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CCT2 (chaperonin containing TCP1 subunit 2)

Identity

Alias_nameschaperonin containing TCP1
Alias_symbol (synonym)Cctb
Other alias99D8.1
CCT-beta
CCTB
HEL-S-100n
PRO1633
TCP-1-beta
HGNC (Hugo) CCT2
LocusID (NCBI) 10576
Atlas_Id 55185
Location 12q15  [Link to chromosome band 12q15]
Location_base_pair Starts at 69585428 and ends at 69601577 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCT2 (12q15) / CXCR5 (11q23.3)CCT2 (12q15) / PAN3 (13q12.2)ELF1 (13q14.11) / CCT2 (12q15)
HMGA2 (12q14.3) / CCT2 (12q15)PDE3A (12p12.2) / CCT2 (12q15)CCT2 12q15 / CXCR5 11q23.3
PDE3A 12p12.2 / CCT2 12q15

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(11;12)(q23;q15) CCT2/CXCR5
t(12;12)(p12;q15) PDE3A/CCT2


External links

Nomenclature
HGNC (Hugo)CCT2   1615
Cards
Entrez_Gene (NCBI)CCT2  10576  chaperonin containing TCP1 subunit 2
Aliases99D8.1; CCT-beta; CCTB; HEL-S-100n; 
PRO1633; TCP-1-beta
GeneCards (Weizmann)CCT2
Ensembl hg19 (Hinxton)ENSG00000166226 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166226 [Gene_View]  ENSG00000166226 [Sequence]  chr12:69585428-69601577 [Contig_View]  CCT2 [Vega]
ICGC DataPortalENSG00000166226
TCGA cBioPortalCCT2
AceView (NCBI)CCT2
Genatlas (Paris)CCT2
WikiGenes10576
SOURCE (Princeton)CCT2
Genetics Home Reference (NIH)CCT2
Genomic and cartography
GoldenPath hg38 (UCSC)CCT2  -     chr12:69585428-69601577 +  12q15   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CCT2  -     12q15   [Description]    (hg19-Feb_2009)
EnsemblCCT2 - 12q15 [CytoView hg19]  CCT2 - 12q15 [CytoView hg38]
Mapping of homologs : NCBICCT2 [Mapview hg19]  CCT2 [Mapview hg38]
OMIM605139   
Gene and transcription
Genbank (Entrez)AA401491 AB451223 AB451346 AF026166 AF026293
RefSeq transcript (Entrez)NM_001198842 NM_006431
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CCT2
Cluster EST : UnigeneHs.189772 [ NCBI ]
CGAP (NCI)Hs.189772
Alternative Splicing GalleryENSG00000166226
Gene ExpressionCCT2 [ NCBI-GEO ]   CCT2 [ EBI - ARRAY_EXPRESS ]   CCT2 [ SEEK ]   CCT2 [ MEM ]
Gene Expression Viewer (FireBrowse)CCT2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10576
GTEX Portal (Tissue expression)CCT2
Human Protein AtlasENSG00000166226-CCT2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP78371   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP78371  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP78371
Splice isoforms : SwissVarP78371
PhosPhoSitePlusP78371
Domaine pattern : Prosite (Expaxy)TCP1_1 (PS00750)    TCP1_2 (PS00751)    TCP1_3 (PS00995)   
Domains : Interpro (EBI)Chap_CCT_beta    Chaperone_TCP-1    Chaperonin_TCP-1_CS    Cpn60/TCP-1    GroEL-like_apical_dom_sf    GROEL-like_equatorial_sf    TCP-1-like_intermed_sf   
Domain families : Pfam (Sanger)Cpn60_TCP1 (PF00118)   
Domain families : Pfam (NCBI)pfam00118   
Conserved Domain (NCBI)CCT2
DMDM Disease mutations10576
Blocks (Seattle)CCT2
SuperfamilyP78371
Human Protein Atlas [tissue]ENSG00000166226-CCT2 [tissue]
Peptide AtlasP78371
HPRD06895
IPIIPI00297779   IPI01022143   IPI01022121   IPI00981169   
Protein Interaction databases
DIP (DOE-UCLA)P78371
IntAct (EBI)P78371
FunCoupENSG00000166226
BioGRIDCCT2
STRING (EMBL)CCT2
ZODIACCCT2
Ontologies - Pathways
QuickGOP78371
Ontology : AmiGOzona pellucida receptor complex  protein binding  ATP binding  extracellular region  cytosol  cytosol  cytosol  chaperonin-containing T-complex  chaperonin-containing T-complex  microtubule  protein folding  protein folding  binding of sperm to zona pellucida  ubiquitin protein ligase binding  positive regulation of telomere maintenance via telomerase  azurophil granule lumen  myelin sheath  neutrophil degranulation  protein binding involved in protein folding  cell body  protein stabilization  unfolded protein binding  chaperone mediated protein folding independent of cofactor  chaperone-mediated protein complex assembly  positive regulation of telomerase activity  extracellular exosome  scaRNA localization to Cajal body  toxin transport  positive regulation of establishment of protein localization to telomere  positive regulation of protein localization to Cajal body  positive regulation of telomerase RNA localization to Cajal body  positive regulation of telomerase RNA localization to Cajal body  
Ontology : EGO-EBIzona pellucida receptor complex  protein binding  ATP binding  extracellular region  cytosol  cytosol  cytosol  chaperonin-containing T-complex  chaperonin-containing T-complex  microtubule  protein folding  protein folding  binding of sperm to zona pellucida  ubiquitin protein ligase binding  positive regulation of telomere maintenance via telomerase  azurophil granule lumen  myelin sheath  neutrophil degranulation  protein binding involved in protein folding  cell body  protein stabilization  unfolded protein binding  chaperone mediated protein folding independent of cofactor  chaperone-mediated protein complex assembly  positive regulation of telomerase activity  extracellular exosome  scaRNA localization to Cajal body  toxin transport  positive regulation of establishment of protein localization to telomere  positive regulation of protein localization to Cajal body  positive regulation of telomerase RNA localization to Cajal body  positive regulation of telomerase RNA localization to Cajal body  
NDEx NetworkCCT2
Atlas of Cancer Signalling NetworkCCT2
Wikipedia pathwaysCCT2
Orthology - Evolution
OrthoDB10576
GeneTree (enSembl)ENSG00000166226
Phylogenetic Trees/Animal Genes : TreeFamCCT2
HOVERGENP78371
HOGENOMP78371
Homologs : HomoloGeneCCT2
Homology/Alignments : Family Browser (UCSC)CCT2
Gene fusions - Rearrangements
Fusion : MitelmanCCT2/CXCR5 [12q15/11q23.3]  
Fusion : MitelmanPDE3A/CCT2 [12p12.2/12q15]  [t(12;12)(p12;q15)]  
Fusion PortalCCT2 12q15 CXCR5 11q23.3 BRCA
Fusion PortalPDE3A 12p12.2 CCT2 12q15 LUAD
Fusion : QuiverCCT2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCCT2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CCT2
dbVarCCT2
ClinVarCCT2
1000_GenomesCCT2 
Exome Variant ServerCCT2
ExAC (Exome Aggregation Consortium)ENSG00000166226
GNOMAD BrowserENSG00000166226
Varsome BrowserCCT2
Genetic variants : HAPMAP10576
Genomic Variants (DGV)CCT2 [DGVbeta]
DECIPHERCCT2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCCT2 
Mutations
ICGC Data PortalCCT2 
TCGA Data PortalCCT2 
Broad Tumor PortalCCT2
OASIS PortalCCT2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCCT2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCCT2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CCT2
DgiDB (Drug Gene Interaction Database)CCT2
DoCM (Curated mutations)CCT2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CCT2 (select a term)
intoGenCCT2
Cancer3DCCT2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605139   
Orphanet
DisGeNETCCT2
MedgenCCT2
Genetic Testing Registry CCT2
NextProtP78371 [Medical]
TSGene10576
GENETestsCCT2
Target ValidationCCT2
Huge Navigator CCT2 [HugePedia]
snp3D : Map Gene to Disease10576
BioCentury BCIQCCT2
ClinGenCCT2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10576
Chemical/Pharm GKB GenePA26179
Clinical trialCCT2
Miscellaneous
canSAR (ICR)CCT2 (select the gene name)
Probes
Litterature
PubMed137 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCCT2
EVEXCCT2
GoPubMedCCT2
iHOPCCT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 10:56:37 CET 2018

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