Atlas of Genetics and Cytogenetics in Oncology and Haematology


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CCR5 (chemokine (C-C motif) receptor 5 (gene/pseudogene))

Identity

Other namesCC-CKR-5
CCCKR5
CCR-5
CD195
CKR-5
CKR5
CMKBR5
IDDM22
HGNC (Hugo) CCR5
LocusID (NCBI) 1234
Location 3p21.31
Location_base_pair Starts at 46411633 and ends at 46417697 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)CCR5   1606
Cards
Entrez_Gene (NCBI)CCR5  1234  chemokine (C-C motif) receptor 5 (gene/pseudogene)
GeneCards (Weizmann)CCR5
Ensembl (Hinxton)ENSG00000160791 [Gene_View]  chr3:46411633-46417697 [Contig_View]  CCR5 [Vega]
ICGC DataPortalENSG00000160791
cBioPortalCCR5
AceView (NCBI)CCR5
Genatlas (Paris)CCR5
WikiGenes1234
SOURCE (Princeton)NM_000579 NM_001100168
Genomic and cartography
GoldenPath (UCSC)CCR5  -  3p21.31   chr3:46411633-46417697 +  3p21.31   [Description]    (hg19-Feb_2009)
EnsemblCCR5 - 3p21.31 [CytoView]
Mapping of homologs : NCBICCR5 [Mapview]
OMIM601373   609532   610379   612522   
Gene and transcription
Genbank (Entrez)AF011500 AF011501 AF011502 AF011503 AF011504
RefSeq transcript (Entrez)NM_000579 NM_001100168
RefSeq genomic (Entrez)AC_000135 NC_000003 NC_018914 NG_012637 NT_022517 NW_001838877 NW_004929309
Consensus coding sequences : CCDS (NCBI)CCR5
Cluster EST : UnigeneHs.450802 [ NCBI ]
CGAP (NCI)Hs.450802
Alternative Splicing : Fast-db (Paris)GSHG0020769
Alternative Splicing GalleryENSG00000160791
Gene ExpressionCCR5 [ NCBI-GEO ]     CCR5 [ SEEK ]   CCR5 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51681 (Uniprot)
NextProtP51681  [Medical]
With graphics : InterProP51681
Splice isoforms : SwissVarP51681 (Swissvar)
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)Chemokine_CCR5 [organisation]   Chemokine_rcpt [organisation]   GPCR_Rhodpsn [organisation]   GPCR_Rhodpsn_7TM [organisation]  
Related proteins : CluSTrP51681
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
DMDM Disease mutations1234
Blocks (Seattle)P51681
PDB (SRS)1ND8    1NE0    1OPN    1OPT    1OPW    2L87    2RLL    2RRS    4MBS   
PDB (PDBSum)1ND8    1NE0    1OPN    1OPT    1OPW    2L87    2RLL    2RRS    4MBS   
PDB (IMB)1ND8    1NE0    1OPN    1OPT    1OPW    2L87    2RLL    2RRS    4MBS   
PDB (RSDB)1ND8    1NE0    1OPN    1OPT    1OPW    2L87    2RLL    2RRS    4MBS   
Human Protein AtlasENSG00000160791 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP51681
HPRD03223
IPIIPI00743929   IPI00940687   
Protein Interaction databases
DIP (DOE-UCLA)P51681
IntAct (EBI)P51681
FunCoupENSG00000160791
BioGRIDCCR5
InParanoidP51681
Interologous Interaction database P51681
IntegromeDBCCR5
STRING (EMBL)CCR5
Ontologies - Pathways
Ontology : AmiGOMAPK cascade  dendritic cell chemotaxis  actin binding  phosphatidylinositol phospholipase C activity  chemokine receptor activity  protein binding  cytoplasm  endosome  plasma membrane  integral component of plasma membrane  calcium ion transport  chemotaxis  inflammatory response  immune response  cellular defense response  cell surface receptor signaling pathway  G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  cell-cell signaling  external side of plasma membrane  cell surface  release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  coreceptor activity  viral process  C-C chemokine receptor activity  C-C chemokine receptor activity  calcium-mediated signaling  C-C chemokine binding  signaling  entry into host cell  chemokine-mediated signaling pathway  chemokine-mediated signaling pathway  chemokine-mediated signaling pathway  chemokine-mediated signaling pathway  response to cholesterol  cellular response to lipopolysaccharide  chemokine (C-C motif) ligand 5 binding  
Ontology : EGO-EBIMAPK cascade  dendritic cell chemotaxis  actin binding  phosphatidylinositol phospholipase C activity  chemokine receptor activity  protein binding  cytoplasm  endosome  plasma membrane  integral component of plasma membrane  calcium ion transport  chemotaxis  inflammatory response  immune response  cellular defense response  cell surface receptor signaling pathway  G-protein coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  cell-cell signaling  external side of plasma membrane  cell surface  release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  coreceptor activity  viral process  C-C chemokine receptor activity  C-C chemokine receptor activity  calcium-mediated signaling  C-C chemokine binding  signaling  entry into host cell  chemokine-mediated signaling pathway  chemokine-mediated signaling pathway  chemokine-mediated signaling pathway  chemokine-mediated signaling pathway  response to cholesterol  cellular response to lipopolysaccharide  chemokine (C-C motif) ligand 5 binding  
Pathways : BIOCARTAIL12 and Stat4 Dependent Signaling Pathway in Th1 Development [Genes]    HIV Induced T Cell Apoptosis [Genes]    Pertussis toxin-insensitive CCR5 Signaling in Macrophage [Genes]    NO2-dependent IL 12 Pathway in NK cells [Genes]    Selective expression of chemokine receptors during T-cell polarization [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway    Endocytosis    Toxoplasmosis    Viral carcinogenesis   
Protein Interaction DatabaseCCR5
Wikipedia pathwaysCCR5
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)CCR5
snp3D : Map Gene to Disease1234
SNP (GeneSNP Utah)CCR5
SNP : HGBaseCCR5
Genetic variants : HAPMAPCCR5
Exome VariantCCR5
1000_GenomesCCR5 
ICGC programENSG00000160791 
Somatic Mutations in Cancer : COSMICCCR5 
CONAN: Copy Number AnalysisCCR5 
Mutations and Diseases : HGMDCCR5
Genomic VariantsCCR5  CCR5 [DGVbeta]
dbVarCCR5
ClinVarCCR5
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM601373    609532    610379    612522   
MedgenCCR5
GENETestsCCR5
Disease Genetic AssociationCCR5
Huge Navigator CCR5 [HugePedia]  CCR5 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneCCR5
Homology/Alignments : Family Browser (UCSC)CCR5
Phylogenetic Trees/Animal Genes : TreeFamCCR5
Chemical/Protein Interactions : CTD1234
Chemical/Pharm GKB GenePA26170
Clinical trialCCR5
Cancer Resource (Charite)ENSG00000160791
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineCCR5
iHOPCCR5
OncoSearchCCR5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 30 13:46:54 CEST 2014

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