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CCT4 (chaperonin containing TCP1 subunit 4)

Identity

Alias_nameschaperonin containing TCP1, subunit 4 (delta)
Alias_symbol (synonym)Cctd
Other aliasCCT-DELTA
SRB
HGNC (Hugo) CCT4
LocusID (NCBI) 10575
Atlas_Id 61601
Location 2p15  [Link to chromosome band 2p15]
Location_base_pair Starts at 61868127 and ends at 61888671 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCT4 (2p15) / AGA (4q34.3)CCT4 (2p15) / ATG5 (6q21)CCT4 (2p15) / CCT4 (2p15)
CLNK (4p16.1) / CCT4 (2p15)USP34 (2p15) / CCT4 (2p15)XPO1 (2p15) / CCT4 (2p15)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CCT4   1617
Cards
Entrez_Gene (NCBI)CCT4  10575  chaperonin containing TCP1 subunit 4
AliasesCCT-DELTA; Cctd; SRB
GeneCards (Weizmann)CCT4
Ensembl hg19 (Hinxton)ENSG00000115484 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115484 [Gene_View]  chr2:61868127-61888671 [Contig_View]  CCT4 [Vega]
ICGC DataPortalENSG00000115484
TCGA cBioPortalCCT4
AceView (NCBI)CCT4
Genatlas (Paris)CCT4
WikiGenes10575
SOURCE (Princeton)CCT4
Genetics Home Reference (NIH)CCT4
Genomic and cartography
GoldenPath hg38 (UCSC)CCT4  -     chr2:61868127-61888671 -  2p15   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CCT4  -     2p15   [Description]    (hg19-Feb_2009)
EnsemblCCT4 - 2p15 [CytoView hg19]  CCT4 - 2p15 [CytoView hg38]
Mapping of homologs : NCBICCT4 [Mapview hg19]  CCT4 [Mapview hg38]
OMIM605142   
Gene and transcription
Genbank (Entrez)AA136129 AF026291 AI439570 AK129860 AK290538
RefSeq transcript (Entrez)NM_001256721 NM_006430
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CCT4
Cluster EST : UnigeneHs.421509 [ NCBI ]
CGAP (NCI)Hs.421509
Alternative Splicing GalleryENSG00000115484
Gene ExpressionCCT4 [ NCBI-GEO ]   CCT4 [ EBI - ARRAY_EXPRESS ]   CCT4 [ SEEK ]   CCT4 [ MEM ]
Gene Expression Viewer (FireBrowse)CCT4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10575
GTEX Portal (Tissue expression)CCT4
Human Protein AtlasENSG00000115484-CCT4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP50991   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP50991  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP50991
Splice isoforms : SwissVarP50991
PhosPhoSitePlusP50991
Domaine pattern : Prosite (Expaxy)TCP1_1 (PS00750)    TCP1_2 (PS00751)    TCP1_3 (PS00995)   
Domains : Interpro (EBI)Chap_CCT_delta    Chaperone_TCP-1    Chaperonin_TCP-1_CS    Cpn60/TCP-1    GroEL-like_apical_dom    GROEL-like_equatorial    TCP-1-like_intermed   
Domain families : Pfam (Sanger)Cpn60_TCP1 (PF00118)   
Domain families : Pfam (NCBI)pfam00118   
Conserved Domain (NCBI)CCT4
DMDM Disease mutations10575
Blocks (Seattle)CCT4
SuperfamilyP50991
Human Protein Atlas [tissue]ENSG00000115484-CCT4 [tissue]
Peptide AtlasP50991
HPRD05506
IPIIPI00302927   IPI01015917   IPI01015038   IPI01014604   
Protein Interaction databases
DIP (DOE-UCLA)P50991
IntAct (EBI)P50991
FunCoupENSG00000115484
BioGRIDCCT4
STRING (EMBL)CCT4
ZODIACCCT4
Ontologies - Pathways
QuickGOP50991
Ontology : AmiGOzona pellucida receptor complex  RNA binding  protein binding  ATP binding  nucleoplasm  centrosome  cytosol  cytosol  chaperonin-containing T-complex  chaperonin-containing T-complex  microtubule  protein folding  'de novo' protein folding  binding of sperm to zona pellucida  positive regulation of telomere maintenance via telomerase  melanosome  cell projection  protein binding involved in protein folding  cell body  protein stabilization  unfolded protein binding  positive regulation of telomerase activity  chaperone-mediated protein folding  extracellular exosome  scaRNA localization to Cajal body  toxin transport  positive regulation of establishment of protein localization to telomere  positive regulation of protein localization to Cajal body  positive regulation of telomerase RNA localization to Cajal body  
Ontology : EGO-EBIzona pellucida receptor complex  RNA binding  protein binding  ATP binding  nucleoplasm  centrosome  cytosol  cytosol  chaperonin-containing T-complex  chaperonin-containing T-complex  microtubule  protein folding  'de novo' protein folding  binding of sperm to zona pellucida  positive regulation of telomere maintenance via telomerase  melanosome  cell projection  protein binding involved in protein folding  cell body  protein stabilization  unfolded protein binding  positive regulation of telomerase activity  chaperone-mediated protein folding  extracellular exosome  scaRNA localization to Cajal body  toxin transport  positive regulation of establishment of protein localization to telomere  positive regulation of protein localization to Cajal body  positive regulation of telomerase RNA localization to Cajal body  
Pathways : BIOCARTAB Cell Survival Pathway [Genes]   
NDEx NetworkCCT4
Atlas of Cancer Signalling NetworkCCT4
Wikipedia pathwaysCCT4
Orthology - Evolution
OrthoDB10575
GeneTree (enSembl)ENSG00000115484
Phylogenetic Trees/Animal Genes : TreeFamCCT4
HOVERGENP50991
HOGENOMP50991
Homologs : HomoloGeneCCT4
Homology/Alignments : Family Browser (UCSC)CCT4
Gene fusions - Rearrangements
Fusion: Tumor Portal CCT4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCCT4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CCT4
dbVarCCT4
ClinVarCCT4
1000_GenomesCCT4 
Exome Variant ServerCCT4
ExAC (Exome Aggregation Consortium)ENSG00000115484
GNOMAD BrowserENSG00000115484
Genetic variants : HAPMAP10575
Genomic Variants (DGV)CCT4 [DGVbeta]
DECIPHERCCT4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCCT4 
Mutations
ICGC Data PortalCCT4 
TCGA Data PortalCCT4 
Broad Tumor PortalCCT4
OASIS PortalCCT4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCCT4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCCT4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CCT4
DgiDB (Drug Gene Interaction Database)CCT4
DoCM (Curated mutations)CCT4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CCT4 (select a term)
intoGenCCT4
Cancer3DCCT4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605142   
Orphanet
MedgenCCT4
Genetic Testing Registry CCT4
NextProtP50991 [Medical]
TSGene10575
GENETestsCCT4
Target ValidationCCT4
Huge Navigator CCT4 [HugePedia]
snp3D : Map Gene to Disease10575
BioCentury BCIQCCT4
ClinGenCCT4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10575
Chemical/Pharm GKB GenePA26181
Clinical trialCCT4
Miscellaneous
canSAR (ICR)CCT4 (select the gene name)
Probes
Litterature
PubMed102 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCCT4
EVEXCCT4
GoPubMedCCT4
iHOPCCT4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 11:41:56 CET 2017

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