
174524632007Regulation of P-TEFb elongation complex activity by CDK9 acetylation.33
245151072014Release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein (snRNP) activates hexamethylene bisacetamide-inducible protein (HEXIM1) transcription.26
183911972008TFIID component TAF7 functionally interacts with both TFIIH and P-TEFb.22
120376722002Physical interaction between pRb and cdk9/cyclinT2 complex.19
198836592010Specificity of Hexim1 and Hexim2 complex formation with cyclin T1/T2, importin alpha and 7SK snRNA.12
284093302017MicroRNA-192 regulates cell proliferation and cell cycle transition in acute myeloid leukemia via interaction with CCNT2.9
168410872007Abrogation of signal-dependent activation of the cdk9/cyclin T2a complex in human RD rhabdomyosarcoma cells.7
163316892006Pkn is a novel partner of cyclin T2a in muscle differentiation.4
155638432004Transcriptional activity and substrate recognition of cyclin T2 from P-TEFb.3

Citation

Dessen P

CCNT2 (cyclin T2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43195/ccnt2