CCR6 (C-C motif chemokine receptor 6)

2007-02-01 Affiliation

Identity

HGNC

CCR6

LOCATION

6q27

LOCUSID

1235

ALIAS

BN-1,C-C

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1235
MIM: 601835
HGNC: 1607
Ensembl: ENSG00000112486

Variants:

dbSNP: 1235
ClinVar: 1235
TCGA: ENSG00000112486
COSMIC: CCR6

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000112486	ENST00000341935	P51684
ENSG00000112486	ENST00000349984	P51684
ENSG00000112486	ENST00000400926	P51684
ENSG00000112486	ENST00000643861	P51684
ENSG00000112486	ENST00000646493	A0A2R8YFT5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Chemokine signaling pathway	KEGG	ko04062
Chemokine signaling pathway	KEGG	hsa04062
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Defensins	REACTOME	R-HSA-1461973
Beta defensins	REACTOME	R-HSA-1461957
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Peptide ligand-binding receptors	REACTOME	R-HSA-375276
Chemokine receptors bind chemokines	REACTOME	R-HSA-380108
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594
Antimicrobial peptides	REACTOME	R-HSA-6803157

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
20453842	2010	Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.	480
19305396	2009	C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE.	360
20511548	2010	Mesenchymal stem cells inhibit human Th17 cell differentiation and function and induce a T regulatory cell phenotype.	155
18097022	2008	Human T cells that are able to produce IL-17 express the chemokine receptor CCR6.	127
19249008	2009	Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease.	109
20334681	2010	Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus.	93
20483750	2010	Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2.	92
20453841	2010	A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.	89
20453841	2010	A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility.	89
12070001	2002	Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity.	85

Citation

Dessen P

CCR6 (C-C motif chemokine receptor 6)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45782/ccr6