CD177 (CD177 molecule)

2015-02-01  

Identity

HGNC
LOCATION
19q13.31
LOCUSID
ALIAS
HNA-2a,HNA2A,NB1,NB1
FUSION GENES

Other Information

Locus ID:

NCBI: 57126
MIM: 162860
HGNC: 30072
Ensembl: ENSG00000204936

Variants:

dbSNP: 57126
ClinVar: 57126
TCGA: ENSG00000204936
COSMIC: CD177

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204936ENST00000378012Q8N6Q3
ENSG00000204936ENST00000607855A0A087X113
ENSG00000204936ENST00000618265A0A087WVM2

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
HemostasisREACTOMER-HSA-109582
Formation of Fibrin Clot (Clotting Cascade)REACTOMER-HSA-140877
Common Pathway of Fibrin Clot FormationREACTOMER-HSA-140875
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
175803082007The neutrophil-specific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31).68
172446762007NB1 mediates surface expression of the ANCA antigen proteinase 3 on human neutrophils.34
211934072011Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-ANCA neutrophil activation.23
222662792012Proteinase 3 contributes to transendothelial migration of NB1-positive neutrophils.23
201947262010Neutrophil transmigration mediated by the neutrophil-specific antigen CD177 is influenced by the endothelial S536N dimorphism of platelet endothelial cell adhesion molecule-1.22
188543172008A hydrophobic patch on proteinase 3, the target of autoantibodies in Wegener granulomatosis, mediates membrane binding via NB1 receptors.21
288079802017CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation.20
204917912010Elevated neutrophil membrane expression of proteinase 3 is dependent upon CD177 expression.17
126238492003Lack of NB1 GP (CD177/HNA-2a) gene transcription in NB1 GP- neutrophils from NB1 GP-expressing individuals and association of low expression with NB1 gene polymorphisms.15
159855442005The Jak2V617F mutation, PRV-1 overexpression, and EEC formation define a similar cohort of MPD patients.15

Citation

Dessen P

CD177 (CD177 molecule)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/54964/cd177