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CD2 (CD2 molecule)

Identity

Alias_namesSRBC
CD2 antigen (p50)
Other aliasLFA-2
T11
HGNC (Hugo) CD2
LocusID (NCBI) 914
Atlas_Id 971
Location 1p13.1  [Link to chromosome band 1p13]
Location_base_pair Starts at 117297086 and ends at 117311851 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
RAP1A (1p13.2) / CD2 (1p13.1)RAP1A 1p13.2 / CD2 1p13.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)CD2   1639
Cards
Entrez_Gene (NCBI)CD2  914  CD2 molecule
AliasesLFA-2; SRBC; T11
GeneCards (Weizmann)CD2
Ensembl hg19 (Hinxton)ENSG00000116824 [Gene_View]  chr1:117297086-117311851 [Contig_View]  CD2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000116824 [Gene_View]  chr1:117297086-117311851 [Contig_View]  CD2 [Vega]
ICGC DataPortalENSG00000116824
TCGA cBioPortalCD2
AceView (NCBI)CD2
Genatlas (Paris)CD2
WikiGenes914
SOURCE (Princeton)CD2
Genetics Home Reference (NIH)CD2
Genomic and cartography
GoldenPath hg19 (UCSC)CD2  -     chr1:117297086-117311851 +  1p13.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)CD2  -     1p13.1   [Description]    (hg38-Dec_2013)
EnsemblCD2 - 1p13.1 [CytoView hg19]  CD2 - 1p13.1 [CytoView hg38]
Mapping of homologs : NCBICD2 [Mapview hg19]  CD2 [Mapview hg38]
OMIM186990   
Gene and transcription
Genbank (Entrez)AK127925 AK223393 AK301154 AK303367 AK310676
RefSeq transcript (Entrez)NM_001767
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)CD2
Cluster EST : UnigeneHs.523500 [ NCBI ]
CGAP (NCI)Hs.523500
Alternative Splicing GalleryENSG00000116824
Gene ExpressionCD2 [ NCBI-GEO ]   CD2 [ EBI - ARRAY_EXPRESS ]   CD2 [ SEEK ]   CD2 [ MEM ]
Gene Expression Viewer (FireBrowse)CD2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)914
GTEX Portal (Tissue expression)CD2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP06729   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP06729  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP06729
Splice isoforms : SwissVarP06729
PhosPhoSitePlusP06729
Domains : Interpro (EBI)CD2    Ig-like_dom    Ig-like_fold    Ig_C2-set    Ig_V-set   
Domain families : Pfam (Sanger)C2-set (PF05790)    V-set (PF07686)   
Domain families : Pfam (NCBI)pfam05790    pfam07686   
Conserved Domain (NCBI)CD2
DMDM Disease mutations914
Blocks (Seattle)CD2
PDB (SRS)1CDB    1GYA    1HNF    1L2Z    1QA9    2J6O    2J7I   
PDB (PDBSum)1CDB    1GYA    1HNF    1L2Z    1QA9    2J6O    2J7I   
PDB (IMB)1CDB    1GYA    1HNF    1L2Z    1QA9    2J6O    2J7I   
PDB (RSDB)1CDB    1GYA    1HNF    1L2Z    1QA9    2J6O    2J7I   
Structural Biology KnowledgeBase1CDB    1GYA    1HNF    1L2Z    1QA9    2J6O    2J7I   
SCOP (Structural Classification of Proteins)1CDB    1GYA    1HNF    1L2Z    1QA9    2J6O    2J7I   
CATH (Classification of proteins structures)1CDB    1GYA    1HNF    1L2Z    1QA9    2J6O    2J7I   
SuperfamilyP06729
Human Protein AtlasENSG00000116824
Peptide AtlasP06729
HPRD01750
IPIIPI00027484   IPI00910919   IPI00909006   
Protein Interaction databases
DIP (DOE-UCLA)P06729
IntAct (EBI)P06729
FunCoupENSG00000116824
BioGRIDCD2
STRING (EMBL)CD2
ZODIACCD2
Ontologies - Pathways
QuickGOP06729
Ontology : AmiGOmembrane raft polarization  receptor activity  receptor binding  protein binding  extracellular region  plasma membrane  integral component of plasma membrane  cell-cell junction  apoptotic process  cell surface receptor signaling pathway  external side of plasma membrane  cytoplasmic side of plasma membrane  cell surface  single organismal cell-cell adhesion  natural killer cell activation  positive regulation of myeloid dendritic cell activation  positive regulation of tumor necrosis factor production  heterotypic cell-cell adhesion  T cell activation  protein homodimerization activity  regulation of T cell differentiation  anchored component of plasma membrane  leukocyte migration  positive regulation of interferon-gamma secretion  positive regulation of interleukin-8 secretion  
Ontology : EGO-EBImembrane raft polarization  receptor activity  receptor binding  protein binding  extracellular region  plasma membrane  integral component of plasma membrane  cell-cell junction  apoptotic process  cell surface receptor signaling pathway  external side of plasma membrane  cytoplasmic side of plasma membrane  cell surface  single organismal cell-cell adhesion  natural killer cell activation  positive regulation of myeloid dendritic cell activation  positive regulation of tumor necrosis factor production  heterotypic cell-cell adhesion  T cell activation  protein homodimerization activity  regulation of T cell differentiation  anchored component of plasma membrane  leukocyte migration  positive regulation of interferon-gamma secretion  positive regulation of interleukin-8 secretion  
Pathways : BIOCARTAIL 17 Signaling Pathway [Genes]    Dendritic cells in regulating TH1 and TH2 Development [Genes]    Stathmin and breast cancer resistance to antimicrotubule agents [Genes]    T Cytotoxic Cell Surface Molecules [Genes]    T Helper Cell Surface Molecules [Genes]    NO2-dependent IL 12 Pathway in NK cells [Genes]   
Pathways : KEGGCell adhesion molecules (CAMs)    Hematopoietic cell lineage   
NDEx NetworkCD2
Atlas of Cancer Signalling NetworkCD2
Wikipedia pathwaysCD2
Orthology - Evolution
OrthoDB914
GeneTree (enSembl)ENSG00000116824
Phylogenetic Trees/Animal Genes : TreeFamCD2
HOVERGENP06729
HOGENOMP06729
Homologs : HomoloGeneCD2
Homology/Alignments : Family Browser (UCSC)CD2
Gene fusions - Rearrangements
Fusion : MitelmanRAP1A/CD2 [1p13.2/1p13.1]  [t(1;1)(p13;p13)]  
Fusion: TCGARAP1A 1p13.2 CD2 1p13.1 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerCD2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)CD2
dbVarCD2
ClinVarCD2
1000_GenomesCD2 
Exome Variant ServerCD2
ExAC (Exome Aggregation Consortium)CD2 (select the gene name)
Genetic variants : HAPMAP914
Genomic Variants (DGV)CD2 [DGVbeta]
DECIPHER (Syndromes)1:117297086-117311851  ENSG00000116824
CONAN: Copy Number AnalysisCD2 
Mutations
ICGC Data PortalCD2 
TCGA Data PortalCD2 
Broad Tumor PortalCD2
OASIS PortalCD2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICCD2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDCD2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch CD2
DgiDB (Drug Gene Interaction Database)CD2
DoCM (Curated mutations)CD2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)CD2 (select a term)
intoGenCD2
Cancer3DCD2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM186990   
Orphanet
MedgenCD2
Genetic Testing Registry CD2
NextProtP06729 [Medical]
TSGene914
GENETestsCD2
Huge Navigator CD2 [HugePedia]
snp3D : Map Gene to Disease914
BioCentury BCIQCD2
ClinGenCD2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD914
Chemical/Pharm GKB GenePA26198
Clinical trialCD2
Miscellaneous
canSAR (ICR)CD2 (select the gene name)
Probes
Litterature
PubMed101 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineCD2
EVEXCD2
GoPubMedCD2
iHOPCD2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:59:20 CET 2017

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