CCRL2 (C-C motif chemokine receptor like 2)

2014-06-01  

Identity

HGNC
CCRL2
LOCATION
3p21.31
LOCUSID
9034
ALIAS
ACKR5,CKRX,CRAM,CRAM-A,CRAM-B,HCR

Other Information

Locus ID:

NCBI: 9034
MIM: 608379
HGNC: 1612
Ensembl: ENSG00000121797

Variants:

dbSNP: 9034
ClinVar: 9034
TCGA: ENSG00000121797
COSMIC: CCRL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121797ENST00000357392O00421
ENSG00000121797ENST00000399036O00421
ENSG00000121797ENST00000399036B2R8C0
ENSG00000121797ENST00000400880O00421
ENSG00000121797ENST00000400880B2R8C0
ENSG00000121797ENST00000400882O00421
ENSG00000121797ENST00000400882B2R8C0
ENSG00000121797ENST00000433848C9JP23

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Chemokine receptors bind chemokinesREACTOMER-HSA-380108

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
187943392008Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis.92
151883572004Up-regulated expression and activation of the orphan chemokine receptor, CCRL2, in rheumatoid arthritis.22
200027842010CCL19 is a specific ligand of the constitutively recycling atypical human chemokine receptor CRAM-B.21
206770142010An approach based on a genome-wide association study reveals candidate loci for narcolepsy.16
231422252012Elevated chemokine CC-motif receptor-like 2 (CCRL2) promotes cell migration and invasion in glioblastoma.9
220461402011Role of exonic variation in chemokine receptor genes on AIDS: CCRL2 F167Y association with pneumocystis pneumonia.7
264876622015The human chemokine receptor CCRL2 suppresses chemotaxis and invasion by blocking CCL2-induced phosphorylation of p38 MAPK in human breast cancer cells.6
265639452015CRAM-A indicates IFN-γ-associated inflammatory response in breast cancer.6
200561782010Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment.5
286001262017Chemokine (CC-motif) receptor-like 2 mRNA is expressed in hepatic stellate cells and is positively associated with characteristics of non-alcoholic steatohepatitis in mice and men.1

Citation

Dessen P

CCRL2 (C-C motif chemokine receptor like 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/53961/ccrl2