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CD151 (CD151 molecule (Raph blood group))

Written2009-07Judith Weidenhofer, Leonie K Ashman
Medical Biochemistry, School of Biomedical Sciences, Pharmacy, University of Newcastle, NSW, Australia

(Note : for Links provided by Atlas : click)

Identity

Alias_namesCD151 antigen
CD151 antigen (Raph blood group)
Alias_symbol (synonym)SFA-1
PETA-3
TSPAN24
RAPH
Other aliasGP27
MER2
PETA3
PETA3F
SFA1
Tspan-24
Tetraspanin-24
HGNC (Hugo) CD151
LocusID (NCBI) 977
Atlas_Id 967
Location 11p15.5  [Link to chromosome band 11p15]
Location_base_pair Starts at 832952 and ends at 838835 bp from pter ( according to hg19-Feb_2009)  [Mapping CD151.png]
Local_order Telomere--PNPLA2--EFCAB4A--CD151--POLR2L--TSPAN4--Centromere.
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CAPRIN1 (11p13) / CD151 (11p15.5)CD151 (11p15.5) / CRACR2B (11p15.5)CD151 (11p15.5) / DRD4 (11p15.5)
CD151 (11p15.5) / EPS8L2 (11p15.5)TSPAN4 (11p15.5) / CD151 (11p15.5)WDTC1 (1p36.11) / CD151 (11p15.5)

DNA/RNA

Note Information sourced from UCSC Genome Database Mar 2006 Assembly (hg18) RefSeq genes and from analysis of mouse gene organisation (Fitter et al., 1998) and human gene structure (Whittock et al., 2001).
 
  The red bars indicate utr and green bars indicate coding exons. The size of each intron is indicated at the top and each exon below. An alternate transcript may be generated from splicing out exon 2 in the 5'utr as indicated with the blue lines.
Description 5884 bp, 9 exons (7 coding).
Transcription mRNA 1574bp (length may vary for utr alternate splicing).
Pseudogene None in humans.

Protein

 
  The red bars indicate transmembrane regions as predicted by TMHMM (Krogh et al., 2001), with the green circles palmitoylation sites (Berditchevski et al., 2002). The blue Y indicates an N-linked glycosylation site (Fitter et al., 1995) and the light blue lines indicate approximate sites of potential di-sulphide bridges (Seigneuret et al., 2001).
Description Size: 253 aa, 28247 Da with a mature protein size of 32 kDa; pI: pH 7.44.
Post-translational modifications include disulphide bridges and an N-linked glycosylation site in the large extracellular loop and 6 palmitoylation sites.
Expression Widely expressed, particularly on epithelial cells, endothelial cells, Schwann cells, muscle cells, megakaryocytes and platelets. Tissues typically display expression restricted to these cell types with lung, kidney, spleen, tonsil and cardiac muscle all having high levels. Low expression detected on fibroblasts, erythrocytes and leukocytes (Sincock et al., 1997).
Highly expressed (mRNA) in: heart, uterus, lung, prostate, liver (adult), spleen, placenta, pancreas.
Low/no expression (mRNA) in: foetal liver, brain, testes, ovaries.
Localisation Plasma membrane, endosomes, endothelial cell junctions and hemidesmosomes in basal epithelial cells (Sincock et al., 1999; Sterk et al., 2000).
Function CD151 is a major component of tetraspanin enriched microdomains, which are platforms for assembly of membrane signalling complexes (Hemler et al., 2005; Charrin et al., 2009). CD151 functions in signal transduction through forming direct complexes with integrins particularly alpha3beta1, alpha6beta1, alpha6beta4 and alphaIIbbeta3, thereby influencing a variety of cell functions including motility and adhesion which are outlined further below. CD151 also affects matrix metalloproteinase activity, with overexpression of CD151 in human melanoma cells resulting in increased expression of MMP9 (Hong et al., 2006). CD151 has been shown to interact with pro-matrix metalloptroteinase 7 in osteoarthritic cartilage and regulate its activity (Fujita et al., 2006). In endothelial cells CD151 associates with the matrix metalloproteinase MT1-MMP and regulates its collagenolytic activity (Yañez-Mó et al., 2008).
Homology Tetraspanin protein family. This protein family has 33 members in humans and is well conserved throughout vertebrates and also present in invertebrates. Key characteristics include the presence of 4 transmembrane domains with both N- and C-terminals in the cytoplasm, conserved cysteine-containing motifs and disulphide bonds in the large extra cellular loop and charged residues in the transmembrane domains.

Mutations

Note Only 3 mutations have been identified in humans to date, two (G533A and C511T), are predicted not to significantly alter CD151 function and are not associated with disease (Karamatic Crew et al., 2004; Karamatic Crew et al., 2008).
Germinal Homozygous 1bp insertion, G383, resulting in a frameshift at Lys127 and a truncated protein at codon 140.
Homozygous G533A substitution resulting in an Arg178His mutation.
Homozygous C511T substitution resulting in an Arg171His mutation.

Implicated in

Note
Note In vitro studies
In vitro assays on Cd151-null keratinocytes, showed lack of migration compared to wild-type keratinocytes (Geary et al., 2008). Over-expression and knock-down studies of CD151 in various cell lines generally show that CD151 promotes migration and adhesion, however these finding are influenced by cell type and extracellular matrix components and primarily appear to be modified by the expression of the integrin alpha3beta1 (Berditchevski et al., 2002; Winterwood et al., 2006; Liu et al., 2007; Yang et al., 2008). CD151 is down-regulated by HIF-1alpha in colon cancer cells and is re-expressed upon normal oxygenation. This is proposed to allow detachment from the primary tumour and re-attachment at sites of metastasis (Chien et al., 2008).
Oncogenesis Increased CD151 expression may lead to enhanced tumour progression and metastatic capacity based on enhanced motility, migration and adhesion of CD151 expressing cells. Antibodies to CD151 blocked in vivo metastasis in model systems (Testa et al., 1999; Zijlstra et al., 2008). Xenograft breast cancer models involving silencing of CD151 showed a delay in tumour formation (Yang et al., 2008). CD151 expression is increased in metastasis compared to primary tumour site in colon cancer (Chien et al. 2008).
  
  
Entity Prostate cancer
Note Immunohistochemical detection of CD151 in a prostate cancer tissue specimens had greater prognostic value than Gleason grading (Ang et al., 2004).
Prognosis High CD151 expression was indicative of poor outcome.
Oncogenesis High CD151 expression indicated poor survival outcome, suggesting a role for CD151 in enhancing tumourigenesis or resistance to treatment. Also refer to 'In vitro studies'.
  
  
Entity Gingival squamous cell carcinoma
Note Real-time PCR analysis of CD151 gene expression compared to GAPDH was analysed (Hirano et al., 2009). Assessment of protein expression by immunohistochemistry correlated with gene expression however no statistical analyses were performed on protein expression.
Prognosis High CD151 expression was indicative of poor outcome.
Oncogenesis High CD151 expression indicated poor survival outcome, suggesting a role for CD151 in enhancing tumourigenesis or resistance to treatment. Also refer to 'In vitro studies'.
  
  
Entity Colon cancer
Note Real-time PCR analysis of CD151 gene expression compared to beta-actin was analysed (Hashida et al., 2003). Assessment of protein expression by immunohistochemistry correlated with gene expression however no statistical analyses were performed on protein expression.
Prognosis High CD151 expression was indicative of poor outcome.
Oncogenesis High CD151 expression indicated poor survival outcome, suggesting a role for CD151 in enhancing tumourigenesis or resistance to treatment. Also refer to 'In vitro studies'.
  
  
Entity Hepatocellular carcinoma
Note Real-time PCR analysis of CD151 gene expression compared to GAPDH was analysed. Assessment of protein expression by immunohistochemistry and immunoblotting generally correlated with gene expression. CD151 expression was increased in hepatocellular carcinomas compared to normal liver tissues (Ke et al., 2009).
Immunohistochemical analysis of tissue microarrays identified a positive correlation between CD151 expression and aggressive histopathological factors such as vascular invasion and poor tumour differentiation. CD151 expression was also indicative of poor outcome (Ke et al., 2009).
Prognosis High CD151 expression was indicative of poor outcome.
Oncogenesis High CD151 expression indicated poor survival outcome, suggesting a role for CD151 in enhancing tumourigenesis or resistance to treatment. Also refer to 'In vitro studies'.
  
  
Entity Non-small cell lung carcinoma
Note Real-time PCR analysis of CD151 gene expression compared to beta-actin was analysed (Tokuhara et al., 2001). Assessment of protein expression by immunohistochemistry correlated with gene expression however no statistical analyses were performed on protein expression.
Prognosis High CD151 expression was indicative of poor outcome.
Oncogenesis High CD151 expression indicated poor survival outcome, suggesting a role for CD151 in enhancing tumourigenesis or resistance to treatment. Also refer to 'In vitro studies'.
  
  
Entity Breast cancer
Note Immunohistochemical analysis of CD151 expression in a cohort of invasive ductal carcinoma identified a significantly higher risk of death from breast cancer in CD151 positive tumours compared to CD151 negative tumours. CD151 expression was also positively associated with the involvement of regional lymph nodes. No associations between CD151 expression and other clinical factors including estrogen receptor status were found (Sadej et al.,2009).
Immunohistochemical analysis of CD151 in breast tissue Microarrays identified positive correlations between CD151 expression and high tumour grade as well as negativity for the estrogen receptor. No other associations were identified between CD151 expression and clinical factors (Yang et al., 2008). Associations between CD151 expression and outcome were not able to be made due to unavailability of data.
Prognosis High CD151 expression was indicative of poor outcome.
Oncogenesis High CD151 expression indicated poor survival outcome, suggesting a role for CD151 in enhancing tumourigenesis or resistance to treatment. Also refer to 'In vitro studies'.
  
  
Entity Pancreatic cancer
Note Immunohistochemical analysis of pancreatic cancer cell lines and pancreatic tumours identified high CD151 expression associated with tumours/cell lines compared to normal tissue. Tumour stroma also expressed CD151 (Geiserich et al., 2005).
Oncogenesis Refer to 'In vitro studies'.
  
  
Entity Neovascularisation/Pathologic Angiogenesis
Note Determined from in vivo studies in Cd151-null mice and in vitro studies of Cd151-null mouse lung endothelial cells (Takeda et al., 2007). Analysis of a rat myocardial ischaemia model also showed that viral delivery of CD151 can promote neovascularisation (Zheng and Liu, 2006).
Disease Cancer, ischaemia
Oncogenesis Lack of Cd151 expression resulted in impaired tumour angiogenesis, suggesting that Cd151 may be involved in promoting tumour angiogenesis.
  
  
Entity Nephropathy
Note CD151 is expressed normally in the kidney particularly in the glomerular basement membrane (Sincock et al., 1997).
Disease Nephropathy in humans (Karamatic Crew et al., 2004).
Cd151-null mice develop progressive renal failure on the FVB/N strain but not the C57BL/6 strain (Sachs et al., 2006; Baleato et al., 2008).
Prognosis Loss of CD151 activity leads to chronic renal failure.
Cytogenetics Homozygous frameshift mutation causing a premature stop codon (codon 140) due to the insertion of 1bp in exon 5 of CD151 (G383).
Hybrid/Mutated Gene Resultant protein lacks the integrin binding domain and causes null expression of the CD151/MER2 antigen (Karamatic Crew et al., 2004).
  
  
Entity Pretibial epidermolysis bullosa
Note The Nephropathy described above is attributed to the same mutation in CD151 and occurs in conjunction with pretibial epidermolysis bullosa and deafness (Karamatic Crew et al., 2004).
Wound repair in wild-type mice is associated with an up-regulation of Cd151 in the migrating epidermis at the wound edge (Cowin et al. 2006).
Disease Pretibial epidermolysis bullosa in humans.
Defective wound repair in Cd151-null mice (Cowin et al. 2006; Geary et al 2008).
Cytogenetics Homozygous frameshift mutation causing a premature stop codon (codon 140) due to the insertion of 1bp in exon 5 of CD151 (G383).
Hybrid/Mutated Gene Resultant protein lacks the integrin binding domain and causes null expression of the CD151/MER2 antigen.
  
  
Entity Deafness
Note This loss of function of CD151 is attributed to the same mutation in CD151 as that described above for nephropathy and pretibial epidermolysis bullosa, with all 3 disorders occurring in the same patients (Karamatic Crew et al., 2004).
Prognosis Progressive deafness occurring by early adulthood.
Cytogenetics Homozygous frameshift mutation causing a premature stop codon (codon 140) due to the insertion of 1bp in exon 5 of CD151 (G383).
Hybrid/Mutated Gene Resultant protein lacks the integrin binding domain and causes null expression of the CD151/MER2 antigen.
  
  
Entity Hemostasis
Note As assessed in Cd151-null mice, loss of Cd151 caused increased bleeding time and decreased clotting ability, suggesting endothelial and/or platelet cell functional defects. Cd151-null mice did not show any overt physiological differences unless challenged (Wright et al., 2004). Further in vitro analysis of Cd151-null platelets showed impaired functions relating to aggregation, spreading and clot retraction (Lau et al., 2004).
  

Bibliography

CD151 protein expression predicts the clinical outcome of low-grade primary prostate cancer better than histologic grading: a new prognostic indicator?
Ang J, Lijovic M, Ashman LK, Kan K, Frauman AG.
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PMID 15533898
 
Deletion of CD151 results in a strain-dependent glomerular disease due to severe alterations of the glomerular basement membrane.
Baleato RM, Guthrie PL, Gubler MC, Ashman LK, Roselli S.
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PMID 18787104
 
Expression of the palmitoylation-deficient CD151 weakens the association of alpha 3 beta 1 integrin with the tetraspanin-enriched microdomains and affects integrin-dependent signaling.
Berditchevski F, Odintsova E, Sawada S, Gilbert E.
J Biol Chem. 2002 Oct 4;277(40):36991-7000. Epub 2002 Jul 10.
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Lateral organization of membrane proteins: tetraspanins spin their web.
Charrin S, le Naour F, Silvie O, Milhiet PE, Boucheix C, Rubinstein E.
Biochem J. 2009 May 13;420(2):133-54. (REVIEW)
PMID 19426143
 
Regulation of CD151 by hypoxia controls cell adhesion and metastasis in colorectal cancer.
Chien CW, Lin SC, Lai YY, Lin BW, Lin SC, Lee JC, Tsai SJ.
Clin Cancer Res. 2008 Dec 15;14(24):8043-51. Epub 2008 Dec 10.
PMID 19073968
 
Wound healing is defective in mice lacking tetraspanin CD151.
Cowin AJ, Adams D, Geary SM, Wright MD, Jones JC, Ashman LK.
J Invest Dermatol. 2006 Mar;126(3):680-9.
PMID 16410781
 
Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms.
Fitter S, Seldin MF, Ashman LK.
Biochim Biophys Acta. 1998 May 29;1398(1):75-85.
PMID 9602068
 
Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3.
Fitter S, Tetaz TJ, Berndt MC, Ashman LK.
Blood. 1995 Aug 15;86(4):1348-55.
PMID 7632941
 
Tetraspanin CD151 is expressed in osteoarthritic cartilage and is involved in pericellular activation of pro-matrix metalloproteinase 7 in osteoarthritic chondrocytes.
Fujita Y, Shiomi T, Yanagimoto S, Matsumoto H, Toyama Y, Okada Y.
Arthritis Rheum. 2006 Oct;54(10):3233-43.
PMID 17009258
 
The role of the tetraspanin CD151 in primary keratinocyte and fibroblast functions: implications for wound healing.
Geary SM, Cowin AJ, Copeland B, Baleato RM, Miyazaki K, Ashman LK.
Exp Cell Res. 2008 Jul 1;314(11-12):2165-75. Epub 2008 May 3.
PMID 18534576
 
Colocalization of the tetraspanins, CO-029 and CD151, with integrins in human pancreatic adenocarcinoma: impact on cell motility.
Gesierich S, Paret C, Hildebrand D, Weitz J, Zgraggen K, Schmitz-Winnenthal FH, Horejsi V, Yoshie O, Herlyn D, Ashman LK, Zoller M.
Clin Cancer Res. 2005 Apr 15;11(8):2840-52.
PMID 15837731
 
Clinical significance of transmembrane 4 superfamily in colon cancer.
Hashida H, Takabayashi A, Tokuhara T, Hattori N, Taki T, Hasegawa H, Satoh S, Kobayashi N, Yamaoka Y, Miyake M.
Br J Cancer. 2003 Jul 7;89(1):158-67.
PMID 12838318
 
Tetraspanin functions and associated microdomains.
Hemler ME.
Nat Rev Mol Cell Biol. 2005 Oct;6(10):801-11. (REVIEW)
PMID 16314869
 
Tetraspanin gene expression levels as potential biomarkers for malignancy of gingival squamous cell carcinoma.
Hirano C, Nagata M, Noman AA, Kitamura N, Ohnishi M, Ohyama T, Kobayashi T, Suzuki K, Yoshizawa M, Izumi N, Fujita H, Takagi R.
Int J Cancer. 2009 Jun 15;124(12):2911-6.
PMID 19330835
 
Homophilic interactions of Tetraspanin CD151 up-regulate motility and matrix metalloproteinase-9 expression of human melanoma cells through adhesion-dependent c-Jun activation signaling pathways.
Hong IK, Jin YJ, Byun HJ, Jeoung DI, Kim YM, Lee H.
J Biol Chem. 2006 Aug 25;281(34):24279-92. Epub 2006 Jun 23.
PMID 16798740
 
Two MER2-negative individuals with the same novel CD151 mutation and evidence for clinical significance of anti-MER2.
Karamatic Crew V, Poole J, Long S, Warke N, Colavecchia C, Burton N, Moulds M, Schlanser G, Wilson L, Noumsi G, Moulds JM, Moulds JJ, Daniels G.
Transfusion. 2008 Sep;48(9):1912-6. Epub 2008 Jun 2.
PMID 18522704
 
Role of overexpression of CD151 and/or c-Met in predicting prognosis of hepatocellular carcinoma.
Ke AW, Shi GM, Zhou J, Wu FZ, Ding ZB, Hu MY, Xu Y, Song ZJ, Wang ZJ, Wu JC, Bai DS, Li JC, Liu KD, Fan J.
Hepatology. 2009 Feb;49(2):491-503.
PMID 19065669
 
Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes.
Krogh A, Larsson B, von Heijne G, Sonnhammer EL.
J Mol Biol. 2001 Jan 19;305(3):567-80.
PMID 11152613
 
The tetraspanin superfamily member CD151 regulates outside-in integrin alphaIIbbeta3 signaling and platelet function.
Lau LM, Wee JL, Wright MD, Moseley GW, Hogarth PM, Ashman LK, Jackson DE.
Blood. 2004 Oct 15;104(8):2368-75. Epub 2004 Jun 29.
PMID 15226180
 
Tetraspanin CD151 promotes cell migration by regulating integrin trafficking.
Liu L, He B, Liu WM, Zhou D, Cox JV, Zhang XA.
J Biol Chem. 2007 Oct 26;282(43):31631-42. Epub 2007 Aug 23.
PMID 17716972
 
Kidney failure in mice lacking the tetraspanin CD151.
Sachs N, Kreft M, van den Bergh Weerman MA, Beynon AJ, Peters TA, Weening JJ, Sonnenberg A.
J Cell Biol. 2006 Oct 9;175(1):33-9. Epub 2006 Oct 2.
PMID 17015618
 
CD151 regulates tumorigenesis by modulating the communication between tumor cells and endothelium.
Sadej R, Romanska H, Baldwin G, Gkirtzimanaki K, Novitskaya V, Filer AD, Krcova Z, Kusinska R, Ehrmann J, Buckley CD, Kordek R, Potemski P, Eliopoulos AG, Lalani el-N, Berditchevski F.
Mol Cancer Res. 2009 Jun;7(6):787-98. Epub 2009 Jun 16.
PMID 19531562
 
Structure of the tetraspanin main extracellular domain. A partially conserved fold with a structurally variable domain insertion.
Seigneuret M, Delaguillaumie A, Lagaudriere-Gesbert C, Conjeaud H.
J Biol Chem. 2001 Oct 26;276(43):40055-64. Epub 2001 Aug 1.
PMID 11483611
 
PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function.
Sincock PM, Fitter S, Parton RG, Berndt MC, Gamble JR, Ashman LK.
J Cell Sci. 1999 Mar;112 ( Pt 6):833-44.
PMID 10036233
 
The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes.
Sterk LM, Geuijen CA, Oomen LC, Calafat J, Janssen H, Sonnenberg A.
J Cell Biol. 2000 May 15;149(4):969-82.
PMID 10811835
 
Deletion of tetraspanin Cd151 results in decreased pathologic angiogenesis in vivo and in vitro.
Takeda Y, Kazarov AR, Butterfield CE, Hopkins BD, Benjamin LE, Kaipainen A, Hemler ME.
Blood. 2007 Feb 15;109(4):1524-32. Epub 2006 Oct 5.
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Eukaryotic expression cloning with an antimetastatic monoclonal antibody identifies a tetraspanin (PETA-3/CD151) as an effector of human tumor cell migration and metastasis.
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Clinical significance of CD151 gene expression in non-small cell lung cancer.
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Genomic organization, amplification, fine mapping, and intragenic polymorphisms of the human hemidesmosomal tetraspanin CD151 gene.
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PMID 11181065
 
A critical role for tetraspanin CD151 in alpha3beta1 and alpha6beta4 integrin-dependent tumor cell functions on laminin-5.
Winterwood NE, Varzavand A, Meland MN, Ashman LK, Stipp CS.
Mol Biol Cell. 2006 Jun;17(6):2707-21. Epub 2006 Mar 29.
PMID 16571677
 
Characterization of mice lacking the tetraspanin superfamily member CD151.
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Mol Cell Biol. 2004 Jul;24(13):5978-88.
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MT1-MMP collagenolytic activity is regulated through association with tetraspanin CD151 in primary endothelial cells.
Yanez-Mo M, Barreiro O, Gonzalo P, Batista A, Megias D, Genis L, Sachs N, Sala-Valdes M, Alonso MA, Montoya MC, Sonnenberg A, Arroyo AG, Sanchez-Madrid F.
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CD151 accelerates breast cancer by regulating alpha 6 integrin function, signaling, and molecular organization.
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Cancer Res. 2008 May 1;68(9):3204-13.
PMID 18451146
 
CD151 gene delivery activates PI3K/Akt pathway and promotes neovascularization after myocardial infarction in rats.
Zheng Z, Liu Z.
Mol Med. 2006 Sep-Oct;12(9-10):214-20.
PMID 17225869
 
The inhibition of tumor cell intravasation and subsequent metastasis via regulation of in vivo tumor cell motility by the tetraspanin CD151.
Zijlstra A, Lewis J, Degryse B, Stuhlmann H, Quigley JP.
Cancer Cell. 2008 Mar;13(3):221-34.
PMID 18328426
 

Citation

This paper should be referenced as such :
Weidenhofer, J ; Ashman, LK
CD151 (CD151 molecule (Raph blood group))
Atlas Genet Cytogenet Oncol Haematol. 2010;14(6):530-535.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/CD151ID967ch11p15.html


External links

Nomenclature
HGNC (Hugo)CD151   1630
LRG (Locus Reference Genomic)LRG_817
Cards
AtlasCD151ID967ch11p15
Entrez_Gene (NCBI)CD151  977  CD151 molecule (Raph blood group)
AliasesGP27; MER2; PETA-3; RAPH; 
SFA1; TSPAN24
GeneCards (Weizmann)CD151
Ensembl hg19 (Hinxton)ENSG00000177697 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000177697 [Gene_View]  chr11:832952-838835 [Contig_View]  CD151 [Vega]
ICGC DataPortalENSG00000177697
TCGA cBioPortalCD151
AceView (NCBI)CD151
Genatlas (Paris)CD151
WikiGenes977
SOURCE (Princeton)CD151
Genetics Home Reference (NIH)CD151
Genomic and cartography
GoldenPath hg38 (UCSC)CD151  -     chr11:832952-838835 +  11p15.5   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CD151  -     11p15.5   [Description]    (hg19-Feb_2009)
EnsemblCD151 - 11p15.5 [CytoView hg19]  CD151 - 11p15.5 [CytoView hg38]
Mapping of homologs : NCBICD151 [Mapview hg19]  CD151 [Mapview hg38]
OMIM179620   602243   609057   
Gene and transcription
Genbank (Entrez)AK130369 AK223186 AK293073 AL161965 AU099249
RefSeq transcript (Entrez)NM_001039490 NM_004357 NM_139029 NM_139030
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CD151
Cluster EST : UnigeneHs.654379 [ NCBI ]
CGAP (NCI)Hs.654379
Alternative Splicing GalleryENSG00000177697
Gene ExpressionCD151 [ NCBI-GEO ]   CD151 [ EBI - ARRAY_EXPRESS ]   CD151 [ SEEK ]   CD151 [ MEM ]
Gene Expression Viewer (FireBrowse)CD151 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)977
GTEX Portal (Tissue expression)CD151
Human Protein AtlasENSG00000177697-CD151 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48509   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP48509  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP48509
Splice isoforms : SwissVarP48509
PhosPhoSitePlusP48509
Domaine pattern : Prosite (Expaxy)TM4_1 (PS00421)   
Domains : Interpro (EBI)Tetraspanin    Tetraspanin/Peripherin    Tetraspanin_CS    Tetraspanin_EC2   
Domain families : Pfam (Sanger)Tetraspannin (PF00335)   
Domain families : Pfam (NCBI)pfam00335   
Conserved Domain (NCBI)CD151
DMDM Disease mutations977
Blocks (Seattle)CD151
SuperfamilyP48509
Human Protein Atlas [tissue]ENSG00000177697-CD151 [tissue]
Peptide AtlasP48509
HPRD03763
IPIIPI00298851   IPI00976802   IPI00913970   IPI01025366   IPI00976681   IPI00982755   IPI00976013   IPI00981460   IPI00978389   IPI00979075   IPI00982114   IPI00980430   IPI00976765   
Protein Interaction databases
DIP (DOE-UCLA)P48509
IntAct (EBI)P48509
FunCoupENSG00000177697
BioGRIDCD151
STRING (EMBL)CD151
ZODIACCD151
Ontologies - Pathways
QuickGOP48509
Ontology : AmiGOintegrin binding  protein binding  basement membrane  cytosol  plasma membrane  integral component of plasma membrane  focal adhesion  cell adhesion  cell surface receptor signaling pathway  membrane  cell migration  hemidesmosome assembly  T cell proliferation  
Ontology : EGO-EBIintegrin binding  protein binding  basement membrane  cytosol  plasma membrane  integral component of plasma membrane  focal adhesion  cell adhesion  cell surface receptor signaling pathway  membrane  cell migration  hemidesmosome assembly  T cell proliferation  
REACTOMEP48509 [protein]
REACTOME PathwaysR-HSA-446107 [pathway]   
NDEx NetworkCD151
Atlas of Cancer Signalling NetworkCD151
Wikipedia pathwaysCD151
Orthology - Evolution
OrthoDB977
GeneTree (enSembl)ENSG00000177697
Phylogenetic Trees/Animal Genes : TreeFamCD151
HOVERGENP48509
HOGENOMP48509
Homologs : HomoloGeneCD151
Homology/Alignments : Family Browser (UCSC)CD151
Gene fusions - Rearrangements
Fusion : MitelmanCD151/CRACR2B [11p15.5/11p15.5]  
Fusion : MitelmanCD151/DRD4 [11p15.5/11p15.5]  [t(11;11)(p15;p15)]  
Fusion : MitelmanCD151/EPS8L2 [11p15.5/11p15.5]  [t(11;11)(p15;p15)]  
Fusion : MitelmanWDTC1/CD151 [1p36.11/11p15.5]  [t(1;11)(p36;p15)]  
Fusion: TCGACD151 11p15.5 EFCAB4A BRCA
Fusion: TCGACD151 11p15.5 EPS8L2 11p15.5 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCD151 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CD151
dbVarCD151
ClinVarCD151
1000_GenomesCD151 
Exome Variant ServerCD151
ExAC (Exome Aggregation Consortium)ENSG00000177697
GNOMAD BrowserENSG00000177697
Genetic variants : HAPMAP977
Genomic Variants (DGV)CD151 [DGVbeta]
DECIPHERCD151 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCD151 
Mutations
ICGC Data PortalCD151 
TCGA Data PortalCD151 
Broad Tumor PortalCD151
OASIS PortalCD151 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCD151  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCD151
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CD151
DgiDB (Drug Gene Interaction Database)CD151
DoCM (Curated mutations)CD151 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CD151 (select a term)
intoGenCD151
NCG5 (London)CD151
Cancer3DCD151(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM179620    602243    609057   
Orphanet21112   
MedgenCD151
Genetic Testing Registry CD151
NextProtP48509 [Medical]
TSGene977
GENETestsCD151
Target ValidationCD151
Huge Navigator CD151 [HugePedia]
snp3D : Map Gene to Disease977
BioCentury BCIQCD151
ClinGenCD151
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD977
Chemical/Pharm GKB GenePA26189
Clinical trialCD151
Miscellaneous
canSAR (ICR)CD151 (select the gene name)
Probes
Litterature
PubMed118 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCD151
EVEXCD151
GoPubMedCD151
iHOPCD151
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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