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CCR4 (C-C motif chemokine receptor 4)

Identity

Alias_nameschemokine (C-C motif) receptor 4
Alias_symbol (synonym)CC-CKR-4
CMKBR4
CKR4
k5-5
ChemR13
CD194
Other aliasHGCN:14099
K5-5
HGNC (Hugo) CCR4
LocusID (NCBI) 1233
Atlas_Id 45869
Location 3p22.3  [Link to chromosome band 3p22]
Location_base_pair Starts at 32951574 and ends at 32954911 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CCR4   1605
Cards
Entrez_Gene (NCBI)CCR4  1233  C-C motif chemokine receptor 4
AliasesCC-CKR-4; CD194; CKR4; CMKBR4; 
ChemR13; HGCN:14099; K5-5
GeneCards (Weizmann)CCR4
Ensembl hg19 (Hinxton)ENSG00000183813 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000183813 [Gene_View]  chr3:32951574-32954911 [Contig_View]  CCR4 [Vega]
ICGC DataPortalENSG00000183813
TCGA cBioPortalCCR4
AceView (NCBI)CCR4
Genatlas (Paris)CCR4
WikiGenes1233
SOURCE (Princeton)CCR4
Genetics Home Reference (NIH)CCR4
Genomic and cartography
GoldenPath hg38 (UCSC)CCR4  -     chr3:32951574-32954911 +  3p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CCR4  -     3p22.3   [Description]    (hg19-Feb_2009)
EnsemblCCR4 - 3p22.3 [CytoView hg19]  CCR4 - 3p22.3 [CytoView hg38]
Mapping of homologs : NCBICCR4 [Mapview hg19]  CCR4 [Mapview hg38]
OMIM604836   
Gene and transcription
Genbank (Entrez)AK292674 BC069139 BC071751 BC074935 CD639869
RefSeq transcript (Entrez)NM_005508
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CCR4
Cluster EST : UnigeneHs.184926 [ NCBI ]
CGAP (NCI)Hs.184926
Alternative Splicing GalleryENSG00000183813
Gene ExpressionCCR4 [ NCBI-GEO ]   CCR4 [ EBI - ARRAY_EXPRESS ]   CCR4 [ SEEK ]   CCR4 [ MEM ]
Gene Expression Viewer (FireBrowse)CCR4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1233
GTEX Portal (Tissue expression)CCR4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51679   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51679  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51679
Splice isoforms : SwissVarP51679
PhosPhoSitePlusP51679
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)Chemokine_CCR4    Chemokine_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Domain families : Smart (EMBL)7TM_GPCR_Srsx (SM01381)  
Conserved Domain (NCBI)CCR4
DMDM Disease mutations1233
Blocks (Seattle)CCR4
SuperfamilyP51679
Human Protein AtlasENSG00000183813
Peptide AtlasP51679
HPRD05324
IPIIPI00019958   
Protein Interaction databases
DIP (DOE-UCLA)P51679
IntAct (EBI)P51679
FunCoupENSG00000183813
BioGRIDCCR4
STRING (EMBL)CCR4
ZODIACCCR4
Ontologies - Pathways
QuickGOP51679
Ontology : AmiGOneuron migration  tolerance induction  chemokine receptor activity  plasma membrane  integral component of plasma membrane  chemotaxis  inflammatory response  immune response  G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  response to radiation  response to bacterium  external side of plasma membrane  C-C chemokine receptor activity  neuronal cell body  response to antibiotic  homeostasis of number of cells  positive regulation of positive chemotaxis  chemokine-mediated signaling pathway  
Ontology : EGO-EBIneuron migration  tolerance induction  chemokine receptor activity  plasma membrane  integral component of plasma membrane  chemotaxis  inflammatory response  immune response  G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  response to radiation  response to bacterium  external side of plasma membrane  C-C chemokine receptor activity  neuronal cell body  response to antibiotic  homeostasis of number of cells  positive regulation of positive chemotaxis  chemokine-mediated signaling pathway  
Pathways : BIOCARTASelective expression of chemokine receptors during T-cell polarization [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway    Viral carcinogenesis   
NDEx NetworkCCR4
Atlas of Cancer Signalling NetworkCCR4
Wikipedia pathwaysCCR4
Orthology - Evolution
OrthoDB1233
GeneTree (enSembl)ENSG00000183813
Phylogenetic Trees/Animal Genes : TreeFamCCR4
HOVERGENP51679
HOGENOMP51679
Homologs : HomoloGeneCCR4
Homology/Alignments : Family Browser (UCSC)CCR4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCCR4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CCR4
dbVarCCR4
ClinVarCCR4
1000_GenomesCCR4 
Exome Variant ServerCCR4
ExAC (Exome Aggregation Consortium)CCR4 (select the gene name)
Genetic variants : HAPMAP1233
Genomic Variants (DGV)CCR4 [DGVbeta]
DECIPHERCCR4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCCR4 
Mutations
ICGC Data PortalCCR4 
TCGA Data PortalCCR4 
Broad Tumor PortalCCR4
OASIS PortalCCR4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCCR4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCCR4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CCR4
DgiDB (Drug Gene Interaction Database)CCR4
DoCM (Curated mutations)CCR4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CCR4 (select a term)
intoGenCCR4
Cancer3DCCR4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604836   
Orphanet
MedgenCCR4
Genetic Testing Registry CCR4
NextProtP51679 [Medical]
TSGene1233
GENETestsCCR4
Target ValidationCCR4
Huge Navigator CCR4 [HugePedia]
snp3D : Map Gene to Disease1233
BioCentury BCIQCCR4
ClinGenCCR4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1233
Chemical/Pharm GKB GenePA26169
Clinical trialCCR4
Miscellaneous
canSAR (ICR)CCR4 (select the gene name)
Probes
Litterature
PubMed79 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCCR4
EVEXCCR4
GoPubMedCCR4
iHOPCCR4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:27:16 CEST 2017

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