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CCT2 (chaperonin containing TCP1 subunit 2)

Identity

Alias (NCBI)99D8.1
CCT-beta
CCTB
HEL-S-100n
PRO1633
TCP-1-beta
HGNC (Hugo) CCT2
HGNC Alias symbCctb
HGNC Previous namechaperonin containing TCP1, subunit 2 (beta)
LocusID (NCBI) 10576
Atlas_Id 55185
Location 12q15  [Link to chromosome band 12q15]
Location_base_pair Starts at 69585459 and ends at 69601570 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCT2 (12q15) / CXCR5 (11q23.3)CCT2 (12q15) / PAN3 (13q12.2)ELF1 (13q14.11) / CCT2 (12q15)
HMGA2 (12q14.3) / CCT2 (12q15)PDE3A (12p12.2) / CCT2 (12q15)CCT2 12q15 / CXCR5 11q23.3
PDE3A 12p12.2 / CCT2 12q15

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)CCT2   1615
Cards
Entrez_Gene (NCBI)CCT2    chaperonin containing TCP1 subunit 2
Aliases99D8.1; CCT-beta; CCTB; HEL-S-100n; 
PRO1633; TCP-1-beta
GeneCards (Weizmann)CCT2
Ensembl hg19 (Hinxton)ENSG00000166226 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166226 [Gene_View]  ENSG00000166226 [Sequence]  chr12:69585459-69601570 [Contig_View]  CCT2 [Vega]
ICGC DataPortalENSG00000166226
TCGA cBioPortalCCT2
AceView (NCBI)CCT2
Genatlas (Paris)CCT2
SOURCE (Princeton)CCT2
Genetics Home Reference (NIH)CCT2
Genomic and cartography
GoldenPath hg38 (UCSC)CCT2  -     chr12:69585459-69601570 +  12q15   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CCT2  -     12q15   [Description]    (hg19-Feb_2009)
GoldenPathCCT2 - 12q15 [CytoView hg19]  CCT2 - 12q15 [CytoView hg38]
ImmunoBaseENSG00000166226
Genome Data Viewer NCBICCT2 [Mapview hg19]  
OMIM605139   
Gene and transcription
Genbank (Entrez)AA401491 AB451223 AB451346 AF026166 AF026293
RefSeq transcript (Entrez)NM_001198842 NM_006431
Consensus coding sequences : CCDS (NCBI)CCT2
Gene ExpressionCCT2 [ NCBI-GEO ]   CCT2 [ EBI - ARRAY_EXPRESS ]   CCT2 [ SEEK ]   CCT2 [ MEM ]
Gene Expression Viewer (FireBrowse)CCT2 [ Firebrowse - Broad ]
GenevisibleExpression of CCT2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10576
GTEX Portal (Tissue expression)CCT2
Human Protein AtlasENSG00000166226-CCT2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP78371   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP78371  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP78371
PhosPhoSitePlusP78371
Domaine pattern : Prosite (Expaxy)TCP1_1 (PS00750)    TCP1_2 (PS00751)    TCP1_3 (PS00995)   
Domains : Interpro (EBI)Chap_CCT_beta    Chaperone_TCP-1    Chaperonin_TCP-1_CS    Cpn60/TCP-1    GroEL-like_apical_dom_sf    GROEL-like_equatorial_sf    TCP-1-like_intermed_sf   
Domain families : Pfam (Sanger)Cpn60_TCP1 (PF00118)   
Domain families : Pfam (NCBI)pfam00118   
Conserved Domain (NCBI)CCT2
PDB (RSDB)6NR8    6NR9    6NRA    6NRB    6NRC    6NRD    6QB8   
PDB Europe6NR8    6NR9    6NRA    6NRB    6NRC    6NRD    6QB8   
PDB (PDBSum)6NR8    6NR9    6NRA    6NRB    6NRC    6NRD    6QB8   
PDB (IMB)6NR8    6NR9    6NRA    6NRB    6NRC    6NRD    6QB8   
Structural Biology KnowledgeBase6NR8    6NR9    6NRA    6NRB    6NRC    6NRD    6QB8   
SCOP (Structural Classification of Proteins)6NR8    6NR9    6NRA    6NRB    6NRC    6NRD    6QB8   
CATH (Classification of proteins structures)6NR8    6NR9    6NRA    6NRB    6NRC    6NRD    6QB8   
SuperfamilyP78371
AlphaFold pdb e-kbP78371   
Human Protein Atlas [tissue]ENSG00000166226-CCT2 [tissue]
HPRD06895
Protein Interaction databases
DIP (DOE-UCLA)P78371
IntAct (EBI)P78371
BioGRIDCCT2
STRING (EMBL)CCT2
ZODIACCCT2
Ontologies - Pathways
QuickGOP78371
Ontology : AmiGOzona pellucida receptor complex  protein binding  ATP binding  extracellular region  cytosol  cytosol  cytosol  chaperonin-containing T-complex  chaperonin-containing T-complex  microtubule  protein folding  protein folding  protein folding  protein folding  binding of sperm to zona pellucida  ubiquitin protein ligase binding  positive regulation of telomere maintenance via telomerase  azurophil granule lumen  neutrophil degranulation  protein folding chaperone  cell body  protein stabilization  unfolded protein binding  unfolded protein binding  chaperone mediated protein folding independent of cofactor  chaperone-mediated protein complex assembly  positive regulation of telomerase activity  extracellular exosome  scaRNA localization to Cajal body  toxin transport  positive regulation of establishment of protein localization to telomere  positive regulation of protein localization to Cajal body  positive regulation of telomerase RNA localization to Cajal body  positive regulation of telomerase RNA localization to Cajal body  
Ontology : EGO-EBIzona pellucida receptor complex  protein binding  ATP binding  extracellular region  cytosol  cytosol  cytosol  chaperonin-containing T-complex  chaperonin-containing T-complex  microtubule  protein folding  protein folding  protein folding  protein folding  binding of sperm to zona pellucida  ubiquitin protein ligase binding  positive regulation of telomere maintenance via telomerase  azurophil granule lumen  neutrophil degranulation  protein folding chaperone  cell body  protein stabilization  unfolded protein binding  unfolded protein binding  chaperone mediated protein folding independent of cofactor  chaperone-mediated protein complex assembly  positive regulation of telomerase activity  extracellular exosome  scaRNA localization to Cajal body  toxin transport  positive regulation of establishment of protein localization to telomere  positive regulation of protein localization to Cajal body  positive regulation of telomerase RNA localization to Cajal body  positive regulation of telomerase RNA localization to Cajal body  
NDEx NetworkCCT2
Atlas of Cancer Signalling NetworkCCT2
Wikipedia pathwaysCCT2
Orthology - Evolution
OrthoDB10576
GeneTree (enSembl)ENSG00000166226
Phylogenetic Trees/Animal Genes : TreeFamCCT2
Homologs : HomoloGeneCCT2
Homology/Alignments : Family Browser (UCSC)CCT2
Gene fusions - Rearrangements
Fusion : MitelmanCCT2/CXCR5 [12q15/11q23.3]  
Fusion : MitelmanPDE3A/CCT2 [12p12.2/12q15]  
Fusion : QuiverCCT2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCCT2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CCT2
dbVarCCT2
ClinVarCCT2
MonarchCCT2
1000_GenomesCCT2 
Exome Variant ServerCCT2
GNOMAD BrowserENSG00000166226
Varsome BrowserCCT2
ACMGCCT2 variants
VarityP78371
Genomic Variants (DGV)CCT2 [DGVbeta]
DECIPHERCCT2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCCT2 
Mutations
ICGC Data PortalCCT2 
TCGA Data PortalCCT2 
Broad Tumor PortalCCT2
OASIS PortalCCT2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCCT2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DCCT2
Mutations and Diseases : HGMDCCT2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaCCT2
DgiDB (Drug Gene Interaction Database)CCT2
DoCM (Curated mutations)CCT2
CIViC (Clinical Interpretations of Variants in Cancer)CCT2
Cancer3DCCT2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605139   
Orphanet
DisGeNETCCT2
MedgenCCT2
Genetic Testing Registry CCT2
NextProtP78371 [Medical]
GENETestsCCT2
Target ValidationCCT2
Huge Navigator CCT2 [HugePedia]
ClinGenCCT2
Clinical trials, drugs, therapy
MyCancerGenomeCCT2
Protein Interactions : CTDCCT2
Pharm GKB GenePA26179
PharosP78371
Clinical trialCCT2
Miscellaneous
canSAR (ICR)CCT2
HarmonizomeCCT2
DataMed IndexCCT2
Probes
Litterature
PubMed216 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXCCT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:02:51 CEST 2021

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