CCR3 (C-C motif chemokine receptor 3)

2007-02-01  

Identity

HGNC
LOCATION
3p21.31
LOCUSID
ALIAS
C

Other Information

Locus ID:

NCBI: 1232
MIM: 601268
HGNC: 1604
Ensembl: ENSG00000183625

Variants:

dbSNP: 1232
ClinVar: 1232
TCGA: ENSG00000183625
COSMIC: CCR3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183625ENST00000357422P51677
ENSG00000183625ENST00000357422A0A024R2Z3
ENSG00000183625ENST00000395940P51677
ENSG00000183625ENST00000395940A0A024R2Z3
ENSG00000183625ENST00000395942P51677
ENSG00000183625ENST00000395942A0A024R2Z3
ENSG00000183625ENST00000452454Q8TDP5
ENSG00000183625ENST00000457243Q8TDP4
ENSG00000183625ENST00000545097P51677

Expression (GTEx)

0
1
2
3

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Cytokine-cytokine receptor interactionKEGGhsa04060
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Chemokine receptors bind chemokinesREACTOMER-HSA-380108
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
183111402008Newly identified genetic risk variants for celiac disease related to the immune response.231
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
195259302009CCR3 is a target for age-related macular degeneration diagnosis and therapy.94
190179982008Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases.73
267563522016Periprostatic adipocytes act as a driving force for prostate cancer progression in obesity.60
146470582003Association of genetic variants of the chemokine receptor CCR5 and its ligands, RANTES and MCP-2, with outcome of HCV infection.50
192476922009Analyses of associations with asthma in four asthma population samples from Canada and Australia.39
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38
128842992003CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11.33
186361242008Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.32

Citation

Dessen P

CCR3 (C-C motif chemokine receptor 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46317/ccr3