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CD19 (CD19 molecule)

Identity

Alias_namesCD19 antigen
Other aliasB4
CVID3
HGNC (Hugo) CD19
LocusID (NCBI) 930
Atlas_Id 969
Location 16p11.2  [Link to chromosome band 16p11]
Location_base_pair Starts at 28931939 and ends at 28939347 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ZNF430 (19p12) / CD19 (16p11.2)ZNF430 19p12 / CD19 16p11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 16 ]
  dic(3;9)(p14;p13) PAX5/FOXP1
dic(7;9)(p11-12;p12-13) PAX5/LOC392027
dic(9;12)(p13;p12) PAX5/SLCO1B3
dic(9;16)(p13;q11) PAX5/?
dic(9;17)(p13;q11) PAX5/TAOK1
dic(9;18)(p13;q11) PAX5/ZNF521
t(1;9)(p13;p12) PAX5/HIPK1
t(7;9)(q11;p12) PAX5/POM121
t(9;9)(p13;p24) PAX5/JAK2::del(9)(p13p24) PAX5/JAK2::inv(9)(p13p24) PAX5/JAK2
t(9;13)(p12;q21) PAX5/DACH1
t(9;15)(p13;q24) PAX5/PML
t(9;15)(p13;q24) PAX5/GOLGA6A
t(9;17)(p13;p12) PAX5/NCOR1
t(9;22)(p13;q13) PAX5/BRD1
t(2;12)(p12;p13) IGK/CCND2::t(12;14)(p13;q32) IGH/CCND2::t(12;22)(p13;q11) IGL/CCND2
t(X;9)(q21;p13) PAX5/DACH2


External links

Nomenclature
HGNC (Hugo)CD19   1633
LRG (Locus Reference Genomic)LRG_35
Cards
Entrez_Gene (NCBI)CD19  930  CD19 molecule
AliasesB4; CVID3
GeneCards (Weizmann)CD19
Ensembl hg19 (Hinxton)ENSG00000177455 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000177455 [Gene_View]  chr16:28931939-28939347 [Contig_View]  CD19 [Vega]
ICGC DataPortalENSG00000177455
TCGA cBioPortalCD19
AceView (NCBI)CD19
Genatlas (Paris)CD19
WikiGenes930
SOURCE (Princeton)CD19
Genetics Home Reference (NIH)CD19
Genomic and cartography
GoldenPath hg38 (UCSC)CD19  -     chr16:28931939-28939347 +  16p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)CD19  -     16p11.2   [Description]    (hg19-Feb_2009)
EnsemblCD19 - 16p11.2 [CytoView hg19]  CD19 - 16p11.2 [CytoView hg38]
Mapping of homologs : NCBICD19 [Mapview hg19]  CD19 [Mapview hg38]
OMIM107265   240500   613493   
Gene and transcription
Genbank (Entrez)AA760729 AK130657 AK301167 AK301363 AK304456
RefSeq transcript (Entrez)NM_001178098 NM_001770
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)CD19
Cluster EST : UnigeneHs.652262 [ NCBI ]
CGAP (NCI)Hs.652262
Alternative Splicing GalleryENSG00000177455
Gene ExpressionCD19 [ NCBI-GEO ]   CD19 [ EBI - ARRAY_EXPRESS ]   CD19 [ SEEK ]   CD19 [ MEM ]
Gene Expression Viewer (FireBrowse)CD19 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)930
GTEX Portal (Tissue expression)CD19
Protein : pattern, domain, 3D structure
UniProt/SwissProtP15391   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP15391  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP15391
Splice isoforms : SwissVarP15391
PhosPhoSitePlusP15391
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_sub   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)IG (SM00409)  
Conserved Domain (NCBI)CD19
DMDM Disease mutations930
Blocks (Seattle)CD19
SuperfamilyP15391
Human Protein AtlasENSG00000177455
Peptide AtlasP15391
HPRD00113
IPIIPI00305031   IPI01010612   IPI00442499   IPI00980816   
Protein Interaction databases
DIP (DOE-UCLA)P15391
IntAct (EBI)P15391
FunCoupENSG00000177455
BioGRIDCD19
STRING (EMBL)CD19
ZODIACCD19
Ontologies - Pathways
QuickGOP15391
Ontology : AmiGOsignal transducer activity, downstream of receptor  protein binding  intracellular  plasma membrane  integral component of plasma membrane  cellular defense response  cell surface receptor signaling pathway  external side of plasma membrane  regulation of phosphatidylinositol 3-kinase signaling  protein complex  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  regulation of immune response  B cell receptor signaling pathway  positive regulation of release of sequestered calcium ion into cytosol  extracellular exosome  
Ontology : EGO-EBIsignal transducer activity, downstream of receptor  protein binding  intracellular  plasma membrane  integral component of plasma membrane  cellular defense response  cell surface receptor signaling pathway  external side of plasma membrane  regulation of phosphatidylinositol 3-kinase signaling  protein complex  phosphatidylinositol phosphorylation  phosphatidylinositol-4,5-bisphosphate 3-kinase activity  phosphatidylinositol-mediated signaling  regulation of immune response  B cell receptor signaling pathway  positive regulation of release of sequestered calcium ion into cytosol  extracellular exosome  
Pathways : KEGGPI3K-Akt signaling pathway    Hematopoietic cell lineage    B cell receptor signaling pathway    Epstein-Barr virus infection    Primary immunodeficiency   
NDEx NetworkCD19
Atlas of Cancer Signalling NetworkCD19
Wikipedia pathwaysCD19
Orthology - Evolution
OrthoDB930
GeneTree (enSembl)ENSG00000177455
Phylogenetic Trees/Animal Genes : TreeFamCD19
HOVERGENP15391
HOGENOMP15391
Homologs : HomoloGeneCD19
Homology/Alignments : Family Browser (UCSC)CD19
Gene fusions - Rearrangements
Fusion : MitelmanZNF430/CD19 [19p12/16p11.2]  [t(16;19)(p11;p12)]  
Fusion: TCGAZNF430 19p12 CD19 16p11.2 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCD19 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CD19
dbVarCD19
ClinVarCD19
1000_GenomesCD19 
Exome Variant ServerCD19
ExAC (Exome Aggregation Consortium)CD19 (select the gene name)
Genetic variants : HAPMAP930
Genomic Variants (DGV)CD19 [DGVbeta]
DECIPHERCD19 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisCD19 
Mutations
ICGC Data PortalCD19 
TCGA Data PortalCD19 
Broad Tumor PortalCD19
OASIS PortalCD19 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCD19  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCD19
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch CD19
DgiDB (Drug Gene Interaction Database)CD19
DoCM (Curated mutations)CD19 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CD19 (select a term)
intoGenCD19
Cancer3DCD19(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM107265    240500    613493   
Orphanet3469   
MedgenCD19
Genetic Testing Registry CD19
NextProtP15391 [Medical]
TSGene930
GENETestsCD19
Target ValidationCD19
Huge Navigator CD19 [HugePedia]
snp3D : Map Gene to Disease930
BioCentury BCIQCD19
ClinGenCD19
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD930
Chemical/Pharm GKB GenePA26192
Clinical trialCD19
Miscellaneous
canSAR (ICR)CD19 (select the gene name)
Probes
Litterature
PubMed109 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCD19
EVEXCD19
GoPubMedCD19
iHOPCD19
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:01:12 CEST 2017

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