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CCR6 (C-C motif chemokine receptor 6)

Identity

Alias_namesSTRL22
chemokine (C-C motif) receptor 6
Alias_symbol (synonym)CKR-L3
GPR-CY4
CMKBR6
GPR29
DRY-6
DCR2
BN-1
CD196
Other aliasC-C CKR-6
CC-CKR-6
CCR-6
CKRL3
DRY6
GPRCY4
HGNC (Hugo) CCR6
LocusID (NCBI) 1235
Atlas_Id 45782
Location 6q27  [Link to chromosome band 6q27]
Location_base_pair Starts at 167122753 and ends at 167139141 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCR6 (6q27) / FGFR1 (8p11.23)CCR6 (6q27) / GABRR2 (6q15)CCR6 (6q27) / WBSCR22 (7q11.23)
PAIP2 (5q31.2) / CCR6 (6q27)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CCR6   1607
Cards
Entrez_Gene (NCBI)CCR6  1235  C-C motif chemokine receptor 6
AliasesBN-1; C-C; CC-CKR-6; CCR-6; 
CD196; CKR-L3; CKRL3; CMKBR6; DCR2; DRY6; GPR29; GPRCY4; STRL22
GeneCards (Weizmann)CCR6
Ensembl hg19 (Hinxton)ENSG00000112486 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112486 [Gene_View]  ENSG00000112486 [Sequence]  chr6:167122753-167139141 [Contig_View]  CCR6 [Vega]
ICGC DataPortalENSG00000112486
TCGA cBioPortalCCR6
AceView (NCBI)CCR6
Genatlas (Paris)CCR6
WikiGenes1235
SOURCE (Princeton)CCR6
Genetics Home Reference (NIH)CCR6
Genomic and cartography
GoldenPath hg38 (UCSC)CCR6  -     chr6:167122753-167139141 +  6q27   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CCR6  -     6q27   [Description]    (hg19-Feb_2009)
EnsemblCCR6 - 6q27 [CytoView hg19]  CCR6 - 6q27 [CytoView hg38]
Mapping of homologs : NCBICCR6 [Mapview hg19]  CCR6 [Mapview hg38]
OMIM601835   
Gene and transcription
Genbank (Entrez)AK223494 AK293015 AY242126 BC037960 CD692892
RefSeq transcript (Entrez)NM_004367 NM_031409
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CCR6
Cluster EST : UnigeneHs.46468 [ NCBI ]
CGAP (NCI)Hs.46468
Alternative Splicing GalleryENSG00000112486
Gene ExpressionCCR6 [ NCBI-GEO ]   CCR6 [ EBI - ARRAY_EXPRESS ]   CCR6 [ SEEK ]   CCR6 [ MEM ]
Gene Expression Viewer (FireBrowse)CCR6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1235
GTEX Portal (Tissue expression)CCR6
Human Protein AtlasENSG00000112486-CCR6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51684   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51684  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51684
Splice isoforms : SwissVarP51684
PhosPhoSitePlusP51684
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)Chemokine_CCR6    Chemokine_rcpt    GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)CCR6
DMDM Disease mutations1235
Blocks (Seattle)CCR6
SuperfamilyP51684
Human Protein Atlas [tissue]ENSG00000112486-CCR6 [tissue]
Peptide AtlasP51684
HPRD03498
IPIIPI00293730   
Protein Interaction databases
DIP (DOE-UCLA)P51684
IntAct (EBI)P51684
FunCoupENSG00000112486
BioGRIDCCR6
STRING (EMBL)CCR6
ZODIACCCR6
Ontologies - Pathways
QuickGOP51684
Ontology : AmiGOdendritic cell chemotaxis  leukocyte migration involved in inflammatory response  chemokine receptor activity  protein binding  intracellular  plasma membrane  integral component of plasma membrane  chemotaxis  chemotaxis  chemotaxis  immune response  humoral immune response  cellular defense response  signal transduction  G protein-coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  external side of plasma membrane  cell surface  positive regulation of epithelial cell migration  C-C chemokine receptor activity  C-C chemokine receptor activity  C-C chemokine receptor activity  calcium-mediated signaling  calcium-mediated signaling  chemokine binding  C-C chemokine binding  C-C chemokine binding  C-C chemokine binding  sperm flagellum  signaling receptor activity  isotype switching to IgA isotypes  cell chemotaxis  cell chemotaxis  positive regulation of flagellated sperm motility involved in capacitation  chemokine-mediated signaling pathway  lymphocyte migration  T cell migration  thymocyte migration  thymocyte migration  sperm midpiece  sperm principal piece  sperm plasma membrane  DN2 thymocyte differentiation  DN3 thymocyte differentiation  regulation of T cell migration  positive regulation of dendritic cell chemotaxis  
Ontology : EGO-EBIdendritic cell chemotaxis  leukocyte migration involved in inflammatory response  chemokine receptor activity  protein binding  intracellular  plasma membrane  integral component of plasma membrane  chemotaxis  chemotaxis  chemotaxis  immune response  humoral immune response  cellular defense response  signal transduction  G protein-coupled receptor signaling pathway  positive regulation of cytosolic calcium ion concentration  external side of plasma membrane  cell surface  positive regulation of epithelial cell migration  C-C chemokine receptor activity  C-C chemokine receptor activity  C-C chemokine receptor activity  calcium-mediated signaling  calcium-mediated signaling  chemokine binding  C-C chemokine binding  C-C chemokine binding  C-C chemokine binding  sperm flagellum  signaling receptor activity  isotype switching to IgA isotypes  cell chemotaxis  cell chemotaxis  positive regulation of flagellated sperm motility involved in capacitation  chemokine-mediated signaling pathway  lymphocyte migration  T cell migration  thymocyte migration  thymocyte migration  sperm midpiece  sperm principal piece  sperm plasma membrane  DN2 thymocyte differentiation  DN3 thymocyte differentiation  regulation of T cell migration  positive regulation of dendritic cell chemotaxis  
Pathways : KEGGCytokine-cytokine receptor interaction    Chemokine signaling pathway   
NDEx NetworkCCR6
Atlas of Cancer Signalling NetworkCCR6
Wikipedia pathwaysCCR6
Orthology - Evolution
OrthoDB1235
GeneTree (enSembl)ENSG00000112486
Phylogenetic Trees/Animal Genes : TreeFamCCR6
HOVERGENP51684
HOGENOMP51684
Homologs : HomoloGeneCCR6
Homology/Alignments : Family Browser (UCSC)CCR6
Gene fusions - Rearrangements
Fusion : QuiverCCR6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCCR6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CCR6
dbVarCCR6
ClinVarCCR6
1000_GenomesCCR6 
Exome Variant ServerCCR6
ExAC (Exome Aggregation Consortium)ENSG00000112486
GNOMAD BrowserENSG00000112486
Varsome BrowserCCR6
Genetic variants : HAPMAP1235
Genomic Variants (DGV)CCR6 [DGVbeta]
DECIPHERCCR6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCCR6 
Mutations
ICGC Data PortalCCR6 
TCGA Data PortalCCR6 
Broad Tumor PortalCCR6
OASIS PortalCCR6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCCR6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCCR6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CCR6
DgiDB (Drug Gene Interaction Database)CCR6
DoCM (Curated mutations)CCR6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CCR6 (select a term)
intoGenCCR6
Cancer3DCCR6(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601835   
Orphanet18906    18905   
DisGeNETCCR6
MedgenCCR6
Genetic Testing Registry CCR6
NextProtP51684 [Medical]
TSGene1235
GENETestsCCR6
Target ValidationCCR6
Huge Navigator CCR6 [HugePedia]
snp3D : Map Gene to Disease1235
BioCentury BCIQCCR6
ClinGenCCR6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1235
Chemical/Pharm GKB GenePA26171
Clinical trialCCR6
Miscellaneous
canSAR (ICR)CCR6 (select the gene name)
Probes
Litterature
PubMed172 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCCR6
EVEXCCR6
GoPubMedCCR6
iHOPCCR6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 10:56:34 CET 2018

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