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CCS (copper chaperone for superoxide dismutase)

Identity

Other alias-
HGNC (Hugo) CCS
LocusID (NCBI) 9973
Atlas_Id 52341
Location 11q13.2  [Link to chromosome band 11q13]
Location_base_pair Starts at 66360690 and ends at 66373490 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
RBM14 (11q13.2) / CCS (11q13.2)RBM4 (11q13.2) / CCS (11q13.2)RBM14 11q13.2 / CCS 11q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CCS   1613
Cards
Entrez_Gene (NCBI)CCS  9973  copper chaperone for superoxide dismutase
Aliases
GeneCards (Weizmann)CCS
Ensembl hg19 (Hinxton)ENSG00000173992 [Gene_View]  chr11:66360690-66373490 [Contig_View]  CCS [Vega]
Ensembl hg38 (Hinxton)ENSG00000173992 [Gene_View]  chr11:66360690-66373490 [Contig_View]  CCS [Vega]
ICGC DataPortalENSG00000173992
TCGA cBioPortalCCS
AceView (NCBI)CCS
Genatlas (Paris)CCS
WikiGenes9973
SOURCE (Princeton)CCS
Genetics Home Reference (NIH)CCS
Genomic and cartography
GoldenPath hg19 (UCSC)CCS  -     chr11:66360690-66373490 +  11q13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CCS  -     11q13.2   [Description]    (hg38-Dec_2013)
EnsemblCCS - 11q13.2 [CytoView hg19]  CCS - 11q13.2 [CytoView hg38]
Mapping of homologs : NCBICCS [Mapview hg19]  CCS [Mapview hg38]
OMIM603864   
Gene and transcription
Genbank (Entrez)AF002210 AY113179 BC105016 BC112055 CR541928
RefSeq transcript (Entrez)NM_005125
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_008733 NT_167190 NW_004929380
Consensus coding sequences : CCDS (NCBI)CCS
Cluster EST : UnigeneHs.502917 [ NCBI ]
CGAP (NCI)Hs.502917
Alternative Splicing GalleryENSG00000173992
Gene ExpressionCCS [ NCBI-GEO ]   CCS [ EBI - ARRAY_EXPRESS ]   CCS [ SEEK ]   CCS [ MEM ]
Gene Expression Viewer (FireBrowse)CCS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9973
GTEX Portal (Tissue expression)CCS
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14618   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14618  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14618
Splice isoforms : SwissVarO14618
PhosPhoSitePlusO14618
Domaine pattern : Prosite (Expaxy)HMA_2 (PS50846)    SOD_CU_ZN_2 (PS00332)   
Domains : Interpro (EBI)Ccs1    HMA_dom    SOD_Cu/Zn_/chaperone    SOD_Cu/Zn_BS    SOD_Cu_Zn_dom   
Domain families : Pfam (Sanger)HMA (PF00403)    Sod_Cu (PF00080)   
Domain families : Pfam (NCBI)pfam00403    pfam00080   
Conserved Domain (NCBI)CCS
DMDM Disease mutations9973
Blocks (Seattle)CCS
PDB (SRS)1DO5    2CRL    2RSQ   
PDB (PDBSum)1DO5    2CRL    2RSQ   
PDB (IMB)1DO5    2CRL    2RSQ   
PDB (RSDB)1DO5    2CRL    2RSQ   
Structural Biology KnowledgeBase1DO5    2CRL    2RSQ   
SCOP (Structural Classification of Proteins)1DO5    2CRL    2RSQ   
CATH (Classification of proteins structures)1DO5    2CRL    2RSQ   
SuperfamilyO14618
Human Protein AtlasENSG00000173992
Peptide AtlasO14618
HPRD04841
IPIIPI00021389   IPI00981151   IPI00980505   IPI00982182   
Protein Interaction databases
DIP (DOE-UCLA)O14618
IntAct (EBI)O14618
FunCoupENSG00000173992
BioGRIDCCS
STRING (EMBL)CCS
ZODIACCCS
Ontologies - Pathways
QuickGOO14618
Ontology : AmiGOresponse to reactive oxygen species  superoxide dismutase activity  copper ion binding  protein binding  nucleus  cytoplasm  cytosol  superoxide metabolic process  zinc ion binding  protein disulfide oxidoreductase activity  intracellular copper ion transport  superoxide dismutase copper chaperone activity  removal of superoxide radicals  positive regulation of oxidoreductase activity  oxidation-reduction process  
Ontology : EGO-EBIresponse to reactive oxygen species  superoxide dismutase activity  copper ion binding  protein binding  nucleus  cytoplasm  cytosol  superoxide metabolic process  zinc ion binding  protein disulfide oxidoreductase activity  intracellular copper ion transport  superoxide dismutase copper chaperone activity  removal of superoxide radicals  positive regulation of oxidoreductase activity  oxidation-reduction process  
Pathways : KEGGAmyotrophic lateral sclerosis (ALS)   
NDEx NetworkCCS
Atlas of Cancer Signalling NetworkCCS
Wikipedia pathwaysCCS
Orthology - Evolution
OrthoDB9973
GeneTree (enSembl)ENSG00000173992
Phylogenetic Trees/Animal Genes : TreeFamCCS
HOVERGENO14618
HOGENOMO14618
Homologs : HomoloGeneCCS
Homology/Alignments : Family Browser (UCSC)CCS
Gene fusions - Rearrangements
Fusion : MitelmanRBM14/CCS [11q13.2/11q13.2]  [t(11;11)(q13;q13)]  
Fusion: TCGARBM14 11q13.2 CCS 11q13.2 KIRC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCCS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CCS
dbVarCCS
ClinVarCCS
1000_GenomesCCS 
Exome Variant ServerCCS
ExAC (Exome Aggregation Consortium)CCS (select the gene name)
Genetic variants : HAPMAP9973
Genomic Variants (DGV)CCS [DGVbeta]
DECIPHER (Syndromes)11:66360690-66373490  ENSG00000173992
CONAN: Copy Number AnalysisCCS 
Mutations
ICGC Data PortalCCS 
TCGA Data PortalCCS 
Broad Tumor PortalCCS
OASIS PortalCCS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCCS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCCS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
BioMutasearch CCS
DgiDB (Drug Gene Interaction Database)CCS
DoCM (Curated mutations)CCS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CCS (select a term)
intoGenCCS
Cancer3DCCS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603864   
Orphanet
MedgenCCS
Genetic Testing Registry CCS
NextProtO14618 [Medical]
TSGene9973
GENETestsCCS
Huge Navigator CCS [HugePedia]
snp3D : Map Gene to Disease9973
BioCentury BCIQCCS
ClinGenCCS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9973
Chemical/Pharm GKB GenePA26177
Clinical trialCCS
Miscellaneous
canSAR (ICR)CCS (select the gene name)
Probes
Litterature
PubMed43 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCCS
EVEXCCS
GoPubMedCCS
iHOPCCS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:59:16 CET 2017

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