Atlas of Genetics and Cytogenetics in Oncology and Haematology

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CCSER1 (coiled-coil serine rich protein 1)

Identity

Alias_namesFAM190A
family with sequence similarity 190, member A
coiled-coil serine-rich protein 1
Alias_symbol (synonym)KIAA1680
Other alias
HGNC (Hugo) CCSER1
LocusID (NCBI) 401145
Atlas_Id 53543
Location 4q22.1  [Link to chromosome band 4q22]
Location_base_pair Starts at 90235031 and ends at 90782003 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCSER1 (4q22.1) / C5orf34 (5p12)CCSER1 (4q22.1) / MMRN1 (4q22.1)CCSER1 (4q22.1) / UGT2A1 (4q13.2)
CENPK (5q12.3) / CCSER1 (4q22.1)CENPP (9q22.31) / CCSER1 (4q22.1)DENND1B (1q31.3) / CCSER1 (4q22.1)
FRAS1 (4q21.21) / CCSER1 (4q22.1)MAPK10 (4q21.3) / CCSER1 (4q22.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 6 ]
  Lung: Translocations in Squamous Cell Carcinoma
t(1;4)(q31;q22) DENND1B/CCSER1
t(4;4)(q13;q22) CCSER1/UGT2A1
t(4;4)(q21;q22) FRAS1/CCSER1
t(4;4)(q21;q22) MAPK10/CCSER1
CCSER1/MMRN1 (4q22)

External links

Nomenclature
HGNC (Hugo)CCSER1   29349
Cards
Entrez_Gene (NCBI)CCSER1  401145  coiled-coil serine rich protein 1
AliasesFAM190A
GeneCards (Weizmann)CCSER1
Ensembl hg19 (Hinxton)ENSG00000184305 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000184305 [Gene_View]  ENSG00000184305 [Sequence]  chr4:90235031-90782003 [Contig_View]  CCSER1 [Vega]
ICGC DataPortalENSG00000184305
TCGA cBioPortalCCSER1
AceView (NCBI)CCSER1
Genatlas (Paris)CCSER1
WikiGenes401145
SOURCE (Princeton)CCSER1
Genetics Home Reference (NIH)CCSER1
Genomic and cartography
GoldenPath hg38 (UCSC)CCSER1  -     chr4:90235031-90782003 +  4q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CCSER1  -     4q22.1   [Description]    (hg19-Feb_2009)
EnsemblCCSER1 - 4q22.1 [CytoView hg19]  CCSER1 - 4q22.1 [CytoView hg38]
Mapping of homologs : NCBICCSER1 [Mapview hg19]  CCSER1 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB051467 AK097436 AK310825 BC021681 BC051694
RefSeq transcript (Entrez)NM_001145065 NM_207491
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CCSER1
Cluster EST : UnigeneHs.654735 [ NCBI ]
CGAP (NCI)Hs.654735
Alternative Splicing GalleryENSG00000184305
Gene ExpressionCCSER1 [ NCBI-GEO ]   CCSER1 [ EBI - ARRAY_EXPRESS ]   CCSER1 [ SEEK ]   CCSER1 [ MEM ]
Gene Expression Viewer (FireBrowse)CCSER1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)401145
GTEX Portal (Tissue expression)CCSER1
Human Protein AtlasENSG00000184305-CCSER1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9C0I3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9C0I3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9C0I3
Splice isoforms : SwissVarQ9C0I3
PhosPhoSitePlusQ9C0I3
Domains : Interpro (EBI)CCSER    CCSER1   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)CCSER1
DMDM Disease mutations401145
Blocks (Seattle)CCSER1
SuperfamilyQ9C0I3
Human Protein Atlas [tissue]ENSG00000184305-CCSER1 [tissue]
Peptide AtlasQ9C0I3
HPRD17561
IPIIPI00902593   IPI00553113   IPI01011336   IPI00967095   IPI00966614   IPI00966848   IPI00964737   IPI00968170   IPI00966224   IPI00967300   
Protein Interaction databases
DIP (DOE-UCLA)Q9C0I3
IntAct (EBI)Q9C0I3
FunCoupENSG00000184305
BioGRIDCCSER1
STRING (EMBL)CCSER1
ZODIACCCSER1
Ontologies - Pathways
QuickGOQ9C0I3
Ontology : AmiGO
Ontology : EGO-EBI
NDEx NetworkCCSER1
Atlas of Cancer Signalling NetworkCCSER1
Wikipedia pathwaysCCSER1
Orthology - Evolution
OrthoDB401145
GeneTree (enSembl)ENSG00000184305
Phylogenetic Trees/Animal Genes : TreeFamCCSER1
HOVERGENQ9C0I3
HOGENOMQ9C0I3
Homologs : HomoloGeneCCSER1
Homology/Alignments : Family Browser (UCSC)CCSER1
Gene fusions - Rearrangements
Fusion : MitelmanCCSER1/MMRN1 [4q22.1/4q22.1]  
Fusion : MitelmanCCSER1/UGT2A1 [4q22.1/4q13.2]  [t(4;4)(q13;q22)]  
Fusion : MitelmanDENND1B/CCSER1 [1q31.3/4q22.1]  [t(1;4)(q31;q22)]  
Fusion : MitelmanFRAS1/CCSER1 [4q21.21/4q22.1]  [t(4;4)(q21;q22)]  
Fusion : MitelmanMAPK10/CCSER1 [4q21.3/4q22.1]  [t(4;4)(q21;q22)]  
Fusion : QuiverCCSER1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCCSER1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CCSER1
dbVarCCSER1
ClinVarCCSER1
1000_GenomesCCSER1 
Exome Variant ServerCCSER1
ExAC (Exome Aggregation Consortium)ENSG00000184305
GNOMAD BrowserENSG00000184305
Varsome BrowserCCSER1
Genetic variants : HAPMAP401145
Genomic Variants (DGV)CCSER1 [DGVbeta]
DECIPHERCCSER1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCCSER1 
Mutations
ICGC Data PortalCCSER1 
TCGA Data PortalCCSER1 
Broad Tumor PortalCCSER1
OASIS PortalCCSER1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDCCSER1
BioMutasearch CCSER1
DgiDB (Drug Gene Interaction Database)CCSER1
DoCM (Curated mutations)CCSER1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CCSER1 (select a term)
intoGenCCSER1
Cancer3DCCSER1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETCCSER1
MedgenCCSER1
Genetic Testing Registry CCSER1
NextProtQ9C0I3 [Medical]
TSGene401145
GENETestsCCSER1
Target ValidationCCSER1
Huge Navigator CCSER1 [HugePedia]
snp3D : Map Gene to Disease401145
BioCentury BCIQCCSER1
ClinGenCCSER1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD401145
Chemical/Pharm GKB GenePA165663936
Clinical trialCCSER1
Miscellaneous
canSAR (ICR)CCSER1 (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCCSER1
EVEXCCSER1
GoPubMedCCSER1
iHOPCCSER1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 10:56:36 CET 2018
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