CD1A (CD1a molecule)

2007-02-01  

Identity

HGNC
CD1A
LOCATION
1q23.1
LOCUSID
909
ALIAS
CD1,FCB6,HTA1,R4,T6
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 909
MIM: 188370
HGNC: 1634
Ensembl: ENSG00000158477

Variants:

dbSNP: 909
ClinVar: 909
TCGA: ENSG00000158477
COSMIC: CD1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158477ENST00000289429P06126

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Hematopoietic cell lineageKEGGko04640
Tight junctionKEGGhsa04530
Hematopoietic cell lineageKEGGhsa04640
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
149910682004Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells.81
157238092005Molecular mechanism of lipopeptide presentation by CD1a.58
263883322015Lipid and small-molecule display by CD1 and MR1.48
276705922016Psoriatic T cells recognize neolipid antigens generated by mast cell phospholipase delivered by exosomes and presented by CD1a.45
183378292008"Dermal dendritic cells" comprise two distinct populations: CD1+ dendritic cells and CD209+ macrophages.41
166702772006Cutting edge: CD1a+ antigen-presenting cells in human dermis respond rapidly to CCR7 ligands.39
205924742010Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function.33
275484352016CD1a on Langerhans cells controls inflammatory skin disease.32
162722862005CD1a-, b-, and c-restricted TCRs recognize both self and foreign antigens.27
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27

Citation

Dessen P

CD1A (CD1a molecule)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45832/cd1a